SI1454903T1 - Tiadiazolinski derivati za zdravljenje raka - Google Patents

Tiadiazolinski derivati za zdravljenje raka

Info

Publication number
SI1454903T1
SI1454903T1 SI200230923T SI200230923T SI1454903T1 SI 1454903 T1 SI1454903 T1 SI 1454903T1 SI 200230923 T SI200230923 T SI 200230923T SI 200230923 T SI200230923 T SI 200230923T SI 1454903 T1 SI1454903 T1 SI 1454903T1
Authority
SI
Slovenia
Prior art keywords
substituted
unsubstituted
treating cancer
unsubstituted lower
hydrogen atom
Prior art date
Application number
SI200230923T
Other languages
English (en)
Inventor
Chikara Murakata
Kazuhiko Kato
Yoshihisa Ohta
Ryuichiro Nakai
Yoshinori Yamashita
Takeshi Takahashi
Tomohisa Nakano
Yoji Ino
Original Assignee
Kyowa Hakko Kirin Co Ltd
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd, Fujifilm Corp filed Critical Kyowa Hakko Kirin Co Ltd
Publication of SI1454903T1 publication Critical patent/SI1454903T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200230923T 2001-12-11 2002-12-11 Tiadiazolinski derivati za zdravljenje raka SI1454903T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001377456 2001-12-11
JP2002237399 2002-08-16
EP02788786A EP1454903B9 (en) 2001-12-11 2002-12-11 Thiadiazoline derivatives for treating cancer
PCT/JP2002/012961 WO2003051854A1 (en) 2001-12-11 2002-12-11 Thiadiazoline derivative

Publications (1)

Publication Number Publication Date
SI1454903T1 true SI1454903T1 (sl) 2010-12-31

Family

ID=26624996

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200230923T SI1454903T1 (sl) 2001-12-11 2002-12-11 Tiadiazolinski derivati za zdravljenje raka
SI200230956T SI1847534T1 (sl) 2001-12-11 2002-12-11 Tiadiazolinski derivati za zdravljenje raka

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200230956T SI1847534T1 (sl) 2001-12-11 2002-12-11 Tiadiazolinski derivati za zdravljenje raka

Country Status (16)

Country Link
US (4) US7425636B2 (sl)
EP (2) EP1454903B9 (sl)
JP (1) JP4272994B2 (sl)
KR (1) KR100915287B1 (sl)
CN (1) CN100484928C (sl)
AT (2) ATE513821T1 (sl)
AU (1) AU2002354465B2 (sl)
CA (1) CA2469801C (sl)
CY (2) CY1112899T1 (sl)
DE (1) DE60237637D1 (sl)
DK (2) DK1847534T3 (sl)
ES (1) ES2350642T3 (sl)
HK (1) HK1107814A1 (sl)
PT (2) PT1454903E (sl)
SI (2) SI1454903T1 (sl)
WO (1) WO2003051854A1 (sl)

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* Cited by examiner, † Cited by third party
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PT1454903E (pt) 2001-12-11 2010-11-09 Kyowa Hakko Kirin Co Ltd Derivados de tiadiazolina para tratamento do cancro
KR101096948B1 (ko) 2003-04-18 2011-12-20 후지필름 홀딩스 가부시끼가이샤 Ｍ기 키네신 저해제
CA2528433A1 (en) * 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivative
WO2004111023A1 (ja) * 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. チアジアゾリン－１－オキシド誘導体
WO2005035512A1 (ja) * 2003-10-10 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. チアジアゾリン誘導体
JPWO2005061707A1 (ja) * 2003-12-24 2007-07-12 協和醗酵工業株式会社 癌細胞のＥｇ５阻害剤に対する感受性を判定する方法
US7449486B2 (en) 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
KR20070114822A (ko) * 2005-03-22 2007-12-04 교와 핫꼬 고교 가부시끼가이샤 조혈기 종양 치료제
CN101193878A (zh) * 2005-03-22 2008-06-04 协和发酵工业株式会社 实体肿瘤治疗剂
UA95907C2 (en) * 2005-05-02 2011-09-26 Эррей Биофарма Инк. Mitotic kinesin inhibitors and methods of use thereof
JPWO2006137490A1 (ja) 2005-06-24 2009-01-22 協和発酵キリン株式会社 再狭窄治療剤
DE102005055354A1 (de) * 2005-11-21 2007-10-31 Merck Patent Gmbh Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine
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WO2008042928A2 (en) * 2006-10-03 2008-04-10 Array Biopharma, Inc. Oxadiazole and thiadiazole derivatives as mitotic kinesin inhibitors and methods of use thereof
AU2008275258A1 (en) 2007-07-12 2009-01-15 Eli Lilly And Company Stable formulations of thiadiazole derivatiive
AR068888A1 (es) 2007-10-19 2009-12-16 Schering Corp Derivados de 1, 3, 4 - tiadiazol, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de la quinesina ksp.

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WO2004111023A1 (ja) 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. チアジアゾリン－１－オキシド誘導体
CA2528433A1 (en) 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivative
WO2005035512A1 (ja) 2003-10-10 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. チアジアゾリン誘導体
US7449486B2 (en) * 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
KR20070114822A (ko) 2005-03-22 2007-12-04 교와 핫꼬 고교 가부시끼가이샤 조혈기 종양 치료제
CN101193878A (zh) * 2005-03-22 2008-06-04 协和发酵工业株式会社 实体肿瘤治疗剂
JPWO2006137490A1 (ja) * 2005-06-24 2009-01-22 協和発酵キリン株式会社 再狭窄治療剤

Also Published As

Publication number Publication date
DK1454903T3 (da) 2010-11-22
EP1847534A3 (en) 2008-09-24
US20080207706A1 (en) 2008-08-28
ATE480527T1 (de) 2010-09-15
EP1847534B1 (en) 2011-06-22
CY1111816T1 (el) 2015-10-07
US20070213380A1 (en) 2007-09-13
ES2350642T3 (es) 2011-01-25
KR100915287B1 (ko) 2009-09-03
HK1107814A1 (en) 2008-04-18
SI1847534T1 (sl) 2011-10-28
JPWO2003051854A1 (ja) 2005-04-28
AU2002354465A1 (en) 2003-06-30
EP1847534B9 (en) 2012-03-21
JP4272994B2 (ja) 2009-06-03
DK1847534T3 (da) 2011-08-29
CN1617864A (zh) 2005-05-18
PT1847534E (pt) 2011-08-01
EP1847534A2 (en) 2007-10-24
CA2469801A1 (en) 2003-06-26
DE60237637D1 (de) 2010-10-21
US7902234B2 (en) 2011-03-08
PT1454903E (pt) 2010-11-09
US20100240716A1 (en) 2010-09-23
CA2469801C (en) 2011-06-21
EP1454903A4 (en) 2005-12-21
CY1112899T1 (el) 2016-04-13
EP1454903B1 (en) 2010-09-08
CN100484928C (zh) 2009-05-06
US20060074113A1 (en) 2006-04-06
WO2003051854A1 (en) 2003-06-26
KR20040072649A (ko) 2004-08-18
EP1454903B9 (en) 2011-10-05
AU2002354465B2 (en) 2008-11-20
US7759371B2 (en) 2010-07-20
EP1454903A1 (en) 2004-09-08
ATE513821T1 (de) 2011-07-15
US7425636B2 (en) 2008-09-16

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