PL1981863T3 - Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe - Google Patents

Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe

Info

Publication number
PL1981863T3
PL1981863T3 PL07704145T PL07704145T PL1981863T3 PL 1981863 T3 PL1981863 T3 PL 1981863T3 PL 07704145 T PL07704145 T PL 07704145T PL 07704145 T PL07704145 T PL 07704145T PL 1981863 T3 PL1981863 T3 PL 1981863T3
Authority
PL
Poland
Prior art keywords
quinazoline derivatives
substituted quinazoline
aminocrotonylamino
preparing
preparing aminocrotonylamino
Prior art date
Application number
PL07704145T
Other languages
English (en)
Inventor
Juergen Schroeder
Georg Dziewas
Thomas Fachinger
Burkhard Jaeger
Carsten Reichel
Svenja Renner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PL1981863T3 publication Critical patent/PL1981863T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
    • C07D293/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL07704145T 2006-01-26 2007-01-25 Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe PL1981863T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06100914 2006-01-26
EP07704145A EP1981863B1 (en) 2006-01-26 2007-01-25 Process for preparing aminocrotonylamino-substituted quinazoline derivatives
PCT/EP2007/050752 WO2007085638A1 (en) 2006-01-26 2007-01-25 Process for preparing aminocrotonylamino-substituted quinazoline derivatives

Publications (1)

Publication Number Publication Date
PL1981863T3 true PL1981863T3 (pl) 2013-03-29

Family

ID=38180518

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07704145T PL1981863T3 (pl) 2006-01-26 2007-01-25 Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe

Country Status (11)

Country Link
US (3) US7960546B2 (pl)
EP (1) EP1981863B1 (pl)
JP (1) JP5241513B2 (pl)
CA (1) CA2639936C (pl)
CY (1) CY1113778T1 (pl)
DK (1) DK1981863T3 (pl)
ES (1) ES2397181T3 (pl)
PL (1) PL1981863T3 (pl)
PT (1) PT1981863E (pl)
SI (1) SI1981863T1 (pl)
WO (1) WO2007085638A1 (pl)

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BRPI1015363A2 (pt) 2009-07-02 2015-08-25 Newgen Therapeutics Inc Compostos de quinazolina contendo fósforo, uso dos mesmos, composição e kit
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CN102898386B (zh) 2011-07-27 2015-07-29 上海医药集团股份有限公司 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
JP2015524400A (ja) 2012-07-19 2015-08-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製
EP2951171A1 (en) * 2013-02-01 2015-12-09 Boehringer Ingelheim International GmbH Radiolabeled quinazoline derivatives
CN104119350B (zh) 2013-04-28 2017-04-12 广东东阳光药业有限公司 氨基喹唑啉类衍生物及其盐和使用方法
CN103254183B (zh) * 2013-05-10 2015-11-11 苏州明锐医药科技有限公司 阿法替尼的制备方法
WO2014180271A1 (zh) * 2013-05-10 2014-11-13 苏州明锐医药科技有限公司 阿法替尼及其中间体的制备方法
CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
CN103288808B (zh) * 2013-05-16 2015-11-11 苏州明锐医药科技有限公司 一种阿法替尼的制备方法
CN104710413B (zh) * 2013-12-16 2019-05-03 江苏豪森药业集团有限公司 二马来酸阿法替尼的制备方法
US9242965B2 (en) * 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN107141261B (zh) * 2014-07-15 2020-05-05 杭州华东医药集团新药研究院有限公司 喹唑啉类化合物及其制备方法和在制备酪氨酸激酶抑制剂中的应用
CN105315263B (zh) * 2014-07-30 2018-11-27 正大天晴药业集团股份有限公司 阿法替尼中间体的合成方法
CN105330652B (zh) * 2014-08-07 2019-04-05 天津法莫西医药科技有限公司 一种阿法替尼的制备方法
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN104447713B (zh) * 2014-11-18 2019-03-29 江苏奥赛康药业股份有限公司 阿法替尼化合物的制备方法
EP3023421A1 (en) 2014-11-21 2016-05-25 Sandoz Ag Crystalline forms of afatinib dimaleate
CN105777655B (zh) * 2014-12-25 2018-02-02 深圳海王医药科技研究院有限公司 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物
CN104592212B (zh) * 2014-12-31 2017-11-10 广东东阳光药业有限公司 一种阿法替尼中间体的制备方法
CN105175400B (zh) * 2015-09-29 2018-04-10 河北神威药业有限公司 一种阿法替尼中间体的制备方法
KR20180086187A (ko) 2015-10-05 2018-07-30 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료
CN107216317B (zh) * 2016-03-21 2020-04-07 上海医药工业研究院 一种阿法替尼中间体的制备方法
CN105669658B (zh) * 2016-04-05 2018-06-29 北京民康百草医药科技有限公司 一种阿法替尼的精制方法
CN106045983A (zh) * 2016-06-02 2016-10-26 苏州富士莱医药股份有限公司 阿法替尼的制备方法
CN107488171B (zh) * 2016-06-10 2020-08-28 山东新时代药业有限公司 一种阿法替尼制备方法
CN105968103B (zh) * 2016-07-18 2018-11-27 山东罗欣药业集团恒欣药业有限公司 抗肿瘤药物阿法替尼的合成方法
CN106243092B (zh) * 2016-07-28 2019-02-15 南京臣功制药股份有限公司 一种高选择性制备马来酸阿法替尼的方法
CN106565692A (zh) * 2016-11-03 2017-04-19 常茂生物化学工程股份有限公司 一种阿法替尼合成工艺的改进方法
CN106908531B (zh) * 2017-02-22 2019-08-06 深圳海王医药科技研究院有限公司 一种高效液相色谱梯度法同时测定萘普替尼光降解产物及其它有关物质的方法
CN110693846B (zh) * 2018-07-10 2021-07-27 杭州华东医药集团新药研究院有限公司 迈华替尼药物组合物及其制备方法
CN110590754A (zh) * 2019-09-21 2019-12-20 广东安诺药业股份有限公司 一种马来酸阿法替尼中间体的制备方法
CN120919131A (zh) 2020-07-09 2025-11-11 德尔塔菲制药股份有限公司 用于治疗伴脑转移的晚期非小细胞肺癌患者的组合药物
WO2023028056A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
IL313670A (en) 2021-12-30 2024-08-01 Biomea Fusion Inc Pyrazine compounds as inhibitors of FLT3

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CA2375259C (en) 1999-06-21 2009-04-28 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
DE10063435A1 (de) * 2000-12-20 2002-07-04 Boehringer Ingelheim Pharma Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
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US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
DE10349113A1 (de) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
PL1948180T3 (pl) 2005-11-11 2013-09-30 Boehringer Ingelheim Int Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2
CA2833852C (en) 2005-11-11 2014-10-21 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
JP5241513B2 (ja) 2006-01-26 2013-07-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アミノクロトニルアミノ置換キナゾリン誘導体の合成方法
US8877764B2 (en) 2006-09-18 2014-11-04 Boehringer Ingelheim International Gmbh Method for treating cancer harboring EGFR mutations
UY31867A (es) * 2008-06-06 2010-01-29 Boehringer Ingelheim Int Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992
JP2012515184A (ja) 2009-01-14 2012-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 大腸がんの治療方法
EP2451445B1 (en) 2009-07-06 2019-04-03 Boehringer Ingelheim International GmbH Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient

Also Published As

Publication number Publication date
PT1981863E (pt) 2012-12-07
US20110207929A1 (en) 2011-08-25
JP2009528981A (ja) 2009-08-13
US20090306378A1 (en) 2009-12-10
SI1981863T1 (sl) 2013-01-31
WO2007085638A1 (en) 2007-08-02
CY1113778T1 (el) 2016-07-27
JP5241513B2 (ja) 2013-07-17
CA2639936A1 (en) 2008-08-02
EP1981863B1 (en) 2012-10-10
CA2639936C (en) 2014-06-17
US8188274B2 (en) 2012-05-29
EP1981863A1 (en) 2008-10-22
ES2397181T3 (es) 2013-03-05
DK1981863T3 (da) 2013-01-02
US7960546B2 (en) 2011-06-14
US8067593B2 (en) 2011-11-29
US20110207932A1 (en) 2011-08-25

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