ZA200005540B - New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same. - Google Patents

New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same.

Info

Publication number
ZA200005540B
ZA200005540B ZA200005540A ZA200005540A ZA200005540B ZA 200005540 B ZA200005540 B ZA 200005540B ZA 200005540 A ZA200005540 A ZA 200005540A ZA 200005540 A ZA200005540 A ZA 200005540A ZA 200005540 B ZA200005540 B ZA 200005540B
Authority
ZA
South Africa
Prior art keywords
phosphodiestrase
inhibitors
producing same
hydroxyindoles
new
Prior art date
Application number
ZA200005540A
Inventor
Norbert Hoefgen
Ute Egerland
Hildegard Poppe
Degenhard Marx
Stefan Szelenyi
Thomas Kronbach
Emmanuel Polymeropoulos
Sabine Heer
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of ZA200005540B publication Critical patent/ZA200005540B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200005540A 1998-04-28 2000-10-10 New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same. ZA200005540B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19818964A DE19818964A1 (en) 1998-04-28 1998-04-28 New hydroxy-indole derivatives useful in treatment of degenerative joint disease, viral and parasitic infections, bronchial, dermatological, neurodegenerative and prostate disorders, etc.

Publications (1)

Publication Number Publication Date
ZA200005540B true ZA200005540B (en) 2001-03-27

Family

ID=7866051

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200005540A ZA200005540B (en) 1998-04-28 2000-10-10 New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same.

Country Status (6)

Country Link
CN (1) CN1321981C (en)
CA (1) CA2270301C (en)
DE (1) DE19818964A1 (en)
HK (1) HK1066804A1 (en)
RU (1) RU2217422C2 (en)
ZA (1) ZA200005540B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962300A1 (en) * 1999-12-23 2001-06-28 Asta Medica Ag New N-benzylindolyl glyoxylic acid derivatives are useful as antitumor agents
TWI323658B (en) 2001-12-06 2010-04-21 Nat Health Research Institutes Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same
AU2003255341A1 (en) * 2002-08-01 2004-02-23 Elbion Ag Method for producing highly pure hydroxy indolyl glyoxylic acid amides
DE10241407A1 (en) * 2002-09-06 2004-03-18 Elbion Ag Treatment of non-allergic rhinitis with selective phosphodiesterase 4 inhibitors
DE10253426B4 (en) 2002-11-15 2005-09-22 Elbion Ag Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and methods for their preparation
DE10318610A1 (en) * 2003-04-24 2004-11-11 Elbion Ag 7-azaindoles and their use as therapeutic agents
DE10318609A1 (en) * 2003-04-24 2004-11-11 Elbion Ag 5-hydroxyindoles with N-oxide groups and their use as therapeutic agents
TW200738677A (en) * 2005-06-27 2007-10-16 Elbion Ag Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
MX2008009022A (en) 2006-01-13 2008-09-24 Wyeth Corp Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192770A (en) * 1990-12-07 1993-03-09 Syntex (U.S.A.) Inc. Serotonergic alpha-oxoacetamides
BR9307570A (en) * 1992-12-02 1999-05-25 Pfizer Catechol ethers as selective pdeiv inhibitors
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
US5502072A (en) * 1993-11-26 1996-03-26 Pfizer Inc. Substituted oxindoles
US5489586A (en) * 1994-03-07 1996-02-06 Warner-Lambert Company Method for treating inflammatory disease in humans
DE19511916A1 (en) * 1994-08-03 1996-02-08 Asta Medica Ag New N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
US5728844A (en) * 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
TW429148B (en) * 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
EP0934307B1 (en) * 1996-06-19 2011-04-27 Aventis Pharma Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
EP0920306A2 (en) * 1996-07-12 1999-06-09 Leukosite, Inc. Chemokine receptor antagonists and methods of use therefor
WO1998008818A1 (en) * 1996-08-26 1998-03-05 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
DE19636150A1 (en) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituted indole-3-glyoxylamides with antiasthmatic, antiallergic and immunosuppressive / immunomodulating effects

Also Published As

Publication number Publication date
CA2270301C (en) 2006-08-22
DE19818964A1 (en) 1999-11-04
CA2270301A1 (en) 1999-10-28
HK1066804A1 (en) 2005-04-01
CN1321981C (en) 2007-06-20
RU2217422C2 (en) 2003-11-27
CN1699342A (en) 2005-11-23

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