AU2002221753A1 - Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same - Google Patents

Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

Info

Publication number
AU2002221753A1
AU2002221753A1 AU2002221753A AU2002221753A AU2002221753A1 AU 2002221753 A1 AU2002221753 A1 AU 2002221753A1 AU 2002221753 A AU2002221753 A AU 2002221753A AU 2002221753 A AU2002221753 A AU 2002221753A AU 2002221753 A1 AU2002221753 A1 AU 2002221753A1
Authority
AU
Australia
Prior art keywords
azaindoles
phosphodiesterase
inhibitors
novel
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2002221753A
Other versions
AU2002221753B2 (en
Inventor
Ute Egerland
Norbert Hofgen
Thomas Kronbach
Hildegard Kuss
Degenhard Marx
Emmanuel Polymeropoulos
Stefan Szelenyi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotie Therapies GmbH
Original Assignee
Biotie Therapies GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10053275A external-priority patent/DE10053275A1/en
Application filed by Biotie Therapies GmbH filed Critical Biotie Therapies GmbH
Priority claimed from PCT/EP2001/012376 external-priority patent/WO2002034747A1/en
Publication of AU2002221753A1 publication Critical patent/AU2002221753A1/en
Application granted granted Critical
Publication of AU2002221753B2 publication Critical patent/AU2002221753B2/en
Assigned to BIOTIE THERAPIES GMBH reassignment BIOTIE THERAPIES GMBH Request to Amend Deed and Register Assignors: ELBION AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

AU2002221753A 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same Ceased AU2002221753B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10053275.6 2000-10-27
DE10053275A DE10053275A1 (en) 2000-10-27 2000-10-27 New 7-aza-indole-3-carboxamides or glyoxylamides, useful e.g. for treating rheumatoid arthritis, osteoporosis, sepsis, asthma or multiple sclerosis are phosphodiesterase-4 and tumor necrosis factor-alpha inhibitors
US24434200P 2000-10-30 2000-10-30
US60/244,342 2000-10-30
PCT/EP2001/012376 WO2002034747A1 (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

Publications (2)

Publication Number Publication Date
AU2002221753A1 true AU2002221753A1 (en) 2002-07-11
AU2002221753B2 AU2002221753B2 (en) 2006-12-14

Family

ID=26007507

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002221753A Ceased AU2002221753B2 (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
AU2175302A Pending AU2175302A (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method forproducing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2175302A Pending AU2175302A (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method forproducing the same

Country Status (28)

Country Link
US (3) US7169787B2 (en)
EP (1) EP1330455B1 (en)
JP (1) JP4233322B2 (en)
KR (2) KR100880586B1 (en)
CN (1) CN1247576C (en)
AR (1) AR034269A1 (en)
AT (1) ATE301121T1 (en)
AU (2) AU2002221753B2 (en)
BG (1) BG66169B1 (en)
BR (1) BR0114903A (en)
CA (1) CA2428468C (en)
CZ (1) CZ20031146A3 (en)
DE (1) DE50106993D1 (en)
DK (1) DK1330455T3 (en)
EE (1) EE05271B1 (en)
ES (1) ES2246349T3 (en)
HK (1) HK1053839A1 (en)
HR (1) HRP20030427B1 (en)
HU (1) HUP0303034A3 (en)
IL (2) IL155386A0 (en)
MX (1) MXPA03003624A (en)
NO (1) NO324947B1 (en)
NZ (1) NZ525369A (en)
PL (1) PL213999B1 (en)
PT (1) PT1330455E (en)
SK (1) SK287774B6 (en)
TW (1) TWI262920B (en)
WO (1) WO2002034747A1 (en)

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US20040014761A1 (en) * 1997-10-28 2004-01-22 Place Virgil A. Treatment of female sexual dysfunction with phosphodiesterase inhibitors
TW200501945A (en) * 2002-11-06 2005-01-16 Celgene Corp Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
DE10318610A1 (en) 2003-04-24 2004-11-11 Elbion Ag 7-azaindoles and their use as therapeutic agents
US20050054691A1 (en) * 2003-08-29 2005-03-10 St. Jude Children's Research Hospital Carboxylesterase inhibitors
CN102060806A (en) * 2003-09-11 2011-05-18 iTherX药品公司 Cytokine inhibitors
JP2008503446A (en) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド PDE4B inhibitor and use thereof
MY144903A (en) 2004-06-17 2011-11-30 Novartis Ag Pyrrolopyridine derivatives and their use as crth2 antagonists
CA2583428A1 (en) * 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
GB0525143D0 (en) 2005-12-09 2006-01-18 Novartis Ag Organic compounds
CA2651732C (en) 2006-05-18 2014-10-14 Mannkind Corporation Intracellular kinase inhibitors
EP2058310A4 (en) * 2006-09-01 2010-11-17 Kyorin Seiyaku Kk Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor comprising the derivative
US8012992B2 (en) 2008-06-30 2011-09-06 Allergan, Inc. Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
ES2478289T3 (en) * 2008-09-22 2014-07-21 Isis Innovation Ltd 5-Azaindole Bisphosphonates
WO2011023696A1 (en) * 2009-08-26 2011-03-03 Nycomed Gmbh Methylpyrrolopyridinecarboxamides
WO2012072727A1 (en) * 2010-12-03 2012-06-07 Biotie Therapies Gmbh Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4
WO2012080329A1 (en) 2010-12-17 2012-06-21 Biotie Therapies Gmbh Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide
CN102584842A (en) * 2011-01-17 2012-07-18 北京大学 Preparation of substituted indole lactam derivative and application of substituted indole lactam derivative as antimalarial agent
US10208043B2 (en) 2012-08-22 2019-02-19 Cornell University Methods for inhibiting fascin
JP6691869B2 (en) * 2014-02-20 2020-05-13 コーネル ユニヴァーシティー Compounds and methods for inhibiting fascin
JP2022504693A (en) 2018-10-12 2022-01-13 ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ ネブラスカ Phosphodiesterase inhibitor

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GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
WO1991009598A1 (en) 1990-01-05 1991-07-11 Pfizer Inc. Azaoxindole derivatives
US5023265A (en) 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
US5811432A (en) 1990-11-09 1998-09-22 Pfizer Inc Azaoxindole derivatives
IL106517A0 (en) 1992-07-28 1994-08-26 Rhone Poulenc Rorer Ltd Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group
WO1994003427A1 (en) 1992-08-06 1994-02-17 Warner-Lambert Company 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties
JP3119758B2 (en) * 1993-02-24 2000-12-25 日清製粉株式会社 7-Azaindole derivative and antiulcer drug containing the same as active ingredient
DK0758233T3 (en) 1994-04-21 2004-03-22 Schering Ag PDE IV inhibitors for the treatment of multiple sclerosis
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
GB9507297D0 (en) 1995-04-07 1995-05-31 Rh Ne Poulenc Rorer Limited New composition of matter
JPH09169665A (en) 1995-12-21 1997-06-30 Kenichi Miyamoto Agent for treatment osteoporosis
JP3601898B2 (en) 1996-02-14 2004-12-15 俊隆 鍋島 Drug-dependent formation inhibitor
AUPO282996A0 (en) * 1996-10-07 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Novel compounds
AU3868500A (en) * 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone

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