SI1076657T1 - New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same - Google Patents
New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing sameInfo
- Publication number
- SI1076657T1 SI1076657T1 SI9930670T SI9930670T SI1076657T1 SI 1076657 T1 SI1076657 T1 SI 1076657T1 SI 9930670 T SI9930670 T SI 9930670T SI 9930670 T SI9930670 T SI 9930670T SI 1076657 T1 SI1076657 T1 SI 1076657T1
- Authority
- SI
- Slovenia
- Prior art keywords
- phosphodiesterase
- inhibitors
- producing same
- hydroxyindoles
- new
- Prior art date
Links
- NLMQHXUGJIAKTH-UHFFFAOYSA-N 4-hydroxyindole Chemical class OC1=CC=CC2=C1C=CN2 NLMQHXUGJIAKTH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19818964A DE19818964A1 (de) | 1998-04-28 | 1998-04-28 | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung |
DE1999117504 DE19917504A1 (de) | 1999-04-17 | 1999-04-17 | Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen |
PCT/EP1999/002792 WO1999055696A1 (fr) | 1998-04-28 | 1999-04-24 | Nouveaux hydroxyindoles, leur utilisation comme inhibiteurs de la phosphodiesterase 4 et leur procede de preparation |
EP99920779A EP1076657B1 (fr) | 1998-04-28 | 1999-04-24 | Nouveaux hydroxyindoles, leur utilisation comme inhibiteurs de la phosphodiesterase 4 et leur procede de preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1076657T1 true SI1076657T1 (en) | 2004-12-31 |
Family
ID=26045814
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9930922T SI1475377T1 (sl) | 1998-04-28 | 1999-04-24 | Indolni derivati in njihova uporaba kot inhibitorji fosfodiesteraze 4 |
SI9930670T SI1076657T1 (en) | 1998-04-28 | 1999-04-24 | New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9930922T SI1475377T1 (sl) | 1998-04-28 | 1999-04-24 | Indolni derivati in njihova uporaba kot inhibitorji fosfodiesteraze 4 |
Country Status (28)
Country | Link |
---|---|
US (8) | US6251923B1 (fr) |
EP (2) | EP1076657B1 (fr) |
JP (2) | JP3842043B2 (fr) |
KR (1) | KR100448748B1 (fr) |
CN (1) | CN1234705C (fr) |
AR (1) | AR016236A1 (fr) |
AT (2) | ATE272631T1 (fr) |
AU (1) | AU748403B2 (fr) |
BG (1) | BG65023B1 (fr) |
BR (1) | BR9910029A (fr) |
CY (1) | CY1105075T1 (fr) |
CZ (1) | CZ20003985A3 (fr) |
DE (2) | DE59913617D1 (fr) |
DK (2) | DK1475377T3 (fr) |
ES (2) | ES2262072T3 (fr) |
HK (1) | HK1035183A1 (fr) |
HU (1) | HUP0101625A3 (fr) |
IL (2) | IL138847A0 (fr) |
NO (1) | NO321867B1 (fr) |
NZ (1) | NZ507406A (fr) |
PL (1) | PL198983B1 (fr) |
PT (2) | PT1076657E (fr) |
SI (2) | SI1475377T1 (fr) |
SK (1) | SK286192B6 (fr) |
TR (1) | TR200003130T2 (fr) |
TW (1) | TW530048B (fr) |
UA (1) | UA59443C2 (fr) |
WO (1) | WO1999055696A1 (fr) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19946301A1 (de) | 1998-04-02 | 2001-04-19 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften |
DE19814838C2 (de) | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
ES2262072T3 (es) * | 1998-04-28 | 2006-11-16 | Elbion Ag | Derivados de indol y su utilizacion como inhibidores de la fosfodiesterasa 4. |
WO2000067802A1 (fr) * | 1999-05-10 | 2000-11-16 | Protarga, Inc. | Compositions d'acides gras -n-substituted indol-3-glyoxyl-amide et leur utilisation |
DE19924138A1 (de) | 1999-05-26 | 2000-11-30 | Henkel Kgaa | Lösbare Klebeverbindungen |
US6469006B1 (en) * | 1999-06-15 | 2002-10-22 | Bristol-Myers Squibb Company | Antiviral indoleoxoacetyl piperazine derivatives |
TWI269654B (en) * | 1999-09-28 | 2007-01-01 | Baxter Healthcare Sa | N-substituted indole-3-glyoxylamide compounds having anti-tumor action |
DE19951599A1 (de) * | 1999-10-27 | 2001-05-23 | Henkel Kgaa | Verfahren zur adhesiven Trennung von Klebeverbunden |
DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
IT1315267B1 (it) * | 1999-12-23 | 2003-02-03 | Novuspharma Spa | Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale |
US6436965B1 (en) | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
US6573262B2 (en) | 2000-07-10 | 2003-06-03 | Bristol-Myers Sqibb Company | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives |
IT1318641B1 (it) * | 2000-07-25 | 2003-08-27 | Novuspharma Spa | Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale. |
DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
DE10037884A1 (de) * | 2000-08-03 | 2002-02-21 | Henkel Kgaa | Verfahren zur beschleunigten Klebstoffaushärtung |
US6903104B2 (en) * | 2001-12-06 | 2005-06-07 | National Health Research Institutes | Indol-3-YL-2-oxoacetamide compounds and methods of use thereof |
AU2003251382A1 (en) | 2002-05-24 | 2003-12-12 | Michel Joyce | Article of clothing with moisture absorbent portion |
UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
TW200400177A (en) | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
US20040038958A1 (en) * | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
KR20050026095A (ko) | 2002-08-01 | 2005-03-14 | 엘비온 아게 | 고도로 순수한 하이드록시 인돌릴 글리옥실산 아미드의제조 방법 |
UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
DE10253426B4 (de) * | 2002-11-15 | 2005-09-22 | Elbion Ag | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
DE10318611A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
DE10318610A1 (de) | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
DE10318609A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
WO2004098578A2 (fr) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprenant un inhibiteur de la pde4 et un antagoniste du tnf? |
WO2004098606A1 (fr) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprenant un inhibiteur de la pde4 et shuil-1r ii |
US7205299B2 (en) * | 2003-06-05 | 2007-04-17 | Zentaris Gmbh | Indole derivatives having an apoptosis-inducing effect |
US7211588B2 (en) * | 2003-07-25 | 2007-05-01 | Zentaris Gmbh | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation |
US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
CN102060806A (zh) | 2003-09-11 | 2011-05-18 | iTherX药品公司 | 细胞因子抑制剂 |
WO2005062851A2 (fr) * | 2003-12-22 | 2005-07-14 | Pappolla Miguel A | Indole-3-propionamide et ses derives |
DE102004031538A1 (de) * | 2004-06-29 | 2006-02-09 | Baxter International Inc., Deerfield | Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit |
CA2584169A1 (fr) * | 2004-10-13 | 2006-04-20 | Kyowa Hakko Kogyo Co., Ltd. | Traitements prophylactiques ou therapeutiques de maladie chronique de la peau |
JPWO2006041120A1 (ja) * | 2004-10-13 | 2008-05-15 | 協和醗酵工業株式会社 | 医薬組成物 |
JP2008519036A (ja) * | 2004-11-08 | 2008-06-05 | バクスター・インターナショナル・インコーポレイテッド | チューブリン阻害化合物のナノ粒子組成物 |
TW200738677A (en) * | 2005-06-27 | 2007-10-16 | Elbion Ag | Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
EP2258359A3 (fr) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline |
US20090221664A1 (en) | 2005-10-19 | 2009-09-03 | Abhijit Ray | Pharmaceutical compositions of muscarinic receptor antagonists |
CA2625153A1 (fr) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
CA2628570A1 (fr) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Procedes, compositions et kits pour le traitement de pathologies |
MX2008009022A (es) | 2006-01-13 | 2008-09-24 | Wyeth Corp | 1h-indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina. |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (fr) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogénèse par modulation de l'angiotensine |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
ATE535244T1 (de) | 2006-07-05 | 2011-12-15 | Nycomed Gmbh | Kombination aus atorvastatin mit einem phosphodiesterase-4-hemmer zur behandlung von entzündlichen lungenerkrankungen |
JP5406716B2 (ja) | 2006-08-07 | 2014-02-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | インドール化合物 |
WO2008030651A1 (fr) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinaisons contenant un dérivé de 4-acylaminopyridine |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2008066807A1 (fr) * | 2006-11-28 | 2008-06-05 | Ziopharm Oncology, Inc. | Utilisation de dérivés d'acide indolyl-3-glyoxylique comprenant de l'indibuline, seuls ou combinés à d'autres agents, pour traiter le cancer |
JP2010513276A (ja) * | 2006-12-13 | 2010-04-30 | ギリード・サイエンシズ・インコーポレーテッド | 肺炎症および気管支収縮の治療のための抗炎症シグナル伝達モジュレーター(AISTM)およびβ−アゴニストの相互プロドラッグとしてのモノホスフェート |
US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
CA2682730A1 (fr) * | 2007-04-11 | 2008-10-23 | Alcon Research, Ltd. | Utilisation d'un inhibiteur de tnf.alpha. et d'une anti-histamine pour traiter la rhinite allergique et la conjonctivite allergique |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
BR112012007091A2 (pt) * | 2009-10-01 | 2016-04-19 | Alcon Res Ltd | composições de olopatadina e seus usos |
AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
WO2013106547A1 (fr) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
CA3010615C (fr) | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Modulateurs de mastocytes et leurs utilisations |
CN113423435A (zh) | 2018-12-28 | 2021-09-21 | 雷杰纳荣制药公司 | 使用花生四烯酸15-脂氧合酶(alox15)抑制剂治疗呼吸系统病症 |
US11674450B1 (en) | 2021-12-13 | 2023-06-13 | Pratt & Whitney Canada Corp. | System and method for synthesizing engine thrust |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870162A (en) * | 1954-04-28 | 1959-01-20 | Upjohn Co | Production of certain tryptamines and compounds produced in the process |
DE1068259B (fr) | 1954-04-28 | 1959-11-05 | ||
US2825734A (en) | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
US2930797A (en) | 1957-11-22 | 1960-03-29 | Upjohn Co | 2-alkyl-3-indoleglyoxylamides |
GB944443A (fr) | 1959-09-25 | 1900-01-01 | ||
US3028393A (en) | 1960-05-11 | 1962-04-03 | Upjohn Co | Novel 1-(3-indoyl)-1, 2-alkanediols and substituted hydroxymethyl 3-in-dolyl ketones |
US3196162A (en) | 1961-03-13 | 1965-07-20 | Merck & Co Inc | Indolyl aliphatic acids |
US3271416A (en) | 1961-10-24 | 1966-09-06 | Merck & Co Inc | Indolyl aliphatic acids |
US3259622A (en) | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
US3238215A (en) | 1963-10-17 | 1966-03-01 | Sterling Drug Inc | 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines |
US3342834A (en) | 1964-03-02 | 1967-09-19 | Merck & Co Inc | Indolyl alkenoic acids |
US3821387A (en) * | 1965-10-23 | 1974-06-28 | Robins Co Inc A H | The treatment of parkinsonism with 3-(omega-substituted alkyl)-indoles |
US3459770A (en) | 1966-12-07 | 1969-08-05 | American Home Prod | Indoleglyoxyloylpyrroles |
US3527261A (en) | 1968-11-12 | 1970-09-08 | Babcock & Wilcox Co | Tube guide apparatus |
US3578669A (en) | 1969-09-16 | 1971-05-11 | Sterling Drug Inc | 1-((2 - substituted - 3 - indolyl) - lower-alkanoyl) - cycloalkyl - lower-alkylpiperidines and 1 - ((2 - hydroxymethyl-3 - indolyl)-lower-alkayl)-cycloalkyl-lower-alkylpiperidines |
US5192770A (en) | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
CA2140440A1 (fr) * | 1992-08-06 | 1994-02-17 | Ellen M. Dobrusin | 2-thioindoles (selenoindoles) et disulfides appparentes (selenides) qui inhibent les proteine-tyrosine-kinases et qui ont des proprietes antitumorales |
NZ257955A (en) | 1992-12-02 | 1996-05-28 | Pfizer | Catechol diethers pharmaceutical compositions |
ES2156120T3 (es) * | 1992-12-08 | 2001-06-16 | Ss Pharmaceutical Co | Derivados arilamidicos. |
US5424329A (en) | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
US5502072A (en) | 1993-11-26 | 1996-03-26 | Pfizer Inc. | Substituted oxindoles |
US5489586A (en) | 1994-03-07 | 1996-02-06 | Warner-Lambert Company | Method for treating inflammatory disease in humans |
DE19511916A1 (de) | 1994-08-03 | 1996-02-08 | Asta Medica Ag | Neue N-Benzylindol- und Benzopyrazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung |
US5965582A (en) | 1994-08-03 | 1999-10-12 | Asta Medica Aktiengesellschaft | N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect |
US5728844A (en) * | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic agents |
TW429148B (en) | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
WO1997048697A1 (fr) | 1996-06-19 | 1997-12-24 | Rhone-Poulenc Rorer Limited | Composes azabicycliques substitues et leur utilisation en tant qu'inhibiteurs de la production de tnf et de la photodiesterase cyclique d'amp |
WO1998002151A2 (fr) | 1996-07-12 | 1998-01-22 | Leukosite, Inc. | Antagonistes des recepteurs de la chemokine et procedes d'utilisation de ces derniers |
AU717430B2 (en) | 1996-08-26 | 2000-03-23 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
ES2262072T3 (es) * | 1998-04-28 | 2006-11-16 | Elbion Ag | Derivados de indol y su utilizacion como inhibidores de la fosfodiesterasa 4. |
IT1315267B1 (it) | 1999-12-23 | 2003-02-03 | Novuspharma Spa | Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale |
-
1999
- 1999-04-24 ES ES04018391T patent/ES2262072T3/es not_active Expired - Lifetime
- 1999-04-24 BR BR9910029-0A patent/BR9910029A/pt not_active Application Discontinuation
- 1999-04-24 HU HU0101625A patent/HUP0101625A3/hu unknown
- 1999-04-24 PT PT99920779T patent/PT1076657E/pt unknown
- 1999-04-24 PT PT04018391T patent/PT1475377E/pt unknown
- 1999-04-24 TR TR2000/03130T patent/TR200003130T2/xx unknown
- 1999-04-24 DE DE59913617T patent/DE59913617D1/de not_active Expired - Fee Related
- 1999-04-24 DK DK04018391T patent/DK1475377T3/da active
- 1999-04-24 ES ES99920779T patent/ES2222706T3/es not_active Expired - Lifetime
- 1999-04-24 AT AT99920779T patent/ATE272631T1/de not_active IP Right Cessation
- 1999-04-24 EP EP99920779A patent/EP1076657B1/fr not_active Expired - Lifetime
- 1999-04-24 AT AT04018391T patent/ATE330955T1/de not_active IP Right Cessation
- 1999-04-24 CZ CZ20003985A patent/CZ20003985A3/cs unknown
- 1999-04-24 NZ NZ507406A patent/NZ507406A/xx unknown
- 1999-04-24 AU AU38229/99A patent/AU748403B2/en not_active Ceased
- 1999-04-24 SK SK1575-2000A patent/SK286192B6/sk not_active IP Right Cessation
- 1999-04-24 IL IL13884799A patent/IL138847A0/xx active IP Right Grant
- 1999-04-24 SI SI9930922T patent/SI1475377T1/sl unknown
- 1999-04-24 EP EP04018391A patent/EP1475377B1/fr not_active Expired - Lifetime
- 1999-04-24 PL PL343569A patent/PL198983B1/pl unknown
- 1999-04-24 DK DK99920779T patent/DK1076657T3/da active
- 1999-04-24 UA UA2000116726A patent/UA59443C2/uk unknown
- 1999-04-24 WO PCT/EP1999/002792 patent/WO1999055696A1/fr active IP Right Grant
- 1999-04-24 SI SI9930670T patent/SI1076657T1/xx unknown
- 1999-04-24 KR KR10-2000-7011992A patent/KR100448748B1/ko not_active IP Right Cessation
- 1999-04-24 DE DE59910142T patent/DE59910142D1/de not_active Expired - Fee Related
- 1999-04-24 CN CNB998079766A patent/CN1234705C/zh not_active Expired - Fee Related
- 1999-04-24 JP JP2000545856A patent/JP3842043B2/ja not_active Expired - Fee Related
- 1999-04-28 TW TW088106886A patent/TW530048B/zh not_active IP Right Cessation
- 1999-04-28 AR ARP990101965A patent/AR016236A1/es active IP Right Grant
- 1999-04-28 US US09/300,973 patent/US6251923B1/en not_active Ceased
-
2000
- 2000-10-04 IL IL138847A patent/IL138847A/en not_active IP Right Cessation
- 2000-10-11 BG BG104842A patent/BG65023B1/bg unknown
- 2000-10-27 NO NO20005454A patent/NO321867B1/no unknown
-
2001
- 2001-08-14 HK HK01105669A patent/HK1035183A1/xx not_active IP Right Cessation
-
2002
- 2002-02-21 US US10/081,807 patent/US6602890B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/080,821 patent/US6545025B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/081,395 patent/US6545158B2/en not_active Expired - Fee Related
- 2002-02-21 US US10/081,642 patent/US7161009B2/en not_active Expired - Fee Related
- 2002-09-19 US US10/176,435 patent/USRE38624E1/en not_active Expired - Fee Related
-
2003
- 2003-01-20 US US10/347,659 patent/US6613794B2/en not_active Expired - Fee Related
-
2004
- 2004-05-27 US US10/856,034 patent/US20040220183A1/en not_active Abandoned
-
2006
- 2006-03-27 JP JP2006086619A patent/JP2006249091A/ja not_active Withdrawn
- 2006-07-07 CY CY20061100948T patent/CY1105075T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0101625A3 (en) | New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same | |
GB2354765B (en) | Dispersion composition and method for producing the same | |
AU6230098A (en) | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors | |
IL141445A0 (en) | Benzazine derivatives as phosphodiesterase 4 inhibitors | |
HUP0103349A3 (en) | Phthalazine derivatives as phosphodiesterase 4 inhibitors | |
SI0950657T1 (en) | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors | |
HUP0303034A3 (en) | Novel 7-azaindole-derivatives, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | |
IL138521A0 (en) | Pyridazinone hydrochloride compound and method for producing the same | |
PL345590A1 (en) | Method for phosphatizing, rerinsing and cathodic electro-dipcoating | |
HUP0002101A3 (en) | Fluoroether compositions, process for producing them and methods for inhibiting their degradation | |
AU2002221753A1 (en) | Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | |
PL348060A1 (en) | Method for producing 3-alkanoylindoles and 3-alkylindoles | |
IL139490A0 (en) | Phthalazine derivatives as phosphodiesterase 4 inhibitors | |
HU9700595D0 (en) | Fluoro-alkyl- and fluoro-alkoxy-substituted heterocyclic bradiquinine-antagonists, process for producing them and their use | |
IL141446A0 (en) | Benzazine derivatives as phosphodiesterase 4 inhibitors | |
PL351616A1 (en) | Polyolefin compositions, method for the production and use thereof | |
ZA200005540B (en) | New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same. | |
HUP0201400A3 (en) | Method for producing 2,2,4,4-tetra-substituted 1,3,5-cyclohexanetriones and their new intermediates | |
HUP0103106A3 (en) | Method for producing 4,6-disubstituted 2-isocyanatopyrimidines and their use as intermediate | |
ZA200303236B (en) | Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same. | |
HUP0000687A3 (en) | Aqueous, hard-surface cleaning composition and method for cleaning hard surfaces | |
HU9900123D0 (en) | 1-isothiazolidinone derivatives of azetidine-2-one, processes for the preparation thereof and use thereof | |
GB2352450B (en) | Method for producing of 2,3-dimethylbutene-1 and 2,3-dimethylbutene-2 | |
HUP0104386A3 (en) | Method for producing l-prolyl-l-m-sarcolysyl-l-p-fluorophenylalanine and derivatives thereof | |
PL347407A1 (en) | Method of obtaining derivatives of 5,6,7,8-tetrahydronaphtalen-2-ole |