ZA200005540B - New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same. - Google Patents
New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same.Info
- Publication number
- ZA200005540B ZA200005540B ZA200005540A ZA200005540A ZA200005540B ZA 200005540 B ZA200005540 B ZA 200005540B ZA 200005540 A ZA200005540 A ZA 200005540A ZA 200005540 A ZA200005540 A ZA 200005540A ZA 200005540 B ZA200005540 B ZA 200005540B
- Authority
- ZA
- South Africa
- Prior art keywords
- phosphodiestrase
- inhibitors
- producing same
- hydroxyindoles
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19818964A DE19818964A1 (en) | 1998-04-28 | 1998-04-28 | New hydroxy-indole derivatives useful in treatment of degenerative joint disease, viral and parasitic infections, bronchial, dermatological, neurodegenerative and prostate disorders, etc. |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200005540B true ZA200005540B (en) | 2001-03-27 |
Family
ID=7866051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200005540A ZA200005540B (en) | 1998-04-28 | 2000-10-10 | New hydroxyindoles, their use as phosphodiestrase 4 inhibitors and method for producing same. |
Country Status (6)
Country | Link |
---|---|
CN (1) | CN1321981C (en) |
CA (1) | CA2270301C (en) |
DE (1) | DE19818964A1 (en) |
HK (1) | HK1066804A1 (en) |
RU (1) | RU2217422C2 (en) |
ZA (1) | ZA200005540B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19962300A1 (en) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | New N-benzylindolyl glyoxylic acid derivatives are useful as antitumor agents |
TWI323658B (en) | 2001-12-06 | 2010-04-21 | Nat Health Research Institutes | Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same |
AU2003255341A1 (en) * | 2002-08-01 | 2004-02-23 | Elbion Ag | Method for producing highly pure hydroxy indolyl glyoxylic acid amides |
DE10241407A1 (en) * | 2002-09-06 | 2004-03-18 | Elbion Ag | Treatment of non-allergic rhinitis with selective phosphodiesterase 4 inhibitors |
DE10253426B4 (en) | 2002-11-15 | 2005-09-22 | Elbion Ag | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and methods for their preparation |
DE10318610A1 (en) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-azaindoles and their use as therapeutic agents |
DE10318609A1 (en) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 5-hydroxyindoles with N-oxide groups and their use as therapeutic agents |
TW200738677A (en) * | 2005-06-27 | 2007-10-16 | Elbion Ag | Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them |
MX2008009022A (en) | 2006-01-13 | 2008-09-24 | Wyeth Corp | Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
BR9307570A (en) * | 1992-12-02 | 1999-05-25 | Pfizer | Catechol ethers as selective pdeiv inhibitors |
US5424329A (en) * | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
US5502072A (en) * | 1993-11-26 | 1996-03-26 | Pfizer Inc. | Substituted oxindoles |
US5489586A (en) * | 1994-03-07 | 1996-02-06 | Warner-Lambert Company | Method for treating inflammatory disease in humans |
DE19511916A1 (en) * | 1994-08-03 | 1996-02-08 | Asta Medica Ag | New N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects |
US5728844A (en) * | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic agents |
TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
EP0934307B1 (en) * | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
EP0920306A2 (en) * | 1996-07-12 | 1999-06-09 | Leukosite, Inc. | Chemokine receptor antagonists and methods of use therefor |
WO1998008818A1 (en) * | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
DE19636150A1 (en) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituted indole-3-glyoxylamides with antiasthmatic, antiallergic and immunosuppressive / immunomodulating effects |
-
1998
- 1998-04-28 DE DE19818964A patent/DE19818964A1/en not_active Ceased
-
1999
- 1999-04-24 CN CNB2005100746573A patent/CN1321981C/en not_active Expired - Fee Related
- 1999-04-24 RU RU2000129678/04A patent/RU2217422C2/en not_active IP Right Cessation
- 1999-04-28 CA CA002270301A patent/CA2270301C/en not_active Expired - Fee Related
-
2000
- 2000-10-10 ZA ZA200005540A patent/ZA200005540B/en unknown
-
2004
- 2004-12-13 HK HK04109841A patent/HK1066804A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2270301C (en) | 2006-08-22 |
DE19818964A1 (en) | 1999-11-04 |
CA2270301A1 (en) | 1999-10-28 |
HK1066804A1 (en) | 2005-04-01 |
CN1321981C (en) | 2007-06-20 |
RU2217422C2 (en) | 2003-11-27 |
CN1699342A (en) | 2005-11-23 |
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