DK1454903T3 - Thiadiazolinderivater til behandling af cancer - Google Patents

Thiadiazolinderivater til behandling af cancer

Info

Publication number
DK1454903T3
DK1454903T3 DK02788786.8T DK02788786T DK1454903T3 DK 1454903 T3 DK1454903 T3 DK 1454903T3 DK 02788786 T DK02788786 T DK 02788786T DK 1454903 T3 DK1454903 T3 DK 1454903T3
Authority
DK
Denmark
Prior art keywords
substituted
unsubstituted
cancer
treatment
unsubstituted lower
Prior art date
Application number
DK02788786.8T
Other languages
English (en)
Inventor
Chikara Murakata
Kazuhiko Kato
Yoshihisa Ohta
Ryuichiro Nakai
Yoshinori Yamashita
Takeshi Takahashi
Tomohisa Nakano
Yoji Ino
Original Assignee
Kyowa Hakko Kirin Co Ltd
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd, Fujifilm Corp filed Critical Kyowa Hakko Kirin Co Ltd
Application granted granted Critical
Publication of DK1454903T3 publication Critical patent/DK1454903T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
DK02788786.8T 2001-12-11 2002-12-11 Thiadiazolinderivater til behandling af cancer DK1454903T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001377456 2001-12-11
JP2002237399 2002-08-16
PCT/JP2002/012961 WO2003051854A1 (en) 2001-12-11 2002-12-11 Thiadiazoline derivative

Publications (1)

Publication Number Publication Date
DK1454903T3 true DK1454903T3 (da) 2010-11-22

Family

ID=26624996

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07015426.5T DK1847534T3 (da) 2001-12-11 2002-12-11 Thiadiazolin-derivater til behandling af kræft
DK02788786.8T DK1454903T3 (da) 2001-12-11 2002-12-11 Thiadiazolinderivater til behandling af cancer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK07015426.5T DK1847534T3 (da) 2001-12-11 2002-12-11 Thiadiazolin-derivater til behandling af kræft

Country Status (16)

Country Link
US (4) US7425636B2 (da)
EP (2) EP1454903B9 (da)
JP (1) JP4272994B2 (da)
KR (1) KR100915287B1 (da)
CN (1) CN100484928C (da)
AT (2) ATE480527T1 (da)
AU (1) AU2002354465B2 (da)
CA (1) CA2469801C (da)
CY (2) CY1112899T1 (da)
DE (1) DE60237637D1 (da)
DK (2) DK1847534T3 (da)
ES (1) ES2350642T3 (da)
HK (1) HK1107814A1 (da)
PT (2) PT1454903E (da)
SI (2) SI1454903T1 (da)
WO (1) WO2003051854A1 (da)

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KR100915287B1 (ko) 2001-12-11 2009-09-03 교와 핫꼬 기린 가부시키가이샤 티아디아졸린 유도체
AU2004230799B2 (en) 2003-04-18 2010-03-18 Fujifilm Corporation Mitotic kinesin inhibitor
EP1632484A4 (en) * 2003-06-10 2008-09-03 Kyowa Hakko Kogyo Kk D RIV OF THIADIAZOLINE
JPWO2004111023A1 (ja) * 2003-06-10 2006-07-27 協和醗酵工業株式会社 チアジアゾリン−１−オキシド誘導体
EP1671957A4 (en) * 2003-10-10 2007-03-14 THIADIAZOLINDERIVATE
JPWO2005061707A1 (ja) * 2003-12-24 2007-07-12 協和醗酵工業株式会社 癌細胞のＥｇ５阻害剤に対する感受性を判定する方法
US7449486B2 (en) * 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
CN101193877A (zh) * 2005-03-22 2008-06-04 协和发酵工业株式会社 造血系统肿瘤治疗剂
TW200714593A (en) * 2005-03-22 2007-04-16 Kyowa Hakko Kogyo Kk Agent for treatment of solid tumor
UA95907C2 (en) * 2005-05-02 2011-09-26 Эррей Биофарма Инк. Mitotic kinesin inhibitors and methods of use thereof
EP1908755A4 (en) * 2005-06-24 2009-06-24 Kyowa Hakko Kirin Co Ltd THERAPEUTIC AGENT AGAINST RESTENOSIS
DE102005055354A1 (de) * 2005-11-21 2007-10-31 Merck Patent Gmbh Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine
DE102006002065B4 (de) * 2006-01-16 2007-11-29 Infineon Technologies Austria Ag Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand
EP2081918A2 (en) * 2006-10-03 2009-07-29 Array Biopharma, Inc. Mitotic kinesin inhibitors and methods of use thereof
AU2008275258A1 (en) 2007-07-12 2009-01-15 Eli Lilly And Company Stable formulations of thiadiazole derivatiive
CA2702922C (en) * 2007-10-19 2018-01-16 Schering Corporation Spiro-condensed 1,3,4-thiadiazole derivatives for inhibiting ksp kinesin activity

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EP1632484A4 (en) 2003-06-10 2008-09-03 Kyowa Hakko Kogyo Kk D RIV OF THIADIAZOLINE
EP1671957A4 (en) 2003-10-10 2007-03-14 THIADIAZOLINDERIVATE
US7449486B2 (en) 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
CN101193877A (zh) 2005-03-22 2008-06-04 协和发酵工业株式会社 造血系统肿瘤治疗剂
TW200714593A (en) 2005-03-22 2007-04-16 Kyowa Hakko Kogyo Kk Agent for treatment of solid tumor
EP1908755A4 (en) 2005-06-24 2009-06-24 Kyowa Hakko Kirin Co Ltd THERAPEUTIC AGENT AGAINST RESTENOSIS

Also Published As

Publication number Publication date
EP1454903B1 (en) 2010-09-08
EP1847534A2 (en) 2007-10-24
EP1847534B1 (en) 2011-06-22
CA2469801C (en) 2011-06-21
EP1847534B9 (en) 2012-03-21
ATE513821T1 (de) 2011-07-15
EP1454903B9 (en) 2011-10-05
SI1847534T1 (sl) 2011-10-28
KR20040072649A (ko) 2004-08-18
AU2002354465A1 (en) 2003-06-30
SI1454903T1 (sl) 2010-12-31
CN100484928C (zh) 2009-05-06
JPWO2003051854A1 (ja) 2005-04-28
US20080207706A1 (en) 2008-08-28
US7425636B2 (en) 2008-09-16
US7759371B2 (en) 2010-07-20
ATE480527T1 (de) 2010-09-15
KR100915287B1 (ko) 2009-09-03
JP4272994B2 (ja) 2009-06-03
EP1454903A1 (en) 2004-09-08
WO2003051854A1 (en) 2003-06-26
CY1112899T1 (el) 2016-04-13
CN1617864A (zh) 2005-05-18
PT1847534E (pt) 2011-08-01
DK1847534T3 (da) 2011-08-29
CA2469801A1 (en) 2003-06-26
EP1454903A4 (en) 2005-12-21
US20060074113A1 (en) 2006-04-06
PT1454903E (pt) 2010-11-09
US20070213380A1 (en) 2007-09-13
US20100240716A1 (en) 2010-09-23
US7902234B2 (en) 2011-03-08
HK1107814A1 (en) 2008-04-18
EP1847534A3 (en) 2008-09-24
AU2002354465B2 (en) 2008-11-20
CY1111816T1 (el) 2015-10-07
ES2350642T3 (es) 2011-01-25
DE60237637D1 (de) 2010-10-21

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