AR116299A1 - Sales de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas - Google Patents

Sales de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas

Info

Publication number
AR116299A1
AR116299A1 ARP190102549A ARP190102549A AR116299A1 AR 116299 A1 AR116299 A1 AR 116299A1 AR P190102549 A ARP190102549 A AR P190102549A AR P190102549 A ARP190102549 A AR P190102549A AR 116299 A1 AR116299 A1 AR 116299A1
Authority
AR
Argentina
Prior art keywords
fluoropropyl
pyrrolidin
benzo
salts
oxiphenil
Prior art date
Application number
ARP190102549A
Other languages
English (en)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of AR116299A1 publication Critical patent/AR116299A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C07C55/07—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Pyrrole Compounds (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En la presente memoria se proporcionan sales de 6-(2,4-diclorefenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo concretamente la sal de oxalato de fórmula (1) y la sal de dibenzoiltartrato de fórmula (2).
ARP190102549A 2018-09-07 2019-09-06 Sales de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas AR116299A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18306177 2018-09-07

Publications (1)

Publication Number Publication Date
AR116299A1 true AR116299A1 (es) 2021-04-21

Family

ID=63637829

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP190102550A AR116300A1 (es) 2018-09-07 2019-09-06 Proceso para la preparación de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo
ARP190102549A AR116299A1 (es) 2018-09-07 2019-09-06 Sales de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP190102550A AR116300A1 (es) 2018-09-07 2019-09-06 Proceso para la preparación de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo

Country Status (18)

Country Link
US (2) US20210188771A1 (es)
EP (2) EP3847157B1 (es)
JP (2) JP7398436B2 (es)
KR (2) KR20210057032A (es)
CN (2) CN112638869A (es)
AR (2) AR116300A1 (es)
AU (2) AU2019335542A1 (es)
BR (2) BR112021003061A2 (es)
CA (2) CA3111466A1 (es)
DK (2) DK3847156T3 (es)
ES (2) ES2923412T3 (es)
HU (2) HUE059362T2 (es)
IL (2) IL281191B (es)
MX (2) MX2021002666A (es)
SG (2) SG11202102059YA (es)
TW (2) TWI803692B (es)
WO (2) WO2020049150A1 (es)
ZA (2) ZA202101006B (es)

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EP3434272A1 (en) 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
AR116300A1 (es) * 2018-09-07 2021-04-21 Sanofi Sa Proceso para la preparación de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo
AU2020399168A1 (en) 2019-12-09 2022-07-28 Sanofi Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative
CN115916769B (zh) 2020-06-28 2024-09-10 深圳扬厉医药技术有限公司 并环吲唑类化合物
JP2023546899A (ja) 2020-10-19 2023-11-08 サノフイ 置換６，７－ジヒドロ－５ｈ－ベンゾ［７］アヌレン化合物およびそれらの誘導体、それらの製造のための方法ならびにそれらの治療的使用
JP2023545552A (ja) 2020-10-19 2023-10-30 サノフイ 置換６，７－ジヒドロ－５ｈ－ベンゾ［７］アヌレン化合物およびそれらの誘導体、それらの製造のための方法ならびにそれらの治療的使用
WO2023125700A1 (zh) 2021-12-28 2023-07-06 南京明德新药研发有限公司 四氢环庚吲唑化合物的盐型、晶型
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WO2023198903A1 (en) 2022-04-15 2023-10-19 Sanofi Novel substituted fluorinated n-propyl-pyrrolidine and n‑propyl-azetidine compounds, processes for their preparation and therapeutic uses thereof
WO2023198904A1 (en) * 2022-04-15 2023-10-19 Sanofi Substituted 6,7-dihydro-5h-benzo[7]annulene derivatives, processes for their preparation and therapeutic uses thereof
WO2023198901A1 (en) 2022-04-15 2023-10-19 Sanofi Novel substituted 4-amino-4-oxo-but-2-enyl derivatives, processes for their preparation and therapeutic uses thereof
WO2023198879A1 (en) 2022-04-15 2023-10-19 Sanofi Novel substituted fluorinated n-propyl-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
WO2023198905A1 (en) 2022-04-15 2023-10-19 Sanofi Novel substituted fluorinated vinyl-n-propyl-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof

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Publication number Publication date
IL281196B (en) 2022-10-01
DK3847156T3 (da) 2022-07-25
HUE059527T2 (hu) 2022-11-28
US20210188771A1 (en) 2021-06-24
AU2019336532A1 (en) 2021-04-01
BR112021003061A2 (pt) 2021-05-11
IL281196B2 (en) 2023-02-01
ES2924738T3 (es) 2022-10-10
TW202024032A (zh) 2020-07-01
EP3847156B1 (en) 2022-05-04
CA3111359A1 (en) 2020-03-12
TW202026280A (zh) 2020-07-16
EP3847157A1 (en) 2021-07-14
DK3847157T3 (da) 2022-08-08
ZA202101006B (en) 2022-08-31
WO2020049150A1 (en) 2020-03-12
BR112021003440A2 (pt) 2021-05-18
AR116300A1 (es) 2021-04-21
EP3847156A1 (en) 2021-07-14
TWI803692B (zh) 2023-06-01
MX2021002666A (es) 2021-07-16
JP2021536468A (ja) 2021-12-27
JP2021536471A (ja) 2021-12-27
CN112638869A (zh) 2021-04-09
JP7398436B2 (ja) 2023-12-14
IL281191B (en) 2022-07-01
JP7413363B2 (ja) 2024-01-15
ES2923412T3 (es) 2022-09-27
AU2019335542A1 (en) 2021-04-01
SG11202102057SA (en) 2021-03-30
MX2021002665A (es) 2021-07-16
CA3111466A1 (en) 2020-03-12
US11713296B2 (en) 2023-08-01
IL281191A (en) 2021-04-29
HUE059362T2 (hu) 2022-11-28
ZA202101079B (en) 2022-09-28
WO2020049153A1 (en) 2020-03-12
EP3847157B1 (en) 2022-05-18
CN112638870A (zh) 2021-04-09
IL281196A (en) 2021-04-29
US20210188772A1 (en) 2021-06-24
KR20210057031A (ko) 2021-05-20
KR20210057032A (ko) 2021-05-20
SG11202102059YA (en) 2021-03-30

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