SG11202003746UA - Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv) - Google Patents
Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv)Info
- Publication number
- SG11202003746UA SG11202003746UA SG11202003746UA SG11202003746UA SG11202003746UA SG 11202003746U A SG11202003746U A SG 11202003746UA SG 11202003746U A SG11202003746U A SG 11202003746UA SG 11202003746U A SG11202003746U A SG 11202003746UA SG 11202003746U A SG11202003746U A SG 11202003746UA
- Authority
- SG
- Singapore
- Prior art keywords
- hbv
- hepatitis
- virus
- novel
- carboxamides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17199676 | 2017-11-02 | ||
| PCT/EP2018/000503 WO2019086142A1 (en) | 2017-11-02 | 2018-11-02 | Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003746UA true SG11202003746UA (en) | 2020-05-28 |
Family
ID=60201937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003746UA SG11202003746UA (en) | 2017-11-02 | 2018-11-02 | Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv) |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US11236087B2 (de) |
| EP (1) | EP3704119A1 (de) |
| JP (1) | JP2021501768A (de) |
| KR (1) | KR20200083552A (de) |
| CN (1) | CN111527087A (de) |
| AR (1) | AR115131A1 (de) |
| AU (1) | AU2018361365C1 (de) |
| BR (1) | BR112020008765A2 (de) |
| CA (1) | CA3081399A1 (de) |
| CL (1) | CL2020001146A1 (de) |
| CU (1) | CU20200045A7 (de) |
| EA (1) | EA202091114A1 (de) |
| EC (1) | ECSP20029569A (de) |
| GE (1) | GEP20227374B (de) |
| IL (1) | IL274297A (de) |
| MA (1) | MA50520A (de) |
| MX (1) | MX2020004838A (de) |
| PH (1) | PH12020550531A1 (de) |
| SG (1) | SG11202003746UA (de) |
| TW (1) | TW201925199A (de) |
| UY (1) | UY37961A (de) |
| WO (1) | WO2019086142A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU20200037A7 (es) * | 2017-11-02 | 2021-03-11 | Aicuris Gmbh & Co Kg | Derivados de indol-2-carboxamidas sustituidos con amino-tiazol activos contra el virus de la hepatitis b (vhb) |
| UY38434A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv) |
| UY38437A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) |
| AR116947A1 (es) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
| US20220218661A1 (en) * | 2018-11-29 | 2022-07-14 | The Research Foundation For The State University Of New York | Compositions and methods for modular control of bioorthogonal ligation |
| AU2020265392A1 (en) * | 2019-04-30 | 2021-12-23 | Aicuris Gmbh & Co. Kg | Novel indolizine-2-carboxamides active against the hepatitis B virus (HBV) |
| EP3962914A1 (de) * | 2019-04-30 | 2022-03-09 | AiCuris GmbH & Co. KG | Neuartige indol-2-carboxamide mit wirksamkeit gegen das hepatitis-b-virus (hbv) |
| US11464783B2 (en) | 2019-06-06 | 2022-10-11 | Aligos Therapeutics, Inc. | Heterocyclic compounds |
| AU2020406139A1 (en) | 2019-12-20 | 2022-06-30 | Bayer Aktiengesellschaft | Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof |
| MX2023005983A (es) | 2020-11-23 | 2023-08-15 | Enanta Pharm Inc | Nuevos agentes antivirales derivados de la espiropirrolidina. |
| WO2022235605A1 (en) | 2021-05-04 | 2022-11-10 | Enanta Pharmaceuticals, Inc. | Novel macrocyclic antiviral agents |
| US11858945B2 (en) | 2021-11-12 | 2024-01-02 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11993600B2 (en) | 2021-12-08 | 2024-05-28 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
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| DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
| WO2000058302A1 (de) | 1999-03-25 | 2000-10-05 | Bayer Aktiengesellschaft | Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b |
| WO2001045712A1 (de) | 1999-12-22 | 2001-06-28 | Bayer Aktiengesellschaft | Arzneimittelkombinationen gegen virale erkrankungen |
| DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| BR0113176A (pt) * | 2000-08-10 | 2003-06-17 | Pharmacia Italia Spa | Compostos biciclo-pirazol, composições farmacêuticas compreendendo os compostos, uso dos compostos na fabricação de medicamentos, processos para a preparação dos compostos, coleção quìmica combinatória e métodos para o tratamento de mamìferos incluindo humanos utilizando os compostos |
| BRPI0408486A (pt) | 2003-03-11 | 2006-04-04 | Pharmacia Italia Spa | derivados de biciclopirazol ativos como inibidores da cinase, processo para a sua preparação e composições farmacêuticas compreendendo-os |
| WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
| JP5023054B2 (ja) | 2005-03-31 | 2012-09-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗バクテリア剤としての二環式ピラゾール化合物 |
| EP1940819A1 (de) | 2005-08-16 | 2008-07-09 | Memory Pharmaceuticals Corporation | Phosphodiesterase-10-inhibitoren |
| EP2370437B1 (de) | 2008-11-25 | 2013-09-04 | Nerviano Medical Sciences S.r.l. | Bicyclische pyrazol- und isoxazolderivate als antitumormittel und antineurodegenerative mittel |
| ES2527363T3 (es) | 2009-12-04 | 2015-01-22 | Nerviano Medical Sciences S.R.L. | Derivados de triciclopirazol |
| WO2012114252A1 (en) * | 2011-02-21 | 2012-08-30 | Actelion Pharmaceuticals Ltd | Novel indole and pyrrolopyridine amides |
| US9399619B2 (en) | 2011-07-01 | 2016-07-26 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against HBV infection |
| EP2794565B1 (de) | 2011-12-21 | 2017-07-26 | Novira Therapeutics Inc. | Hepatitis-b-viruzide |
| CN104302626B (zh) | 2012-01-06 | 2016-09-07 | 爱尔兰詹森科学公司 | 4,4-二取代的-1,4-二氢嘧啶及其作为治疗乙型肝炎的药物的用途 |
| NZ704752A (en) | 2012-08-28 | 2018-06-29 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
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| WO2014165128A2 (en) | 2013-03-12 | 2014-10-09 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
| EP2997032B1 (de) | 2013-05-17 | 2018-07-25 | F.Hoffmann-La Roche Ag | 6-verbrückte heteroaryldihydropyrimidine zur behandlung und prophylaxe von hepatitis-b-virus-infektionen |
| MX366787B (es) | 2013-05-17 | 2019-07-23 | Janssen Sciences Ireland Uc | Derivados de sulfamoiltiofenamida y su uso como medicamentos para tratar la hepatitis b. |
| SG11201600522UA (en) | 2013-07-25 | 2016-02-26 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| AU2014337298B2 (en) | 2013-10-18 | 2018-12-06 | Indiana University Research And Technology Corporation | Hepatitis B viral assembly effectors |
| ES2777248T3 (es) | 2013-11-14 | 2020-08-04 | Novira Therapeutics Inc | Derivados de azepano y métodos de tratar infecciones por hepatitis B |
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| EA030115B9 (ru) | 2014-03-07 | 2018-09-28 | Ф. Хоффманн-Ля Рош Аг | Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b |
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-
2018
- 2018-11-02 AR ARP180103201A patent/AR115131A1/es unknown
- 2018-11-02 EP EP18811147.0A patent/EP3704119A1/de not_active Withdrawn
- 2018-11-02 MA MA050520A patent/MA50520A/fr unknown
- 2018-11-02 AU AU2018361365A patent/AU2018361365C1/en not_active Ceased
- 2018-11-02 SG SG11202003746UA patent/SG11202003746UA/en unknown
- 2018-11-02 CA CA3081399A patent/CA3081399A1/en active Pending
- 2018-11-02 EA EA202091114A patent/EA202091114A1/ru unknown
- 2018-11-02 BR BR112020008765-3A patent/BR112020008765A2/pt not_active Application Discontinuation
- 2018-11-02 JP JP2020524546A patent/JP2021501768A/ja active Pending
- 2018-11-02 TW TW107139066A patent/TW201925199A/zh unknown
- 2018-11-02 US US16/760,929 patent/US11236087B2/en active Active
- 2018-11-02 CU CU2020000045A patent/CU20200045A7/es unknown
- 2018-11-02 WO PCT/EP2018/000503 patent/WO2019086142A1/en unknown
- 2018-11-02 KR KR1020207015663A patent/KR20200083552A/ko not_active Application Discontinuation
- 2018-11-02 GE GEAP201815353A patent/GEP20227374B/en unknown
- 2018-11-02 CN CN201880079565.XA patent/CN111527087A/zh active Pending
- 2018-11-02 MX MX2020004838A patent/MX2020004838A/es unknown
- 2018-11-05 UY UY0001037961A patent/UY37961A/es not_active Application Discontinuation
-
2020
- 2020-04-27 IL IL274297A patent/IL274297A/en unknown
- 2020-04-30 CL CL2020001146A patent/CL2020001146A1/es unknown
- 2020-04-30 PH PH12020550531A patent/PH12020550531A1/en unknown
- 2020-06-01 EC ECSENADI202029569A patent/ECSP20029569A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP20029569A (es) | 2020-07-31 |
| AU2018361365B2 (en) | 2021-04-01 |
| TW201925199A (zh) | 2019-07-01 |
| EA202091114A1 (ru) | 2020-07-24 |
| MX2020004838A (es) | 2020-10-16 |
| UY37961A (es) | 2019-05-31 |
| MA50520A (fr) | 2020-09-09 |
| JP2021501768A (ja) | 2021-01-21 |
| EP3704119A1 (de) | 2020-09-09 |
| BR112020008765A2 (pt) | 2020-10-20 |
| US11236087B2 (en) | 2022-02-01 |
| CA3081399A1 (en) | 2019-05-09 |
| CU20200045A7 (es) | 2021-03-11 |
| PH12020550531A1 (en) | 2021-03-22 |
| AR115131A1 (es) | 2020-12-02 |
| US20210179608A1 (en) | 2021-06-17 |
| CL2020001146A1 (es) | 2020-10-09 |
| AU2018361365A1 (en) | 2020-05-21 |
| KR20200083552A (ko) | 2020-07-08 |
| CN111527087A (zh) | 2020-08-11 |
| IL274297A (en) | 2020-06-30 |
| AU2018361365C1 (en) | 2021-08-05 |
| WO2019086142A1 (en) | 2019-05-09 |
| GEP20227374B (en) | 2022-04-25 |
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