SG10201801402XA - Processes of making and crystalline forms of a mdm2 inhibitor - Google Patents

Processes of making and crystalline forms of a mdm2 inhibitor

Info

Publication number
SG10201801402XA
SG10201801402XA SG10201801402XA SG10201801402XA SG10201801402XA SG 10201801402X A SG10201801402X A SG 10201801402XA SG 10201801402X A SG10201801402X A SG 10201801402XA SG 10201801402X A SG10201801402X A SG 10201801402XA SG 10201801402X A SG10201801402X A SG 10201801402XA
Authority
SG
Singapore
Prior art keywords
processes
making
crystalline forms
mdm2 inhibitor
mdm2
Prior art date
Application number
SG10201801402XA
Other languages
English (en)
Inventor
Matthew Bio
Sebastien Caille
Brian Cochran
Yuanqing Fang
Brian Fox
Brian Lucas
Lawrence Mcgee
Filisaty Vounatsos
Sean Wiedemann
Sarah Wortman
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51063849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201801402X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG10201801402XA publication Critical patent/SG10201801402XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/25—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Epoxy Compounds (AREA)
SG10201801402XA 2013-06-10 2014-06-09 Processes of making and crystalline forms of a mdm2 inhibitor SG10201801402XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361833196P 2013-06-10 2013-06-10

Publications (1)

Publication Number Publication Date
SG10201801402XA true SG10201801402XA (en) 2018-04-27

Family

ID=51063849

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201801402XA SG10201801402XA (en) 2013-06-10 2014-06-09 Processes of making and crystalline forms of a mdm2 inhibitor
SG11201509896VA SG11201509896VA (en) 2013-06-10 2014-06-09 Processes of making and crystalline forms of a mdm2 inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201509896VA SG11201509896VA (en) 2013-06-10 2014-06-09 Processes of making and crystalline forms of a mdm2 inhibitor

Country Status (37)

Country Link
US (10) US9376386B2 (fr)
EP (2) EP3008039B1 (fr)
JP (4) JP6998655B2 (fr)
KR (3) KR20210121270A (fr)
CN (3) CN105358530A (fr)
AP (1) AP2015008891A0 (fr)
AR (2) AR096582A1 (fr)
AU (4) AU2014278428B2 (fr)
BR (2) BR112015031004B1 (fr)
CA (4) CA3201958A1 (fr)
CL (3) CL2015003589A1 (fr)
CR (2) CR20210290A (fr)
CY (1) CY1123661T1 (fr)
DK (1) DK3008039T3 (fr)
EA (3) EA202091612A1 (fr)
ES (1) ES2851023T3 (fr)
HR (1) HRP20202065T1 (fr)
HU (1) HUE053047T2 (fr)
IL (4) IL297860A (fr)
JO (2) JOP20200296A1 (fr)
LT (1) LT3008039T (fr)
MA (3) MA38714A1 (fr)
MX (2) MX2015016856A (fr)
MY (1) MY194848A (fr)
NZ (1) NZ714821A (fr)
PE (2) PE20160113A1 (fr)
PH (1) PH12015502705B1 (fr)
PL (1) PL3008039T3 (fr)
PT (1) PT3008039T (fr)
RS (1) RS61192B1 (fr)
SG (2) SG10201801402XA (fr)
SI (1) SI3008039T1 (fr)
TN (1) TN2015000521A1 (fr)
TW (3) TWI791153B (fr)
UA (1) UA121301C2 (fr)
UY (1) UY35605A (fr)
WO (1) WO2014200937A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
CA2850166C (fr) 2011-09-27 2019-12-03 Amgen Inc. Heterocycles utilises comme inhibiteurs de mdm2 dans le traitement du cancer
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CA2906538C (fr) 2013-03-14 2021-02-02 Ana Gonzalez Buenrostro Composes morpholinone d'acide heteroaryle utilises comme inhibiteurs de mdm2 pour le traitement du cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
ES2916721T3 (es) 2013-11-11 2022-07-05 Amgen Inc Terapia de combinación que incluye un inhibidor de MDM2 y uno o más agentes farmacéuticamente activos adicionales para el tratamiento de cánceres
WO2017201449A1 (fr) 2016-05-20 2017-11-23 Genentech, Inc. Conjugués anticorps-protac et procédés d'utilisation
CR20200576A (es) * 2018-04-30 2021-04-30 Kartos Therapeutics Inc Métodos para tratar cáncer
AU2019273850A1 (en) * 2018-05-25 2021-01-07 Kartos Therapeutics, Inc. Methods of treating myeloproliferative neoplasms
WO2020047424A1 (fr) 2018-08-31 2020-03-05 Amgen, Inc. Procédés de préparation d'un inhibiteur de mdm2
CN110963958A (zh) * 2018-09-30 2020-04-07 上海长森药业有限公司 一种mdm2抑制剂，及其制备方法、药物组合物和应用
GB201919219D0 (en) 2019-12-23 2020-02-05 Otsuka Pharma Co Ltd Cancer biomarkers
WO2021236474A1 (fr) * 2020-05-22 2021-11-25 Merck Sharp & Dohme Corp. Nouveaux procédés de préparation de conjugués de la protéine il-2
EP4204812A2 (fr) 2020-08-27 2023-07-05 Otsuka Pharmaceutical Co., Ltd. Biomarqueurs pour la thérapie anticancéreuse utilisant des antagonistes de mdm2
GB202103080D0 (en) 2021-03-04 2021-04-21 Otsuka Pharma Co Ltd Cancer biomarkers
CA3227793A1 (fr) * 2021-08-05 2023-02-09 Yong Moon Choi Forme cristalline de phenylcarbamate et methode de fabrication
WO2023039161A1 (fr) * 2021-09-09 2023-03-16 Kartos Therapeutics Procédés de traitement du cancer dépendant de l'expression du gène myc
WO2023056069A1 (fr) 2021-09-30 2023-04-06 Angiex, Inc. Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2483213A (en) * 1947-06-14 1949-09-27 American Cyanamid Co Alpha naphthalene sulfonic anhydride
CH436295A (de) 1961-11-13 1967-05-31 Mcneilab Inc Verfahren zur Herstellung neuer 3-Morpholinone
US3518236A (en) * 1967-07-20 1970-06-30 Uniroyal Inc Acceleration of sulfur-vulcanization of rubber with sulfinic acids and derivatives
DE3246148A1 (de) 1982-12-14 1984-06-14 Troponwerke GmbH & Co KG, 5000 Köln Pyrazolo(4.3-b)(1.4)oxazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2604472B2 (ja) 1989-07-12 1997-04-30 株式会社クラレ 重合性組成物
WO1995023135A1 (fr) 1991-03-07 1995-08-31 Fisons Corporation Derives de diphenyl-2-piperidinone et -2-pyrrolidinone possedant une activite anticonvulsivante et neuroprotectrice
US5334720A (en) 1991-03-07 1994-08-02 Fisons Corporation Diphenyl-1-(aminoalkyl)-2-piperidinone and -2-pyrrolidinone derivatives having anticonvulsant properties
ATE219077T1 (de) 1994-08-19 2002-06-15 Abbott Lab Endothelin antagoniste
WO1997030045A1 (fr) 1996-02-13 1997-08-21 Abbott Laboratories Derives de pyrrolidine a substitution benzo-1,3-dioxolyl et benzofuranyl servant d'antagonistes de l'endotheline
US6159990A (en) 1997-06-18 2000-12-12 Synaptic Pharmaceutical Corporation Oxazolidinones as α1A receptor antagonists
PL342500A1 (en) 1997-08-04 2001-06-04 Abbott Lab Derivatives of pyrolydin-3-carboxylic acid and their application as endothelin antagonists
AU1910299A (en) 1997-12-18 1999-07-05 Eli Lilly And Company Peptidomimetic template-based combinatorial libraries
US6770658B2 (en) 1998-09-09 2004-08-03 Inflazyme Pharmaceuticals Ltd. Substituted γ-phenyl-Δ-lactams and uses related thereto
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
DE19951418A1 (de) * 1999-10-26 2001-05-03 Merck Patent Gmbh Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
WO2002017912A1 (fr) 2000-08-31 2002-03-07 Abbott Laboratories Antagonistes de l'endotheline
US7229500B2 (en) * 2000-11-20 2007-06-12 Parallel Synthesis Technologies, Inc. Methods and devices for high throughput crystallization
WO2002060894A2 (fr) 2001-01-30 2002-08-08 Bristol-Myers Squibb Company Lactames sulfonamide inhibiteurs de facteur xa
AU2002305450A1 (en) 2001-05-08 2002-11-18 Yale University Proteomimetic compounds and methods
EP1395560A1 (fr) 2001-05-23 2004-03-10 Ucb, S.A. Derives d'acide alcanoique 2-oxo-piperidinyl- et 2-oxo-azepanyle destines au traitement de l'epilepsie et d'autres troubles neurologiques
MXPA04005906A (es) 2001-12-18 2004-09-13 Hoffmann La Roche Cis-2,4,5-trifenil-.imidazolinas y uso de la misma para tratamiento de tumores.
US6860940B2 (en) * 2002-02-11 2005-03-01 The Regents Of The University Of California Automated macromolecular crystallization screening
US6916833B2 (en) * 2003-03-13 2005-07-12 Hoffmann-La Roche Inc. Substituted piperidines
US7425638B2 (en) 2003-06-17 2008-09-16 Hoffmann-La Roche Inc. Cis-imidazolines
AU2005243465B2 (en) 2004-05-18 2011-08-25 F. Hoffmann-La Roche Ag Novel CIS-imidazolines
US7893278B2 (en) 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
JP2007297283A (ja) * 2004-07-28 2007-11-15 Santen Pharmaceut Co Ltd 新規桂皮酸関連化合物
US7354944B2 (en) 2004-10-18 2008-04-08 Amgen Inc. Thiadiazole compounds and methods of use
MX2007010054A (es) 2005-02-18 2007-09-21 Mitsubishi Pharma Corp Sal de un derivado de prolina, solvato de la misma y metodo de produccion de la misma.
TWI314552B (en) 2005-03-16 2009-09-11 Hoffmann La Roche Novel cis-2,4,5-triaryl-imidazolines,their use as anti-cancer medicaments and their manufacture process
CA2603258A1 (fr) 2005-04-04 2006-10-12 Eisai Co., Ltd. Composes dihydropyridine et compositions pour maux de tete
MX2007015511A (es) * 2005-06-07 2008-03-06 Univ Ramot Sales novedosas de farmacos sicotropicos conjugados y procesos para prepararlas.
US7893268B2 (en) * 2005-07-27 2011-02-22 University Of Toledo Epithiolone analogues
CN101316823B (zh) 2005-12-01 2013-05-22 霍夫曼-拉罗奇有限公司 用作抗癌剂的作为p53和MDM2蛋白之间相互作用的抑制剂的2,4,5-三苯基咪唑啉衍生物
EA200801716A1 (ru) 2006-01-18 2009-04-28 Амген Инк. Тиазольные соединения и их применение
US20070213341A1 (en) 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives
WO2008005268A1 (fr) 2006-06-30 2008-01-10 Schering Corporation Pipéridines substituées qui augmentent l'activité p53 et leurs utilisations
WO2008010953A2 (fr) 2006-07-19 2008-01-24 University Of Georgia Research Foundation, Inc. Dicétoacides de pyridinone : inhibiteurs de la réplication du vih dans une thérapie combinée
US7618989B2 (en) 2006-08-15 2009-11-17 Wyeth Tricyclic oxazolidone derivatives useful as PR modulators
US20080045560A1 (en) 2006-08-15 2008-02-21 Wyeth Pyrrolidine and related derivatives useful as PR modulators
TW200831080A (en) 2006-12-15 2008-08-01 Irm Llc Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
GB0722769D0 (en) 2007-11-21 2008-01-02 Biolipox Ab New compounds
CA2680783C (fr) 2007-03-23 2012-04-24 Amgen Inc. Composes heterocycliques et leurs utilisations
NZ579834A (en) 2007-03-23 2012-03-30 Amgen Inc Heterocyclic compounds as selective inhibitors of PI3K activity
SI2139882T1 (sl) 2007-03-23 2014-03-31 Amgen Inc. 3-substituirani kinolinski ali kinoksalinski derivati in njihoba uporaba kot inhibitorji fosfatidilinozitol 3-kinaze (pi3k)
US7625895B2 (en) 2007-04-12 2009-12-01 Hoffmann-Le Roche Inc. Diphenyl-dihydro-imidazopyridinones
WO2008130614A2 (fr) 2007-04-20 2008-10-30 University Of Pittsburg-Of The Commonwealth System Of Higher Education Antagonistes p53/mdm2/mdm4 sélectifs et à action double
US7834179B2 (en) 2007-05-23 2010-11-16 Hoffmann-La Roche Inc. Spiroindolinone derivatives
WO2009004430A1 (fr) 2007-06-29 2009-01-08 Pfizer Inc. N-benzyl oxazolidinones et composés hétérocycliques apparentés comme potentialisateurs de récepteurs du glutamate
EP2176238B1 (fr) 2007-07-09 2012-04-18 AstraZeneca AB Dérivés de morpholino pyrimidine utilisés dans des maladies liées à une kinase mtor et/ou à pi3k
EP2173728A2 (fr) 2007-07-17 2010-04-14 Amgen Inc. Modulateurs hétérocycliques de pkb
AU2008276512A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
PE20091008A1 (es) 2007-08-02 2009-08-10 Amgen Inc Derivados heterociclicos como moduladores de fosfoinositida 3-cinasa
KR101203020B1 (ko) 2007-10-09 2012-11-20 에프. 호프만-라 로슈 아게 카이랄 시스-이미다졸린
US7776875B2 (en) 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
EP2231661A1 (fr) 2007-12-19 2010-09-29 Amgen, Inc. Inhibiteurs de la pi3 kinase
JP2011507799A (ja) 2007-12-26 2011-03-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 癲癇のためのａｍｐａ受容体アンタゴニストおよびゾニサミド
CN102036956A (zh) 2008-03-21 2011-04-27 柯罗瑞恩制药有限公司 取代的吡咯烷和哌啶化合物、它们的衍生物、以及用于治疗疼痛的方法
EP2307400B1 (fr) 2008-05-30 2014-04-23 Amgen, Inc Inhibiteurs de la pi3 kinase
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
WO2010030704A2 (fr) * 2008-09-10 2010-03-18 Achaogen, Inc. Analogues d’aminoglycosides antibactériens
TW201011009A (en) 2008-09-15 2010-03-16 Priaxon Ag Novel pyrrolidin-2-ones
BRPI0919325A2 (pt) 2008-09-18 2021-03-30 F.Hoffmann-La Roche Ag Pirrolidina-2-carboxamidas substituídas
WO2010083246A1 (fr) 2009-01-15 2010-07-22 Amgen Inc. Thiazoles substitués par fluoroisoquinoléine et leurs méthodes d'application
EP2398791A1 (fr) 2009-02-18 2011-12-28 Amgen, Inc Composés d'indole ou benzimidazole convenant comme inhibiteurs de la kinase mtor
MX2011009796A (es) 2009-03-20 2011-12-14 Amgen Inc Inhibidores de la cinasa pi3.
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
AU2010249040B2 (en) 2009-05-13 2013-08-22 Amgen Inc. Heteroaryl compounds as PIKK inhibitors
EP2445898A2 (fr) 2009-06-25 2012-05-02 Amgen, Inc Composés hétérocycliques et leurs utilisations
SG176986A1 (en) 2009-06-25 2012-02-28 Amgen Inc Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases
JP2012531438A (ja) 2009-06-25 2012-12-10 アムジエン・インコーポレーテツド 複素環式化合物およびその使用
CA2765819A1 (fr) 2009-06-25 2010-12-29 Amgen Inc. Composes heterocycliques et leurs utilisations en tant qu'inhibiteurs de l'activite p13 k
MX2012002420A (es) 2009-08-26 2012-06-27 Novartis Ag Compuestos de heteroarilo tetra-sustituidos y su uso como moduladores de mdm2 y/o mdm4.
CN102596981A (zh) * 2009-10-09 2012-07-18 尔察祯有限公司 抗菌氨基糖苷类类似物
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
JP2013519980A (ja) * 2010-02-10 2013-05-30 モチイ，インコーポレイテッド（ディービーエー ヴォクサ） 収差補正暗視野電子顕微鏡
IT1399923B1 (it) * 2010-05-11 2013-05-09 Cbb Net S A Procedimento di preparazione di sali dell'acido (r) alfa-lipoico loro formulazione ed uso nelle composizioni farmaceutiche in forma di compresse che li contengono
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
ES2637113T3 (es) * 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
CN102153557B (zh) 2011-01-21 2013-03-20 中国科学院上海有机化学研究所 具有乙二胺骨架的多手性中心氮杂环卡宾前体盐、合成方法及用途
WO2012147953A1 (fr) * 2011-04-28 2012-11-01 大塚化学株式会社 Nouveau procédé de production d'azodicarbonamide
TW201309651A (zh) * 2011-06-29 2013-03-01 Otsuka Pharma Co Ltd 阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）無水物Ｂ形結晶微粒子之製造方法
CA2850166C (fr) 2011-09-27 2019-12-03 Amgen Inc. Heterocycles utilises comme inhibiteurs de mdm2 dans le traitement du cancer
CN103373951B (zh) * 2012-04-28 2016-03-09 上海医药工业研究院 一种拉帕替尼中间体的制备方法
MX362896B (es) 2013-02-19 2019-02-22 Amgen Inc Cis-morfolinona y otros compuestos como inhibidores de mdm2 para el tratamiento del cáncer.
WO2014134201A1 (fr) 2013-02-28 2014-09-04 Amgen Inc. Inhibiteur mdm2 dérivé de l'acide benzoïque pour le traitement du cancer
CA2906538C (fr) 2013-03-14 2021-02-02 Ana Gonzalez Buenrostro Composes morpholinone d'acide heteroaryle utilises comme inhibiteurs de mdm2 pour le traitement du cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط

Also Published As

Publication number Publication date
US9757367B2 (en) 2017-09-12
US20180092898A1 (en) 2018-04-05
NZ714821A (en) 2020-10-30
PE20160113A1 (es) 2016-03-03
IL266504A (en) 2019-07-31
TWI791153B (zh) 2023-02-01
CA2914723C (fr) 2021-06-15
PL3008039T3 (pl) 2021-04-19
NZ753956A (en) 2020-12-18
US9623018B2 (en) 2017-04-18
CN110627708A (zh) 2019-12-31
US20160289178A1 (en) 2016-10-06
US20140364455A1 (en) 2014-12-11
IL242622A0 (en) 2016-02-01
PH12015502705A1 (en) 2016-03-14
EP3008039A1 (fr) 2016-04-20
SG11201509896VA (en) 2016-01-28
AU2014278428B2 (en) 2018-11-15
CY1123661T1 (el) 2022-03-24
US9801867B2 (en) 2017-10-31
US20160289190A1 (en) 2016-10-06
US9855259B2 (en) 2018-01-02
MX2019012007A (es) 2019-11-11
JP7263439B2 (ja) 2023-04-24
IL281807B2 (en) 2023-04-01
MA53572A1 (fr) 2021-10-29
JOP20200296A1 (ar) 2017-06-16
CN110003092A (zh) 2019-07-12
IL297860A (en) 2023-01-01
WO2014200937A1 (fr) 2014-12-18
PE20210153A1 (es) 2021-01-26
US20230301974A1 (en) 2023-09-28
CA3200532A1 (fr) 2014-12-18
BR122020003153B1 (pt) 2022-09-27
AR119727A2 (es) 2022-01-05
TN2015000521A1 (en) 2017-04-06
MA43288A1 (fr) 2020-04-30
MA43288B1 (fr) 2020-10-28
CA2914723A1 (fr) 2014-12-18
US20160289243A1 (en) 2016-10-06
CA3201958A1 (fr) 2014-12-18
EA031254B1 (ru) 2018-12-28
MY194848A (en) 2022-12-19
KR20210121270A (ko) 2021-10-07
CN105358530A (zh) 2016-02-24
AU2020267169B2 (en) 2022-08-25
CL2019000056A1 (es) 2019-05-03
IL242622B (en) 2019-06-30
AR096582A1 (es) 2016-01-20
KR20160018576A (ko) 2016-02-17
CR20160010A (es) 2016-02-04
EP3805232A1 (fr) 2021-04-14
MA38714A1 (fr) 2017-10-31
JP2023089126A (ja) 2023-06-27
RS61192B1 (sr) 2021-01-29
TW201536743A (zh) 2015-10-01
CL2021000566A1 (es) 2021-09-03
US20220280496A1 (en) 2022-09-08
HUE053047T2 (hu) 2021-06-28
TW202035370A (zh) 2020-10-01
JP2020147573A (ja) 2020-09-17
DK3008039T3 (da) 2021-01-04
US20160264526A1 (en) 2016-09-15
EP3008039B1 (fr) 2020-11-11
JP6891322B2 (ja) 2021-06-18
ES2851023T3 (es) 2021-09-02
JP2016528179A (ja) 2016-09-15
PH12015502705B1 (en) 2016-03-14
US20200281912A1 (en) 2020-09-10
SI3008039T1 (sl) 2021-03-31
JO3768B1 (ar) 2021-01-31
TWI698428B (zh) 2020-07-11
TW201922705A (zh) 2019-06-16
CA3115609A1 (fr) 2014-12-18
US9376386B2 (en) 2016-06-28
AU2014278428A1 (en) 2015-11-26
BR112015031004A2 (pt) 2020-05-12
CR20210290A (es) 2021-07-23
TWI649306B (zh) 2019-02-01
AU2022271425A1 (en) 2022-12-22
US20160287570A1 (en) 2016-10-06
MX2015016856A (es) 2016-04-07
BR112015031004B1 (pt) 2022-09-20
AU2018260844A1 (en) 2018-11-22
JP6998655B2 (ja) 2022-02-04
EA202091612A1 (ru) 2020-10-05
AU2020267169A1 (en) 2020-12-03
CL2015003589A1 (es) 2016-06-17
UA121301C2 (uk) 2020-05-12
UY35605A (es) 2015-01-30
EA201592305A1 (ru) 2016-05-31
PT3008039T (pt) 2021-01-13
JP2021130685A (ja) 2021-09-09
IL281807A (en) 2021-05-31
AU2018260844B2 (en) 2020-08-13
CA3115609C (fr) 2023-08-08
IL281807B (en) 2022-12-01
IL266504B (en) 2021-04-29
HRP20202065T1 (hr) 2021-02-19
AP2015008891A0 (en) 2015-11-30
KR20230019216A (ko) 2023-02-07
EA201891642A1 (ru) 2019-08-30
LT3008039T (lt) 2021-01-25

Similar Documents

Publication Publication Date Title
IL281807A (en) Processes for the production of crystalline forms of an MDM2 inhibitor
IL268452A (en) Manufacturing processes and intermediates for the preparation of a JAK inhibitor
GB201313840D0 (en) Method of Manufacturing a Component
GB201313841D0 (en) Method of Manufacturing a Component
GB201313839D0 (en) Method of Manufacturing a Component
ZA201702252B (en) A selective inhibitor of prosphatidylinositol 3-kinase-gamma
LT3293176T (lt) Pde4 inhibitoriaus kristalinė forma
HK1222339A1 (zh) 金屬-β-內酰胺酶的抑制劑
GB201315841D0 (en) A substrate and a method of manufacturing a substrate
ZA201506677B (en) Firelog and method of making a firelog
SG11201508998PA (en) Methods of forming a substrate opening
EP2959896A4 (fr) Inhibiteur de la phosphorylation de protéine t
GB201320897D0 (en) Methods of manufacturing a polyolefin product and a case