SI1981863T1 - Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatov - Google Patents
Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatovInfo
- Publication number
- SI1981863T1 SI1981863T1 SI200731098T SI200731098T SI1981863T1 SI 1981863 T1 SI1981863 T1 SI 1981863T1 SI 200731098 T SI200731098 T SI 200731098T SI 200731098 T SI200731098 T SI 200731098T SI 1981863 T1 SI1981863 T1 SI 1981863T1
- Authority
- SI
- Slovenia
- Prior art keywords
- quinazoline derivatives
- substituted quinazoline
- aminocrotonylamino
- preparing
- preparing aminocrotonylamino
- Prior art date
Links
- -1 aminocrotonylamino-substituted quinazoline Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
- C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
- C07D293/04—Five-membered rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100914 | 2006-01-26 | ||
| PCT/EP2007/050752 WO2007085638A1 (en) | 2006-01-26 | 2007-01-25 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
| EP07704145A EP1981863B1 (en) | 2006-01-26 | 2007-01-25 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1981863T1 true SI1981863T1 (sl) | 2013-01-31 |
Family
ID=38180518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200731098T SI1981863T1 (sl) | 2006-01-26 | 2007-01-25 | Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatov |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7960546B2 (sl) |
| EP (1) | EP1981863B1 (sl) |
| JP (1) | JP5241513B2 (sl) |
| CA (1) | CA2639936C (sl) |
| CY (1) | CY1113778T1 (sl) |
| DK (1) | DK1981863T3 (sl) |
| ES (1) | ES2397181T3 (sl) |
| PL (1) | PL1981863T3 (sl) |
| PT (1) | PT1981863E (sl) |
| SI (1) | SI1981863T1 (sl) |
| WO (1) | WO2007085638A1 (sl) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1731511B1 (de) | 1999-06-21 | 2015-08-12 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US7019012B2 (en) * | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| US7197160B2 (en) | 2001-03-05 | 2007-03-27 | Digimarc Corporation | Geographic information systems using digital watermarks |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10349113A1 (de) * | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| DK1948180T3 (da) * | 2005-11-11 | 2013-05-27 | Boehringer Ingelheim Int | Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer |
| EP3173084B1 (en) | 2005-11-11 | 2019-10-23 | Boehringer Ingelheim International GmbH | Quinazoline derivatives for the treatment of cancer diseases |
| EP1981863B1 (en) * | 2006-01-26 | 2012-10-10 | Boehringer Ingelheim International GmbH | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
| RU2492864C2 (ru) * | 2006-09-18 | 2013-09-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ лечения рака, несущего мутации egfr |
| UY31867A (es) | 2008-06-06 | 2010-01-29 | Boehringer Ingelheim Int | Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992 |
| WO2011002523A1 (en) * | 2009-07-02 | 2011-01-06 | Kanionusa Inc. | Phosphorus containing quinazoline compounds and methods of use |
| US9545381B2 (en) | 2009-07-06 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
| LT2608792T (lt) | 2010-08-26 | 2018-01-10 | Boehringer Ingelheim International Gmbh | Egfr inhibitoriaus vartojimo būdai |
| CA2828713C (en) | 2011-03-04 | 2022-08-16 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compounds and methods of use |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| WO2012155339A1 (zh) | 2011-05-17 | 2012-11-22 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
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| EP2951171A1 (en) * | 2013-02-01 | 2015-12-09 | Boehringer Ingelheim International GmbH | Radiolabeled quinazoline derivatives |
| CN104119350B (zh) | 2013-04-28 | 2017-04-12 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
| CN103254156B (zh) * | 2013-05-10 | 2015-08-26 | 苏州明锐医药科技有限公司 | 阿法替尼中间体的制备方法 |
| WO2014180271A1 (zh) * | 2013-05-10 | 2014-11-13 | 苏州明锐医药科技有限公司 | 阿法替尼及其中间体的制备方法 |
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| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
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| CN104447713B (zh) * | 2014-11-18 | 2019-03-29 | 江苏奥赛康药业股份有限公司 | 阿法替尼化合物的制备方法 |
| EP3023421A1 (en) | 2014-11-21 | 2016-05-25 | Sandoz Ag | Crystalline forms of afatinib dimaleate |
| CN105777655B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物 |
| CN104592212B (zh) * | 2014-12-31 | 2017-11-10 | 广东东阳光药业有限公司 | 一种阿法替尼中间体的制备方法 |
| CN105175400B (zh) * | 2015-09-29 | 2018-04-10 | 河北神威药业有限公司 | 一种阿法替尼中间体的制备方法 |
| US20190112317A1 (en) | 2015-10-05 | 2019-04-18 | The Trustees Of Columbia University In The City Of New York | Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies |
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| CN105669658B (zh) * | 2016-04-05 | 2018-06-29 | 北京民康百草医药科技有限公司 | 一种阿法替尼的精制方法 |
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| CN106565692A (zh) * | 2016-11-03 | 2017-04-19 | 常茂生物化学工程股份有限公司 | 一种阿法替尼合成工艺的改进方法 |
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| CN110693846B (zh) * | 2018-07-10 | 2021-07-27 | 杭州华东医药集团新药研究院有限公司 | 迈华替尼药物组合物及其制备方法 |
| CN110590754A (zh) * | 2019-09-21 | 2019-12-20 | 广东安诺药业股份有限公司 | 一种马来酸阿法替尼中间体的制备方法 |
| CN112770759A (zh) | 2020-07-09 | 2021-05-07 | 德尔塔菲制药股份有限公司 | 用于治疗伴脑转移的晚期非小细胞肺癌患者的组合药物 |
| WO2023028056A1 (en) | 2021-08-24 | 2023-03-02 | Genentech, Inc. | 3-amino piperidyl sodium channel inhibitors |
| US11945785B2 (en) | 2021-12-30 | 2024-04-02 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of FLT3 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1731511B1 (de) | 1999-06-21 | 2015-08-12 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10063435A1 (de) * | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10221018A1 (de) | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20030225079A1 (en) | 2002-05-11 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy |
| US7223749B2 (en) | 2003-02-20 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| DE10307165A1 (de) | 2003-02-20 | 2004-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| DK1948180T3 (da) | 2005-11-11 | 2013-05-27 | Boehringer Ingelheim Int | Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer |
| EP3173084B1 (en) | 2005-11-11 | 2019-10-23 | Boehringer Ingelheim International GmbH | Quinazoline derivatives for the treatment of cancer diseases |
| EP1981863B1 (en) | 2006-01-26 | 2012-10-10 | Boehringer Ingelheim International GmbH | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
| RU2492864C2 (ru) | 2006-09-18 | 2013-09-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ лечения рака, несущего мутации egfr |
| UY31867A (es) | 2008-06-06 | 2010-01-29 | Boehringer Ingelheim Int | Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992 |
| US20120157472A1 (en) | 2009-01-14 | 2012-06-21 | Boehringer Ingelheim International Gmbh | Method for treating colorectal cancer |
| US9545381B2 (en) | 2009-07-06 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
-
2007
- 2007-01-25 EP EP07704145A patent/EP1981863B1/en active Active
- 2007-01-25 US US12/162,037 patent/US7960546B2/en active Active
- 2007-01-25 PT PT77041457T patent/PT1981863E/pt unknown
- 2007-01-25 WO PCT/EP2007/050752 patent/WO2007085638A1/en active Application Filing
- 2007-01-25 DK DK07704145.7T patent/DK1981863T3/da active
- 2007-01-25 CA CA2639936A patent/CA2639936C/en active Active
- 2007-01-25 PL PL07704145T patent/PL1981863T3/pl unknown
- 2007-01-25 JP JP2008551791A patent/JP5241513B2/ja active Active
- 2007-01-25 ES ES07704145T patent/ES2397181T3/es active Active
- 2007-01-25 SI SI200731098T patent/SI1981863T1/sl unknown
-
2011
- 2011-05-05 US US13/101,195 patent/US8188274B2/en active Active
- 2011-05-05 US US13/101,198 patent/US8067593B2/en active Active
-
2013
- 2013-01-07 CY CY20131100010T patent/CY1113778T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8188274B2 (en) | 2012-05-29 |
| ES2397181T3 (es) | 2013-03-05 |
| EP1981863B1 (en) | 2012-10-10 |
| CY1113778T1 (el) | 2016-07-27 |
| US20110207929A1 (en) | 2011-08-25 |
| US20090306378A1 (en) | 2009-12-10 |
| US20110207932A1 (en) | 2011-08-25 |
| PL1981863T3 (pl) | 2013-03-29 |
| CA2639936A1 (en) | 2008-08-02 |
| CA2639936C (en) | 2014-06-17 |
| WO2007085638A1 (en) | 2007-08-02 |
| JP5241513B2 (ja) | 2013-07-17 |
| US7960546B2 (en) | 2011-06-14 |
| EP1981863A1 (en) | 2008-10-22 |
| DK1981863T3 (da) | 2013-01-02 |
| US8067593B2 (en) | 2011-11-29 |
| JP2009528981A (ja) | 2009-08-13 |
| PT1981863E (pt) | 2012-12-07 |
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