SI21302A - Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino - Google Patents
Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino Download PDFInfo
- Publication number
- SI21302A SI21302A SI200200244A SI200200244A SI21302A SI 21302 A SI21302 A SI 21302A SI 200200244 A SI200200244 A SI 200200244A SI 200200244 A SI200200244 A SI 200200244A SI 21302 A SI21302 A SI 21302A
- Authority
- SI
- Slovenia
- Prior art keywords
- gas
- pharmaceutical
- active ingredient
- amorphous active
- stable
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 35
- 239000004480 active ingredient Substances 0.000 title claims description 41
- 229940127557 pharmaceutical product Drugs 0.000 title claims description 33
- 229960001770 atorvastatin calcium Drugs 0.000 claims abstract description 64
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 claims abstract description 63
- 238000000034 method Methods 0.000 claims abstract description 46
- 239000013543 active substance Substances 0.000 claims abstract description 27
- 230000006641 stabilisation Effects 0.000 claims abstract description 17
- 238000011105 stabilization Methods 0.000 claims abstract description 17
- 239000012298 atmosphere Substances 0.000 claims description 44
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 29
- 239000011261 inert gas Substances 0.000 claims description 21
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 20
- 239000007789 gas Substances 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 238000004806 packaging method and process Methods 0.000 claims description 12
- 229910052786 argon Inorganic materials 0.000 claims description 10
- 230000000087 stabilizing effect Effects 0.000 claims description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 8
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 8
- 239000008188 pellet Substances 0.000 claims description 7
- 239000004033 plastic Substances 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 229920001519 homopolymer Polymers 0.000 claims description 6
- 238000007664 blowing Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229940126534 drug product Drugs 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 description 27
- 229910052760 oxygen Inorganic materials 0.000 description 27
- 239000000126 substance Substances 0.000 description 27
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 26
- 239000007857 degradation product Substances 0.000 description 23
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 102100029077 3-hydroxy-3-methylglutaryl-coenzyme A reductase Human genes 0.000 description 2
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 description 2
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 150000002596 lactones Chemical group 0.000 description 2
- 229960001021 lactose monohydrate Drugs 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XUKUURHRXDUEBC-SVBPBHIXSA-N (3s,5s)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@H](O)C[C@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-SVBPBHIXSA-N 0.000 description 1
- 101710158485 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960005370 atorvastatin Drugs 0.000 description 1
- 238000005422 blasting Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000013039 cover film Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200200244A SI21302A (sl) | 2002-10-11 | 2002-10-11 | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
| TW092127769A TWI320709B (en) | 2002-10-11 | 2003-10-07 | Stabilized pharmaceutical composition comprising an amorphous active substance |
| SK5006-2007U SK5233Y1 (en) | 2002-10-11 | 2003-10-10 | Stabilized pharmaceutical preparation comprising amorphous atorvastatin calcium and method for packaging and stabilisation thereof |
| PCT/EP2003/011265 WO2004032920A1 (en) | 2002-10-11 | 2003-10-10 | Stabilized pharmaceutical preparation comprising an amorphous active substance |
| CNB2003801009910A CN100372529C (zh) | 2002-10-11 | 2003-10-10 | 包含无定形活性物质的稳定药物制剂 |
| AT03770970T ATE354362T1 (de) | 2002-10-11 | 2003-10-10 | Stabilisierte pharmazeutische zusammensetzung enthaltend einen amorphen wirkstoff |
| AU2003280361A AU2003280361B2 (en) | 2002-10-11 | 2003-10-10 | Stabilized pharmaceutical preparation comprising an amorphous active substance |
| ES03770970T ES2285205T3 (es) | 2002-10-11 | 2003-10-10 | Preparacion farmaceutica estable que comprende una substancia activa amorfa. |
| DE20321455U DE20321455U1 (de) | 2002-10-11 | 2003-10-10 | Stabilisiertes pharmazeutisches Erzeugnis, das einen amorphen Wirkstoff enthält |
| DE60312049T DE60312049T2 (de) | 2002-10-11 | 2003-10-10 | Stabilisierte pharmazeutische zusammensetzung enthaltend einen amorphen wirkstoff |
| PT03770970T PT1608362E (pt) | 2002-10-11 | 2003-10-10 | Preparação farmacêutica estabilizada incluindo uma substância activa amorfa |
| UAA200504398A UA85544C2 (ru) | 2002-10-11 | 2003-10-10 | Стабилизированный фармацевтический препарат аморфного аторвастатина кальция |
| MEP-2008-842A ME00514B (me) | 2002-10-11 | 2003-10-10 | Stabilizovani farmaceutski preparat koji sadrži amorfnu aktivnu supstancu |
| DK03770970T DK1608362T3 (da) | 2002-10-11 | 2003-10-10 | Stabiliseret farmaceutisk præparat indeholdende en amorf aktiv forbindelse |
| CZ200718450U CZ17610U1 (cs) | 2002-10-11 | 2003-10-10 | Stabilizovaný farmaceutický prípravek obsahující amorfní kalcium-atorvastatin |
| EP03770970A EP1608362B1 (en) | 2002-10-11 | 2003-10-10 | Stabilized pharmaceutical preparation comprising an amorphous active substance |
| YU20050273A RS51819B (sr) | 2002-10-11 | 2003-10-10 | Stabilizovani farmaceutski preparat koji sadrži amorfnu aktivnu supstancu |
| US10/683,683 US20040077708A1 (en) | 2002-10-11 | 2003-10-10 | Stablized pharmaceutical composition comprising an amorphous active substance |
| ARP030103710A AR041588A1 (es) | 2002-10-11 | 2003-10-10 | Composicion farmaceutica estabilizada que comprende una sustancia activa amorfa |
| RU2005114485/15A RU2358727C2 (ru) | 2002-10-11 | 2003-10-10 | Стабилизированный фармацевтический препарат, включающий аморфное активное вещество |
| SI200330805T SI1608362T1 (sl) | 2002-10-11 | 2003-10-10 | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
| DK200700025U DK200700025U4 (da) | 2002-10-11 | 2007-01-25 | Stabiliseret farmaceutisk præparat indeholdende en amorf aktiv forbindelse |
| FI20070036U FI7617U1 (fi) | 2002-10-11 | 2007-01-26 | Amorfisen aktiivisen ainesosan stabiloitu farmaseuttinen valmiste |
| AT0010907U AT10424U1 (de) | 2002-10-11 | 2007-02-20 | Fertigarzneimittel, enthaltend ein in inertgas gelagertes, amorphes atorvastatin-ca |
| CY20071100681T CY1106608T1 (el) | 2002-10-11 | 2007-05-21 | Σταθεροποιημενα φαρμακευτικα σκευασματα που περιλαμβανουν μια αμορφη δραστικη ουσια |
| US11/923,059 US20090012150A1 (en) | 2002-10-11 | 2007-10-24 | Stablized Pharmaceutical Composition Comprising an Amorphous Active Substance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200200244A SI21302A (sl) | 2002-10-11 | 2002-10-11 | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI21302A true SI21302A (sl) | 2004-04-30 |
Family
ID=32091984
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200200244A SI21302A (sl) | 2002-10-11 | 2002-10-11 | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
| SI200330805T SI1608362T1 (sl) | 2002-10-11 | 2003-10-10 | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200330805T SI1608362T1 (sl) | 2002-10-11 | 2003-10-10 | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20040077708A1 (ru) |
| EP (1) | EP1608362B1 (ru) |
| CN (1) | CN100372529C (ru) |
| AR (1) | AR041588A1 (ru) |
| AT (2) | ATE354362T1 (ru) |
| AU (1) | AU2003280361B2 (ru) |
| CY (1) | CY1106608T1 (ru) |
| CZ (1) | CZ17610U1 (ru) |
| DE (2) | DE20321455U1 (ru) |
| DK (2) | DK1608362T3 (ru) |
| ES (1) | ES2285205T3 (ru) |
| FI (1) | FI7617U1 (ru) |
| ME (1) | ME00514B (ru) |
| PT (1) | PT1608362E (ru) |
| RS (1) | RS51819B (ru) |
| RU (1) | RU2358727C2 (ru) |
| SI (2) | SI21302A (ru) |
| SK (1) | SK5233Y1 (ru) |
| TW (1) | TWI320709B (ru) |
| UA (1) | UA85544C2 (ru) |
| WO (1) | WO2004032920A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8044086B2 (en) | 2004-07-16 | 2011-10-25 | Lek Pharmaceuticals D.D. | Oxidative degradation products of atorvastatin calcium |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI20109A (sl) * | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
| US7411075B1 (en) * | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
| IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| US7501450B2 (en) | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| AU2002351271A1 (en) | 2001-12-21 | 2003-07-24 | Nektar Therapeutics | Capsule package with moisture barrier |
| PL379195A1 (pl) * | 2003-08-05 | 2006-07-24 | Zentiva, A.S. | Sposoby stabilizacji atorwastatyny |
| WO2005092852A1 (en) * | 2004-03-17 | 2005-10-06 | Ranbaxy Laboratories Limited | Process for the production of atorvastatin calcium in amorphous form |
| KR20070106680A (ko) * | 2004-09-30 | 2007-11-05 | 닥터 레디스 레보러터리즈 리미티드 | 비정질 아토르바스타틴 칼슘 |
| JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
| TWI318571B (en) * | 2005-06-10 | 2009-12-21 | Lilly Co Eli | Formulation of a thienopyridine platelet aggregation inhibitor |
| US20090216029A1 (en) * | 2005-09-16 | 2009-08-27 | Yatendra Kumar | Process for the production of atorvastatin calcium in amorphous form |
| CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
| US20090247603A1 (en) | 2005-12-23 | 2009-10-01 | Orbus Pharma, Inc. | Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor |
| EP1810667A1 (en) * | 2006-01-20 | 2007-07-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising amorphous atorvastatin |
| GB2450117A (en) * | 2007-06-13 | 2008-12-17 | Reckitt Benckiser Healthcare | A water- and oxygen-occlusive blister tablet pack |
| JP2010534644A (ja) * | 2007-07-27 | 2010-11-11 | シプラ・リミテッド | 医薬組成物およびその製造方法 |
| US20090071855A1 (en) * | 2007-09-14 | 2009-03-19 | Bahuguna Sumit | Packaging for amorphous statins and compositions thereof |
| EP2127628A1 (en) * | 2008-05-27 | 2009-12-02 | Ranbaxy Laboratories Limited | Unit dose pack |
| KR20120128599A (ko) | 2009-12-25 | 2012-11-27 | 사와이세이야쿠 가부시키가이샤 | 아트로바스타틴 함유 피복 제제 |
| WO2013072770A2 (en) | 2011-11-15 | 2013-05-23 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical formulations comprising atorvastatin and glimepiride |
| CN102525942A (zh) * | 2012-01-05 | 2012-07-04 | 金陵药业股份有限公司 | 一种阿托伐他汀钙肠溶微丸及其制备方法 |
| US10874624B2 (en) * | 2015-02-03 | 2020-12-29 | Kadmon Pharmaceuticals, Llc | Stable trientine formulations |
| US10905113B2 (en) | 2015-11-12 | 2021-02-02 | Regents Of The University Of Minnesota | Compositions and method for storing liquid biospecimens |
| EP3184103A1 (en) | 2015-12-21 | 2017-06-28 | Hexal AG | Pharmaceutical composition comprising atorvastatin or a salt thereof |
| US11968975B2 (en) | 2019-04-30 | 2024-04-30 | Regents Of The University Of Minnesota | Compositions and methods for storing liquid biospecimens |
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| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| CA2201354A1 (en) * | 1994-09-30 | 1996-04-11 | Becton, Dickinson And Company | Method for forming and packaging iontophoretic drug delivery patches and the like to increase stability and shelf-life |
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| US6293393B1 (en) * | 2000-07-18 | 2001-09-25 | Sdk Co., Inc. | Apparatus and methods for packaging and distributing combinations of foods and beverages |
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| EP1241110A1 (en) | 2001-03-16 | 2002-09-18 | Pfizer Products Inc. | Dispensing unit for oxygen-sensitive drugs |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8044086B2 (en) | 2004-07-16 | 2011-10-25 | Lek Pharmaceuticals D.D. | Oxidative degradation products of atorvastatin calcium |
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