SI0937074T1 - Benzonaphthyridines as bronchial therapeutics - Google Patents

Benzonaphthyridines as bronchial therapeutics

Info

Publication number
SI0937074T1
SI0937074T1 SI9730535T SI9730535T SI0937074T1 SI 0937074 T1 SI0937074 T1 SI 0937074T1 SI 9730535 T SI9730535 T SI 9730535T SI 9730535 T SI9730535 T SI 9730535T SI 0937074 T1 SI0937074 T1 SI 0937074T1
Authority
SI
Slovenia
Prior art keywords
pct
benzonaphthyridines
bronchial therapeutics
date
sec
Prior art date
Application number
SI9730535T
Other languages
English (en)
Slovenian (sl)
Inventor
Beate Schmidt
Hermann Amschler
Wolf-R�diger ULRICH
Thomas Martin
Thomas Br
Armin Hatzelmann
Karl Sanders
Rolf Beume
Hildegard Boss
Dietrich H�FNER
Hans-Peter Kley
Karl-Josef Goebel
Dieter Flockerzi
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of SI0937074T1 publication Critical patent/SI0937074T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
SI9730535T 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics SI0937074T1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19646298 1996-11-11
EP96118188 1996-11-13
DE19739056 1997-09-05
PCT/EP1997/006096 WO1998021208A1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics
EP97950093A EP0937074B1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Publications (1)

Publication Number Publication Date
SI0937074T1 true SI0937074T1 (en) 2003-08-31

Family

ID=27216810

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730535T SI0937074T1 (en) 1996-11-11 1997-11-05 Benzonaphthyridines as bronchial therapeutics

Country Status (31)

Country Link
US (1) US6008215A (pt)
EP (1) EP0937074B1 (pt)
JP (1) JP4223075B2 (pt)
KR (1) KR100484045B1 (pt)
CN (1) CN1090188C (pt)
AT (1) ATE234300T1 (pt)
AU (1) AU733129B2 (pt)
BG (1) BG63695B1 (pt)
BR (1) BR9713338B1 (pt)
CA (1) CA2270964C (pt)
CY (1) CY2476B1 (pt)
CZ (1) CZ288752B6 (pt)
DE (1) DE69719778T2 (pt)
DK (1) DK0937074T3 (pt)
EA (1) EA001551B1 (pt)
EE (1) EE03829B1 (pt)
ES (1) ES2195189T3 (pt)
GE (1) GEP20012390B (pt)
HK (1) HK1022151A1 (pt)
HU (1) HU226981B1 (pt)
ID (1) ID22042A (pt)
IL (1) IL129054A (pt)
NO (1) NO312764B1 (pt)
NZ (1) NZ334976A (pt)
PL (1) PL189641B1 (pt)
PT (1) PT937074E (pt)
RS (1) RS49607B (pt)
SI (1) SI0937074T1 (pt)
SK (1) SK283269B6 (pt)
TR (1) TR199900856T2 (pt)
WO (1) WO1998021208A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1075477T3 (da) 1998-05-05 2003-06-30 Altana Pharma Ag Nye benzonaphthyridin-N-oxider
AU5970199A (en) * 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
DE60033918D1 (de) * 1999-01-15 2007-04-26 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
CA2359404A1 (en) 1999-01-15 2000-07-20 Beate Gutterer Phenanthridine-n-oxides with pde-iv inhibiting activity
PL205670B1 (pl) * 1999-01-15 2010-05-31 Nycomed Gmbh Nowa 6-fenylofenantrydyna, jej zastosowanie oraz lek zawierający ten związek
ES2241571T3 (es) 1999-01-15 2005-11-01 Altana Pharma Ag N-oxidos de fenantrinida con actividad inhividora de pde-iv.
JP5038568B2 (ja) * 1999-08-21 2012-10-03 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 協力剤の組合せ物
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
DK1377574T3 (da) * 2001-02-21 2005-04-25 Altana Pharma Ag 6-phenylbenzonaphtyridiner
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
RS20050117A (en) * 2002-08-17 2007-06-04 Altana Pharma Ag., Novel benzonaphthyridines
DE60313331T2 (de) * 2002-09-04 2008-01-03 Nycomed Gmbh Neue benzonaphthyridine
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
CN104817534A (zh) 2004-03-03 2015-08-05 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
AU2005223386A1 (en) * 2004-03-17 2005-09-29 Nycomed Gmbh Novel N- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE3/4 inhibitors
WO2006027344A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors
AU2005281703B2 (en) * 2004-09-08 2011-11-17 Takeda Gmbh Novel 3-thia-10-aza-phenanthrene derivatives
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
DK2061765T3 (en) * 2006-09-01 2015-01-26 Senhwa Biosciences Inc Serine-threonine protein kinase AND PARP-MODULATOR
BRPI0911681B8 (pt) 2008-04-23 2021-05-25 Rigel Pharmaceuticals Inc composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds

Also Published As

Publication number Publication date
GEP20012390B (en) 2001-03-25
ES2195189T3 (es) 2003-12-01
IL129054A (en) 2002-07-25
BG63695B1 (bg) 2002-09-30
DK0937074T3 (da) 2003-06-23
NZ334976A (en) 2000-10-27
SK283269B6 (sk) 2003-04-01
RS49607B (sr) 2007-06-04
HUP0000426A3 (en) 2001-04-28
NO992282D0 (no) 1999-05-11
CN1090188C (zh) 2002-09-04
TR199900856T2 (xx) 1999-07-21
NO992282L (no) 1999-05-11
ID22042A (id) 1999-08-26
KR20000053100A (ko) 2000-08-25
EE9900105A (et) 1999-10-15
BG103310A (en) 2000-05-31
JP2001503442A (ja) 2001-03-13
BR9713338B1 (pt) 2009-12-01
US6008215A (en) 1999-12-28
ATE234300T1 (de) 2003-03-15
YU19499A (sh) 2001-09-28
HUP0000426A2 (hu) 2001-02-28
BR9713338A (pt) 2000-05-09
PT937074E (pt) 2003-07-31
CZ288752B6 (cs) 2001-08-15
HU226981B1 (hu) 2010-04-28
KR100484045B1 (ko) 2005-04-20
HK1022151A1 (en) 2000-07-28
CN1236367A (zh) 1999-11-24
CA2270964A1 (en) 1998-05-22
NO312764B1 (no) 2002-07-01
CA2270964C (en) 2007-07-31
CY2476B1 (en) 2005-05-03
IL129054A0 (en) 2000-02-17
DE69719778T2 (de) 2004-02-05
WO1998021208A1 (en) 1998-05-22
EP0937074B1 (en) 2003-03-12
AU5317098A (en) 1998-06-03
AU733129B2 (en) 2001-05-10
CZ167599A3 (cs) 1999-11-17
DE69719778D1 (de) 2003-04-17
EA001551B1 (ru) 2001-04-23
SK62399A3 (en) 1999-10-08
PL189641B1 (pl) 2005-09-30
JP4223075B2 (ja) 2009-02-12
EA199900421A1 (ru) 1999-10-28
PL333429A1 (en) 1999-12-06
EP0937074A1 (en) 1999-08-25
EE03829B1 (et) 2002-08-15

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