SI0736525T1 - Benzonitriles as 5-HT agonists and antagonists - Google Patents

Benzonitriles as 5-HT agonists and antagonists

Info

Publication number
SI0736525T1
SI0736525T1 SI9630240T SI9630240T SI0736525T1 SI 0736525 T1 SI0736525 T1 SI 0736525T1 SI 9630240 T SI9630240 T SI 9630240T SI 9630240 T SI9630240 T SI 9630240T SI 0736525 T1 SI0736525 T1 SI 0736525T1
Authority
SI
Slovenia
Prior art keywords
benzonitriles
agonists
antagonists
Prior art date
Application number
SI9630240T
Other languages
English (en)
Inventor
Henning Dr Boettcher
Karl Ulrich Dr Buehring
Hartmut Dr Greiner
Gerd Bartoszyk
Christoph Dr Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SI0736525T1 publication Critical patent/SI0736525T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
SI9630240T 1995-04-05 1996-03-28 Benzonitriles as 5-HT agonists and antagonists SI0736525T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19512639A DE19512639A1 (de) 1995-04-05 1995-04-05 Benzonitrile und -fluoride
EP96104955A EP0736525B1 (de) 1995-04-05 1996-03-28 Benzonitrile als 5-HT Agonisten und Antagonisten

Publications (1)

Publication Number Publication Date
SI0736525T1 true SI0736525T1 (en) 2001-02-28

Family

ID=7758788

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630240T SI0736525T1 (en) 1995-04-05 1996-03-28 Benzonitriles as 5-HT agonists and antagonists

Country Status (28)

Country Link
US (1) US6310068B1 (zh)
EP (1) EP0736525B1 (zh)
JP (1) JP3834098B2 (zh)
KR (1) KR100437751B1 (zh)
CN (1) CN1072209C (zh)
AR (1) AR002982A1 (zh)
AT (1) ATE194595T1 (zh)
AU (1) AU709708B2 (zh)
BR (1) BR9601275A (zh)
CA (1) CA2173418C (zh)
CO (1) CO4700469A1 (zh)
CY (1) CY2242B1 (zh)
CZ (1) CZ289449B6 (zh)
DE (2) DE19512639A1 (zh)
DK (1) DK0736525T3 (zh)
ES (1) ES2150039T3 (zh)
GR (1) GR3034514T3 (zh)
HU (1) HUP9600876A3 (zh)
NO (1) NO305903B1 (zh)
PL (1) PL183147B1 (zh)
PT (1) PT736525E (zh)
RU (1) RU2168508C2 (zh)
SI (1) SI0736525T1 (zh)
SK (1) SK281457B6 (zh)
TR (1) TR199600286A2 (zh)
TW (1) TW323279B (zh)
UA (1) UA45325C2 (zh)
ZA (1) ZA962768B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
IL143979A0 (en) * 1999-01-07 2002-04-21 American Home Prod Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (de) * 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
PL204331B1 (pl) * 2000-11-14 2010-01-29 Merck Patent Gmbh Zastosowanie związków będących kombinowanymi selektywnymi inhibitorami wychwytu zwrotnego serotoniny (5-HT)(SSRIs) i agonistami receptora 5-HT1A do wytwarzania leków weterynaryjnych
UA76130C2 (en) * 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
SI1450799T1 (sl) * 2001-12-03 2007-02-28 Bayer Pharmaceuticals Corp Aril secninske spojine v kombinaciji z drugimi citostaticnimi ali citotoksicnimi sredstvi za zdravljenje cloveskih rakov
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
AU2003209119A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
JP4860474B2 (ja) 2003-05-20 2012-01-25 バイエル、ファーマシューテイカルズ、コーポレイション Ｐｄｇｆｒによって仲介される病気のためのジアリール尿素
DK1663978T3 (da) 2003-07-23 2008-04-07 Bayer Pharmaceuticals Corp Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser
TWI367098B (en) * 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
CN102875538A (zh) * 2012-10-16 2013-01-16 北京诚创思达医药科技有限公司 维拉唑酮或其盐酸盐的制备方法
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
US9714232B2 (en) 2013-12-20 2017-07-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
US11285153B2 (en) 2017-09-29 2022-03-29 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1075156A (en) 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
US3468882A (en) 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate

Also Published As

Publication number Publication date
CY2242B1 (en) 2003-07-04
NO961346D0 (no) 1996-04-02
PT736525E (pt) 2000-12-29
ATE194595T1 (de) 2000-07-15
HUP9600876A2 (hu) 1998-09-28
NO305903B1 (no) 1999-08-16
HUP9600876A3 (en) 2000-04-28
TW323279B (zh) 1997-12-21
UA45325C2 (uk) 2002-04-15
DE59605568D1 (de) 2000-08-17
ZA962768B (en) 1996-11-13
BR9601275A (pt) 1998-01-13
CN1072209C (zh) 2001-10-03
AU5040896A (en) 1996-10-17
JP3834098B2 (ja) 2006-10-18
EP0736525B1 (de) 2000-07-12
CZ96496A3 (en) 1996-10-16
PL313632A1 (en) 1996-10-14
GR3034514T3 (en) 2000-12-29
AR002982A1 (es) 1998-05-27
EP0736525A1 (de) 1996-10-09
AU709708B2 (en) 1999-09-02
ES2150039T3 (es) 2000-11-16
HU9600876D0 (en) 1996-05-28
CA2173418A1 (en) 1996-10-06
CO4700469A1 (es) 1998-12-29
CA2173418C (en) 2007-06-12
KR100437751B1 (ko) 2004-08-25
SK281457B6 (sk) 2001-03-12
RU2168508C2 (ru) 2001-06-10
JPH09151174A (ja) 1997-06-10
SK40396A3 (en) 1996-11-06
NO961346L (no) 1996-10-07
CN1137036A (zh) 1996-12-04
TR199600286A2 (tr) 1997-03-21
PL183147B1 (pl) 2002-05-31
KR960037675A (ko) 1996-11-19
CZ289449B6 (cs) 2002-01-16
DE19512639A1 (de) 1996-10-10
DK0736525T3 (da) 2000-10-30
US6310068B1 (en) 2001-10-30

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