SG183660A1 - Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same - Google Patents
Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same Download PDFInfo
- Publication number
- SG183660A1 SG183660A1 SG2012055968A SG2012055968A SG183660A1 SG 183660 A1 SG183660 A1 SG 183660A1 SG 2012055968 A SG2012055968 A SG 2012055968A SG 2012055968 A SG2012055968 A SG 2012055968A SG 183660 A1 SG183660 A1 SG 183660A1
- Authority
- SG
- Singapore
- Prior art keywords
- membrane
- media
- sorber
- sample
- coating
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 37
- 150000003141 primary amines Chemical class 0.000 title claims abstract description 5
- 239000012528 membrane Substances 0.000 title abstract description 153
- 238000001179 sorption measurement Methods 0.000 title abstract description 18
- 238000004587 chromatography analysis Methods 0.000 title abstract description 15
- 238000000746 purification Methods 0.000 title abstract description 10
- 238000004255 ion exchange chromatography Methods 0.000 title abstract description 3
- 239000012535 impurity Substances 0.000 claims abstract description 28
- 238000005349 anion exchange Methods 0.000 claims abstract description 15
- 239000000523 sample Substances 0.000 claims abstract description 13
- 150000001450 anions Chemical class 0.000 claims abstract description 12
- 239000012472 biological sample Substances 0.000 claims abstract description 9
- 239000011248 coating agent Substances 0.000 claims description 43
- 238000000576 coating method Methods 0.000 claims description 43
- 239000000758 substrate Substances 0.000 claims description 38
- 238000005341 cation exchange Methods 0.000 claims description 13
- 238000001042 affinity chromatography Methods 0.000 claims description 6
- 238000011068 loading method Methods 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000012521 purified sample Substances 0.000 claims 3
- 238000005277 cation exchange chromatography Methods 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000027455 binding Effects 0.000 abstract description 37
- 229920000642 polymer Polymers 0.000 abstract description 33
- 108090000623 proteins and genes Proteins 0.000 abstract description 24
- 102000004169 proteins and genes Human genes 0.000 abstract description 24
- 239000003446 ligand Substances 0.000 abstract description 9
- 238000010790 dilution Methods 0.000 abstract description 5
- 239000012895 dilution Substances 0.000 abstract description 5
- 238000005498 polishing Methods 0.000 abstract description 5
- 150000001768 cations Chemical class 0.000 abstract description 4
- 229920000083 poly(allylamine) Polymers 0.000 abstract description 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract description 4
- 101710120037 Toxin CcdB Proteins 0.000 abstract description 3
- 125000002091 cationic group Chemical group 0.000 abstract description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 32
- 239000011324 bead Substances 0.000 description 24
- 239000011148 porous material Substances 0.000 description 24
- 230000004907 flux Effects 0.000 description 18
- 239000000463 material Substances 0.000 description 18
- 239000000835 fiber Substances 0.000 description 17
- 239000004971 Cross linker Substances 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 241000700605 Viruses Species 0.000 description 15
- 230000002209 hydrophobic effect Effects 0.000 description 15
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 15
- 239000002253 acid Substances 0.000 description 14
- -1 ammonium ions Chemical class 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 11
- 230000035699 permeability Effects 0.000 description 11
- 239000004094 surface-active agent Substances 0.000 description 11
- 230000000274 adsorptive effect Effects 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 10
- 238000004132 cross linking Methods 0.000 description 10
- 239000010410 layer Substances 0.000 description 10
- 229920002518 Polyallylamine hydrochloride Polymers 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000017 hydrogel Substances 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 238000009736 wetting Methods 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 150000001412 amines Chemical class 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 6
- 239000004745 nonwoven fabric Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 229920000936 Agarose Polymers 0.000 description 5
- 239000002156 adsorbate Substances 0.000 description 5
- 125000003277 amino group Chemical group 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000002158 endotoxin Substances 0.000 description 5
- 239000004744 fabric Substances 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 229920000768 polyamine Polymers 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 229920002684 Sepharose Polymers 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000010306 acid treatment Methods 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 150000003863 ammonium salts Chemical class 0.000 description 4
- 229920001688 coating polymer Polymers 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000002759 woven fabric Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 108010039918 Polylysine Proteins 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000012501 chromatography medium Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 239000012982 microporous membrane Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 229920000656 polylysine Polymers 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 description 3
- 238000003892 spreading Methods 0.000 description 3
- 230000007480 spreading Effects 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 239000003011 anion exchange membrane Substances 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940126587 biotherapeutics Drugs 0.000 description 2
- 239000013622 capto Q Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- PQVSTLUFSYVLTO-UHFFFAOYSA-N ethyl n-ethoxycarbonylcarbamate Chemical compound CCOC(=O)NC(=O)OCC PQVSTLUFSYVLTO-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- GLXDVVHUTZTUQK-UHFFFAOYSA-M lithium hydroxide monohydrate Substances [Li+].O.[OH-] GLXDVVHUTZTUQK-UHFFFAOYSA-M 0.000 description 2
- 229940040692 lithium hydroxide monohydrate Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920002492 poly(sulfone) Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012414 sterilization procedure Methods 0.000 description 2
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical group NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 150000003512 tertiary amines Chemical class 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- PUVAFTRIIUSGLK-UHFFFAOYSA-M trimethyl(oxiran-2-ylmethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC1CO1 PUVAFTRIIUSGLK-UHFFFAOYSA-M 0.000 description 2
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- AOBIOSPNXBMOAT-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane Chemical compound C1OC1COCCOCC1CO1 AOBIOSPNXBMOAT-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- GEHMBYLTCISYNY-UHFFFAOYSA-N Ammonium sulfamate Chemical class [NH4+].NS([O-])(=O)=O GEHMBYLTCISYNY-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 241000763212 Lype Species 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000491 Polyphenylsulfone Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000006177 biological buffer Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000012930 cell culture fluid Substances 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 238000012444 downstream purification process Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 229920002113 octoxynol Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000013047 polymeric layer Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/328—Polymers on the carrier being further modified
- B01J20/3282—Crosslinked polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/12—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96465307P | 2007-08-14 | 2007-08-14 | |
| US7070808P | 2008-03-25 | 2008-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG183660A1 true SG183660A1 (en) | 2012-09-27 |
Family
ID=40042617
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200805944-6A SG150458A1 (en) | 2007-08-14 | 2008-08-12 | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| SG2012055968A SG183660A1 (en) | 2007-08-14 | 2008-08-12 | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| SG2012055661A SG183083A1 (en) | 2007-08-14 | 2008-08-12 | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200805944-6A SG150458A1 (en) | 2007-08-14 | 2008-08-12 | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012055661A SG183083A1 (en) | 2007-08-14 | 2008-08-12 | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
Country Status (5)
| Country | Link |
|---|---|
| US (6) | US9433922B2 (enExample) |
| EP (2) | EP2027921B1 (enExample) |
| JP (3) | JP5031695B2 (enExample) |
| CN (1) | CN105457335B (enExample) |
| SG (3) | SG150458A1 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7479222B2 (en) * | 2004-02-05 | 2009-01-20 | Millipore Corporation | Porous adsorptive or chromatographic media |
| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
| EP2043767B1 (en) | 2006-07-14 | 2020-03-25 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
| US8163886B2 (en) | 2006-12-21 | 2012-04-24 | Emd Millipore Corporation | Purification of proteins |
| US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US8653246B2 (en) * | 2007-10-26 | 2014-02-18 | Asahi Kasei Chemicals Corporation | Method for purifying protein |
| US20090130738A1 (en) * | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| WO2009146321A1 (en) | 2008-05-30 | 2009-12-03 | 3M Innovative Properties Company | Ligand functionalized substrates |
| EP2522692B1 (en) | 2008-05-30 | 2014-06-18 | 3M Innovative Properties Company | Ligand monomers and copolymers made therewith |
| WO2009145722A1 (en) * | 2008-05-30 | 2009-12-03 | Ge Healthcare Bio-Sciences Ab | Separation method utilizing polyallylamine ligands |
| ES2749232T3 (es) | 2008-12-16 | 2020-03-19 | Emd Millipore Corp | Reactor de tanque agitado y procedimiento |
| DE102009005479A1 (de) * | 2009-01-21 | 2010-07-22 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren für die Stofftrennung |
| US20100218681A1 (en) * | 2009-02-27 | 2010-09-02 | General Electric Company | Membranes comprising amino acid mobile carriers |
| US8382883B2 (en) | 2009-02-27 | 2013-02-26 | General Electric Company | Membranes comprising amino acid mobile carriers |
| US9441011B2 (en) | 2009-07-03 | 2016-09-13 | Asahi Kasei Chemicals Corporation | Method for purification of antibody using porous membrane having amino group and alkyl group both bound to graft chain immobilized on porous substrate |
| CN102574911B (zh) * | 2009-08-07 | 2017-06-06 | Emd密理博公司 | 从样品的一或多种杂质中纯化靶蛋白的方法 |
| FR2949780A1 (fr) * | 2009-09-04 | 2011-03-11 | Commissariat Energie Atomique | Procedure d'extraction rapide des hepatotoxines cellulaires de cyanobacteries toxiques |
| DE102009040180A1 (de) * | 2009-09-07 | 2011-03-17 | Dionex Benelux B.V. | Strömungssteuerung bei der räumlichen Chromatografie |
| US8377672B2 (en) | 2010-02-18 | 2013-02-19 | 3M Innovative Properties Company | Ligand functionalized polymers |
| EP2889625B1 (en) * | 2010-03-03 | 2016-09-14 | 3M Innovative Properties Company | Ligand guanidinyl functionalized polymers |
| JP2011225568A (ja) * | 2010-04-20 | 2011-11-10 | Millipore Corp | 第一級アミンによる核酸からのウイルス及び／又はタンパク質の分離 |
| US20120077249A1 (en) * | 2010-04-20 | 2012-03-29 | Millipore Corporation | Separation Of Virus And/Or Protein From Nucleic Acids By Primary Amines |
| WO2011140406A1 (en) * | 2010-05-07 | 2011-11-10 | Millipore Corporation | Enhanced clarification media |
| WO2011140405A1 (en) * | 2010-05-07 | 2011-11-10 | Millipore Corporation | Enhanced clarification media |
| SG10201804385YA (en) | 2010-05-17 | 2018-06-28 | Emd Millipore Corp | Stimulus responsive polymers for the purification of biomolecules |
| MY161534A (en) | 2010-05-25 | 2017-04-28 | Genentech Inc | Methods of purifying polypeptides |
| EP2598223B1 (en) | 2010-07-30 | 2022-04-06 | EMD Millipore Corporation | Chromatography media and method |
| DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
| AU2011325341B2 (en) | 2010-11-01 | 2015-12-17 | Dpx Holdings B.V. | Single unit ion exchange chromatography antibody purification |
| US20130306545A1 (en) | 2010-12-27 | 2013-11-21 | Asahi Kasei Chemicals Corporation | Adsorption/separation membrane module, method for producing adsorption/separation membrane module, and partition member |
| EP2545989A1 (en) | 2011-07-13 | 2013-01-16 | InstrAction GmbH | Composite material for chromatographic applications |
| TWI457165B (zh) | 2011-09-30 | 2014-10-21 | Asahi Kasei Chemicals Corp | Purification of proteins |
| EP2793021A4 (en) | 2011-12-15 | 2015-08-19 | Asahi Kasei Chemicals Corp | PROTEINADSORBENS |
| IL267585B (en) | 2011-12-22 | 2022-09-01 | Genentech Inc | Ion exchange membrane chromatography |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| WO2014123486A1 (en) | 2013-02-06 | 2014-08-14 | Agency For Science, Technology And Research | Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations |
| BR112016004437A2 (pt) | 2013-09-13 | 2017-10-17 | Genentech Inc | métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit |
| CN105722532A (zh) | 2013-09-13 | 2016-06-29 | 豪夫迈·罗氏有限公司 | 包含纯化的重组多肽的方法和组合物 |
| EP3048109A4 (en) * | 2013-09-17 | 2017-04-19 | Kaneka Corporation | Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom |
| EP2986307A4 (en) | 2014-01-03 | 2017-04-12 | Bio-rad Laboratories, Inc. | Removal of impurities from protein a eluates |
| EP3094391B1 (en) * | 2014-01-17 | 2024-11-20 | Repligen Corporation | Sterilizing chromatography columns |
| JP2017510452A (ja) * | 2014-03-07 | 2017-04-13 | エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ | 生物学的生成物の分画のための装置及び方法 |
| US11680080B2 (en) * | 2014-03-13 | 2023-06-20 | Folim G. Halaka | Purification columns and methods |
| EP3116645B1 (en) * | 2014-03-14 | 2019-04-10 | GE Healthcare BioProcess R&D AB | Separation matrices for purification of biological particles |
| JP2016006410A (ja) * | 2014-05-27 | 2016-01-14 | Jnc株式会社 | クロマトグラフィー担体およびそれを用いたタンパク質精製方法 |
| US10280195B2 (en) * | 2014-05-28 | 2019-05-07 | Agency For Science, Technology And Research | Virus reduction method |
| CN106574915B (zh) * | 2014-07-25 | 2019-10-11 | 旭化成医疗株式会社 | 阳离子交换色谱载体及其使用方法 |
| SG11201700030UA (en) | 2014-09-02 | 2017-02-27 | Emd Millipore Corp | High surface area fiber media with nano-fibrillated surface features |
| CN104399538A (zh) * | 2014-09-24 | 2015-03-11 | 中国科学院福建物质结构研究所 | 一种化合物、其制备方法及作为离子交换材料的应用 |
| US20170298091A1 (en) | 2014-12-08 | 2017-10-19 | Emd Millipore Corporation | Mixed Bed Ion Exchange Adsorber |
| CN105080623B (zh) * | 2015-08-14 | 2018-02-16 | 中国科学院福建物质结构研究所 | 一种用于分离和/或提取稀土元素的离子交换剂 |
| EP3349885A4 (en) * | 2015-09-16 | 2019-06-19 | Evoqua Water Technologies LLC | GAMMA RADIATION OF ION-EXCHANGE RESINS FOR REMOVAL OF HALOGENATED IMPURITIES |
| GB201602938D0 (en) * | 2016-02-19 | 2016-04-06 | Ucb Biopharma Sprl | Protein purification |
| WO2018050849A1 (en) * | 2016-09-15 | 2018-03-22 | Klawego Gmbh & Co. Kg | The use of a polymeric mesh for the purification of macromolecules |
| GB201616758D0 (en) * | 2016-10-03 | 2016-11-16 | Ge Healthcare Bio Sciences Ab | Novel chromatography media |
| CN109964123A (zh) * | 2016-11-18 | 2019-07-02 | 捷恩智株式会社 | 抗体的纯化方法 |
| WO2019170634A1 (en) | 2018-03-05 | 2019-09-12 | Chiral Technologies Europe Sas | Composite material for bioseparations |
| WO2019170635A1 (en) | 2018-03-05 | 2019-09-12 | Chiral Technologies Europe Sas | Composite material for bioseparations |
| CN119881293A (zh) | 2018-03-21 | 2025-04-25 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| US12485364B2 (en) | 2018-08-10 | 2025-12-02 | Clemson University Research Foundation | Multi-modal ion-exchange membranes for rapid separations |
| US11045773B2 (en) | 2018-08-31 | 2021-06-29 | Pall Corporation | Salt tolerant porous medium |
| US10737259B2 (en) | 2018-08-31 | 2020-08-11 | Pall Corporation | Salt tolerant anion exchange medium |
| CN113015567A (zh) * | 2018-11-21 | 2021-06-22 | 美国富士电子材料股份有限公司 | 化学液体制造装置以及化学液体制造方法 |
| WO2020123714A1 (en) | 2018-12-12 | 2020-06-18 | Purilogics, LLC | Affinity membrane and method of preparation |
| CN109881483B (zh) * | 2019-01-24 | 2021-12-17 | 浙江理工大学 | 一种利用金属-有机框架材料功能化改性聚丙烯/纤维素水刺无纺布的方法及其应用 |
| EP4385618A1 (en) | 2022-12-16 | 2024-06-19 | Chiral Technologies Europe SAS | Composite material for bioseparations |
| CN120586667A (zh) * | 2024-03-05 | 2025-09-05 | 苏州纳微科技股份有限公司 | 复合膜材及其制备方法与应用 |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898310A (en) | 1956-08-08 | 1959-08-04 | Pfaudler Permutit Inc | Highly-basic anion exchange resins from epihalohydrins and tertiary - amino containing alkylenepolyamines |
| GB932660A (en) | 1960-06-22 | 1963-07-31 | Wolfen Filmfab Veb | Process for the manufacture of anion-selective diaphragms |
| US3462429A (en) | 1964-11-25 | 1969-08-19 | Us Army | 2-(3-(morpholinopropyl)amino)ethanethiol or its acid addition salts |
| US3527712A (en) | 1967-03-07 | 1970-09-08 | Marine Colloids Inc | Dried agarose gel,method of preparation thereof,and production of aqueous agarose gel |
| US3926864A (en) | 1971-06-21 | 1975-12-16 | Ionics | Ion exchange membranes having a macroporous surface area |
| US3714010A (en) | 1972-01-06 | 1973-01-30 | Us Interior | Preparation of anion exchange membranes from cellulosic sheets |
| US4335017A (en) | 1975-12-15 | 1982-06-15 | United Kingdom Atomic Energy Authority | Composite materials comprising deformable xerogel within the pores of particulate rigid supports useful in chromatography |
| HU177419B (en) | 1978-07-13 | 1981-10-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing threedimensional,retentive polymers consisting of cyclodextrin and polyvinylalcohol units,capable of forming inclusion complexes in the form of bead,fibre or mainly block |
| GB2083827B (en) | 1980-09-11 | 1984-03-28 | Atomic Energy Authority Uk | Biologically active composites |
| IL65131A0 (en) | 1982-02-28 | 1982-04-30 | Yeda Res & Dev | Process for the production of agarose-polyaldehyde beads and their biological applications |
| US4431545A (en) | 1982-05-07 | 1984-02-14 | Pall Corporation | Microporous filter system and process |
| CH660852A5 (de) | 1982-11-23 | 1987-05-29 | Aligena Ag | Dynamische membranen, die sich als duenne polymerschichten auf poroesen, polymeren traegermaterialien befinden. |
| US4861705A (en) | 1983-01-31 | 1989-08-29 | Yeda Research And Development Company, Ltd. | Method for removing components of biological fluids |
| US4512896A (en) | 1983-02-07 | 1985-04-23 | Yale University | Transfer of macromolecules from a chromatographic substrate to an immobilizing matrix |
| WO1984003053A1 (en) | 1983-02-14 | 1984-08-16 | Amf Inc | Modified polysaccharide supports |
| US4743373A (en) | 1983-06-17 | 1988-05-10 | Cuno Incorporated | Chromatography column |
| US4496461A (en) | 1983-06-17 | 1985-01-29 | Amf Incorporated | Chromatography column |
| US4540625A (en) | 1984-01-09 | 1985-09-10 | Hughes Aircraft Company | Flexible air permeable non-woven fabric filters |
| US4618533A (en) | 1984-11-30 | 1986-10-21 | Millipore Corporation | Porous membrane having hydrophilic surface and process |
| JPS6255084A (ja) | 1985-04-04 | 1987-03-10 | ジエネツクス・コ−ポレイシヨン | 生体の固定化方法及びそれから得られた不溶化生体複合体 |
| US6136200A (en) | 1985-06-27 | 2000-10-24 | Polymer Research Corporation | Treatment for paint and lacquer waste water |
| US4980067A (en) | 1985-07-23 | 1990-12-25 | Cuno, Inc. | Polyionene-transformed microporous membrane |
| US4895661A (en) | 1987-01-08 | 1990-01-23 | Filmtec Corporation | Alkali resistant hyperfiltration membrane |
| GB2201904B (en) | 1987-02-14 | 1990-12-19 | Domnick Hunter Filters Ltd | Device for liquid chromatography or immobilised enzyme reaction |
| DE3736087C2 (de) | 1987-10-24 | 1997-03-06 | Serva Feinbiochem Gmbh & Co | Gewebe zur Herstellung von Elektrophoresegelen |
| US5277915A (en) | 1987-10-30 | 1994-01-11 | Fmc Corporation | Gel-in-matrix containing a fractured hydrogel |
| EP0328256A1 (en) | 1988-01-21 | 1989-08-16 | Owens-Corning Fiberglas Corporation | Glass fibers coated with agarose for use as column packing or chromatographic media for bioseparations |
| US5114585A (en) | 1988-03-01 | 1992-05-19 | Gelman Sciences, Inc. | Charged porous filter |
| FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
| JPH02180899A (ja) | 1988-12-31 | 1990-07-13 | Tosoh Corp | 免疫グロブリンの精製方法 |
| US4968532A (en) | 1989-01-13 | 1990-11-06 | Ciba-Geigy Corporation | Process for graft copolymerization on surfaces of preformed substrates to modify surface properties |
| IL89970A (en) | 1989-04-14 | 1994-10-21 | Weizmann Kiryat Membrane Prod | Composite membranes containing a coated layer of crosslinked polyaromatic polymers and/or sulfonated poly (haloalkylenes) |
| GB8913183D0 (en) | 1989-06-08 | 1989-07-26 | Central Blood Lab Authority | Chemical products |
| US4944879A (en) | 1989-07-27 | 1990-07-31 | Millipore Corporation | Membrane having hydrophilic surface |
| US5075432A (en) | 1989-08-11 | 1991-12-24 | Edward Vanzo | Spherical cyclodextrin polymer beads |
| US5009759A (en) | 1989-09-22 | 1991-04-23 | Board Of Regents, The University Of Texas System | Methods for producing agarose gels having variable pore sizes |
| US5328603A (en) | 1990-03-20 | 1994-07-12 | The Center For Innovative Technology | Lignocellulosic and cellulosic beads for use in affinity and immunoaffinity chromatography of high molecular weight proteins |
| GB9011378D0 (en) | 1990-05-22 | 1990-07-11 | Bio Isolates Ltd | Cellulosic sponge adsorbent medium |
| US5096561A (en) | 1990-07-02 | 1992-03-17 | Masud Akhtar | Thin film ionic conductors, methods and devices |
| US5104729A (en) | 1990-08-20 | 1992-04-14 | Monsanto Company | Process for surface modifying a support membrane and product produced |
| US5151189A (en) | 1990-09-17 | 1992-09-29 | Gelman Sciences, Inc. | Cationic charge modified microporous membrane |
| US5137633A (en) | 1991-06-26 | 1992-08-11 | Millipore Corporation | Hydrophobic membrane having hydrophilic and charged surface and process |
| EP0586268B1 (en) | 1992-07-06 | 2000-02-23 | Terumo Kabushiki Kaisha | A pathogenic substance removing material and a blood filter comprising said material |
| JPH0615167A (ja) | 1992-07-06 | 1994-01-25 | Terumo Corp | 多孔性分離膜 |
| US5583162A (en) | 1994-06-06 | 1996-12-10 | Biopore Corporation | Polymeric microbeads and method of preparation |
| DE69520042T2 (de) | 1994-07-28 | 2001-07-19 | Millipore Corp., Bedford | Porösesverbundmembran und verfahren |
| KR100275591B1 (ko) * | 1994-10-28 | 2001-02-01 | 크리스타 헤르 조크 | 단백질 키나아제 npk-110 |
| US5522994A (en) | 1995-02-01 | 1996-06-04 | Cornell Research Foundation, Inc. | Single column chromatographic determination of small molecules in mixtures with large molecules |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| AU5309396A (en) | 1995-04-13 | 1996-10-30 | Travenol Laboratories (Israel) Ltd. | Leukocyte filtration method and apparatus |
| US5531899A (en) | 1995-06-06 | 1996-07-02 | Millipore Investment Holdings Limited | Ion exchange polyethylene membrane and process |
| FR2737730B1 (fr) | 1995-08-10 | 1997-09-05 | Pasteur Merieux Serums Vacc | Procede de purification de virus par chromatographie |
| US5814372A (en) | 1995-10-19 | 1998-09-29 | Millipore Corporation | Process for forming porous composite membrane |
| SE9600590D0 (sv) | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| US5814567A (en) | 1996-06-14 | 1998-09-29 | Kimberly-Clark Worldwide, Inc. | Durable hydrophilic coating for a porous hydrophobic substrate |
| US20010009756A1 (en) | 1998-01-06 | 2001-07-26 | Derek Hei | Flow devices for the reduction of compounds from biological compositions and methods of use |
| US5897779A (en) | 1997-02-13 | 1999-04-27 | Minnesota Mining And Manufacturing Company | Spiral wound extraction cartridge |
| FR2772639B1 (fr) | 1997-12-24 | 2000-02-04 | Hospal Ind | Utilisation d'un polymere neutre ou cationique pour prevenir l'activation de la phase contact du sang ou du plasma en contact avec une membrane semi-permeable |
| PL347472A1 (en) | 1998-08-14 | 2002-04-08 | Merck & Co Inc | Process for purifying human papillomavirus virus-like particles |
| DE19900681B4 (de) * | 1999-01-04 | 2007-04-12 | Sartorius Ag | Verwendung von Anionaustauschermembranen zur Entfernung von Endotoxinen aus Nukleinsäure-haltigen Lösungen |
| EP1147226B1 (en) | 1999-01-27 | 2013-01-23 | Folim G. Halaka | Materials and methods for the purification of polyelectrolytes |
| CA2364839C (en) | 1999-02-25 | 2008-08-19 | Pall Corporation | Negatively charged membrane |
| DE60043597D1 (de) | 1999-02-25 | 2010-02-04 | Pall Corp | Positiv geladene Membran |
| EP1614459B1 (en) | 1999-02-25 | 2007-07-18 | Pall Corporation | Positively charged membrane |
| US6780327B1 (en) | 1999-02-25 | 2004-08-24 | Pall Corporation | Positively charged membrane |
| SE9901825D0 (sv) | 1999-05-20 | 1999-05-20 | Amersham Pharm Biotech Ab | Foamed material filled with inner material |
| WO2001008792A2 (en) | 1999-07-30 | 2001-02-08 | Genentech, Inc. | Charged filtration membranes and uses therefor |
| US6497747B1 (en) | 1999-09-24 | 2002-12-24 | Praxair Technology, Inc. | Production and use of improved polyimide separation membranes |
| SE9904197D0 (sv) | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
| AU1811301A (en) | 1999-12-02 | 2001-06-12 | General Hospital Corporation, The | Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon |
| CA2395820A1 (en) | 1999-12-29 | 2001-07-05 | Genzyme Corporation | Method using filtration aids for the separation of virus vectors from nucleic acids and other cellular contaminants |
| JP4788056B2 (ja) | 2000-04-13 | 2011-10-05 | Ｊｓｒ株式会社 | ウイルス濃縮材料 |
| JP2003531720A (ja) | 2000-04-28 | 2003-10-28 | ミリポア・コーポレイション | フィルターカートリッジおよびフィルターカートリッジを製造する方法 |
| JP2002045176A (ja) | 2000-05-22 | 2002-02-12 | Jsr Corp | ウイルス濃縮方法 |
| DE10028447A1 (de) | 2000-06-14 | 2001-12-20 | Merck Patent Gmbh | Verfahren zur Herstellung von monolithischen Chromatographiesäulen |
| JP2002210377A (ja) | 2001-01-22 | 2002-07-30 | Tosoh Corp | アニオン交換体、その製造方法及びそれを用いた用途 |
| WO2003007814A1 (en) | 2001-07-18 | 2003-01-30 | Agilex Biosciences, Inc. | Device and method for collecting, transporting and recovering low molecular weight analytes in saliva |
| CA2454323C (en) | 2001-07-20 | 2011-05-31 | Mcmaster University | Asymmetric gel-filled microporous membranes |
| US6913694B2 (en) | 2001-11-06 | 2005-07-05 | Saehan Industries Incorporation | Selective membrane having a high fouling resistance |
| ATE452930T1 (de) | 2001-11-21 | 2010-01-15 | Porex Corp | Diskrete hydrophil-hydrophobe poröse materialien und herstellungsverfahren dafür |
| US20030201229A1 (en) | 2002-02-04 | 2003-10-30 | Martin Siwak | Process for prefiltration of a protein solution |
| US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| US7073671B2 (en) | 2002-06-07 | 2006-07-11 | Millipore Corporation | Microporous membrane substrate having caustic stable, low protein binding surface |
| US7101947B2 (en) | 2002-06-14 | 2006-09-05 | Florida State University Research Foundation, Inc. | Polyelectrolyte complex films for analytical and membrane separation of chiral compounds |
| DE10228148B4 (de) | 2002-06-24 | 2006-08-24 | Saehan Industries Inc. | Selektive Membran mit hoher Fouling-Beständigkeit |
| DK1545574T3 (da) | 2002-09-13 | 2014-09-08 | Biogen Idec Inc | Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi |
| US20040127648A1 (en) | 2002-12-31 | 2004-07-01 | Ciphergen Biosystems, Inc. | Sorbent and method for the separation of plasmid DNA |
| DE602004024190D1 (de) | 2003-02-19 | 2009-12-31 | Natrix Separations Inc | Geträgerte poröse gele umfassende verbundmaterialien |
| EP1597400B8 (en) | 2003-02-25 | 2013-10-09 | MedImmune, LLC | Methods of producing influenza vaccine compositions |
| GB0304576D0 (en) * | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| JP2004283295A (ja) * | 2003-03-20 | 2004-10-14 | Toray Ind Inc | リガンド固定化材料およびその製造方法 |
| US20040206693A1 (en) | 2003-04-16 | 2004-10-21 | John Charkoudian | Crosslinked cellulosic membrane |
| US20040206694A1 (en) | 2003-04-16 | 2004-10-21 | John Charkoudian | Epoxide-crosslinked, charged cellulosic membrane |
| CN100535007C (zh) * | 2003-08-21 | 2009-09-02 | 诺沃挪第克公司 | 胰高血糖素样肽的纯化 |
| US7318898B2 (en) | 2003-11-18 | 2008-01-15 | Exxonmobil Research And Engineering Company | Polymeric membrane wafer assembly and method |
| WO2005078028A1 (en) | 2004-02-05 | 2005-08-25 | Millipore Corporation | Method of forming polysaccharide structures |
| CN1960803A (zh) | 2004-02-05 | 2007-05-09 | 米利波尔公司 | 多孔的吸附或色谱介质 |
| US7687619B2 (en) | 2004-02-05 | 2010-03-30 | Millipore Corporation | Room temperature stable agarose solutions |
| WO2005077529A1 (en) | 2004-02-05 | 2005-08-25 | Millipore Corporation | Porous adsorptive or chromatographic media |
| US7479222B2 (en) | 2004-02-05 | 2009-01-20 | Millipore Corporation | Porous adsorptive or chromatographic media |
| US7959979B2 (en) | 2004-02-05 | 2011-06-14 | Millipore Corporation | Method of forming coated structures |
| SE0400501D0 (sv) * | 2004-02-27 | 2004-02-27 | Amersham Biosciences Ab | Antibody purification |
| JP2008500972A (ja) | 2004-05-14 | 2008-01-17 | キリンファーマ株式会社 | 免疫グロブリンの精製方法 |
| PL1765866T3 (pl) * | 2004-06-07 | 2014-06-30 | Therapure Biopharma Inc | Wydzielanie białek osocza lub surowicy |
| CA2550834C (en) | 2005-06-24 | 2013-04-23 | Innovative Chemical Technologies Canada Ltd. | Clay control additive for wellbore fluids |
| CA2613659C (en) | 2005-06-29 | 2012-01-31 | The Procter & Gamble Company | Use of an effervescent product to clean soiled dishes by hand washing |
| WO2007108955A1 (en) * | 2006-03-20 | 2007-09-27 | Medarex, Inc. | Protein purification |
| JP2008021800A (ja) * | 2006-07-12 | 2008-01-31 | Sanyo Electric Co Ltd | 半導体装置およびその製造方法 |
| EP2043767B1 (en) | 2006-07-14 | 2020-03-25 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
| US8382987B2 (en) | 2006-09-27 | 2013-02-26 | Alessandra Luchini | Method for harvesting nanoparticles and sequestering biomarkers |
| US7935518B2 (en) | 2006-09-27 | 2011-05-03 | Alessandra Luchini | Smart hydrogel particles for biomarker harvesting |
| US9433922B2 (en) | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US20090130738A1 (en) | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| WO2009145722A1 (en) | 2008-05-30 | 2009-12-03 | Ge Healthcare Bio-Sciences Ab | Separation method utilizing polyallylamine ligands |
| US20120077249A1 (en) | 2010-04-20 | 2012-03-29 | Millipore Corporation | Separation Of Virus And/Or Protein From Nucleic Acids By Primary Amines |
| WO2011140406A1 (en) | 2010-05-07 | 2011-11-10 | Millipore Corporation | Enhanced clarification media |
| WO2011140405A1 (en) | 2010-05-07 | 2011-11-10 | Millipore Corporation | Enhanced clarification media |
-
2008
- 2008-08-04 US US12/221,496 patent/US9433922B2/en not_active Expired - Fee Related
- 2008-08-12 SG SG200805944-6A patent/SG150458A1/en unknown
- 2008-08-12 SG SG2012055968A patent/SG183660A1/en unknown
- 2008-08-12 SG SG2012055661A patent/SG183083A1/en unknown
- 2008-08-13 EP EP08162316.7A patent/EP2027921B1/en active Active
- 2008-08-13 EP EP20110150305 patent/EP2319622A3/en not_active Withdrawn
- 2008-08-14 JP JP2008209029A patent/JP5031695B2/ja not_active Expired - Fee Related
- 2008-08-14 CN CN201510744950.XA patent/CN105457335B/zh not_active Expired - Fee Related
-
2010
- 2010-04-21 US US12/764,340 patent/US20100200507A1/en not_active Abandoned
-
2011
- 2011-06-23 US US13/167,297 patent/US8137561B2/en not_active Expired - Fee Related
- 2011-06-23 US US13/167,291 patent/US20110284446A1/en not_active Abandoned
- 2011-08-08 JP JP2011173342A patent/JP5743796B2/ja not_active Expired - Fee Related
- 2011-08-08 JP JP2011173327A patent/JP5743795B2/ja not_active Expired - Fee Related
- 2011-12-29 US US13/339,503 patent/US20120121819A1/en not_active Abandoned
-
2012
- 2012-02-01 US US13/363,397 patent/US8435406B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012018171A (ja) | 2012-01-26 |
| EP2027921B1 (en) | 2020-04-22 |
| US20090050566A1 (en) | 2009-02-26 |
| JP2011247903A (ja) | 2011-12-08 |
| EP2319622A2 (en) | 2011-05-11 |
| US20110288277A1 (en) | 2011-11-24 |
| EP2027921A2 (en) | 2009-02-25 |
| US8137561B2 (en) | 2012-03-20 |
| SG150458A1 (en) | 2009-03-30 |
| CN105457335A (zh) | 2016-04-06 |
| US20120121819A1 (en) | 2012-05-17 |
| JP5031695B2 (ja) | 2012-09-19 |
| JP5743795B2 (ja) | 2015-07-01 |
| CN105457335B (zh) | 2019-07-26 |
| US8435406B2 (en) | 2013-05-07 |
| JP2009053191A (ja) | 2009-03-12 |
| SG183083A1 (en) | 2012-08-30 |
| US20110284446A1 (en) | 2011-11-24 |
| EP2319622A3 (en) | 2012-05-02 |
| JP5743796B2 (ja) | 2015-07-01 |
| US20120193278A1 (en) | 2012-08-02 |
| US20100200507A1 (en) | 2010-08-12 |
| US9433922B2 (en) | 2016-09-06 |
| EP2027921A3 (en) | 2011-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8435406B2 (en) | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same | |
| EP2386628A1 (en) | Separation of viruses from nucleic acids using a membrane coated with polymeric primary amines | |
| US12479931B2 (en) | Porous polymeric cellulose prepared via cellulose crosslinking | |
| EP2060316B1 (en) | Media for membrane ion exchange chromatography | |
| US9295928B2 (en) | Porous adsorptive or chromatographic media | |
| US7479223B2 (en) | Porous adsorptive or chromatographic media | |
| CN101444757B (zh) | 多孔性吸附介质,含有该介质的吸附装置和层析系统 | |
| US20050218068A1 (en) | Filter cartridge | |
| JP2003251120A (ja) | 微粒子・金属不純物精密濾過用フィルターカートリッジ | |
| JP2011225568A (ja) | 第一級アミンによる核酸からのウイルス及び／又はタンパク質の分離 |