US4650750A
(en)
|
1982-02-01 |
1987-03-17 |
Giese Roger W |
Method of chemical analysis employing molecular release tag compounds
|
US5516931A
(en)
|
1982-02-01 |
1996-05-14 |
Northeastern University |
Release tag compounds producing ketone signal groups
|
US4709016A
(en)
|
1982-02-01 |
1987-11-24 |
Northeastern University |
Molecular analytical release tags and their use in chemical analysis
|
US5650270A
(en)
|
1982-02-01 |
1997-07-22 |
Northeastern University |
Molecular analytical release tags and their use in chemical analysis
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
US5360811A
(en)
|
1990-03-13 |
1994-11-01 |
Hoechst-Roussel Pharmaceuticals Incorporated |
1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
|
JP3545461B2
(ja)
|
1993-09-10 |
2004-07-21 |
エーザイ株式会社 |
二環式ヘテロ環含有スルホンアミド誘導体
|
WO1996007655A1
(fr)
|
1994-09-06 |
1996-03-14 |
Banyu Pharmaceutical Co., Ltd. |
Nouveau derive de carbapenem
|
US6281230B1
(en)
|
1996-07-24 |
2001-08-28 |
Celgene Corporation |
Isoindolines, method of use, and pharmaceutical compositions
|
US6306663B1
(en)
|
1999-02-12 |
2001-10-23 |
Proteinex, Inc. |
Controlling protein levels in eucaryotic organisms
|
JP4078074B2
(ja)
|
1999-12-10 |
2008-04-23 |
ファイザー・プロダクツ・インク |
ピロロ[2,3−d]ピリミジン化合物
|
DE10002509A1
(de)
|
2000-01-21 |
2001-07-26 |
Gruenenthal Gmbh |
Substituierte Glutarimide
|
AU2001241798A1
(en)
|
2000-02-28 |
2001-09-12 |
Sugen, Inc. |
3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
US7208157B2
(en)
|
2000-09-08 |
2007-04-24 |
California Institute Of Technology |
Proteolysis targeting chimeric pharmaceutical
|
EP1322750A4
(en)
|
2000-09-08 |
2004-09-29 |
California Inst Of Techn |
PROTEOLYSIC CHIMERAL PHARMACEUTICAL
|
DE60217322T2
(de)
|
2001-04-27 |
2007-10-04 |
Zenyaku Kogyo K.K. |
Heterocyclische verbindung und antitumormittel, das diese als wirkstoff enthält
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
WO2004019973A1
(en)
|
2002-08-14 |
2004-03-11 |
Atugen Ag |
Use of protein kinase n beta
|
SG160211A1
(en)
|
2003-04-03 |
2010-04-29 |
Semafore Pharmaceuticals Inc |
Pi-3 kinase inhibitor prodrugs
|
CA2527583C
(en)
|
2003-05-30 |
2013-12-17 |
Giorgio Attardo |
Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
|
AU2004257167B2
(en)
|
2003-07-03 |
2012-03-29 |
The Trustees Of The University Of Pennsylvania |
Inhibition of Syk kinase expression
|
JP4398263B2
(ja)
|
2004-01-13 |
2010-01-13 |
富士通株式会社 |
経路設計方法
|
CN101031569B
(zh)
|
2004-05-13 |
2011-06-22 |
艾科斯有限公司 |
作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ox40l抗體
|
EP2161275A1
(en)
|
2005-01-19 |
2010-03-10 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
EP2343320B1
(en)
|
2005-03-25 |
2017-10-25 |
GITR, Inc. |
Anti-gitr antibodies and uses thereof
|
KR101509440B1
(ko)
|
2005-05-12 |
2015-04-07 |
애브비 바하마스 리미티드 |
아폽토시스 촉진제
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
MX2007015942A
(es)
|
2005-07-01 |
2008-03-07 |
Medarex Inc |
Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada.
|
US7402325B2
(en)
|
2005-07-28 |
2008-07-22 |
Phoenix Biotechnology, Inc. |
Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
|
CN103819416A
(zh)
|
2005-10-07 |
2014-05-28 |
埃克塞里艾克西斯公司 |
N-(3-氨基-喹喔啉-2-基)-磺酰胺衍生物及其作为磷脂酰肌醇3-激酶抑制剂的用途
|
WO2007053452A1
(en)
|
2005-11-01 |
2007-05-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
HUE030235T2
(en)
|
2005-12-13 |
2017-04-28 |
Incyte Holdings Corp |
Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors
|
WO2007078990A2
(en)
|
2005-12-23 |
2007-07-12 |
Zealand Pharma A/S |
Modified lysine-mimetic compounds
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
CN101472930B
(zh)
|
2006-04-26 |
2011-12-14 |
霍夫曼-拉罗奇有限公司 |
用作PI3K抑制剂的噻吩并[3,2-d]嘧啶的衍生物
|
EP2526933B1
(en)
|
2006-09-22 |
2015-02-25 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
US20100279316A1
(en)
|
2007-01-19 |
2010-11-04 |
Leonid Gorelik |
Antibodies to Phosphorylated IRAK4
|
ES2557930T3
(es)
|
2007-03-12 |
2016-01-29 |
Ym Biosciences Australia Pty Ltd |
Compuestos de fenilaminopirimidina y usos de los mismos
|
WO2008118802A1
(en)
|
2007-03-23 |
2008-10-02 |
Regents Of The University Of Minnesota |
Therapeutic compounds
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
ES2591281T3
(es)
|
2007-07-12 |
2016-11-25 |
Gitr, Inc. |
Terapias de combinación que emplean moléculas de enlazamiento a GITR
|
US8370032B2
(en)
|
2007-07-12 |
2013-02-05 |
Toyota Motor Engineering & Manufacturing North America, Inc. |
Systems and methods for shift control for vehicular transmission
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
CA2960659C
(en)
|
2007-11-09 |
2021-07-13 |
The Salk Institute For Biological Studies |
Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors
|
CN101932325B
(zh)
|
2007-11-30 |
2014-05-28 |
新联基因公司 |
Ido抑制剂
|
ES2602577T3
(es)
|
2008-03-11 |
2017-02-21 |
Incyte Holdings Corporation |
Derivados de azetidina y ciclobutano como inhibidores de JAK
|
EP2291187B1
(en)
|
2008-04-24 |
2018-08-15 |
Newlink Genetics Corporation |
Ido inhibitors
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
TWI686405B
(zh)
|
2008-12-09 |
2020-03-01 |
建南德克公司 |
抗pd-l1抗體及其於增進t細胞功能之用途
|
US8921037B2
(en)
|
2008-12-16 |
2014-12-30 |
Bo Han |
PF4-depleted platelet rich plasma preparations and methods for hard and soft tissue repair
|
KR101790802B1
(ko)
|
2009-09-03 |
2017-10-27 |
머크 샤프 앤드 돔 코포레이션 |
항-gitr 항체
|
JP2012254939A
(ja)
|
2009-10-07 |
2012-12-27 |
Astellas Pharma Inc |
オキサゾール化合物
|
US8722720B2
(en)
|
2009-10-28 |
2014-05-13 |
Newlink Genetics Corporation |
Imidazole derivatives as IDO inhibitors
|
ES2722300T3
(es)
|
2009-12-10 |
2019-08-09 |
Hoffmann La Roche |
Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso
|
PH12018501083A1
(en)
|
2010-03-04 |
2019-02-18 |
Macrogenics Inc |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
CN102918060B
(zh)
|
2010-03-05 |
2016-04-06 |
霍夫曼-拉罗奇有限公司 |
抗人csf-1r抗体及其用途
|
US9221910B2
(en)
|
2010-03-05 |
2015-12-29 |
Hoffmann-La Roche Inc. |
Antibodies against human CSF-1R
|
US8114621B2
(en)
|
2010-03-12 |
2012-02-14 |
Saladax Biomedical Inc. |
Lenalidomide and thalidomide immunoassays
|
SI2566517T1
(sl)
|
2010-05-04 |
2019-01-31 |
Five Prime Therapeutics, Inc. |
Protitelesa, ki vežejo CSF1R
|
CN103153335A
(zh)
|
2010-06-30 |
2013-06-12 |
布兰代斯大学 |
小分子靶定的蛋白质降解
|
RU2604062C2
(ru)
|
2010-07-13 |
2016-12-10 |
Ф.Хоффманн-Ля Рош Аг |
ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА И ТИЕНО[3,2-b]ПИРИМИДИНА В КАЧЕСТВЕ МОДУЛЯТОРОВ IRAK-4
|
EP2614082B1
(en)
|
2010-09-09 |
2018-10-03 |
Pfizer Inc |
4-1bb binding molecules
|
EP2730564B1
(en)
|
2010-11-19 |
2018-04-18 |
Ligand Pharmaceuticals Inc. |
Heterocycle amines and uses thereof
|
WO2012078559A2
(en)
|
2010-12-07 |
2012-06-14 |
Yale University |
Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
|
BR122021026169B1
(pt)
|
2010-12-09 |
2023-12-12 |
The Trustees Of The University Of Pennsylvania |
Uso de uma célula
|
US9073892B2
(en)
|
2010-12-20 |
2015-07-07 |
Merck Serono S.A. |
Indazolyl triazol derivatives
|
WO2012097013A1
(en)
|
2011-01-10 |
2012-07-19 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
EP2688872A4
(en)
|
2011-03-22 |
2014-08-27 |
Merck Sharp & Dohme |
AMIDOPYRAZOLHEMMER OF INTERLEUKIN RECEPTOR-MEDIATED KINASES
|
NO2694640T3
(pt)
|
2011-04-15 |
2018-03-17 |
|
|
RU2625034C2
(ru)
|
2011-04-20 |
2017-07-11 |
МЕДИММЬЮН, ЭлЭлСи |
Антитела и другие молекулы, которые связывают в7-н1 и pd-1
|
BR112014003799B1
(pt)
|
2011-08-31 |
2021-01-05 |
Huntsman Advanced Materials Licensing (Switzerland) Gmbh |
processo para a impregnação de um reator de núcleo de ar ou uma parte de um reator de núcleo de ar, e, reator de núcleo de ar impregnado ou parte de um reator de núcleo de ar
|
WO2013042137A1
(en)
|
2011-09-19 |
2013-03-28 |
Aurigene Discovery Technologies Limited |
Bicyclic heterocycles as irak4 inhibitors
|
WO2013066729A1
(en)
|
2011-10-31 |
2013-05-10 |
Merck Sharp & Dohme Corp. |
Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
|
BR112014012819B1
(pt)
|
2011-11-28 |
2022-08-16 |
Merck Patent Gmbh |
Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
|
WO2013087699A1
(en)
|
2011-12-15 |
2013-06-20 |
F. Hoffmann-La Roche Ag |
Antibodies against human csf-1r and uses thereof
|
TW201728592A
(zh)
|
2012-01-10 |
2017-08-16 |
林伯士艾瑞斯公司 |
Irak抑制劑及其用途
|
WO2013106646A2
(en)
|
2012-01-12 |
2013-07-18 |
Yale University |
Compounds and methods for the inhibition of vcb e3 ubiquitin ligase
|
CA2861066C
(en)
|
2012-01-12 |
2024-01-02 |
Yale University |
Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
|
WO2013106612A1
(en)
|
2012-01-13 |
2013-07-18 |
Bristol-Myers Squibb Company |
Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors
|
ES2630705T3
(es)
|
2012-01-13 |
2017-08-23 |
Bristol-Myers Squibb Company |
Compuestos de piridilo sustituidos con triazolilo útiles como inhibidores de cinasas
|
CN104254533B
(zh)
|
2012-01-13 |
2017-09-08 |
百时美施贵宝公司 |
用作激酶抑制剂的噻唑或噻二唑取代的吡啶基化合物
|
CA2861122A1
(en)
|
2012-02-06 |
2013-08-15 |
Genentech, Inc. |
Compositions and methods for using csf1r inhibitors
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
BR112014028013A2
(pt)
|
2012-05-11 |
2018-02-27 |
Five Prime Therapeutics Inc |
métodos para tratar uma condição associada com artrite reumatoide, artrite reumatoide, lesões de pele, nefrite lúpica, lúpus, uma condição inflamatória, distúrbio de cd16+, método para reduzir o número de monócitos cd16+, métodos para desacelerar a progressão de uma condição renal,de formação de panos e de perda óssea
|
UY34887A
(es)
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
ES2589558T3
(es)
|
2012-07-10 |
2016-11-15 |
Ares Trading S.A. |
Derivados de pirimidin pirazolilo
|
WO2014011906A2
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
WO2014011911A2
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
WO2014011902A1
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
KR102414005B1
(ko)
|
2012-08-09 |
2022-06-27 |
셀진 코포레이션 |
3-(4-((4-모르포리노메틸)벤질)옥시)-1-옥소이소인돌린-2-일)피페리딘-2,6-디온을 이용한 암의 치료방법
|
US20140079699A1
(en)
|
2012-08-31 |
2014-03-20 |
Five Prime Therapeutics, Inc. |
Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
|
JP6302912B2
(ja)
|
2012-09-19 |
2018-03-28 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
2−オキソ−2,3,4,5−テトラヒドロ−1h−ベンゾ[b]ジアゼピン及びがんの治療におけるその使用
|
US9586948B2
(en)
|
2012-10-08 |
2017-03-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
US9598440B2
(en)
|
2012-10-08 |
2017-03-21 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
PE20150953A1
(es)
|
2012-11-08 |
2015-06-20 |
Bristol Myers Squibb Co |
Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa
|
KR102233252B1
(ko)
|
2012-11-08 |
2021-03-26 |
브리스톨-마이어스 스큅 컴퍼니 |
IL-12, IL-23 및/또는 IFNα 반응의 조절제로서 유용한 알킬-아미드-치환된 피리딜 화합물
|
GB201311910D0
(en)
|
2013-07-03 |
2013-08-14 |
Glaxosmithkline Ip Dev Ltd |
Novel Compounds
|
AU2014214254B2
(en)
|
2013-02-07 |
2018-03-29 |
Merck Patent Gmbh |
Macrocyclic Pyridazinone derivatives
|
SG11201506100XA
(en)
|
2013-02-07 |
2015-09-29 |
Merck Patent Gmbh |
Pyridazinone-amides derivatives
|
WO2014143672A1
(en)
|
2013-03-15 |
2014-09-18 |
Biogen Idec Ma Inc. |
Macrocyclic compounds as irak4 inhibitors for the treatment of inflammatory diseases
|
EP3049086A4
(en)
|
2013-09-27 |
2017-02-22 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
EA201690713A1
(ru)
|
2013-10-04 |
2016-08-31 |
Инфинити Фармасьютикалз, Инк. |
Гетероциклические соединения и их применения
|
EA201690952A1
(ru)
|
2013-11-08 |
2016-08-31 |
Такеда Фармасьютикал Компани Лимитед |
Пиразол для лечения аутоиммунных расстройств
|
RU2016122563A
(ru)
|
2013-11-18 |
2017-12-25 |
Ф. Хоффманн-Ля Рош Аг |
Тетрагидробензодиазепиноны
|
CN110156770B
(zh)
|
2013-11-27 |
2022-10-04 |
圣诺康生命科学公司 |
作为tam族激酶抑制剂的氨基吡啶衍生物
|
TWI667233B
(zh)
|
2013-12-19 |
2019-08-01 |
德商拜耳製藥公司 |
新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
|
UY35935A
(es)
|
2014-01-03 |
2015-06-30 |
Bristol Myers Squibb Company Una Corporación Del Estado De Delaware |
Compuestos de nicotinamida sustituida con heteroarilo como inhibidores de quinasa y moduladores de irak-4
|
SG11201605408RA
(en)
|
2014-01-10 |
2016-07-28 |
Aurigene Discovery Tech Ltd |
Indazole compounds as irak4 inhibitors
|
DK3094329T3
(en)
|
2014-01-13 |
2018-11-19 |
Aurigene Discovery Tech Ltd |
BICYCLIC HETEROCYCLYL DERIVATIVES AS IRAC4 INHIBITORS
|
EP3119760A1
(en)
|
2014-03-17 |
2017-01-25 |
F. Hoffmann-La Roche AG |
Piperidine-dione derivatives
|
WO2015140051A1
(en)
|
2014-03-19 |
2015-09-24 |
Boehringer Ingelheim International Gmbh |
Heteroaryl sik inhibitors
|
EA032559B1
(ru)
|
2014-04-04 |
2019-06-28 |
Пфайзер Инк. |
Бициклические аннелированные гетероарильные или арильные соединения и их применение в качестве ингибиторов irak4
|
US20160058872A1
(en)
|
2014-04-14 |
2016-03-03 |
Arvinas, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
JP6778114B2
(ja)
|
2014-04-14 |
2020-10-28 |
アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. |
イミド系タンパク質分解モジュレーター及び関連する使用方法
|
CA2945819A1
(en)
|
2014-04-22 |
2015-10-29 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
BR112016029853A2
(pt)
|
2014-06-20 |
2017-08-22 |
Aurigene Discovery Tech Ltd |
compostos de indazol substituído como inibidores de irak4
|
WO2015200795A1
(en)
|
2014-06-27 |
2015-12-30 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases
|
TW201613872A
(en)
|
2014-07-18 |
2016-04-16 |
Biogen Ma Inc |
IRAK4 inhibiting agents
|
US20160022642A1
(en)
|
2014-07-25 |
2016-01-28 |
Yale University |
Compounds Useful for Promoting Protein Degradation and Methods Using Same
|
US10071164B2
(en)
|
2014-08-11 |
2018-09-11 |
Yale University |
Estrogen-related receptor alpha based protac compounds and associated methods of use
|
WO2016053769A1
(en)
|
2014-09-30 |
2016-04-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of irak4 activity
|
US9943516B2
(en)
|
2014-09-30 |
2018-04-17 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
US9932350B2
(en)
|
2014-09-30 |
2018-04-03 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
EP3200787B1
(en)
|
2014-09-30 |
2019-09-04 |
Merck Sharp & Dohme Corp. |
Inhibitors of irak4 activity
|
AU2015349899B9
(en)
|
2014-11-20 |
2020-06-25 |
Merck Patent Gmbh |
Heteroaryl compounds as IRAK inhibitors and uses thereof
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
JP6815318B2
(ja)
|
2014-12-23 |
2021-01-20 |
ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド |
二官能性分子によって標的化タンパク質分解を誘導する方法
|
KR20220029783A
(ko)
|
2015-01-20 |
2022-03-08 |
아비나스 오퍼레이션스, 인코포레이티드 |
안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법
|
US20170327469A1
(en)
|
2015-01-20 |
2017-11-16 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
WO2016144846A1
(en)
*
|
2015-03-12 |
2016-09-15 |
Merck Sharp & Dohme Corp. |
Pyrazolopyrimidine inhibitors of irak4 activity
|
WO2016144847A1
(en)
|
2015-03-12 |
2016-09-15 |
Merck Sharp & Dohme Corp. |
Pyrrolopyridazine inhibitors of irak4 activity
|
US10155765B2
(en)
|
2015-03-12 |
2018-12-18 |
Merck Sharp & Dohme Corp. |
Carboxamide inhibitors of IRAK4 activity
|
EP3268003B1
(en)
|
2015-03-12 |
2020-07-29 |
Merck Sharp & Dohme Corp. |
Thienopyrazine inhibitors of irak4 activity
|
EP3268006B1
(en)
|
2015-03-12 |
2020-01-08 |
Merck Sharp & Dohme Corp. |
Pyrrolotriazine inhibitors of irak4 activity
|
MX2017011919A
(es)
|
2015-03-18 |
2018-05-22 |
Arvinas Inc |
Compuestos y metodos para la degradacion mejorada de proteinas especificas.
|
EP3286181B1
(en)
|
2015-04-22 |
2021-01-27 |
Rigel Pharmaceuticals, Inc. |
Pyrazole compounds and method for making and using the compounds
|
GB201506871D0
(en)
|
2015-04-22 |
2015-06-03 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
WO2016174183A1
(en)
|
2015-04-30 |
2016-11-03 |
Bayer Pharma Aktiengesellschaft |
Combinations of inhibitors of irak4 with inhibitors of btk
|
EP3302572B8
(en)
|
2015-06-04 |
2021-03-24 |
Arvinas Operations, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
EP3302482A4
(en)
|
2015-06-05 |
2018-12-19 |
Arvinas, Inc. |
Tank-binding kinase-1 protacs and associated methods of use
|
AU2016276963C1
(en)
|
2015-06-12 |
2021-08-05 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
CN107849039B
(zh)
|
2015-06-24 |
2020-07-03 |
百时美施贵宝公司 |
经杂芳基取代的氨基吡啶化合物
|
CN105085620B
(zh)
|
2015-06-25 |
2018-05-08 |
中山大学附属第一医院 |
一种靶向泛素化降解Smad3的化合物
|
WO2017004133A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
US9848583B2
(en)
|
2015-07-02 |
2017-12-26 |
Ellis Junior Smith |
Retractable leash
|
WO2017007612A1
(en)
|
2015-07-07 |
2017-01-12 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
AU2016291578C1
(en)
|
2015-07-10 |
2021-07-15 |
Arvinas Operations, Inc. |
MDM2-based modulators of proteolysis and associated methods of use
|
RU2018105094A
(ru)
|
2015-07-13 |
2019-08-14 |
Арвинас, Инк. |
Модуляторы протеолиза на основе аланина и связанные с ними способы применения
|
US10669234B2
(en)
|
2015-07-14 |
2020-06-02 |
Mission Therapeutics Limited |
Cyanopyrrolidines as dub inhibitors for the treatment of cancer
|
BR112018000624A2
(pt)
|
2015-07-15 |
2018-09-18 |
Aurigene Discovery Technologies Limited |
compostos de indazol e azaindazol como inibidores de irak-4
|
AU2016293446A1
(en)
|
2015-07-15 |
2018-02-15 |
Aurigene Discovery Technologies Limited |
Substituted aza compounds as IRAK-4 inhibitors
|
WO2017030814A1
(en)
|
2015-08-19 |
2017-02-23 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
WO2017033093A1
(en)
|
2015-08-27 |
2017-03-02 |
Pfizer Inc. |
Bicyclic-fused heteroaryl or aryl compounds as irak4 modulators
|
GB201516243D0
(en)
*
|
2015-09-14 |
2015-10-28 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
EP3350177B1
(en)
|
2015-09-18 |
2021-07-07 |
Merck Patent GmbH |
Heteroaryl compounds as irak inhibitors and uses thereof
|
CA2996318C
(en)
|
2015-09-18 |
2023-10-10 |
Merck Patent Gmbh |
Heteroaryl compounds as irak inhibitors and uses thereof
|
CN108289957A
(zh)
|
2015-10-02 |
2018-07-17 |
达纳-法伯癌症研究所股份有限公司 |
溴区结构域抑制剂和检查点阻断的组合疗法
|
WO2017059280A1
(en)
|
2015-10-02 |
2017-04-06 |
The University Of North Carolina At Chapel Hill |
Novel pan-tam inhibitors and mer/axl dual inhibitors
|
CN108366992A
(zh)
|
2015-11-02 |
2018-08-03 |
耶鲁大学 |
蛋白水解靶向嵌合体化合物及其制备和应用方法
|
WO2017108723A2
(en)
|
2015-12-22 |
2017-06-29 |
F. Hoffmann-La Roche Ag |
PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
|
US20190016703A1
(en)
|
2015-12-30 |
2019-01-17 |
Dana-Farber Cancer Institute, Inc. |
Bifunctional compounds for her3 degradation and methods of use
|
US20200216454A1
(en)
|
2015-12-30 |
2020-07-09 |
Dana-Farber Cancer Institute, Inc. |
Bifunctional molecules for her3 degradation and methods of use
|
ES2904557T3
(es)
|
2016-01-20 |
2022-04-05 |
Biogen Ma Inc |
Agentes inhibidores de irak4
|
US11395820B2
(en)
|
2016-03-16 |
2022-07-26 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Small molecules against cereblon to enhance effector t cell function
|
US20170281784A1
(en)
|
2016-04-05 |
2017-10-05 |
Arvinas, Inc. |
Protein-protein interaction inducing technology
|
CN113788818A
(zh)
|
2016-04-06 |
2021-12-14 |
密执安大学评议会 |
Mdm2蛋白质降解剂
|
US10759808B2
(en)
|
2016-04-06 |
2020-09-01 |
The Regents Of The University Of Michigan |
Monofunctional intermediates for ligand-dependent target protein degradation
|
WO2017197056A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Bromodomain targeting degronimers for target protein degradation
|
CN109562113A
(zh)
|
2016-05-10 |
2019-04-02 |
C4医药公司 |
用于靶蛋白降解的螺环降解决定子体
|
EP3455218A4
(en)
|
2016-05-10 |
2019-12-18 |
C4 Therapeutics, Inc. |
C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
|
WO2017197051A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Amine-linked c3-glutarimide degronimers for target protein degradation
|
WO2017197055A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Heterocyclic degronimers for target protein degradation
|
WO2017201069A1
(en)
|
2016-05-18 |
2017-11-23 |
Biotheryx, Inc. |
Oxoindoline derivatives as protein function modulators
|
EP3458101B1
(en)
|
2016-05-20 |
2020-12-30 |
H. Hoffnabb-La Roche Ag |
Protac antibody conjugates and methods of use
|
WO2017205766A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
WO2017205762A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
WO2017207385A1
(de)
|
2016-05-31 |
2017-12-07 |
Bayer Pharma Aktiengesellschaft |
Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
|
GB201610147D0
(en)
|
2016-06-10 |
2016-07-27 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
JP7065840B2
(ja)
|
2016-06-27 |
2022-05-12 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
2,4-ジアミノ-ピリミジン化合物ならびに該化合物の作製法および使用法
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
JP2019196309A
(ja)
|
2016-09-15 |
2019-11-14 |
武田薬品工業株式会社 |
複素環化合物
|
WO2018089736A1
(en)
*
|
2016-11-10 |
2018-05-17 |
Dana-Farber Cancer Institute, Inc. |
Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use
|
JP7308146B2
(ja)
|
2016-11-22 |
2023-07-13 |
ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド |
インターロイキン1受容体関連キナーゼの阻害剤およびその使用
|
AU2017382406A1
(en)
*
|
2016-12-23 |
2019-04-18 |
Arvinas Operations, Inc. |
EGFR proteolysis targeting chimeric molecules and associated methods of use
|
JP7266526B6
(ja)
*
|
2017-01-26 |
2024-02-15 |
アルビナス・オペレーションズ・インコーポレイテッド |
エストロゲン受容体タンパク質分解性の調節因子およびその関連方法
|
MX2019009046A
(es)
|
2017-01-31 |
2019-10-30 |
Arvinas Operations Inc |
Ligandos de cereblon y compuestos bifuncionales que comprenden el mismo.
|
JOP20180011A1
(ar)
|
2017-02-16 |
2019-01-30 |
Gilead Sciences Inc |
مشتقات بيرولو [1، 2-b]بيريدازين
|
PT3621960T
(pt)
|
2017-05-11 |
2021-09-16 |
Bristol Myers Squibb Co |
Tienopiridinas e benzotiofenos úteis como inibidores de irak4
|
CN110769822A
(zh)
|
2017-06-20 |
2020-02-07 |
C4医药公司 |
用于蛋白降解的n/o-连接的降解决定子和降解决定子体
|
EP3679026A1
(en)
|
2017-09-04 |
2020-07-15 |
C4 Therapeutics, Inc. |
Glutarimide
|
AU2018338314A1
(en)
|
2017-09-22 |
2020-04-09 |
Kymera Therapeutics, Inc |
Protein degraders and uses thereof
|
EP3684366A4
(en)
|
2017-09-22 |
2021-09-08 |
Kymera Therapeutics, Inc. |
CRBN LIGANDS AND USES OF THE LATEST
|
EP3700901A1
(en)
|
2017-10-24 |
2020-09-02 |
Genentech, Inc. |
(4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
|
WO2019084030A1
(en)
|
2017-10-24 |
2019-05-02 |
Genentech, Inc. |
(4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE
|
WO2019099868A2
(en)
|
2017-11-16 |
2019-05-23 |
C4 Therapeutics, Inc. |
Degraders and degrons for targeted protein degradation
|
WO2019099926A1
(en)
|
2017-11-17 |
2019-05-23 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
|
JP2021508703A
(ja)
*
|
2017-12-26 |
2021-03-11 |
カイメラ セラピューティクス, インコーポレイテッド |
Irak分解剤およびそれらの使用
|
EP3737666A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
PROTEIN DEGRADANTS AND USES THEREOF
|
EP3737675A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
CRBN LIGANDS AND THEIR USES
|
WO2019160915A1
(en)
*
|
2018-02-14 |
2019-08-22 |
Dana-Farber Cancer Institute, Inc. |
Irak degraders and uses thereof
|
AU2019225166A1
(en)
|
2018-02-23 |
2020-08-06 |
Dana-Farber Cancer Institute, Inc. |
Small molecules for inducing selective protein degradation and uses thereof
|
EP3578561A1
(en)
|
2018-06-04 |
2019-12-11 |
F. Hoffmann-La Roche AG |
Spiro compounds
|
WO2020010210A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Mertk degraders and uses thereof
|
US20220348556A1
(en)
|
2018-07-06 |
2022-11-03 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
EP3817748A4
(en)
|
2018-07-06 |
2022-08-24 |
Kymera Therapeutics, Inc. |
TRICYCLIC CRBN LIGANDS AND USES THEREOF
|
AU2019307631A1
(en)
|
2018-07-20 |
2020-12-17 |
Dana-Farber Cancer Institute, Inc. |
Degraders that target proteins via KEAP1
|
SG11202105424PA
(en)
|
2018-11-30 |
2021-06-29 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
US20230072658A1
(en)
|
2019-06-10 |
2023-03-09 |
Kymera Therapeutics, Inc. |
Smarca degraders and uses thereof
|
US20220324880A1
(en)
|
2019-06-10 |
2022-10-13 |
Kymara Therapeutics, Inc. |
Smarca inhibitors and uses thereof
|
WO2020251969A1
(en)
|
2019-06-10 |
2020-12-17 |
Kymera Therapeutics, Inc. |
Smarca degraders and uses thereof
|
US20230149549A1
(en)
|
2019-06-10 |
2023-05-18 |
Kymera Therapeutics, Inc |
Smarca degraders and uses thereof
|
EP3989966A4
(en)
|
2019-06-28 |
2023-09-27 |
Kymera Therapeutics, Inc. |
IRAQ DEGRADERS AND USES THEREOF
|
WO2020264490A1
(en)
|
2019-06-28 |
2020-12-30 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
WO2021011631A1
(en)
|
2019-07-15 |
2021-01-21 |
Kymera Therapeutics, Inc. |
Fused-glutarimide crbn ligands and uses thereof
|
US20230093080A1
(en)
|
2019-07-15 |
2023-03-23 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
WO2021011868A1
(en)
|
2019-07-17 |
2021-01-21 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
WO2021011871A1
(en)
|
2019-07-17 |
2021-01-21 |
Kymera Therapeutics, Inc. |
Mertk degraders and uses thereof
|
EP4031243A1
(en)
|
2019-09-16 |
2022-07-27 |
Novartis AG |
Glue degraders and methods of use thereof
|
WO2021127278A1
(en)
|
2019-12-17 |
2021-06-24 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
EP4076524A4
(en)
|
2019-12-17 |
2023-11-29 |
Kymera Therapeutics, Inc. |
IRAQ DEGRADERS AND USES THEREOF
|
IL293917A
(en)
|
2019-12-17 |
2022-08-01 |
Kymera Therapeutics Inc |
Iraq joints and their uses
|