SI0770622T1 - Cyclic adhesion inhibitors - Google Patents

Cyclic adhesion inhibitors

Info

Publication number
SI0770622T1
SI0770622T1 SI9630172T SI9630172T SI0770622T1 SI 0770622 T1 SI0770622 T1 SI 0770622T1 SI 9630172 T SI9630172 T SI 9630172T SI 9630172 T SI9630172 T SI 9630172T SI 0770622 T1 SI0770622 T1 SI 0770622T1
Authority
SI
Slovenia
Prior art keywords
adhesion inhibitors
cyclic adhesion
cyclic
inhibitors
adhesion
Prior art date
Application number
SI9630172T
Other languages
English (en)
Slovenian (sl)
Inventor
Alfred Dr. Jonczyk
Simon Dr. Goodman
Beate Dr. Diefenbach
Arne Dr. Sutter
G�nter Dr. H�lzmann
Horst Prof. Kessler
Michael Dechantsreiter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SI0770622T1 publication Critical patent/SI0770622T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI9630172T 1995-09-15 1996-08-31 Cyclic adhesion inhibitors SI0770622T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19534177A DE19534177A1 (de) 1995-09-15 1995-09-15 Cyclische Adhäsionsinhibitoren
EP96113972A EP0770622B1 (de) 1995-09-15 1996-08-31 Cyclische Adhäsionsinhibitoren

Publications (1)

Publication Number Publication Date
SI0770622T1 true SI0770622T1 (en) 2000-08-31

Family

ID=7772215

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630172T SI0770622T1 (en) 1995-09-15 1996-08-31 Cyclic adhesion inhibitors

Country Status (29)

Country Link
US (1) US6001961A (no)
EP (1) EP0770622B1 (no)
JP (3) JP4115550B2 (no)
KR (1) KR100438244B1 (no)
CN (1) CN1203090C (no)
AR (1) AR003574A1 (no)
AT (1) ATE189461T1 (no)
AU (1) AU717574B2 (no)
BR (1) BR9603751A (no)
CA (1) CA2185489C (no)
CO (1) CO4750841A1 (no)
CZ (1) CZ286713B6 (no)
DE (2) DE19534177A1 (no)
DK (1) DK0770622T3 (no)
ES (1) ES2144179T3 (no)
GR (1) GR3033293T3 (no)
HU (1) HU224614B1 (no)
ID (1) ID18770A (no)
MX (1) MX9604100A (no)
NO (1) NO316946B1 (no)
PL (1) PL185125B1 (no)
PT (1) PT770622E (no)
RU (1) RU2157379C2 (no)
SI (1) SI0770622T1 (no)
SK (1) SK282391B6 (no)
TR (1) TR199600716A2 (no)
TW (1) TW517064B (no)
UA (1) UA49799C2 (no)
ZA (1) ZA967768B (no)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753230A (en) 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US7053041B1 (en) 1996-05-31 2006-05-30 The Scripps Research Institute Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
DE19613933A1 (de) * 1996-04-06 1997-10-09 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
JP2002515036A (ja) * 1996-05-31 2002-05-21 ザ スクリップス リサーチ インスティテュート α▲下V▼β▲下5▼媒介血管形成の抑制に有用な方法および組成物
SK163298A3 (en) 1996-05-31 1999-07-12 Scripps Research Inst Methods and compositions useful for inhibition of 'alpha'v'beta'5 mediated angiogenesis
EP0917878A4 (en) * 1997-02-26 2004-05-19 Toray Industries REMEDIES FOR HEPATITIS
DE19842415A1 (de) * 1998-09-16 2000-03-23 Merck Patent Gmbh Pharmazeutische Zubereitung
WO2000038730A2 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia
US6521593B1 (en) * 1999-02-01 2003-02-18 Childrens Hospital Los Angeles Methods for inhibiting brain tumor growth
SI1156823T1 (sl) * 1999-02-12 2009-02-28 Scripps Research Inst Postopki za zdravljenje tumorjev in metastaz z uporabo kombinacije antiangiogenikov in imunoterapij
UA71608C2 (en) 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
EA011384B1 (ru) 1999-06-01 2009-02-27 Байоджен Айдек Ма Инк. Способ лечения воспалительного заболевания
US6518244B2 (en) 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
DK1381382T3 (da) 2000-11-01 2009-02-02 Merck Patent Gmbh Fremgangsmåder og præparater til behandling af öjensygdomme
US20040029788A1 (en) * 2000-11-01 2004-02-12 Hans-Markus Bender Methods and compositions for the treatment of diseases of the eye
PL206142B1 (pl) * 2001-01-09 2010-07-30 Merck Patent Gmbhmerck Patent Gmbh Kompozycja i zestaw farmaceutyczny do leczenia nowotworów i przerzutów nowotworowych oraz ich zastosowanie
UA83791C2 (ru) * 2001-04-13 2008-08-26 Байоджен Айдек Ма Инк. Антитело против vla-1, фармацевтическая композиция, которая его содержит, и из применение для лечения индивидуума с иммунологическим расстройством, опосредованным vla-1
RU2316337C2 (ru) 2001-04-24 2008-02-10 Мерк Патент Гмбх КОМБИНИРОВАННАЯ ТЕРАПИЯ, ИСПОЛЬЗУЮЩАЯ АНТИАНГИОГЕННЫЕ СРЕДСТВА И TNF-α
MXPA04007770A (es) * 2002-02-14 2004-10-15 Merck Patent Gmbh Metodos y composiciones para tratamiento de enfermedades de los ojos.
DE10228049A1 (de) * 2002-06-24 2004-01-15 Merck Patent Gmbh Flüssige Zubereitung enthaltend Oligopeptide
TWI476206B (zh) 2003-07-18 2015-03-11 Amgen Inc 對肝細胞生長因子具專一性之結合劑
DE10337863A1 (de) * 2003-08-18 2005-03-17 Merck Patent Gmbh Verwendung von Chromen-4-on-Derivaten
US9181303B2 (en) 2005-12-22 2015-11-10 Novabiotics Limited Treatment of bacterial infections with cyclic antimicrobial peptides
RU2463308C2 (ru) * 2005-12-22 2012-10-10 НоваБиотикс Лимитед Циклические противомикробные пептиды
US20080108664A1 (en) 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
EP1973569B1 (en) 2006-01-18 2013-05-22 Merck Patent GmbH Specific therapy using integrin ligands for treating cancer
ATE489380T1 (de) * 2006-02-10 2010-12-15 Amgen Inc Hydratformen von amg706
DK2034830T3 (da) 2006-05-25 2014-10-27 Biogen Idec Inc Anti-vla-1-antistof til behandling af slagtilfælde
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
PL2101805T3 (pl) 2007-01-18 2013-04-30 Merck Patent Gmbh Ligandy integryn do stosowania w leczeniu nowotworów
US20080241270A1 (en) * 2007-03-30 2008-10-02 Neal Robert A Fluid composition for inhibiting surgical adhesion formation and related method of production
US20090053280A1 (en) * 2007-05-15 2009-02-26 Michael Joner Coating stents with cyclic rgd peptides or mimetics
EP2526967A1 (en) 2007-07-17 2012-11-28 Merck Patent GmbH Engineered anti-alpha v-integrin hybrid antibodies
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
EA201591355A1 (ru) 2007-08-21 2016-04-29 Амген Инк. АНТИГЕНСВЯЗЫВАЮЩИЕ БЕЛКИ, СВЯЗЫВАЮЩИЕ c-fms ЧЕЛОВЕКА
EP2259768B1 (en) * 2008-04-08 2019-05-22 Merck Patent GmbH Compositions containing cyclic peptides and methods of use
AU2009331955B2 (en) 2008-12-23 2015-09-24 Merck Patent Gmbh Biomarkers for inhibitors with anti-angiogenic activity
EP2432801B1 (en) * 2009-05-20 2016-03-23 Merck Patent GmbH Novel solid materials of {[2s, 5r,8s,11s)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid} and methods for obtaining them
WO2010136168A2 (en) 2009-05-25 2010-12-02 Merck Patent Gmbh Continuous administration of integrin ligands for treating cancer
MX2012006450A (es) 2009-12-10 2012-06-28 Merck Patent Gmbh Composicion farmaceutica que comprende oligopeptidos.
EP2407478A1 (en) 2010-07-14 2012-01-18 GENETADI Biotech, S.L. New cyclotetrapeptides with pro-angiogenic properties
CN103153328A (zh) 2010-07-16 2013-06-12 默克专利股份有限公司 肽在乳腺癌和/或骨转移灶的治疗中的用途
WO2012016188A2 (en) * 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
WO2012069149A1 (en) 2010-11-23 2012-05-31 Merck Patent Gmbh Solution comprising cyclic oligopeptides
JP6320042B2 (ja) 2011-02-11 2018-05-09 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung 前立腺癌治療のための抗アルファ−vインテグリン抗体
WO2012110200A1 (en) 2011-02-18 2012-08-23 Merck Patent Gmbh Cyclic peptide cyclo (l -arginyl - glycyl - l -aspartyl - d - phenylalanyl - n-methyl - l -valyl), compositions thereof, and use thereof in methods for treating graft -versus - host disease
WO2012146729A1 (en) * 2011-04-29 2012-11-01 Philipps-Universität Marburg Lasso peptides as scaffolds for peptide grafting
US10478501B2 (en) * 2011-06-09 2019-11-19 Merck Patent Gmbh Method of treating disorders using a pharmaceutical composition of oligopeptides
WO2013025939A2 (en) 2011-08-16 2013-02-21 Indiana University Research And Technology Corporation Compounds and methods for treating cancer by inhibiting the urokinase receptor
US10160808B2 (en) 2012-02-16 2018-12-25 Santarus, Inc. Anti-VLA1 (CD49A) antibody pharmaceutical compositions
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
WO2014036022A1 (en) 2012-08-29 2014-03-06 Amgen Inc. Quinazolinone compounds and derivatives thereof
EP4249471A3 (en) 2013-09-24 2023-10-18 FUJIFILM Corporation Pharmaceutical composition of a nitrogen-containing compound or salt thereof, or metal complex thereof
EP3275883B1 (en) 2015-03-25 2021-06-02 FUJIFILM Corporation Method for producing novel nitrogen-containing compound or salt thereof, and production intermediate of same
KR20180100302A (ko) * 2015-10-23 2018-09-10 우니베르지태트 트벤테 인테그린 결합 펩티드 및 그의 용도
JP7034914B2 (ja) 2015-11-23 2022-03-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 線維症および/または線維性疾患の治療のための抗α-vインテグリン抗体
EP3207937A1 (en) 2016-02-17 2017-08-23 Royal College of Surgeons in Ireland A method of treating or preventing sepsis
LT3558955T (lt) 2016-12-22 2021-11-10 Amgen Inc. Benzizotiazolo, izotiazolo[3,4-b]piridazino ir ftalazino, pirido[2,3-d] piridazino ir pirido[2,3-d]pirimidino dariniai, kaip kras g12c inhibitoriai, skirti plaučių, kasos arba storosios žarnos vėžio gydymui
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
TWI731264B (zh) 2017-09-08 2021-06-21 美商安進公司 Kras g12c抑制劑以及其使用方法
MX2020011582A (es) 2018-05-04 2020-11-24 Amgen Inc Inhibidores de kras g12c y metodos para su uso.
JP7266043B2 (ja) 2018-05-04 2023-04-27 アムジエン・インコーポレーテツド KRas G12C阻害剤及びそれを使用する方法
JP7361720B2 (ja) 2018-05-10 2023-10-16 アムジエン・インコーポレーテツド がんの治療のためのkras g12c阻害剤
EP3802535B1 (en) 2018-06-01 2022-12-14 Amgen, Inc Kras g12c inhibitors and methods of using the same
AU2019284472B2 (en) 2018-06-11 2024-05-30 Amgen Inc. KRAS G12C inhibitors for treating cancer
AU2019336588B2 (en) 2018-06-12 2022-07-28 Amgen Inc. KRAS G12C inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Kras g12c阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
EP3883565A1 (en) 2018-11-19 2021-09-29 Amgen Inc. Kras g12c inhibitors and methods of using the same
ES2953821T3 (es) 2018-12-20 2023-11-16 Amgen Inc Inhibidores de KIF18A
WO2020132653A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Heteroaryl amides useful as kif18a inhibitors
US11236069B2 (en) 2018-12-20 2022-02-01 Amgen Inc. KIF18A inhibitors
AU2020232616A1 (en) 2019-03-01 2021-09-09 Revolution Medicines, Inc. Bicyclic heterocyclyl compounds and uses thereof
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
US11236091B2 (en) 2019-05-21 2022-02-01 Amgen Inc. Solid state forms
CN114391012A (zh) 2019-08-02 2022-04-22 美国安进公司 作为kif18a抑制剂的吡啶衍生物
JP2022542394A (ja) 2019-08-02 2022-10-03 アムジエン・インコーポレーテツド Kif18a阻害剤として有用なヘテロアリールアミド
IL292315A (en) 2019-11-14 2022-06-01 Amgen Inc Improved synthesis of a kras g12c inhibitory compound
TW202140011A (zh) 2020-01-07 2021-11-01 美商銳新醫藥公司 Shp2抑制劑給藥和治療癌症的方法
WO2021224234A1 (en) 2020-05-04 2021-11-11 Helmholtz-Zentrum für Infektionsforschung GmbH Antiviral use of cilengitide
PE20231207A1 (es) 2020-09-15 2023-08-17 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer
CA3208998A1 (en) 2021-01-22 2022-07-28 Steven Kerrigan Treatment of coronavirus
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
US4517686A (en) * 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4508921A (en) * 1984-06-28 1985-04-02 Merck & Co., Inc. Process for preparation of alpha-alkyl amino acids
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren

Also Published As

Publication number Publication date
CN1203090C (zh) 2005-05-25
GR3033293T3 (en) 2000-09-29
HU224614B1 (hu) 2005-11-28
DK0770622T3 (da) 2000-07-03
HUP9602507A3 (en) 1998-01-28
BR9603751A (pt) 1998-06-02
JPH09132593A (ja) 1997-05-20
PL185125B1 (pl) 2003-02-28
CA2185489C (en) 2007-05-08
HU9602507D0 (en) 1996-11-28
CZ264396A3 (en) 1997-04-16
NO963853D0 (no) 1996-09-13
MX9604100A (es) 1997-08-30
CO4750841A1 (es) 1999-03-31
ATE189461T1 (de) 2000-02-15
SK116796A3 (en) 2001-05-10
EP0770622B1 (de) 2000-02-02
AU6558096A (en) 1997-03-20
UA49799C2 (uk) 2002-10-15
HUP9602507A2 (en) 1997-08-28
NO316946B1 (no) 2004-07-05
NO963853L (no) 1997-03-17
KR970015598A (ko) 1997-04-28
SK282391B6 (sk) 2002-01-07
RU2157379C2 (ru) 2000-10-10
EP0770622A3 (de) 1997-07-02
CA2185489A1 (en) 1997-03-16
ES2144179T3 (es) 2000-06-01
DE19534177A1 (de) 1997-03-20
PT770622E (pt) 2000-07-31
DE59604363D1 (de) 2000-03-09
EP0770622A2 (de) 1997-05-02
CZ286713B6 (en) 2000-06-14
CN1149588A (zh) 1997-05-14
AU717574B2 (en) 2000-03-30
ZA967768B (en) 1997-04-07
TR199600716A2 (tr) 1997-04-22
TW517064B (en) 2003-01-11
JP2007186525A (ja) 2007-07-26
AR003574A1 (es) 1998-08-05
ID18770A (id) 1998-05-07
PL316071A1 (en) 1997-03-17
JP4115550B2 (ja) 2008-07-09
US6001961A (en) 1999-12-14
KR100438244B1 (ko) 2004-08-25
JP2007016042A (ja) 2007-01-25
JP4116062B2 (ja) 2008-07-09
TR199600716A3 (no) 1997-04-22

Similar Documents

Publication Publication Date Title
PL316071A1 (en) Cyclic adhesion inhibitors
HK1010888A1 (en) Cell adhesion inhibitors
EP0835109A4 (en) PYRIDINONE-BASED THROMBIN INHIBITORS
IL122923A0 (en) Cyclic gmp-specific phosphodiesterase inhibitors
PL321759A1 (en) Novel thrombosin inhibitors
PL320995A1 (en) Fibronectin adhesion inhibitors
GB9611422D0 (en) Coated scale inhibitors
GB9505169D0 (en) Waveform
AU2568897A (en) Cyclic adhesion inhibitors
PL325013A1 (en) Profile endopepsidase inhibitors
AU6049796A (en) Lysyloxidase inhibitors
HK1046359A1 (en) Neuraminidase inhibitors
GB9516446D0 (en) Icing inhibitors
AU6860296A (en) Cycloanthelmintic inhibitors
SI0904285T1 (en) Cyclic adhesion inhibitors
ZA934819B (en) Cyclic adhesion inhibitors.
SI0805796T1 (en) Cell adhesion inhibitors
GB9506496D0 (en) Adhesives
GB9502530D0 (en) Adhesives
GB9511237D0 (en) Adhesives
GB9516487D0 (en) Adhesives
GB9524798D0 (en) Adhesives