AR016236A1 - Compuestos de hidroxiindol, utiles como inhibidores de la 4- fosfodiestearasas, procedimiento para prepararlos, utilizacion de dichos compuestos, medicamentos que contienen dichos compuestos, procedimiento para prepararlos - Google Patents

Compuestos de hidroxiindol, utiles como inhibidores de la 4- fosfodiestearasas, procedimiento para prepararlos, utilizacion de dichos compuestos, medicamentos que contienen dichos compuestos, procedimiento para prepararlos

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Publication number
AR016236A1
AR016236A1 ARP990101965A ARP990101965A AR016236A1 AR 016236 A1 AR016236 A1 AR 016236A1 AR P990101965 A ARP990101965 A AR P990101965A AR P990101965 A ARP990101965 A AR P990101965A AR 016236 A1 AR016236 A1 AR 016236A1
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Argentina
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alkyl
aryl
compounds
prepare
procedure
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ARP990101965A
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English (en)
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Elbion Ag
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Priority claimed from DE19818964A external-priority patent/DE19818964A1/de
Priority claimed from DE1999117504 external-priority patent/DE19917504A1/de
Application filed by Elbion Ag filed Critical Elbion Ag
Publication of AR016236A1 publication Critical patent/AR016236A1/es

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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Se revelan hidroxiindoles de aplicacion como inhibidores de la fosfodiesterasa 4, de formula (1), donde: R1 y R5 representan alquilo C1-12, de cadena rectao ramificada, dado el caso, una o más veces sustituido por -OH, -SH, -NH2, NHalquilo C1-6, -N(a lquilo C1-6)2, -NHarilo C1-14, -N(arilo C6-14)2, N(alquil C1-6)(arilo C6-14), -NHCOR6, -NO2, -CN, -F, -Cl, -Br, -I, -O-alquilo C1-6, -O-arilo C6-14, -O(CO)R6, -S-alquilo C1-6, -S-arilo C6-14, -SOR6, -SO3H, -SO2R6,-OSO2alquilo C1-6, -OSO2arilo C6- 14, -(CS)R6, -COOH, -(CO)R6, carbociclos mono, bi o tricíclicos saturados o una o más veces insaturados, con 3-14 eslabones,heterociclos mono, bi o tricíclicos saturados o una o más veces insaturado, con 5-15 eslabones y 1-6 heteroátomos, quepreferentem ente son N, O y S, donde losgrupos arilo C6-14 y los sustituyentes carbocíclicos o heterocíclicos incluidos, a su vez pueden estar una o más veces sustituido por R4, alquenilo C2-12, unao más veces insaturado, de cadena recta oramificada, dado el ca so, sustituido una o más veces por -OH, -SH, -NH2, -NHalquilo C1-6, -N(alquilo C1-6)2,-NHarilo C6-14, -N(arilo C6-14)2, -N(alquil C1-6)(arilo C6-14), -NHCOR6, -NO2, -CN, -F, -Cl, -Br, -I, -O-alquilo C1-6, -O-arilo C6-14,O(CO)R6, -S-alquiloC1-6, -S-a rilo C6-14, -SOR6, -SO3H, SO2R6, -OSO2alquilo C1-6, -OSO2arilo C6-14, -(CS)R6, -COOH, -(CO)R6, carbociclos mono, bi o tricíclicos saturados o una omás veces insaturado, con 3-14 eslabones, heterociclos mono, bi otricíclicos saturados o una o más vec es insaturados, con 5-15 eslabones y 1-6 heteroátomosque preferentemente son N, O y S, donde los grupos arilo C6-14 y los sustituyentes carbocíclicos y heterocíclicos incluidos, a su vez pueden estar una omásveces sustituido por R4, carbociclos mono , bi o tricíclicos saturados o una o más veces insaturado, con 3-147 eslabones, dado el caso, una o más vecessustituido por -OH, -SH, -NH2, -NHalquilo C1-6, -N(alquilo C1-6)2, -NHarilo C6-14, -N(arilo C6-14)2, -N(alquil C1-6)(arilo C6-14), -NHCOR6, - NO2, -CN, -F, -Cl,-Br, -I, -O-alquilo C1-6, -O-arilo C6-14, O(CO)R6, -S-alquilo C1-6, -S-arilo C6-14, -SOR6, -SO3H, -SO2R6, -OSO2alquilo C1-6, -OSO2arilo C6-14, -(CS)R6, -COOH,
ARP990101965A 1998-04-28 1999-04-28 Compuestos de hidroxiindol, utiles como inhibidores de la 4- fosfodiestearasas, procedimiento para prepararlos, utilizacion de dichos compuestos, medicamentos que contienen dichos compuestos, procedimiento para prepararlos AR016236A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19818964A DE19818964A1 (de) 1998-04-28 1998-04-28 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE1999117504 DE19917504A1 (de) 1999-04-17 1999-04-17 Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen

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AR016236A1 true AR016236A1 (es) 2001-06-20

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DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
JP3842043B2 (ja) * 1998-04-28 2006-11-08 エルビオン アクチエンゲゼルシャフト 新規ヒドロキシインドール、ホスホジエステラーゼ４のインヒビタとしてのその使用及びその製法
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
DE19924138A1 (de) 1999-05-26 2000-11-30 Henkel Kgaa Lösbare Klebeverbindungen
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