SG94780A1 - Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors - Google Patents

Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors

Info

Publication number
SG94780A1
SG94780A1 SG200101308A SG200101308A SG94780A1 SG 94780 A1 SG94780 A1 SG 94780A1 SG 200101308 A SG200101308 A SG 200101308A SG 200101308 A SG200101308 A SG 200101308A SG 94780 A1 SG94780 A1 SG 94780A1
Authority
SG
Singapore
Prior art keywords
protease inhibitors
making hiv
intermediates
methods
hiv
Prior art date
Application number
SG200101308A
Other languages
English (en)
Inventor
Kathleen R Whitten
Michael E Deason
Original Assignee
Agouron Pharma
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma, Japan Tobacco Inc filed Critical Agouron Pharma
Publication of SG94780A1 publication Critical patent/SG94780A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/287—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG200101308A 1996-09-05 1997-09-04 Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors SG94780A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70841196A 1996-09-05 1996-09-05

Publications (1)

Publication Number Publication Date
SG94780A1 true SG94780A1 (en) 2003-03-18

Family

ID=24845703

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200101308A SG94780A1 (en) 1996-09-05 1997-09-04 Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors

Country Status (33)

Country Link
EP (2) EP0927165B1 (uk)
JP (3) JP4149000B2 (uk)
KR (1) KR100563289B1 (uk)
CN (2) CN1305854C (uk)
AP (2) AP1322A (uk)
AT (2) ATE309990T1 (uk)
AU (2) AU740369B2 (uk)
BG (2) BG64793B1 (uk)
BR (1) BR9713192A (uk)
CA (1) CA2264756A1 (uk)
CZ (2) CZ298174B6 (uk)
DE (2) DE69734689T2 (uk)
DK (2) DK1361216T3 (uk)
EA (1) EA002051B1 (uk)
EE (1) EE04465B1 (uk)
ES (2) ES2210573T3 (uk)
GE (1) GEP20022799B (uk)
HK (1) HK1062171A1 (uk)
HU (1) HUP0000028A3 (uk)
IL (1) IL128567A (uk)
IS (1) IS2030B (uk)
NO (1) NO313287B1 (uk)
NZ (1) NZ334909A (uk)
OA (1) OA10988A (uk)
PL (2) PL198408B1 (uk)
PT (1) PT927165E (uk)
SG (1) SG94780A1 (uk)
SI (2) SI1361216T1 (uk)
SK (2) SK284899B6 (uk)
TR (1) TR199900473T2 (uk)
UA (1) UA67727C2 (uk)
WO (1) WO1998009951A2 (uk)
YU (1) YU11599A (uk)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0579223A1 (en) * 1992-07-17 1994-01-19 Mitsubishi Chemical Corporation Carboxylic acid derivatives having 5 alpha-reductase inhibitory activity
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07248183A (ja) * 1994-03-11 1995-09-26 Osaka Gas Co Ltd 浴室兼用衣類乾燥室
JP3298293B2 (ja) * 1994-03-14 2002-07-02 松下電器産業株式会社 厨芥処理機
AU4953796A (en) * 1995-03-15 1996-10-02 Sanyko Company, Limited Dipeptide compounds having ahpba structure
DE69634345T2 (de) * 1995-09-26 2006-03-02 Japan Tobacco Inc. Verfahren zur herstellung von amid-derivaten und ihren zwischenverbindungen
EP0984000B1 (en) * 1995-09-26 2008-12-03 Japan Tabacco Inc. Process for producing amide derivatives and intermediate compounds
US5962704A (en) * 1995-09-26 1999-10-05 Japan Tobacco Inc. Production of amide derivatives and intermediate compounds therefor
WO1997030993A1 (de) * 1996-02-24 1997-08-28 Basf Aktiengesellschaft Pyrazol-4-yl-hetaroylderivate als herbizide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0579223A1 (en) * 1992-07-17 1994-01-19 Mitsubishi Chemical Corporation Carboxylic acid derivatives having 5 alpha-reductase inhibitory activity
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors

Also Published As

Publication number Publication date
HUP0000028A3 (en) 2003-05-28
PL201758B1 (pl) 2009-05-29
DE69734689T2 (de) 2006-06-08
CZ298174B6 (cs) 2007-07-11
CA2264756A1 (en) 1998-03-12
IL128567A0 (en) 2000-01-31
AP9901497A0 (en) 1999-06-30
CN1537846A (zh) 2004-10-20
PT927165E (pt) 2004-04-30
AU1473602A (en) 2002-03-14
EP1361216A1 (en) 2003-11-12
ES2210573T3 (es) 2004-07-01
NO991072L (no) 1999-03-04
TR199900473T2 (xx) 1999-06-21
DE69726298T2 (de) 2004-05-27
CZ298175B6 (cs) 2007-07-11
JP4149000B2 (ja) 2008-09-10
ATE254603T1 (de) 2003-12-15
ES2252586T3 (es) 2006-05-16
IS4982A (is) 1999-02-19
EP0927165B1 (en) 2003-11-19
EA002051B1 (ru) 2001-12-24
JP2001500495A (ja) 2001-01-16
HK1062171A1 (en) 2004-10-21
DK0927165T3 (da) 2004-03-15
WO1998009951A3 (en) 1998-07-09
JP2008056693A (ja) 2008-03-13
UA67727C2 (uk) 2004-07-15
SI1361216T1 (sl) 2006-02-28
IL128567A (en) 2004-03-28
AP1322A (en) 2004-11-04
PL331801A1 (en) 1999-08-02
SI0927165T1 (en) 2004-04-30
EP1361216B1 (en) 2005-11-16
KR20010029489A (ko) 2001-04-06
CN1183117C (zh) 2005-01-05
OA10988A (en) 2001-11-01
WO1998009951A2 (en) 1998-03-12
NZ334909A (en) 2000-06-23
BG65237B1 (bg) 2007-09-28
EE04465B1 (et) 2005-04-15
BG64793B1 (bg) 2006-04-28
AU4331797A (en) 1998-03-26
AP2003002938A0 (en) 2003-12-31
EA199900257A1 (ru) 1999-08-26
NO991072D0 (no) 1999-03-04
DE69726298D1 (de) 2003-12-24
DE69734689D1 (de) 2005-12-22
CN1232455A (zh) 1999-10-20
AU740369B2 (en) 2001-11-01
CZ71699A3 (cs) 1999-06-16
NO313287B1 (no) 2002-09-09
GEP20022799B (en) 2002-09-25
DK1361216T3 (da) 2006-01-23
BR9713192A (pt) 1999-12-21
ATE309990T1 (de) 2005-12-15
JP2008088178A (ja) 2008-04-17
SK28299A3 (en) 1999-11-08
CN1305854C (zh) 2007-03-21
EP0927165A2 (en) 1999-07-07
YU11599A (sh) 2000-03-21
PL198408B1 (pl) 2008-06-30
AU766155B2 (en) 2003-10-09
IS2030B (is) 2005-08-15
BG103305A (en) 2000-01-31
HUP0000028A2 (hu) 2000-05-28
SK285278B6 (sk) 2006-10-05
KR100563289B1 (ko) 2006-03-22
EE9900109A (et) 1999-12-15
SK284899B6 (sk) 2006-02-02

Similar Documents

Publication Publication Date Title
PL331856A1 (en) Heterocyclic inhibitors of metaloprotease
HUP9700602A3 (en) New inhibitors of bone-resorption and vitronectine-receptor-antagonists
PL333364A1 (en) Novel compounds and method of using them
PL327569A1 (en) Promedications of thrombosin inhibitors
IL122186A (en) Heterocycles as inhibitors of leucotype adhesion and as vla-4-antagonists
PL318128A1 (en) Polymer-polyol and method of obtaining polymer-polyols
PL331047A1 (en) Novel amidinic derivatives and their application as inhibitors of thrombosin
PL334846A1 (en) Sulphamidic inhibitors of metaloproteases
PL331920A1 (en) Spirocyclic inhibitors of metaloproteases
PL334975A1 (en) Application of gasto-intestinal lipase inhibitors
PL332482A1 (en) Intermediate compounds for and method of obtaining olanzaoine
PL318452A1 (en) Method of obtaining peroxyperfluoropolyoxyalkylenes
ZA977868B (en) Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors.
PL330400A1 (en) Method of obtaining azacyclohexapeptides
HUP0004855A3 (en) Method for the synthesis of quinoline derivatives and intermediates
HUP0003958A3 (en) Process for preparation of 4-aryl-piperidines and intermediates
ZA977619B (en) Naphthyl compounds intermediates compositions and methods of use
PL333984A1 (en) Method of obtaining n-substituted 3-hydroxypyrazoles
PL332077A1 (en) Method of obtaining omepraole
PL332141A1 (en) Method of obtaining fluoxetin
PL313419A1 (en) Method of obtaining beta-naphtole
PL333977A1 (en) Method of obtaining benzisothiazolyn-3-ones
AP9901497A0 (en) Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors
PL320529A1 (en) Apparatus for combined drilling of blast-holes and anchor-holes
NO990018D0 (no) Belegg og fremgangsmÕte for fremstilling derav