BR9910029A - Hidróxi indóis, sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação - Google Patents

Hidróxi indóis, sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação

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Publication number
BR9910029A
BR9910029A BR9910029-0A BR9910029A BR9910029A BR 9910029 A BR9910029 A BR 9910029A BR 9910029 A BR9910029 A BR 9910029A BR 9910029 A BR9910029 A BR 9910029A
Authority
BR
Brazil
Prior art keywords
phosphodiesterase
inhibitors
preparation
application
indols
Prior art date
Application number
BR9910029-0A
Other languages
English (en)
Inventor
Hildegard Poppe
Thomas Kronbach
Norbert Hoefgen
Ute Egerland
Degenhard Marx
Stefan Szelenyi
Emmanuel Polymeropoulos
Sabine Heer
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19818964A external-priority patent/DE19818964A1/de
Priority claimed from DE1999117504 external-priority patent/DE19917504A1/de
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of BR9910029A publication Critical patent/BR9910029A/pt

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Patente de Invenção: <B>"HIDRóXI INDóIS, SUA APLICAçãO COMO INIBIDORES DA FOSFODIESTERASE 4 E PROCESSO PARA SUA PREPARAçãO"<D>. Hidroxiindóis da fórmula (1), nos quais R¹, R^ 5^ representam C~ 1...12~-alquila, C~ 2..12~-alquenila, carbociclos monocíclicos, bicíclicos, ou tricíclicos; heterociclos monocíclicos, bicíclicos, ou tricíclicos, espirociclos carbocíclicos ou heterocíclicos; R², R³ podem ser hidrogênio ou -OH, sendo que pelo menos um dos dois substituintes deve ser -OH; sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação.
BR9910029-0A 1998-04-28 1999-04-24 Hidróxi indóis, sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação BR9910029A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19818964A DE19818964A1 (de) 1998-04-28 1998-04-28 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE1999117504 DE19917504A1 (de) 1999-04-17 1999-04-17 Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen
PCT/EP1999/002792 WO1999055696A1 (de) 1998-04-28 1999-04-24 Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
BR9910029A true BR9910029A (pt) 2000-12-26

Family

ID=26045814

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910029-0A BR9910029A (pt) 1998-04-28 1999-04-24 Hidróxi indóis, sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação

Country Status (28)

Country Link
US (8) US6251923B1 (pt)
EP (2) EP1076657B1 (pt)
JP (2) JP3842043B2 (pt)
KR (1) KR100448748B1 (pt)
CN (1) CN1234705C (pt)
AR (1) AR016236A1 (pt)
AT (2) ATE330955T1 (pt)
AU (1) AU748403B2 (pt)
BG (1) BG65023B1 (pt)
BR (1) BR9910029A (pt)
CY (1) CY1105075T1 (pt)
CZ (1) CZ20003985A3 (pt)
DE (2) DE59913617D1 (pt)
DK (2) DK1475377T3 (pt)
ES (2) ES2222706T3 (pt)
HK (1) HK1035183A1 (pt)
HU (1) HUP0101625A3 (pt)
IL (2) IL138847A0 (pt)
NO (1) NO321867B1 (pt)
NZ (1) NZ507406A (pt)
PL (1) PL198983B1 (pt)
PT (2) PT1475377E (pt)
SI (2) SI1475377T1 (pt)
SK (1) SK286192B6 (pt)
TR (1) TR200003130T2 (pt)
TW (1) TW530048B (pt)
UA (1) UA59443C2 (pt)
WO (1) WO1999055696A1 (pt)

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DE10037884A1 (de) * 2000-08-03 2002-02-21 Henkel Kgaa Verfahren zur beschleunigten Klebstoffaushärtung
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UA78999C2 (en) 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
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US20040038958A1 (en) * 2002-07-11 2004-02-26 Chris Rundfeldt Topical treatment of skin diseases
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