SG11201605046YA - Tagged chimeric effector molecules and receptors thereof - Google Patents
Tagged chimeric effector molecules and receptors thereofInfo
- Publication number
- SG11201605046YA SG11201605046YA SG11201605046YA SG11201605046YA SG11201605046YA SG 11201605046Y A SG11201605046Y A SG 11201605046YA SG 11201605046Y A SG11201605046Y A SG 11201605046YA SG 11201605046Y A SG11201605046Y A SG 11201605046YA SG 11201605046Y A SG11201605046Y A SG 11201605046YA
- Authority
- SG
- Singapore
- Prior art keywords
- receptors
- effector molecules
- chimeric effector
- tagged chimeric
- tagged
- Prior art date
Links
- 239000012636 effector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361919201P | 2013-12-20 | 2013-12-20 | |
PCT/US2014/072007 WO2015095895A1 (fr) | 2013-12-20 | 2014-12-22 | Molécules effectrices chimériques marquées et leurs récepteurs |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201605046YA true SG11201605046YA (en) | 2016-07-28 |
Family
ID=52396818
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201605046YA SG11201605046YA (en) | 2013-12-20 | 2014-12-22 | Tagged chimeric effector molecules and receptors thereof |
SG10201804439PA SG10201804439PA (en) | 2013-12-20 | 2014-12-22 | Tagged chimeric effector molecules and receptors thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201804439PA SG10201804439PA (en) | 2013-12-20 | 2014-12-22 | Tagged chimeric effector molecules and receptors thereof |
Country Status (25)
Country | Link |
---|---|
US (3) | US10494434B2 (fr) |
EP (1) | EP3083671B1 (fr) |
JP (4) | JP6942467B2 (fr) |
KR (2) | KR102483822B1 (fr) |
CN (2) | CN113354744A (fr) |
AU (3) | AU2014368892B2 (fr) |
BR (1) | BR112016014156A8 (fr) |
CA (1) | CA2933707A1 (fr) |
CY (1) | CY1123747T1 (fr) |
DK (1) | DK3083671T3 (fr) |
ES (1) | ES2837856T3 (fr) |
HR (1) | HRP20201906T1 (fr) |
HU (1) | HUE052573T2 (fr) |
IL (1) | IL245845B (fr) |
LT (1) | LT3083671T (fr) |
MX (1) | MX2016007927A (fr) |
MY (1) | MY178233A (fr) |
NZ (2) | NZ720520A (fr) |
PL (1) | PL3083671T3 (fr) |
PT (1) | PT3083671T (fr) |
RS (1) | RS61223B1 (fr) |
RU (1) | RU2729463C2 (fr) |
SG (2) | SG11201605046YA (fr) |
SI (1) | SI3083671T1 (fr) |
WO (1) | WO2015095895A1 (fr) |
Families Citing this family (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2013224027B2 (en) | 2012-02-23 | 2019-01-24 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
WO2014117121A1 (fr) | 2013-01-28 | 2014-07-31 | St. Jude Children's Research Hospital, Inc. | Récepteur chimérique à spécificité nkg2d adapté pour être utilisé en thérapie cellulaire contre le cancer et les maladies infectieuses |
MY178233A (en) * | 2013-12-20 | 2020-10-07 | Hutchinson Fred Cancer Res | Tagged chimeric effector molecules and receptors thereof |
US10323077B2 (en) * | 2014-02-10 | 2019-06-18 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
CN106687125B (zh) | 2014-03-12 | 2021-12-14 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤 |
US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
EP3132247B1 (fr) | 2014-04-16 | 2021-08-18 | Juno Therapeutics GmbH | Méthodes, kits et appareil pour la multiplication d'une population de cellules |
AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
CN107531800B (zh) * | 2014-07-25 | 2021-08-10 | 赛拉福柯蒂斯公司 | 用于嵌合抗原受体分子的调控表达的慢病毒载体 |
TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
GB201415344D0 (en) * | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Protein |
MA41346A (fr) | 2015-01-12 | 2017-11-21 | Juno Therapeutics Inc | Eléments régulateurs post-transcriptionnels d'hépatite modifiée |
CA2973964A1 (fr) | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Anticorps et recepteurs antigeniques chimeriques specifiques de ror1 |
DK3250606T3 (da) * | 2015-01-26 | 2021-01-04 | Cellectis | ANTI-CLL1-specifikke enkeltkædede kimære antigenreceptorer (SCCARS) til cancerimmunterapi |
US10336824B2 (en) | 2015-03-13 | 2019-07-02 | Cytomx Therapeutics, Inc. | Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of thereof |
WO2017075571A1 (fr) | 2015-10-30 | 2017-05-04 | Children's National Medical Center | Génération de lymphocytes t spécifiques contre l'antigène du vph à partir d'une population de lymphocytes t naïfs |
GB201504840D0 (en) * | 2015-03-23 | 2015-05-06 | Ucl Business Plc | Chimeric antigen receptor |
EP3288569A4 (fr) * | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Cellules souches/progénitrices hématopoïétiques et effectrices non t modifiées, et leurs utilisations |
EP3288570A4 (fr) * | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Cellules souches modifiées et leurs utilisations |
CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
MA42447A (fr) | 2015-07-13 | 2018-05-23 | Cytomx Therapeutics Inc | Anticorps anti-pd-1, anticorps anti-pd-1 activables, et leurs procédés d'utilisation |
RU2724738C2 (ru) | 2015-08-05 | 2020-06-25 | СеллабМЕД ИНК. | Химерный антигенный рецептор и т-клетки, в которых экспрессируется химерный антигенный рецептор |
CA2995036A1 (fr) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Degradation modulable de proteine endogene |
RU2021134624A (ru) | 2015-10-22 | 2022-03-15 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
AU2016343809B2 (en) * | 2015-10-30 | 2022-08-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
EP3368077A4 (fr) | 2015-10-30 | 2019-10-16 | Aleta Biotherapeutics Inc. | Compositions et méthodes de transduction tumorale |
EP3407919A4 (fr) * | 2016-01-28 | 2019-09-04 | The Regents of the University of California | Méthodes de multiplication et d'enrichissement sélectifs de cellules transduites avec des récepteurs d'antigènes chimériques et de traitement d'une infection par le vih |
CN108884144B (zh) | 2016-03-18 | 2023-03-14 | 弗雷德哈钦森癌症中心 | 用于cd20免疫疗法的组合物和方法 |
WO2017172952A1 (fr) | 2016-04-01 | 2017-10-05 | Promab Biotechnologies, Inc. | Cellules car-t cd19 marquées par flag |
CN106399255B (zh) * | 2016-04-13 | 2019-10-18 | 阿思科力(苏州)生物科技有限公司 | Pd-1 car-t细胞及其制备方法和应用 |
RU2018139811A (ru) * | 2016-04-15 | 2020-05-15 | Займворкс Инк. | Мультиспецифические антигенсвязывающие конструкции, нацеливающие иммунотерапевтические средства |
CN105907719B (zh) * | 2016-04-18 | 2019-10-18 | 阿思科力(苏州)生物科技有限公司 | Anti ROBO1 CAR-T细胞及其制备和应用 |
CN107365387B (zh) | 2016-05-12 | 2022-03-15 | 阿思科力(苏州)生物科技有限公司 | 一种双特异性抗原结合构建体及其制备方法和应用 |
US11339225B2 (en) | 2016-05-12 | 2022-05-24 | Asclepius (Suzhou) Technology Company Group, Co., Ltd. | Bispecific antigen-binding construct and preparation method and use thereof |
WO2017201281A1 (fr) * | 2016-05-18 | 2017-11-23 | Mayo Foundation For Medical Education And Research | Ciblage de pd-l1 sur des cellules tumorales |
CN107522786A (zh) * | 2016-06-20 | 2017-12-29 | 深圳市体内生物医药科技有限公司 | 一种分子、表达其的细胞及其制备方法和用途 |
MX2019000641A (es) * | 2016-07-15 | 2019-06-10 | Poseida Therapeutics Inc | Composiciones de mucina1-receptor de antigeno quimerico y metodos para su uso. |
AU2017299854A1 (en) * | 2016-07-18 | 2019-01-31 | Helix Biopharma Corp. | CAR immune cells directed to carcinoembryonic antigen related cell adhesion molecule 6 to treat cancer |
CA3032498A1 (fr) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions et methodes de reprogrammation de tcr en utilisant des proteines de fusion |
AU2017307610B2 (en) * | 2016-08-04 | 2023-10-05 | Memorial Sloan-Kettering Cancer Center | Cancer antigen targets and uses thereof |
JP7217970B2 (ja) | 2016-10-07 | 2023-02-06 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を用いてt細胞受容体をリプログラミングするための組成物及び方法 |
CN110139669A (zh) | 2016-11-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | T细胞疗法和btk抑制剂的组合疗法 |
CA3044593A1 (fr) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions et methodes de reprogrammation de tcr au moyen de proteines de fusion |
US20190358262A1 (en) | 2016-12-03 | 2019-11-28 | Juno Therapeutics, Inc. | Methods for modulation of car-t cells |
CN106701827A (zh) * | 2016-12-05 | 2017-05-24 | 刘晓明 | 表达cd19和cd20抗体基因嵌合抗原受体t细胞的转化及扩增培养与保存方法 |
JP7275043B2 (ja) * | 2016-12-16 | 2023-05-17 | ビー-モーゲン・バイオテクノロジーズ,インコーポレーテッド | 増大したhATファミリートランスポゾン媒介遺伝子導入ならびに関連する組成物、システムおよび方法 |
WO2018128486A1 (fr) * | 2017-01-05 | 2018-07-12 | 한국생명공학연구원 | Récepteur antigénique chimérique anti-ceacam6 se liant de manière spécifique à ceacam6 |
EP3571221A2 (fr) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Conjugués de surface cellulaire et compositions cellulaires et méthodes associées |
EP3580212A4 (fr) | 2017-02-08 | 2021-03-17 | Dana Farber Cancer Institute, Inc. | Régulation de récepteurs d'antigènes chimériques |
US11397183B2 (en) | 2017-02-09 | 2022-07-26 | Fred Hutchinson Cancer Center | Biomarkers and uses thereof for selecting immunotherapy intervention |
AU2018222749B2 (en) | 2017-02-17 | 2024-04-18 | Fred Hutchinson Cancer Center | Combination therapies for treatment of BCMA-related cancers and autoimmune disorders |
CN117384929A (zh) | 2017-03-27 | 2024-01-12 | 新加坡国立大学 | 一种编码由细胞表达的嵌合受体的多核苷酸 |
MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
WO2018187791A1 (fr) | 2017-04-07 | 2018-10-11 | Juno Therapeutics, Inc | Cellules génétiquement modifiées exprimant un antigène membranaire spécifique de la prostate (psma) ou une forme modifiée de celui-ci et procédés associés |
JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
US10858443B2 (en) * | 2017-05-31 | 2020-12-08 | Trustees Of Boston University | Synthetic notch protein for modulating gene expression |
WO2018222949A1 (fr) | 2017-06-01 | 2018-12-06 | Cytomx Therapeutics, Inc. | Anticorps anti-pdl1 activables, et leurs procédés d'utilisation |
CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
CN107098969B (zh) * | 2017-06-28 | 2018-10-12 | 武汉波睿达生物科技有限公司 | 一种治疗hiv感染的嵌合抗原受体的重组基因构建及其应用 |
CN107541499B (zh) * | 2017-07-27 | 2020-04-14 | 山东兴瑞生物科技有限公司 | 一种靶向免疫检测点tnfr2的cik的制备及其应用 |
WO2019033057A1 (fr) * | 2017-08-11 | 2019-02-14 | Fred Hutchinson Cancer Research Center | Tcr de braf spécifiques et utilisations associées |
WO2019040899A1 (fr) * | 2017-08-25 | 2019-02-28 | Ichan School Of Medicine At Mount Sinai | Protéines de fusion comprenant des marqueurs détectables, molécules d'acide nucléique et procédé de suivi d'une cellule |
JP7407701B2 (ja) * | 2017-09-06 | 2024-01-04 | フレッド ハッチンソン キャンサー センター | strepタグ特異的キメラ受容体およびその使用 |
EP3678689A1 (fr) | 2017-09-06 | 2020-07-15 | Fred Hutchinson Cancer Research Center | Protéines de liaison spécifiques d'une étiquette strep et leurs utilisations |
MA50079A (fr) | 2017-09-07 | 2020-07-15 | Juno Therapeutics Inc | Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire |
SG11202003543WA (en) | 2017-10-18 | 2020-05-28 | Intrexon Corp | Polypeptide compositions comprising spacers |
CN109706120A (zh) * | 2017-10-26 | 2019-05-03 | 深圳宾德生物技术有限公司 | 一种双靶点特异性t淋巴细胞及其制备方法和应用 |
US11066475B2 (en) | 2017-11-01 | 2021-07-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides |
CA3082328A1 (fr) | 2017-11-14 | 2019-05-23 | Green Cross Lab Cell Corporation | Anticorps anti-her2 ou fragment de liaison a l'antigene de celui-ci, et recepteur antigenique chimerique le comprenant |
US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
CN109810995B (zh) * | 2017-12-06 | 2020-10-02 | 阿思科力(苏州)生物科技有限公司 | 编码car的核苷酸序列、表达该car的robo1 car-nk细胞及其制备和应用 |
EA202091407A1 (ru) | 2017-12-08 | 2020-10-20 | Джуно Терапьютикс, Инк. | Состав бессывороточной среды для культивирования клеток и способы его применения |
EP3720480A2 (fr) | 2017-12-08 | 2020-10-14 | Juno Therapeutics, Inc. | Marqueurs phénotypiques pour thérapie cellulaire et procédés associés |
EP3746117A1 (fr) | 2018-01-31 | 2020-12-09 | Celgene Corporation | Polythérapie utilisant une thérapie cellulaire adoptive et un inhibiteur de point de contrôle |
WO2019152957A1 (fr) * | 2018-02-02 | 2019-08-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Lymphocytes t de type adn-récepteur antigénique chimérique pour immunothérapie |
US20210023170A1 (en) * | 2018-02-12 | 2021-01-28 | University Of Florida Research Foundation, Incorporated | Fviii chimeric antigen receptor tregs for tolerance induction in hemophilia a |
JP2021514631A (ja) | 2018-02-26 | 2021-06-17 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞免疫療法のための組成物および方法 |
EP3765093A4 (fr) * | 2018-03-15 | 2021-12-08 | Fundamental Solutions Corporation | Système complexe de récepteurs d'immunocytes programmable |
BR112020022185A2 (pt) | 2018-05-03 | 2021-02-02 | Juno Therapeutics Inc | terapia de combinação de uma terapia de células t do receptor de antígeno quimérico (car) e um inibidor de quinase |
US20210223248A1 (en) | 2018-06-01 | 2021-07-22 | Fred Hutchinson Cancer Research Center | Biomarkers, uses thereof for selecting immunotherapy intervention, and immunotherapy methods |
WO2019241557A1 (fr) * | 2018-06-15 | 2019-12-19 | The Regents Of The University Of California | Récepteurs antigéniques chimériques de fragments de fusion et utilisations associées |
CN110856724B (zh) * | 2018-08-24 | 2022-05-27 | 杭州康万达医药科技有限公司 | 包含核酸及car修饰的免疫细胞的治疗剂及其应用 |
CN109136244A (zh) * | 2018-08-31 | 2019-01-04 | 河北璋达生物科技有限公司 | 一种可诱导凋亡的携带检测标签的cd20嵌合抗原受体t淋巴细胞及其应用 |
EP3847188A1 (fr) * | 2018-09-03 | 2021-07-14 | Technische Universität München | Étiquette à double peptide combinant la réversibilité et la fonctionnalisation flexible |
JP7510413B2 (ja) | 2018-11-01 | 2024-07-03 | ジュノー セラピューティクス インコーポレイテッド | B細胞成熟抗原に特異的なキメラ抗原受容体を使用する処置方法 |
US20220008465A1 (en) | 2018-11-16 | 2022-01-13 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
CN109467598B (zh) * | 2018-11-28 | 2021-11-09 | 生命谷(海南)生物科技股份有限公司 | 肿瘤相关基因notch1突变短肽及其应用 |
AU2019387497A1 (en) | 2018-11-30 | 2021-06-24 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
WO2020113188A2 (fr) | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Méthodes de dosage et de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
EA202192103A1 (ru) | 2019-01-29 | 2021-12-15 | Джуно Терапьютикс, Инк. | Антитела и химерные антигенные рецепторы, специфичные к орфанному рецептору типа рецеторной тирозинкиназы 1 (ror1) |
EP3773918A4 (fr) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | Récepteurs d'antigènes chimériques anti-cd19 et leurs utilisations en immunothérapie |
EP3725370A1 (fr) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Anticorps anti-pd-l1 modifiés et procédés et utilisations pour le traitement d'une maladie neurodégénérative |
SG11202113356XA (en) | 2019-06-12 | 2021-12-30 | Juno Therapeutics Inc | Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein |
CN110358734B (zh) * | 2019-06-13 | 2020-08-25 | 首都医科大学宣武医院 | 以Tcm为主要效应成分的CAR-T制备方法及其应用 |
BR112022000005A2 (pt) | 2019-07-03 | 2022-04-12 | Peptidream Inc | Agentes de ligação a cd38 e usos dos mesmos |
US20210040174A1 (en) * | 2019-08-08 | 2021-02-11 | Navrogen, Inc. | Composition and Use of Humoral Immune Suppressor Antagonists for the Treatment of Humoral Immune Suppressed Diseases |
MX2022005524A (es) | 2019-11-07 | 2022-08-25 | Juno Therapeutics Inc | Combinacion de una terapia de celulas t y (s)-3-[4-(4-morfolin-4-i lmetil-benciloxi)-1-oxo-1,3-dihidro-isoindol-2-il]-piperidino-2,6 -diona. |
CN110734931A (zh) * | 2019-11-18 | 2020-01-31 | 山东省齐鲁细胞治疗工程技术有限公司 | 一种靶向CD19的人源化scFv嵌合抗原受体T细胞及制备方法、应用 |
WO2021101349A1 (fr) * | 2019-11-21 | 2021-05-27 | 에이비엘바이오 주식회사 | Anticorps se liant à ror1 et à b7-h3, conjugué anticorps-médicament le contenant et utilisation associée |
CN113677704B (zh) * | 2019-11-22 | 2024-03-26 | 南通壹宸生物医药科技有限公司 | Psma抗体及其应用 |
IL293393A (en) | 2019-12-06 | 2022-07-01 | Juno Therapeutics Inc | Cell therapy-related toxicity and response-related methods for the treatment of b-cell malignancies |
AU2021209940A1 (en) | 2020-01-24 | 2022-08-04 | Juno Therapeutics, Inc. | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
JP2023519098A (ja) | 2020-02-12 | 2023-05-10 | ジュノー セラピューティクス インコーポレイテッド | Cd19指向性キメラ抗原受容体t細胞組成物ならびにその方法および使用 |
IL296103A (en) | 2020-03-05 | 2022-11-01 | Neotx Therapeutics Ltd | Methods and preparations for treating cancer with immune cells |
CN113402612A (zh) * | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
WO2021190550A1 (fr) * | 2020-03-25 | 2021-09-30 | 上海先博生物科技有限公司 | Récepteur antigénique chimérique contenant un peptide protecteur, et son utilisation |
WO2021231657A1 (fr) | 2020-05-13 | 2021-11-18 | Juno Therapeutics, Inc. | Procédés d'identification de caractéristiques associées à une réponse clinique et leurs utilisations |
CN112592408B (zh) * | 2020-07-20 | 2021-08-17 | 北京鼎成肽源生物技术有限公司 | 一种靶向c-Met的单链抗体、嵌合抗原受体、重组载体、CAR-T细胞及应用 |
WO2022036495A1 (fr) * | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Co-stimulateurs de cellules présentatrices d'antigène de lymphocytes et leurs utilisations |
CA3197423A1 (fr) * | 2020-11-04 | 2022-05-12 | Daniel Getts | Compositions de proteines de fusion chimeriques modifiees et leurs procedes d'utilisation |
WO2022133030A1 (fr) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Polythérapie de thérapie cellulaire et d'inhibiteur de bcl2 |
TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
KR102671408B1 (ko) * | 2021-02-26 | 2024-06-04 | 진화섭 | HLA class II에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
US20240108654A1 (en) | 2021-03-03 | 2024-04-04 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
JP2024512004A (ja) | 2021-03-17 | 2024-03-18 | マイエロイド・セラピューティクス,インコーポレーテッド | 操作されたキメラ融合タンパク質組成物およびその使用方法 |
US20240181052A1 (en) | 2021-03-29 | 2024-06-06 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
AU2022252220A1 (en) | 2021-03-29 | 2023-10-12 | Juno Therapeutics, Inc. | Combination of a car t cell therapy and an immunomodulatory compound for treatment of lymphoma |
EP4319794A2 (fr) * | 2021-04-08 | 2024-02-14 | Artiva Biotherapeutics, Inc. | Récepteur d'antigène chimère comprenant un anticorps anti-cd19 ou un fragment de liaison à l'antigène de celui-ci et cellules tueuses naturelles le comprenant |
CN113549158B (zh) * | 2021-07-19 | 2022-10-21 | 广州百暨基因科技有限公司 | 包含突变型il15以及嵌合抗原受体的融合蛋白 |
EP4414787A1 (fr) | 2021-10-06 | 2024-08-14 | Asahi Kasei Kabushiki Kaisha | Procédé de fabrication de plaque d'impression et procédé d'impression |
EP4426722A1 (fr) * | 2021-11-02 | 2024-09-11 | Fred Hutchinson Cancer Center | Traitements contre cancers utilisant des thérapies ciblant des cellules et protocoles de recherche associés |
WO2023081715A1 (fr) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Association d'une thérapie de lymphocytes car t avec des inhibiteurs de tyrosine kinase de bruton et procédés d'utilisation associés |
WO2023215725A1 (fr) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions et méthodes pour l'immunothérapie cellulaire |
WO2023250400A1 (fr) | 2022-06-22 | 2023-12-28 | Juno Therapeutics, Inc. | Méthodes de traitement pour thérapie de deuxième ligne par cellules car-t ciblées par cd19 |
WO2024054944A1 (fr) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combinaison de thérapie cellulaire t et de dosage continu ou intermittent d'inhibiteurs de dgk |
CN116179495A (zh) * | 2022-11-28 | 2023-05-30 | 上海恩凯细胞技术有限公司 | 转基因免疫细胞及其应用 |
US20240285762A1 (en) | 2023-02-28 | 2024-08-29 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
EP0737207B1 (fr) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibiteurs de la plasmine humaine derives des domaines de kunitz |
NZ337002A (en) * | 1995-02-24 | 2005-07-29 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
JP2002504328A (ja) * | 1998-02-23 | 2002-02-12 | アーク・セラピューティックス・リミテッド | ビオチン結合性レセプター分子 |
AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
CA2339182C (fr) | 1998-07-31 | 2010-04-06 | Genzyme Corporation | Amelioration du fonctionnement cardiaque par transplantation de cellules souches mesenchymateuses |
AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
EP1189943A1 (fr) * | 1999-06-09 | 2002-03-27 | Whitehead Institute For Biomedical Research | Methode de mesure du ciblage de la membrane plasmique par glut4 |
IL142025A0 (en) | 1999-07-20 | 2002-03-10 | Morphosys Ag | Novel methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds |
AU2001264946A1 (en) | 2000-05-24 | 2001-12-03 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US7399633B2 (en) | 2000-10-27 | 2008-07-15 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
EP1227321A1 (fr) * | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Purification fonctionelle de lymphocytes T antigène-spécifiques par marquage réversible aux multimères MHC |
DE10113776B4 (de) * | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
US7132286B2 (en) | 2001-06-18 | 2006-11-07 | Psychiatric Genomics, Inc. | Method for neural stem cell differentiation using valproate |
DE10137792A1 (de) | 2001-08-06 | 2003-02-27 | Erdmann Volker | Verfahren zur Genexpression |
CA2460184A1 (fr) | 2001-09-14 | 2003-03-27 | Stem Cell Therapeutics Inc. | Augmentation du nombre de cellules souche neuronales induites par la prolactine |
US8735153B2 (en) | 2001-09-24 | 2014-05-27 | Sangamo Biosciences, Inc. | Modulation of stem cells using zinc finger proteins |
EP1485475B2 (fr) | 2002-03-15 | 2017-09-20 | Cellectis | Meganucleases hybrides et monocatenaires et leur utilisation |
EP1546198A1 (fr) | 2002-07-31 | 2005-06-29 | Stem Cell Therapeutics Inc. | Procede d'amelioration de la proliferation, de la differentiation et de la survie de cellules souches neurales au moyen du polypeptide d'activation d'adenylate cyclase hypophysaire (pacap) |
ES2559763T3 (es) | 2002-09-10 | 2016-02-15 | Affimed Gmbh | Anticuerpo humano específico de CD3 con propiedades inmunosupresoras |
US7575925B2 (en) | 2002-12-10 | 2009-08-18 | Sunnybrook Health Sciences Centre | Cell preparations comprising cells of the T cell lineage and methods of making and using them |
AU2004208031B2 (en) | 2003-01-28 | 2009-10-08 | Cellectis | Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof. |
CA2530582C (fr) | 2003-06-23 | 2014-09-09 | A&G Pharmaceutical, Inc. | Compositions et procedes pour rendre a des cellules tumorales leur sensibilite a un traitement antitumoral et induire l'apoptose |
DK1791865T3 (da) | 2004-06-29 | 2010-11-01 | Immunocore Ltd | Celler der udtrykker en modificeret T-cellerecptor |
ES2323651T3 (es) | 2005-01-05 | 2009-07-22 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. | Dominios sinteticos de inmunoglobulina con propiedades de union elaborados por ingenieria en regiones de la molecula diferentes de las regiones que determinan la complementariedad. |
WO2006076678A2 (fr) | 2005-01-13 | 2006-07-20 | The Johns Hopkins University | Vaccins comportant des antigenes de cellules souches de la prostate et leurs utilisations |
GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
DK2650365T3 (en) | 2005-10-18 | 2016-12-05 | Prec Biosciences | RATIONAL MEGANUCLEASES constructed with altered sequence specificity and DNA binding affinity |
US20090220501A1 (en) | 2006-01-30 | 2009-09-03 | Fey Georg H | Anti-CD19 Antibody, Immunotoxin and Treatment Method |
EP1829895A1 (fr) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Molécule bispécifique anti-TLR9 et anti-CD32 contenant un épitope de lymphocyte T pour le traitement des allergies |
EP1878744A1 (fr) | 2006-07-13 | 2008-01-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Epitope-tag pour des récepteurs de cellules T exprimés en surface, leurs utilisations et méthode de selection de cellules hôtes les exprimant |
US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
US20100105136A1 (en) * | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
MX2009005496A (es) | 2006-11-30 | 2009-06-03 | Medipost Co Ltd | Uso de una composicion que contiene una celula madre mesenquimal derivada de sangre del cordon umbilical humano para inducir diferenciacion y proliferacion de celulas precursoras neurales o celulas madre neurales a celulas neurales. |
CA2684878A1 (fr) | 2007-01-09 | 2008-07-17 | Lead Pharma Cel Models Ip B.V. | Obtention de nouvelles cellules progenitrices de cardiomyocytes et cardiomyocytes obtenues a partir de ces cellules |
US20090042795A1 (en) | 2007-06-05 | 2009-02-12 | Pasan Fernando | Cardiac stem cell proliferation proteins, fragments thereof and methods of modulating stem cell proliferation and differentiation |
CA2700391A1 (fr) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Proteines de repetition de tatou mises au point |
KR101319499B1 (ko) | 2008-02-22 | 2013-10-17 | 엘지디스플레이 주식회사 | 화학적 자기조립 방법을 이용한 나노선 혹은탄소나노튜브의 적층 및 패턴형성 방법과, 이를 적용한액정표시장치의 제조방법 |
US8822647B2 (en) | 2008-08-26 | 2014-09-02 | City Of Hope | Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells |
US8546307B2 (en) | 2008-10-03 | 2013-10-01 | Xoma Technology, Ltd. | Triple tag sequence and methods of use thereof |
CA3092340A1 (fr) | 2008-11-21 | 2010-05-27 | Universiteit Stellenbosch | Levure exprimant des cellulases pour saccharification et fermentation simultanees utilisant la cellulose |
EP2210903A1 (fr) | 2009-01-21 | 2010-07-28 | Monoclonal Antibodies Therapeutics | Anticorps monoclonaux anti-CD 160 et leurs utilisations |
EP2424882A2 (fr) * | 2009-02-05 | 2012-03-07 | Intercell AG | PEPTIDES PROTECTEURS CONTRE E. FAECALIS, PROCÉDÉS ET UTILISATIONS LIÉS À CEUX-CI& xA; |
ES2641612T3 (es) | 2009-04-17 | 2017-11-10 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a oligómeros de beta A y uso de los mismos |
EP2258719A1 (fr) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Récepteur de lymphocyte T à cibles multiples |
EP2483301A1 (fr) * | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Récepteurs d'antigènes chimériques anti-récepteur 2 du facteur de croissance de l'endothélium vasculaire, et leur utilisation pour le traitement du cancer |
JP2013517761A (ja) * | 2010-01-21 | 2013-05-20 | オキシレイン ユーケー リミテッド | 酵母細胞の表面上にポリペプチドをディスプレイするための方法および組成物 |
CN103025344B (zh) | 2010-05-17 | 2016-06-29 | 桑格摩生物科学股份有限公司 | 新型dna-结合蛋白及其用途 |
GB201008682D0 (en) | 2010-05-25 | 2010-07-07 | Vib Vzw | Epitope tag for affinity based applications |
EP2590661B1 (fr) | 2010-07-06 | 2019-11-06 | Nanologica AB | Procédé amélioré de différenciation de cellules souches in vivo par la libération de proteines morphogenes grace à de la silice mésoporeuse et ingrédients pharmaceutiques correspondants. |
EP2614151B1 (fr) | 2010-09-08 | 2019-07-24 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukine 15 en tant que marqueur sélectionnable pour transfert génétique dans les lymphocytes |
US20120107282A1 (en) | 2010-10-01 | 2012-05-03 | S. Biomedics Co., Ltd. | Neural stem cell composition capable of treating cancer and method of treatment |
WO2012068378A1 (fr) | 2010-11-17 | 2012-05-24 | Wake Forest University Health Sciences | Différentiation de cellules souches à l'aide de biomatières kératiniques |
DK3214091T3 (en) | 2010-12-09 | 2019-01-07 | Univ Pennsylvania | USE OF CHEMICAL ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF CANCER |
WO2012082841A2 (fr) * | 2010-12-14 | 2012-06-21 | University Of Maryland, Baltimore | Lymphocytes t exprimant un récepteur d'antigène chimérique anti-étiquette universel et méthodes de traitement du cancer |
WO2012127464A2 (fr) | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Lymphocytes t constitutivement activés pour l'utilisation dans une thérapie cellulaire adoptive |
ES2942455T3 (es) | 2011-04-13 | 2023-06-01 | Bristol Myers Squibb Co | Proteínas de fusión Fc que comprenden enlazadores o disposiciones nuevos |
US20120308530A1 (en) | 2011-06-03 | 2012-12-06 | Beijing Allgens Medical Science & Technology Co., Ltd. | Materials Composition and Methods to Control Neural Progenitor and Stem Cell Attachment, Proliferation and Guide Cell Differentiation |
JP6120848B2 (ja) | 2011-08-15 | 2017-04-26 | メディミューン,エルエルシー | 抗b7−h4抗体およびその使用 |
WO2013044225A1 (fr) * | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | Récepteur immunitaire universel exprimé par des lymphocytes t pour le ciblage d'antigènes divers et multiples |
EP2782587B1 (fr) | 2011-11-21 | 2018-11-07 | Ramot at Tel Aviv University, Ltd. | Cellules neuronales dérivées de cellules souches pour la thérapie cellulaire dans des troubles neurologiques |
EP2790711A4 (fr) | 2011-12-12 | 2015-07-29 | Univ California | Méthodes d'utilisation de compositions de cellules souches neurales pour traiter des lésions du système nerveux central |
US9587220B2 (en) | 2012-01-27 | 2017-03-07 | Kyoto University | Method for inducing cardiac differentiation of pluripotent stem cell |
EP3594245A1 (fr) * | 2012-02-13 | 2020-01-15 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Récepteurs d'antigènes chimériques bispécifiques et leurs utilisations thérapeutiques |
AU2013224027B2 (en) | 2012-02-23 | 2019-01-24 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
HUE038850T2 (hu) | 2012-05-25 | 2018-11-28 | Univ California | Eljárások és kompozíciók cél-DNS RNS-irányított módosításához és transzkripció RNS-irányított modulálásához |
US10780118B2 (en) | 2012-08-20 | 2020-09-22 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
EP3064585B1 (fr) | 2012-12-12 | 2020-02-05 | The Broad Institute, Inc. | Fabrication et optimisation de systèmes, procédés et compositions d'enzyme améliorés pour la manipulation de séquences |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
RU2015129551A (ru) | 2012-12-19 | 2017-01-25 | Эмплиммьюн, Инк. | Антитела к в7-н4 человека и их применение |
WO2014099671A1 (fr) | 2012-12-20 | 2014-06-26 | Bluebird Bio, Inc. | Récepteurs d'antigène chimériques et cellules immunitaires ciblant des malignités à cellules b |
AU2014268364A1 (en) | 2013-05-24 | 2015-12-10 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
US9816070B2 (en) | 2013-06-14 | 2017-11-14 | Massachusetts Institute Of Technology | Articles and methods for stem cell differentiation |
MX2016005689A (es) | 2013-10-31 | 2016-08-08 | Hutchinson Fred Cancer Res | Celulas no t efectoras y madre/progenitoras hematopoyeticas modificadas y usos de estas. |
EP2871189A1 (fr) | 2013-11-07 | 2015-05-13 | Institut Pasteur | Anticorps TAG anti Strep monoclonaux à affinité élevée |
CA2930877A1 (fr) | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Systeme crips-cas, materiels et procedes |
CA2930215C (fr) | 2013-11-21 | 2021-04-27 | Ucl Business Plc | Cellule comprenant plus d'un recepteur antigenique chimerique |
MY178233A (en) * | 2013-12-20 | 2020-10-07 | Hutchinson Fred Cancer Res | Tagged chimeric effector molecules and receptors thereof |
WO2015105522A1 (fr) | 2014-01-13 | 2015-07-16 | Forman Stephen J | Récepteurs d'antigènes chimères (car) comprenant des mutations dans la région de l'espaceur fc et procédés pour leur utilisation |
GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
WO2016040724A1 (fr) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anticorps anti-b7-h4 et immunoconjugués |
EP3201232A1 (fr) | 2014-10-03 | 2017-08-09 | Dana-Farber Cancer Institute, Inc. | Anticorps dirigés contre le récepteur du facteur de nécrose tumorale induit par glucocorticoïdes (gitr) et leurs procédés d'utilisation |
PT3295951T (pt) | 2015-02-19 | 2020-07-21 | Compugen Ltd | Anticorpos anti-pvrig e métodos de utilização |
EP3288569A4 (fr) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Cellules souches/progénitrices hématopoïétiques et effectrices non t modifiées, et leurs utilisations |
EP3288570A4 (fr) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Cellules souches modifiées et leurs utilisations |
JO3620B1 (ar) | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
EP3571221A2 (fr) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Conjugués de surface cellulaire et compositions cellulaires et méthodes associées |
EP3678689A1 (fr) | 2017-09-06 | 2020-07-15 | Fred Hutchinson Cancer Research Center | Protéines de liaison spécifiques d'une étiquette strep et leurs utilisations |
JP7407701B2 (ja) | 2017-09-06 | 2024-01-04 | フレッド ハッチンソン キャンサー センター | strepタグ特異的キメラ受容体およびその使用 |
-
2014
- 2014-12-22 MY MYPI2016001073A patent/MY178233A/en unknown
- 2014-12-22 US US15/106,657 patent/US10494434B2/en active Active
- 2014-12-22 KR KR1020167017510A patent/KR102483822B1/ko active IP Right Grant
- 2014-12-22 BR BR112016014156A patent/BR112016014156A8/pt active Search and Examination
- 2014-12-22 KR KR1020227046118A patent/KR20230007559A/ko active IP Right Grant
- 2014-12-22 PT PT148307705T patent/PT3083671T/pt unknown
- 2014-12-22 CA CA2933707A patent/CA2933707A1/fr active Pending
- 2014-12-22 RS RS20201392A patent/RS61223B1/sr unknown
- 2014-12-22 SI SI201431722T patent/SI3083671T1/sl unknown
- 2014-12-22 DK DK14830770.5T patent/DK3083671T3/da active
- 2014-12-22 PL PL14830770.5T patent/PL3083671T3/pl unknown
- 2014-12-22 EP EP14830770.5A patent/EP3083671B1/fr active Active
- 2014-12-22 CN CN202110592499.XA patent/CN113354744A/zh active Pending
- 2014-12-22 SG SG11201605046YA patent/SG11201605046YA/en unknown
- 2014-12-22 CN CN201480075007.8A patent/CN105980402B/zh active Active
- 2014-12-22 JP JP2016540620A patent/JP6942467B2/ja active Active
- 2014-12-22 LT LTEP14830770.5T patent/LT3083671T/lt unknown
- 2014-12-22 ES ES14830770T patent/ES2837856T3/es active Active
- 2014-12-22 HU HUE14830770A patent/HUE052573T2/hu unknown
- 2014-12-22 MX MX2016007927A patent/MX2016007927A/es unknown
- 2014-12-22 RU RU2016129045A patent/RU2729463C2/ru active
- 2014-12-22 SG SG10201804439PA patent/SG10201804439PA/en unknown
- 2014-12-22 WO PCT/US2014/072007 patent/WO2015095895A1/fr active Application Filing
- 2014-12-22 NZ NZ720520A patent/NZ720520A/en unknown
- 2014-12-22 AU AU2014368892A patent/AU2014368892B2/en active Active
- 2014-12-22 NZ NZ759969A patent/NZ759969A/en unknown
-
2016
- 2016-05-25 IL IL245845A patent/IL245845B/en active IP Right Grant
-
2019
- 2019-03-04 JP JP2019038969A patent/JP2019083821A/ja active Pending
- 2019-09-13 AU AU2019229438A patent/AU2019229438B2/en active Active
- 2019-10-25 US US16/664,706 patent/US11046766B2/en active Active
-
2020
- 2020-11-30 HR HRP20201906TT patent/HRP20201906T1/hr unknown
- 2020-12-23 CY CY20201101218T patent/CY1123747T1/el unknown
-
2021
- 2021-05-24 US US17/329,115 patent/US11993652B2/en active Active
- 2021-06-29 AU AU2021204475A patent/AU2021204475B2/en active Active
- 2021-07-14 JP JP2021116355A patent/JP2021164482A/ja active Pending
-
2022
- 2022-10-05 JP JP2022161138A patent/JP2022176327A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL245845B (en) | Tagged chimeric effector molecules and receptors for them | |
IL261743B (en) | and their uses 33–il antibodies against | |
IL261547B (en) | Antibodies against pesidine and their uses | |
IL245040B (en) | Antibodies against pdgfr-beta and their uses | |
IL246287B (en) | Fabs antibodies one by one and their uses | |
IL243974A0 (en) | Antibodies against -prlr and uses | |
ZA201508896B (en) | Anti-c10orf54 antibodies and uses thereof | |
SG10201709715RA (en) | Anti-b7-h5 antibodies and their uses | |
SG11201509260RA (en) | Chimeric fvii-xten molecules and uses thereof | |
SG11201509116VA (en) | Anti-tweakr antibodies and uses thereof | |
ZA201603596B (en) | Fabs-in-tandem immunoglobulin and uses thereof | |
GB2514324B (en) | Modified tubular |