SI2102196T1 - Postopek za pripravo nebivolola - Google Patents
Postopek za pripravo nebivololaInfo
- Publication number
- SI2102196T1 SI2102196T1 SI200731051T SI200731051T SI2102196T1 SI 2102196 T1 SI2102196 T1 SI 2102196T1 SI 200731051 T SI200731051 T SI 200731051T SI 200731051 T SI200731051 T SI 200731051T SI 2102196 T1 SI2102196 T1 SI 2102196T1
- Authority
- SI
- Slovenia
- Prior art keywords
- preparing nebivolol
- nebivolol
- preparing
- Prior art date
Links
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960000619 nebivolol Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06124838 | 2006-11-27 | ||
| EP07846784A EP2102196B1 (en) | 2006-11-27 | 2007-11-23 | Process for preparing nebivolol |
| PCT/EP2007/010184 WO2008064826A1 (en) | 2006-11-27 | 2007-11-23 | Process for preparing nebivolol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2102196T1 true SI2102196T1 (sl) | 2012-12-31 |
Family
ID=39128268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200731051T SI2102196T1 (sl) | 2006-11-27 | 2007-11-23 | Postopek za pripravo nebivolola |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8003810B2 (sl) |
| EP (1) | EP2102196B1 (sl) |
| JP (2) | JP5281012B2 (sl) |
| CN (1) | CN101541791B (sl) |
| BR (1) | BRPI0719367B8 (sl) |
| CA (1) | CA2668436C (sl) |
| ES (1) | ES2391911T3 (sl) |
| IL (1) | IL198568A (sl) |
| PL (1) | PL2102196T3 (sl) |
| PT (1) | PT2102196E (sl) |
| SI (1) | SI2102196T1 (sl) |
| WO (1) | WO2008064826A1 (sl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2102196B1 (en) * | 2006-11-27 | 2012-08-01 | ZaCh System S.p.A. | Process for preparing nebivolol |
| ITMI20080547A1 (it) * | 2008-03-31 | 2009-10-01 | Zach System Spa | Processo di preparazione di nebivololo |
| IT1395354B1 (it) | 2009-07-23 | 2012-09-14 | Zach System Spa | Processo di preparazione di nebivololo |
| IT1397962B1 (it) | 2010-02-11 | 2013-02-04 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
| US8785664B2 (en) | 2010-02-11 | 2014-07-22 | Menarini International Operations Luxembourg S.A. | Process for the preparation of nebivolol |
| CN102190647A (zh) * | 2010-03-12 | 2011-09-21 | 浙江海翔药业股份有限公司 | 一种奈比洛尔的中间体的制备方法 |
| CN102344431B (zh) * | 2010-08-05 | 2014-03-26 | 成都康弘药业集团股份有限公司 | 一种制备奈必洛尔盐酸盐的方法 |
| IT1402974B1 (it) | 2010-11-30 | 2013-09-27 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
| CN102180855B (zh) * | 2011-03-01 | 2015-11-25 | 浙江华海药业股份有限公司 | 一种奈必洛尔中间体的提纯方法 |
| EP2907810A1 (en) | 2014-02-14 | 2015-08-19 | Corden Pharma International GmbH | A new method for producing nebivolol hydrochloride of high purity |
| ES2700973T3 (es) | 2014-02-14 | 2019-02-20 | Corden Pharma Int Gmbh | Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol |
| DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
| KR102529680B1 (ko) | 2015-05-19 | 2023-05-09 | 저장 아우선 파마슈티칼 씨오., 엘티디. | 네비볼롤 합성방법 및 그의 중간 화합물 |
| CN105085499B (zh) * | 2015-08-07 | 2018-09-25 | 上海现代制药海门有限公司 | 盐酸奈必洛尔中间体混合物的结晶分离方法 |
| ITUB20160227A1 (it) | 2016-01-21 | 2017-07-21 | Menarini Int Operations Luxembourg Sa | Processo per la sintesi di intermedi di Nebivololo |
| US10744087B2 (en) | 2018-03-22 | 2020-08-18 | Incarda Therapeutics, Inc. | Method to slow ventricular rate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337432C (en) * | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| US5665890A (en) * | 1995-03-14 | 1997-09-09 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
| WO2003018520A1 (en) * | 2001-08-22 | 2003-03-06 | Rhodia Pharma Solutions Inc. | Improved hydrolytic kinetic resolution of epoxides |
| US6639087B2 (en) * | 2001-08-22 | 2003-10-28 | Rhodia Pharma Solutions Inc. | Kinetic resolution method |
| HU227236B1 (en) * | 2002-11-06 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol |
| US20070014733A1 (en) * | 2005-01-31 | 2007-01-18 | O'donnell John P | Hydroxylated nebivolol metabolites |
| CN100387586C (zh) * | 2005-03-18 | 2008-05-14 | 中国科学院理化技术研究所 | 手性2-胺基-1-(6-氟-3,4-二氢苯并吡喃基)乙醇的合成方法 |
| EP2102196B1 (en) * | 2006-11-27 | 2012-08-01 | ZaCh System S.p.A. | Process for preparing nebivolol |
-
2007
- 2007-11-23 EP EP07846784A patent/EP2102196B1/en active Active
- 2007-11-23 WO PCT/EP2007/010184 patent/WO2008064826A1/en active Application Filing
- 2007-11-23 CA CA2668436A patent/CA2668436C/en active Active
- 2007-11-23 JP JP2009537551A patent/JP5281012B2/ja active Active
- 2007-11-23 SI SI200731051T patent/SI2102196T1/sl unknown
- 2007-11-23 BR BRPI0719367A patent/BRPI0719367B8/pt active IP Right Grant
- 2007-11-23 US US12/515,581 patent/US8003810B2/en not_active Expired - Fee Related
- 2007-11-23 ES ES07846784T patent/ES2391911T3/es active Active
- 2007-11-23 PL PL07846784T patent/PL2102196T3/pl unknown
- 2007-11-23 CN CN200780043750.5A patent/CN101541791B/zh active Active
- 2007-11-23 PT PT07846784T patent/PT2102196E/pt unknown
-
2009
- 2009-05-05 IL IL198568A patent/IL198568A/en active IP Right Grant
-
2013
- 2013-05-22 JP JP2013108326A patent/JP2013209404A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2102196A1 (en) | 2009-09-23 |
| BRPI0719367B1 (pt) | 2021-03-23 |
| WO2008064826A8 (en) | 2008-07-17 |
| EP2102196B1 (en) | 2012-08-01 |
| BRPI0719367A2 (pt) | 2014-02-11 |
| BRPI0719367B8 (pt) | 2021-05-25 |
| JP2010510968A (ja) | 2010-04-08 |
| PL2102196T3 (pl) | 2012-12-31 |
| JP2013209404A (ja) | 2013-10-10 |
| CN101541791B (zh) | 2014-01-29 |
| CA2668436A1 (en) | 2008-06-05 |
| CA2668436C (en) | 2015-10-13 |
| US20100076206A1 (en) | 2010-03-25 |
| IL198568A (en) | 2013-11-28 |
| AU2007324895A1 (en) | 2008-06-05 |
| CN101541791A (zh) | 2009-09-23 |
| WO2008064826A1 (en) | 2008-06-05 |
| ES2391911T3 (es) | 2012-12-03 |
| IL198568A0 (en) | 2010-02-17 |
| PT2102196E (pt) | 2012-10-31 |
| US8003810B2 (en) | 2011-08-23 |
| JP5281012B2 (ja) | 2013-09-04 |
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