UA85544C2 - Стабилизированный фармацевтический препарат аморфного аторвастатина кальция - Google Patents

Стабилизированный фармацевтический препарат аморфного аторвастатина кальция

Info

Publication number
UA85544C2
UA85544C2 UAA200504398A UA2005004398A UA85544C2 UA 85544 C2 UA85544 C2 UA 85544C2 UA A200504398 A UAA200504398 A UA A200504398A UA 2005004398 A UA2005004398 A UA 2005004398A UA 85544 C2 UA85544 C2 UA 85544C2
Authority
UA
Ukraine
Prior art keywords
amorphous active
pharmaceutical preparation
active calcium
stabilized pharmaceutical
active substance
Prior art date
Application number
UAA200504398A
Other languages
English (en)
Ukrainian (uk)
Inventor
Андрей Бастарда
Матея Салобир
Рок Грахек
Original Assignee
Лек Фармасьютикалз Д.Д.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32091984&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA85544(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Лек Фармасьютикалз Д.Д. filed Critical Лек Фармасьютикалз Д.Д.
Publication of UA85544C2 publication Critical patent/UA85544C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к фармацевтической композиции, которая содержит аморфный аторвастатин кальция, и способу ее стабилизации. С целью повышения стабильности указанной композиции ее хранят в атмосфере инертного газа.
UAA200504398A 2002-10-11 2003-10-10 Стабилизированный фармацевтический препарат аморфного аторвастатина кальция UA85544C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200200244A SI21302A (sl) 2002-10-11 2002-10-11 Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino

Publications (1)

Publication Number Publication Date
UA85544C2 true UA85544C2 (ru) 2009-02-10

Family

ID=32091984

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200504398A UA85544C2 (ru) 2002-10-11 2003-10-10 Стабилизированный фармацевтический препарат аморфного аторвастатина кальция

Country Status (21)

Country Link
US (2) US20040077708A1 (ru)
EP (1) EP1608362B1 (ru)
CN (1) CN100372529C (ru)
AR (1) AR041588A1 (ru)
AT (2) ATE354362T1 (ru)
AU (1) AU2003280361B2 (ru)
CY (1) CY1106608T1 (ru)
CZ (1) CZ17610U1 (ru)
DE (2) DE20321455U1 (ru)
DK (2) DK1608362T3 (ru)
ES (1) ES2285205T3 (ru)
FI (1) FI7617U1 (ru)
ME (1) ME00514B (ru)
PT (1) PT1608362E (ru)
RS (1) RS51819B (ru)
RU (1) RU2358727C2 (ru)
SI (2) SI21302A (ru)
SK (1) SK5233Y1 (ru)
TW (1) TWI320709B (ru)
UA (1) UA85544C2 (ru)
WO (1) WO2004032920A1 (ru)

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Publication number Priority date Publication date Assignee Title
SI20109A (sl) * 1998-12-16 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Stabilna farmacevtska formulacija
US7411075B1 (en) * 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
WO2003057593A1 (en) 2001-12-21 2003-07-17 Nektar Therapeutics Capsule package with moisture barrier
RS20060081A (en) * 2003-08-05 2008-06-05 Zentiva A.S., Methods for the stabilization of atorvastatin
EP1727795B1 (en) 2004-03-17 2012-02-15 Ranbaxy Laboratories Limited Process for the production of atorvastatin calcium in amorphous form
CA2573969C (en) 2004-07-16 2014-02-04 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
CA2582449A1 (en) * 2004-09-30 2006-04-13 Dr. Reddy's Laboratories Ltd. Amorphous atorvastatin calcium
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
TWI318571B (en) * 2005-06-10 2009-12-21 Lilly Co Eli Formulation of a thienopyridine platelet aggregation inhibitor
US20090216029A1 (en) * 2005-09-16 2009-08-27 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
US20090247603A1 (en) 2005-12-23 2009-10-01 Orbus Pharma, Inc. Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor
EP1810667A1 (en) * 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
GB2450117A (en) * 2007-06-13 2008-12-17 Reckitt Benckiser Healthcare A water- and oxygen-occlusive blister tablet pack
AU2008281640A1 (en) * 2007-07-27 2009-02-05 Cipla Limited Pharmaceutical compositions and process for making them
US20090071855A1 (en) * 2007-09-14 2009-03-19 Bahuguna Sumit Packaging for amorphous statins and compositions thereof
EP2127628A1 (en) * 2008-05-27 2009-12-02 Ranbaxy Laboratories Limited Unit dose pack
EP2522348B1 (en) 2009-12-25 2016-05-25 Sawai Pharmaceutical Co., Ltd. Atorvastatin-containing coated preparation
RU2014124118A (ru) 2011-11-15 2015-12-27 Др. Редди'С Лабораторис Лтд. Фармацевтические препараты, включающие аторвастатин и глимепирид
CN102525942A (zh) * 2012-01-05 2012-07-04 金陵药业股份有限公司 一种阿托伐他汀钙肠溶微丸及其制备方法
CN107530311A (zh) * 2015-02-03 2018-01-02 卡德门制药有限公司 稳定的曲恩汀制剂
US10905113B2 (en) 2015-11-12 2021-02-02 Regents Of The University Of Minnesota Compositions and method for storing liquid biospecimens
EP3184103A1 (en) 2015-12-21 2017-06-28 Hexal AG Pharmaceutical composition comprising atorvastatin or a salt thereof
US11968975B2 (en) 2019-04-30 2024-04-30 Regents Of The University Of Minnesota Compositions and methods for storing liquid biospecimens

Family Cites Families (15)

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FR2194418B2 (ru) * 1971-08-02 1977-01-28 Sada Pietro
DE2625164A1 (de) * 1976-06-04 1977-12-15 Goedecke Ag Fluessige oder halbfeste arzneiformen oder kosmetische zubereitungen
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
JPH10509694A (ja) * 1994-09-30 1998-09-22 ベクトン・ディッキンソン・アンド・カンパニー 安定性及び在庫期間を増すためにイオン浸透療法による薬剤投与パッチ等を形成し且つ包装するための方法
GB9425783D0 (en) * 1994-12-21 1995-02-22 Ethical Pharma Ltd Packaging of patches
HRP960313B1 (en) 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
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US6407278B2 (en) * 1998-11-16 2002-06-18 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and methods for the preparation and use of the same
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AU2000250960A1 (en) * 2000-06-09 2001-12-17 Lek Pharmaceuticals D.D. Stable pharmaceutical product and formulation
US6293393B1 (en) * 2000-07-18 2001-09-25 Sdk Co., Inc. Apparatus and methods for packaging and distributing combinations of foods and beverages
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
EP1241110A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Dispensing unit for oxygen-sensitive drugs

Also Published As

Publication number Publication date
FI7617U1 (fi) 2007-09-28
CY1106608T1 (el) 2012-01-25
TWI320709B (en) 2010-02-21
CN1703215A (zh) 2005-11-30
US20090012150A1 (en) 2009-01-08
AU2003280361B2 (en) 2009-02-26
DK200700025U1 (da) 2007-06-08
ATE354362T1 (de) 2007-03-15
SK5233Y1 (en) 2009-09-07
AU2003280361A1 (en) 2004-05-04
RS51819B (sr) 2011-12-31
DK1608362T3 (da) 2007-05-14
TW200501947A (en) 2005-01-16
ME00514B (me) 2011-10-10
RU2005114485A (ru) 2006-01-27
RS20050273A (en) 2007-06-04
SI1608362T1 (sl) 2007-12-31
EP1608362A1 (en) 2005-12-28
DE60312049T2 (de) 2007-10-04
CN100372529C (zh) 2008-03-05
ES2285205T3 (es) 2007-11-16
DK200700025U4 (da) 2008-03-14
FIU20070036U0 (fi) 2007-01-26
US20040077708A1 (en) 2004-04-22
DE60312049D1 (de) 2007-04-05
SI21302A (sl) 2004-04-30
WO2004032920A1 (en) 2004-04-22
EP1608362B1 (en) 2007-02-21
RU2358727C2 (ru) 2009-06-20
DE20321455U1 (de) 2007-05-24
PT1608362E (pt) 2007-05-31
AT10424U1 (de) 2009-03-15
CZ17610U1 (cs) 2007-06-18
SK50062007U1 (en) 2009-03-05
AR041588A1 (es) 2005-05-26

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