SG11202102059YA - Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof - Google Patents
Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereofInfo
- Publication number
- SG11202102059YA SG11202102059YA SG11202102059YA SG11202102059YA SG11202102059YA SG 11202102059Y A SG11202102059Y A SG 11202102059YA SG 11202102059Y A SG11202102059Y A SG 11202102059YA SG 11202102059Y A SG11202102059Y A SG 11202102059YA SG 11202102059Y A SG11202102059Y A SG 11202102059YA
- Authority
- SG
- Singapore
- Prior art keywords
- annulene
- oxyphenyl
- fluoropropyl
- pyrrolidin
- dichlorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Pyrrole Compounds (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18306177 | 2018-09-07 | ||
PCT/EP2019/073823 WO2020049150A1 (en) | 2018-09-07 | 2019-09-06 | Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202102059YA true SG11202102059YA (en) | 2021-03-30 |
Family
ID=63637829
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202102059YA SG11202102059YA (en) | 2018-09-07 | 2019-09-06 | Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof |
SG11202102057SA SG11202102057SA (en) | 2018-09-07 | 2019-09-06 | Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202102057SA SG11202102057SA (en) | 2018-09-07 | 2019-09-06 | Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate |
Country Status (18)
Country | Link |
---|---|
US (2) | US11713296B2 (es) |
EP (2) | EP3847157B1 (es) |
JP (2) | JP7398436B2 (es) |
KR (2) | KR20210057032A (es) |
CN (2) | CN112638869A (es) |
AR (2) | AR116299A1 (es) |
AU (2) | AU2019335542A1 (es) |
BR (2) | BR112021003061A2 (es) |
CA (2) | CA3111359A1 (es) |
DK (2) | DK3847157T3 (es) |
ES (2) | ES2923412T3 (es) |
HU (2) | HUE059527T2 (es) |
IL (2) | IL281191B (es) |
MX (2) | MX2021002666A (es) |
SG (2) | SG11202102059YA (es) |
TW (2) | TWI803692B (es) |
WO (2) | WO2020049153A1 (es) |
ZA (2) | ZA202101006B (es) |
Families Citing this family (13)
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EP3434272A1 (en) | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
CN112638869A (zh) * | 2018-09-07 | 2021-04-09 | 赛诺菲 | 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法 |
KR20220113695A (ko) | 2019-12-09 | 2022-08-16 | 사노피 | 7h-벤조[7]아눌렌-2-카르복실산 유도체의 결정질 형태 |
WO2022001971A1 (zh) | 2020-06-28 | 2022-01-06 | 南京明德新药研发有限公司 | 并环吲唑类化合物 |
KR20230095996A (ko) | 2020-10-19 | 2023-06-29 | 사노피 | 치환 6,7-디히드로-5h-벤조[7]아눌렌 화합물 및 이의 유도체, 이의 제조 방법 및 이의 치료적 용도 |
MX2023004506A (es) | 2020-10-19 | 2023-05-10 | Sanofi Sa | Compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos y sus derivados, procesos para su preparacion y usos terapeuticos de los mismos. |
CN118679157A (zh) | 2021-12-28 | 2024-09-20 | 深圳扬厉医药技术有限公司 | 四氢环庚吲唑化合物的盐型、晶型 |
WO2023187086A1 (en) | 2022-03-31 | 2023-10-05 | Sanofi | Amorphous solid form of amcenestrant |
WO2023198901A1 (en) | 2022-04-15 | 2023-10-19 | Sanofi | Novel substituted 4-amino-4-oxo-but-2-enyl derivatives, processes for their preparation and therapeutic uses thereof |
WO2023198904A1 (en) * | 2022-04-15 | 2023-10-19 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene derivatives, processes for their preparation and therapeutic uses thereof |
WO2023198879A1 (en) | 2022-04-15 | 2023-10-19 | Sanofi | Novel substituted fluorinated n-propyl-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
WO2023198903A1 (en) | 2022-04-15 | 2023-10-19 | Sanofi | Novel substituted fluorinated n-propyl-pyrrolidine and n‑propyl-azetidine compounds, processes for their preparation and therapeutic uses thereof |
WO2023198905A1 (en) | 2022-04-15 | 2023-10-19 | Sanofi | Novel substituted fluorinated vinyl-n-propyl-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
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EP3434272A1 (en) | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
CN112638869A (zh) | 2018-09-07 | 2021-04-09 | 赛诺菲 | 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法 |
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2019
- 2019-09-06 CN CN201980058342.XA patent/CN112638869A/zh active Pending
- 2019-09-06 IL IL281191A patent/IL281191B/en unknown
- 2019-09-06 BR BR112021003061-1A patent/BR112021003061A2/pt unknown
- 2019-09-06 DK DK19765711.7T patent/DK3847157T3/da active
- 2019-09-06 KR KR1020217006752A patent/KR20210057032A/ko active Search and Examination
- 2019-09-06 AU AU2019335542A patent/AU2019335542A1/en active Pending
- 2019-09-06 WO PCT/EP2019/073827 patent/WO2020049153A1/en unknown
- 2019-09-06 CA CA3111359A patent/CA3111359A1/en active Pending
- 2019-09-06 BR BR112021003440-4A patent/BR112021003440A2/pt unknown
- 2019-09-06 CA CA3111466A patent/CA3111466A1/en active Pending
- 2019-09-06 TW TW108132201A patent/TWI803692B/zh active
- 2019-09-06 DK DK19765710.9T patent/DK3847156T3/da active
- 2019-09-06 MX MX2021002666A patent/MX2021002666A/es unknown
- 2019-09-06 WO PCT/EP2019/073823 patent/WO2020049150A1/en unknown
- 2019-09-06 ES ES19765710T patent/ES2923412T3/es active Active
- 2019-09-06 HU HUE19765711A patent/HUE059527T2/hu unknown
- 2019-09-06 AR ARP190102549A patent/AR116299A1/es unknown
- 2019-09-06 AR ARP190102550A patent/AR116300A1/es unknown
- 2019-09-06 ES ES19765711T patent/ES2924738T3/es active Active
- 2019-09-06 KR KR1020217006751A patent/KR20210057031A/ko active Search and Examination
- 2019-09-06 EP EP19765711.7A patent/EP3847157B1/en active Active
- 2019-09-06 SG SG11202102059YA patent/SG11202102059YA/en unknown
- 2019-09-06 CN CN201980058412.1A patent/CN112638870A/zh active Pending
- 2019-09-06 TW TW108132203A patent/TW202026280A/zh unknown
- 2019-09-06 SG SG11202102057SA patent/SG11202102057SA/en unknown
- 2019-09-06 JP JP2021512678A patent/JP7398436B2/ja active Active
- 2019-09-06 HU HUE19765710A patent/HUE059362T2/hu unknown
- 2019-09-06 EP EP19765710.9A patent/EP3847156B1/en active Active
- 2019-09-06 JP JP2021512672A patent/JP7413363B2/ja active Active
- 2019-09-06 AU AU2019336532A patent/AU2019336532A1/en active Pending
- 2019-09-06 MX MX2021002665A patent/MX2021002665A/es unknown
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2021
- 2021-02-15 ZA ZA2021/01006A patent/ZA202101006B/en unknown
- 2021-02-17 ZA ZA2021/01079A patent/ZA202101079B/en unknown
- 2021-03-02 IL IL281196A patent/IL281196B2/en unknown
- 2021-03-05 US US17/193,776 patent/US11713296B2/en active Active
- 2021-03-05 US US17/193,706 patent/US20210188771A1/en active Pending
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