SI1103545T1 - 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide - Google Patents

2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide

Info

Publication number
SI1103545T1
SI1103545T1 SI200030246T SI200030246T SI1103545T1 SI 1103545 T1 SI1103545 T1 SI 1103545T1 SI 200030246 T SI200030246 T SI 200030246T SI 200030246 T SI200030246 T SI 200030246T SI 1103545 T1 SI1103545 T1 SI 1103545T1
Authority
SI
Slovenia
Prior art keywords
isobutyramide
morpholin
pyridin
tolyl
trifluoromethyl
Prior art date
Application number
SI200030246T
Other languages
English (en)
Slovenian (sl)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SI1103545T1 publication Critical patent/SI1103545T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SI200030246T 1999-11-29 2000-11-21 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide SI1103545T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29
EP00125450A EP1103545B1 (en) 1999-11-29 2000-11-21 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide

Publications (1)

Publication Number Publication Date
SI1103545T1 true SI1103545T1 (en) 2004-02-29

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030246T SI1103545T1 (en) 1999-11-29 2000-11-21 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide

Country Status (50)

Country Link
EP (1) EP1103545B1 (pl)
JP (1) JP3480835B2 (pl)
KR (1) KR100390117B1 (pl)
CN (1) CN1152016C (pl)
AR (1) AR033659A1 (pl)
AT (1) ATE253561T1 (pl)
AU (1) AU775292B2 (pl)
BG (1) BG64622B1 (pl)
BR (1) BRPI0005616B8 (pl)
CA (1) CA2326529C (pl)
CO (1) CO5251405A1 (pl)
CZ (1) CZ299286B6 (pl)
DE (2) DE60006340T2 (pl)
DK (1) DK1103545T3 (pl)
DO (1) DOP2000000106A (pl)
EA (1) EA004404B1 (pl)
ES (2) ES2208205T3 (pl)
FR (1) FR2801590A1 (pl)
GB (1) GB2356863A (pl)
GC (1) GC0000151A (pl)
GE (1) GEP20022763B (pl)
GT (1) GT200000197A (pl)
HK (1) HK1036759A1 (pl)
HR (1) HRP20000809A2 (pl)
HU (1) HU224703B1 (pl)
ID (1) ID28483A (pl)
IL (1) IL139868A (pl)
IS (1) IS2212B (pl)
IT (1) IT1320120B1 (pl)
JO (1) JO2298B1 (pl)
MA (1) MA26754A1 (pl)
MX (1) MXPA00011672A (pl)
MY (1) MY127426A (pl)
NO (1) NO317264B1 (pl)
NZ (1) NZ508386A (pl)
OA (1) OA11513A (pl)
PA (1) PA8507201A1 (pl)
PE (1) PE20010901A1 (pl)
PL (1) PL195957B1 (pl)
PT (1) PT1103545E (pl)
SG (1) SG97171A1 (pl)
SI (1) SI1103545T1 (pl)
SK (1) SK285373B6 (pl)
SV (1) SV2002000227A (pl)
TN (1) TNSN00226A1 (pl)
TR (1) TR200302077T4 (pl)
UA (1) UA70326C2 (pl)
UY (1) UY26458A1 (pl)
YU (1) YU73400A (pl)
ZA (1) ZA200006964B (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20013046A3 (cs) 1999-02-24 2002-02-13 F. Hoffmann-La Roche Ag Fenylové a pyridinylové deriváty
SE1035115T5 (sv) * 1999-02-24 2015-08-04 Hoffmann La Roche 4-fenylpyridin-derivat och deras anvaendning som NK-1 receptor-antagonister
MXPA03000366A (es) * 2000-07-14 2003-05-27 Hoffmann La Roche N-oxidos como profarmacos antagonistas del receptor nk1 de derivados de 4-fenil-piridina.
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
BR0307257A (pt) * 2002-01-31 2004-12-14 Hoffmann La Roche Polimorfismos genéticos no gene da pré-pró-taquicinina
PL1643998T3 (pl) 2003-07-03 2008-01-31 Hoffmann La Roche Podwójni antagoniści NK1/NK3 do leczenia schizofrenii
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
WO2006002860A1 (en) 2004-07-06 2006-01-12 F. Hoffmann-La Roche Ag Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists
RU2007129642A (ru) 2005-02-25 2009-03-27 Ф.Хоффманн-Ля Рош Аг (Ch) Таблетки с улучшенным распределением лекарственного вещества
PT1863767E (pt) * 2005-03-23 2009-03-27 Hoffmann La Roche Metabolitos para antagonistas de nk-1 para vómitos
MY143784A (en) 2005-09-23 2011-07-15 Hoffmann La Roche Novel dosage formulation
US8093268B2 (en) 2007-01-24 2012-01-10 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
BR112015021982B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos e seus usos para a modulação de hemoglobina
AU2014347644B2 (en) 2013-11-08 2018-06-14 Kissei Pharmaceutical Co., Ltd. Carboxymethyl piperidine derivative
CN114181195A (zh) 2014-02-07 2022-03-15 全球血液疗法股份有限公司 一种化合物的结晶多晶型物
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919245A3 (en) * 1991-09-20 2000-11-15 Glaxo Group Limited NK-1 receptor antagonist and a systemic antiinflammatory corticosteroid for the treatment of emesis
IL106142A (en) * 1992-06-29 1997-03-18 Merck & Co Inc Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
EP0737192B1 (en) * 1993-12-29 2001-10-31 Merck Sharp & Dohme Ltd. Substituted morpholine derivatives and their use as therapeutic agents
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
ES2194937T3 (es) * 1995-03-24 2003-12-01 Takeda Chemical Industries Ltd Compuestos ciclicos, su produccion y uso como antagonistas de los receptores de taquiquinina.
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
SE1035115T5 (sv) * 1999-02-24 2015-08-04 Hoffmann La Roche 4-fenylpyridin-derivat och deras anvaendning som NK-1 receptor-antagonister
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
MXPA03000366A (es) * 2000-07-14 2003-05-27 Hoffmann La Roche N-oxidos como profarmacos antagonistas del receptor nk1 de derivados de 4-fenil-piridina.
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
DE10058310A1 (de) 2001-05-31
DK1103545T3 (da) 2004-03-15
ES2208205T3 (es) 2004-06-16
ES2171134A1 (es) 2002-08-16
AU7178700A (en) 2001-05-31
HU224703B1 (en) 2006-01-30
CN1297888A (zh) 2001-06-06
GB0028566D0 (en) 2001-01-10
JP3480835B2 (ja) 2003-12-22
IS5725A (is) 2001-05-29
EA200001114A2 (ru) 2001-08-27
MA26754A1 (fr) 2004-12-20
IL139868A0 (en) 2002-02-10
OA11513A (fr) 2004-02-03
DE60006340T2 (de) 2004-09-09
FR2801590A1 (fr) 2001-06-01
IL139868A (en) 2009-09-01
CZ299286B6 (cs) 2008-06-04
HK1036759A1 (en) 2002-01-18
PL195957B1 (pl) 2007-11-30
MY127426A (en) 2006-11-30
SK285373B6 (sk) 2006-12-07
UA70326C2 (en) 2004-10-15
CA2326529C (en) 2009-12-22
DOP2000000106A (es) 2002-07-30
BRPI0005616B1 (pt) 2017-12-12
EA200001114A3 (ru) 2001-12-24
ITMI20002575A1 (it) 2002-05-29
NO317264B1 (no) 2004-09-27
KR20010051983A (ko) 2001-06-25
TNSN00226A1 (fr) 2002-05-30
MXPA00011672A (es) 2002-08-20
ATE253561T1 (de) 2003-11-15
UY26458A1 (es) 2001-05-31
CN1152016C (zh) 2004-06-02
BRPI0005616B8 (pt) 2021-07-06
GC0000151A (en) 2005-06-29
EP1103545B1 (en) 2003-11-05
NZ508386A (en) 2003-02-28
HUP0004725A2 (hu) 2002-04-29
NO20006012L (no) 2001-05-30
IS2212B (is) 2007-02-15
ZA200006964B (en) 2001-06-05
EA004404B1 (ru) 2004-04-29
SV2002000227A (es) 2002-02-05
HU0004725D0 (pl) 2001-02-28
KR100390117B1 (ko) 2003-07-04
AR033659A1 (es) 2004-01-07
YU73400A (sh) 2003-02-28
BG64622B1 (bg) 2005-09-30
GEP20022763B (en) 2002-08-26
GB2356863A (en) 2001-06-06
DE60006340D1 (de) 2003-12-11
PT1103545E (pt) 2004-03-31
ID28483A (id) 2001-05-31
BR0005616A (pt) 2001-07-17
GT200000197A (es) 2002-05-22
EP1103545A1 (en) 2001-05-30
SK17932000A3 (sk) 2001-11-06
AU775292B2 (en) 2004-07-29
JP2001151754A (ja) 2001-06-05
HRP20000809A2 (en) 2001-12-31
TR200302077T4 (tr) 2004-01-21
BG104992A (en) 2001-11-30
PA8507201A1 (es) 2002-02-21
JO2298B1 (en) 2005-09-12
SG97171A1 (en) 2003-07-18
CO5251405A1 (es) 2003-02-28
CA2326529A1 (en) 2001-05-29
PL344147A1 (en) 2001-06-04
CZ20004399A3 (cs) 2001-07-11
NO20006012D0 (no) 2000-11-28
IT1320120B1 (it) 2003-11-18
PE20010901A1 (es) 2001-09-20

Similar Documents

Publication Publication Date Title
HK1036759A1 (en) 2-(3,5- bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide
AP2001002230A0 (en) 2-(4-Pyridyl) amino-6- dialkoxyphenyl-pyrido ¬2,3-d¾ pyrimidin-7-0 nes
IL162721A0 (en) 2-(Pyridin-2-ylamino)-pyridoÄ2,3-dÜpyrimidin-7-ones
PL370480A1 (pl) Aminopirymidyny i aminopirydyny
HRP20020969A2 (en) Substituted pyridine herbicides
SI2308855T1 (sl) 2,4-diaminopirimidinski derivati
PL342670A1 (en) Derivatives of 2-(purin-9-yl) tetrahydrofurane-3,4-diole
PL342396A1 (en) Derivatives of 2-(purin-9-yl) tetrahydrofurano-3,4-diole
GB2361235B (en) 2,2,6,6 Diethyl-dimethyl-1-alkoxy-piperidine compounds and their corresponding 1-oxides
HK1069136A1 (en) 2-(3,5-Bis-trifluoromethyl-phenyl)-N-Ä6-(1,1-dioxo-1lambda 6-thiomorpholin-4-yl)-4-(2-methyl or 4-fluoro-2-methyl substituted) phenyl-pyridin-3-ylÜ-N-methyl-isobutyramide
HUP0401684A3 (en) Nicotinic acid-heterocyclyl-amides and analogous pyrimidine derivatives serving as pesticides
PL335161A1 (en) 2-amino-6-(2-substituted-4-phenoxy)-substituted pyridines
AU3819200A (en) 2,4-diamino-pyrimidine derivatives
GB0028027D0 (en) Web browser cookie management
AU6878500A (en) Novel 2-(2-pyridyl)pyrimidine derivatives
ZA986189B (en) Substituted 2-(benzaryl)pyridines.
IL159571A0 (en) 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1,-DIOXO-1lamda6-THIOMORPHOLIN-4-YL)-4-(2-METHYL OR 4-FLUORO-2-METHYL SUBSTITUTED) PHENYL-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE
GB0012376D0 (en) 3,4,5-tricyanophenyl derivatives
GB0024111D0 (en) Buzzhopper web
GB9909482D0 (en) 2-(Purin-9-yl)-tetahydrofuran-3,4-diol derivatives
GB9805090D0 (en) Aminopyridines
GB9913635D0 (en) Modified surfaces
GB9930702D0 (en) New herbicides
GB9900047D0 (en) Thermoregulatory clothing