SG10201608914WA - Differentiation of human embryonic stem cells into single hormonal insulin positive cells - Google Patents

Differentiation of human embryonic stem cells into single hormonal insulin positive cells

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Publication number
SG10201608914WA
SG10201608914WA SG10201608914WA SG10201608914WA SG10201608914WA SG 10201608914W A SG10201608914W A SG 10201608914WA SG 10201608914W A SG10201608914W A SG 10201608914WA SG 10201608914W A SG10201608914W A SG 10201608914WA SG 10201608914W A SG10201608914W A SG 10201608914WA
Authority
SG
Singapore
Prior art keywords
differentiation
embryonic stem
human embryonic
insulin positive
cells
Prior art date
Application number
SG10201608914WA
Other languages
English (en)
Inventor
Alireza Rezania
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of SG10201608914WA publication Critical patent/SG10201608914WA/en

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
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    • C12N2500/00Specific components of cell culture medium
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    • C12N2500/34Sugars
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    • C12N2500/00Specific components of cell culture medium
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    • C12N2500/38Vitamins
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/117Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/19Growth and differentiation factors [GDF]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/41Hedgehog proteins; Cyclopamine (inhibitor)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • C12N2501/72Transferases (EC 2.)
    • C12N2501/727Kinases (EC 2.7.)
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG10201608914WA 2011-12-22 2012-12-07 Differentiation of human embryonic stem cells into single hormonal insulin positive cells SG10201608914WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161579351P 2011-12-22 2011-12-22

Publications (1)

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SG10201608914WA true SG10201608914WA (en) 2016-12-29

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SG10201608914WA SG10201608914WA (en) 2011-12-22 2012-12-07 Differentiation of human embryonic stem cells into single hormonal insulin positive cells
SG11201403473QA SG11201403473QA (en) 2011-12-22 2012-12-07 Differentiation of human embryonic stem cells into single hormonal insulin positive cells

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Country Status (15)

Country Link
US (4) US9388386B2 (fr)
EP (1) EP2794857A4 (fr)
JP (4) JP6441080B2 (fr)
KR (2) KR102090751B1 (fr)
CN (1) CN105143446B (fr)
AR (1) AR089426A1 (fr)
AU (3) AU2012355698B2 (fr)
BR (1) BR112014015417A8 (fr)
CA (1) CA2860107C (fr)
HK (1) HK1203552A1 (fr)
MX (1) MX2014007744A (fr)
PH (1) PH12014501429A1 (fr)
RU (2) RU2668798C2 (fr)
SG (2) SG10201608914WA (fr)
WO (1) WO2013095953A1 (fr)

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