SE512835C2 - Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare - Google Patents
Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmareInfo
- Publication number
- SE512835C2 SE512835C2 SE9600073A SE9600073A SE512835C2 SE 512835 C2 SE512835 C2 SE 512835C2 SE 9600073 A SE9600073 A SE 9600073A SE 9600073 A SE9600073 A SE 9600073A SE 512835 C2 SE512835 C2 SE 512835C2
- Authority
- SE
- Sweden
- Prior art keywords
- dosage form
- tableted
- effervescent
- units
- individual
- Prior art date
Links
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
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- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 235000010210 aluminium Nutrition 0.000 description 1
- 229960004543 anhydrous citric acid Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
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- 208000027687 belching Diseases 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
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- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
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- 235000020188 drinking water Nutrition 0.000 description 1
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- 229960003276 erythromycin Drugs 0.000 description 1
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- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
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- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
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- 239000000347 magnesium hydroxide Substances 0.000 description 1
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- FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 description 1
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- 150000007530 organic bases Chemical class 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 150000003022 phthalic acids Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (33)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600073A SE512835C2 (sv) | 1996-01-08 | 1996-01-08 | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| PT96944727T PT814783E (pt) | 1996-01-08 | 1996-12-20 | Formas de dosagem efervescente de unidades multiplas que compreendem um inibidor da bomba de protoes |
| AT96944727T ATE251451T1 (de) | 1996-01-08 | 1996-12-20 | Aus mehreren einzeleinheiten zusammengesetzte dosierungsformen enthaltend einem protonen pumpen inhibitor |
| PCT/SE1996/001738 WO1997025030A1 (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising protonpump inhibitor |
| HU0000976A HUP0000976A3 (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent tablet dosage forms comprising protonpump inhibitor |
| DK96944727T DK0814783T3 (da) | 1996-01-08 | 1996-12-20 | Opbruselige multienhedsdoseringsformer, der omfatter en protonpumpeinhibitor |
| CA002214027A CA2214027C (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising proton pump inhibitor |
| BR9607367A BR9607367A (pt) | 1996-01-08 | 1996-12-20 | Forma de múltipla dosagem unitária em tablete efervecente processos para preparação da mesma para a inibição de secreção de ácido gástrico em mamíferos e no homem e para o tratamento de doenças gastrointestinais inflamatórias em maniferos e no homem e uso da forma de dosagem em tablete efervecente |
| NZ325978A NZ325978A (en) | 1996-01-08 | 1996-12-20 | Enteric coated effervescent tablet containing a proton pump inhibitor, in particular, s-omeprazole |
| KR1019970706237A KR100459363B1 (ko) | 1996-01-08 | 1996-12-20 | 양성자펌프억제제를함유하는다단위발포성제형 |
| MX9706768A MX9706768A (es) | 1996-01-08 | 1996-12-20 | Formas de dosificacion efervecente de unidades multiples que contienen inhibidor de la bomba de protones. |
| SK1171-97A SK117197A3 (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising protonpump inhibitor |
| IL12165396A IL121653A (en) | 1996-01-08 | 1996-12-20 | Vibrant dosage forms with multiple units that include a proton pump inhibitor |
| TR97/00918T TR199700918T1 (xx) | 1996-01-08 | 1996-12-20 | �oklu birimli efervesan dozaj formlar�. |
| CZ972807A CZ280797A3 (cs) | 1996-01-08 | 1996-12-20 | Vícesložková efervescentní léková forma zahrnující inhibitor protonové pumpy |
| JP52513297A JP4638561B2 (ja) | 1996-01-08 | 1996-12-20 | プロトンポンプ抑制剤を含有するマルチプルユニットの沸騰剤形 |
| US08/793,077 US6132770A (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising proton pump inhibitor |
| EE9700189A EE9700189A (et) | 1996-01-08 | 1996-12-20 | Mitmikühikuline kihisev annusvorm, mis sisaldab prootonpumba inhibiitorit |
| PL96322161A PL322161A1 (en) | 1996-01-08 | 1996-12-20 | Multiple-component single-dose effervescent administration forms containing the protonic pump inhibitor |
| EP96944727A EP0814783B1 (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising protonpump inhibitor |
| DE69630286T DE69630286T2 (de) | 1996-01-08 | 1996-12-20 | Aus mehreren einzeleinheiten zusammengesetzte dosierungsformen enthaltend einem protonen pumpen inhibitor |
| ES96944727T ES2208775T3 (es) | 1996-01-08 | 1996-12-20 | Formas de dosificacion efervescentes de multiples unidades que comprenden inhibidor de la bomba de protones. |
| CNB961937637A CN100335043C (zh) | 1996-01-08 | 1996-12-20 | 片剂化多重单元泡腾剂剂型口服药物组合物及其生产方法 |
| SI9630657T SI0814783T1 (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising protonpump inhibitor |
| AU13242/97A AU712325B2 (en) | 1996-01-08 | 1996-12-20 | Multiple unit effervescent dosage forms comprising protonpump inhibitor |
| YU70196A YU70196A (sh) | 1996-01-08 | 1996-12-26 | Tabletirani šumeći oblici doziranja i postupci za njihovo dobijanje |
| ARP960105897A AR005280A1 (es) | 1996-01-08 | 1996-12-26 | Forma de dosis efervescente unitaria multiple en tabletas, proceso para su fabricacion y uso de dicha forma para la fabricacion de medicamentos. |
| ZA9610939A ZA9610939B (en) | 1996-01-08 | 1996-12-30 | Multiple unit effervescent dosage forms |
| HR9600073-2A HRP970005A2 (en) | 1996-01-08 | 1997-01-03 | Multiple unit effervescent dosage forms |
| TNTNSN97002A TNSN97002A1 (fr) | 1996-01-08 | 1997-01-06 | Presentations effervescentes a unites de prise multiples |
| IDP970023A ID15819A (id) | 1996-01-08 | 1997-01-08 | Bentuk sediaan efervesen satuan ganda |
| IS4551A IS4551A (is) | 1996-01-08 | 1997-08-25 | Freyðandi fjöleininga-skammtaform sem inniheldur prótónupumpublokkara |
| NO19974051A NO319999B1 (no) | 1996-01-08 | 1997-09-03 | Tabletterte, brusende multippelenhet-doseringsformer omfattende en protonpumpeinhibitor, fremgangsmate for fremstilling av slike doseringsformer, og anvendelse derav. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600073A SE512835C2 (sv) | 1996-01-08 | 1996-01-08 | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9600073D0 SE9600073D0 (sv) | 1996-01-08 |
| SE9600073L SE9600073L (sv) | 1997-07-09 |
| SE512835C2 true SE512835C2 (sv) | 2000-05-22 |
Family
ID=20400971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9600073A SE512835C2 (sv) | 1996-01-08 | 1996-01-08 | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6132770A (sk) |
| EP (1) | EP0814783B1 (sk) |
| JP (1) | JP4638561B2 (sk) |
| KR (1) | KR100459363B1 (sk) |
| CN (1) | CN100335043C (sk) |
| AR (1) | AR005280A1 (sk) |
| AT (1) | ATE251451T1 (sk) |
| AU (1) | AU712325B2 (sk) |
| BR (1) | BR9607367A (sk) |
| CA (1) | CA2214027C (sk) |
| CZ (1) | CZ280797A3 (sk) |
| DE (1) | DE69630286T2 (sk) |
| DK (1) | DK0814783T3 (sk) |
| EE (1) | EE9700189A (sk) |
| ES (1) | ES2208775T3 (sk) |
| HR (1) | HRP970005A2 (sk) |
| HU (1) | HUP0000976A3 (sk) |
| ID (1) | ID15819A (sk) |
| IL (1) | IL121653A (sk) |
| IS (1) | IS4551A (sk) |
| MX (1) | MX9706768A (sk) |
| NO (1) | NO319999B1 (sk) |
| NZ (1) | NZ325978A (sk) |
| PL (1) | PL322161A1 (sk) |
| PT (1) | PT814783E (sk) |
| SE (1) | SE512835C2 (sk) |
| SI (1) | SI0814783T1 (sk) |
| SK (1) | SK117197A3 (sk) |
| TN (1) | TNSN97002A1 (sk) |
| TR (1) | TR199700918T1 (sk) |
| WO (1) | WO1997025030A1 (sk) |
| YU (1) | YU70196A (sk) |
| ZA (1) | ZA9610939B (sk) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6558952B1 (en) * | 1992-12-14 | 2003-05-06 | Waratah Pharmaceuticals, Inc. | Treatment for diabetes |
| US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| SE512835C2 (sv) * | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| SE9702533D0 (sv) | 1997-07-01 | 1997-07-01 | Astra Ab | New oral formulation |
| ATE260090T1 (de) * | 1997-12-08 | 2004-03-15 | Altana Pharma Ag | Neue suppositoriumsform mit säureempfindliche wirkstoffe |
| JP2002501897A (ja) * | 1998-01-30 | 2002-01-22 | セプラコール， インク． | Ｒ−ランソプラゾール組成物及び方法 |
| DK1736144T3 (en) * | 1998-05-18 | 2015-12-07 | Takeda Pharmaceutical | Orally disintegrating tablets. |
| MY154010A (en) * | 1998-07-28 | 2015-04-30 | Takeda Pharmaceutical | Rapidly disintegrable solid preparation |
| IL145688A0 (en) * | 1999-03-29 | 2002-06-30 | American Home Prod | Coating system |
| US6174902B1 (en) | 1999-04-28 | 2001-01-16 | Sepracor Inc. | R-rabeprazole compositions and methods |
| YU86001A (sh) | 1999-06-07 | 2004-07-15 | Altana Pharma Ag. | Novi preparat i oblik, u kojem se daje lek, koji sadrži aktivno jedinjenje labilno prema kiselini |
| US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
| AU2001296908A1 (en) * | 2000-09-29 | 2002-04-08 | Geneva Pharmaceuticals, Inc. | Proton pump inhibitor formulation |
| WO2002045694A1 (en) | 2000-12-07 | 2002-06-13 | Altana Pharma Ag | Rapidly disintegrating tablet comprising an acid-labile active ingredient |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| US20020192299A1 (en) * | 2000-12-28 | 2002-12-19 | Rajneesh Taneja | Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination |
| EP1469839A2 (en) * | 2002-01-25 | 2004-10-27 | Santarus, Inc. | Transmucosal delivery of proton pump inhibitors |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| BR0308785A (pt) * | 2002-03-27 | 2005-01-11 | Altana Pharma Ag | Derivados de alcoxipiridina |
| FR2838647B1 (fr) * | 2002-04-23 | 2006-02-17 | Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant | |
| US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
| US20040005362A1 (en) * | 2002-07-03 | 2004-01-08 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
| US20040082618A1 (en) * | 2002-07-03 | 2004-04-29 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
| US20070243251A1 (en) * | 2002-12-20 | 2007-10-18 | Rajneesh Taneja | Dosage Forms Containing A PPI, NSAID, and Buffer |
| US20040121004A1 (en) * | 2002-12-20 | 2004-06-24 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| WO2004066924A2 (en) * | 2003-01-24 | 2004-08-12 | Andrx Labs Llc | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid |
| PT1606261E (pt) | 2003-03-10 | 2010-01-11 | Nycomed Gmbh | Novo processo para a preparação de roflumilast |
| CA2519211A1 (en) * | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Release control compositions |
| ES2234393B2 (es) * | 2003-04-29 | 2006-09-01 | Laboratorios Belmac, S.A. | "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido". |
| CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
| PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
| CA2531564C (en) * | 2003-07-18 | 2016-01-19 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| BRPI0415038A (pt) | 2003-10-01 | 2006-12-12 | Altana Pharma Ag | derivados de imidazo (4,5-b) piridina como inibidores sem ser da sintase que podem ser induzidos |
| EA200600601A1 (ru) | 2003-10-01 | 2006-10-27 | Алтана Фарма Аг | Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы |
| WO2005030770A1 (en) | 2003-10-01 | 2005-04-07 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| RS20060196A (en) | 2003-10-01 | 2008-08-07 | Altana Pharma Ag., | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2601250C (en) | 2005-03-16 | 2014-10-28 | Nycomed Gmbh | Taste masked dosage form containing roflumilast |
| US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| CA2619475C (en) * | 2005-08-15 | 2015-09-29 | Solvay Pharmaceuticals Gmbh | Controlled release pharmaceutical compositions for acid labile drugs |
| EP1785135A1 (en) * | 2005-11-10 | 2007-05-16 | Laboratorios Del Dr. Esteve, S.A. | New stabilized galenic formulations comprising lansoprazole and their preparation |
| US20070141151A1 (en) * | 2005-12-20 | 2007-06-21 | Silver David I | Lansoprazole orally disintegrating tablets |
| EP1983827A4 (en) | 2006-02-01 | 2013-07-10 | Stuart L Weg | USE OF ANTIFUNGAL COMPOSITIONS FOR TREATING UPPER GASTROINTESTINAL CONDITIONS |
| EP1837016A3 (en) * | 2006-03-08 | 2008-01-02 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical multiple-unit composition |
| EP1834634A3 (en) * | 2006-03-08 | 2007-10-03 | Rentschler Pharma GmbH | Pharmaceutical multiple-unit composition |
| US20090068263A1 (en) * | 2006-04-20 | 2009-03-12 | Themis Laboratories Private Limited | Multiple unit compositions |
| JP2009538901A (ja) * | 2006-06-01 | 2009-11-12 | デクセル ファーマ テクノロジーズ エルティーディー． | 複式ユニット製薬的製剤 |
| RU2467747C2 (ru) * | 2006-07-25 | 2012-11-27 | Векта Лтд. | Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi |
| EP2044932A1 (en) * | 2007-10-04 | 2009-04-08 | Laboratorios del Dr. Esteve S.A. | Mechanical protective layer for solid dosage forms |
| EP2044929A1 (en) * | 2007-10-04 | 2009-04-08 | Laboratorios del Dr. Esteve S.A. | Oral fast distintegrating tablets |
| EP3193843A1 (en) | 2014-09-17 | 2017-07-26 | Steerlife India Private Limited | Effervescent composition and method of making it |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| WO2017098481A1 (en) | 2015-12-12 | 2017-06-15 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| CN112574835A (zh) * | 2019-09-30 | 2021-03-30 | 埃科莱布美国股份有限公司 | 泡腾片清洁剂及其用途 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535031A (en) * | 1978-09-04 | 1980-03-11 | Shin Etsu Chem Co Ltd | Enteric coating composition |
| JPS5598120A (en) * | 1979-01-16 | 1980-07-25 | Shin Etsu Chem Co Ltd | Preparation of drug having enteric coating |
| US4289751A (en) * | 1979-06-29 | 1981-09-15 | Merck & Co., Inc. | Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof |
| FR2471186A1 (fr) * | 1979-12-10 | 1981-06-19 | Roussel Uclaf | Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation |
| US4340582A (en) * | 1981-01-15 | 1982-07-20 | Abbott Laboratories | Erythromycin base tablets |
| US4377568A (en) * | 1981-08-12 | 1983-03-22 | Merck Sharp & Dohme (I.A.) Corp. | Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same |
| DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
| JPS5973529A (ja) * | 1982-10-12 | 1984-04-25 | Sankyo Co Ltd | 被覆固形製剤の製造法 |
| US4525339A (en) * | 1982-10-15 | 1985-06-25 | Hoffmann-La Roche Inc. | Enteric coated oral dosage form |
| US4518433A (en) * | 1982-11-08 | 1985-05-21 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
| GB2132887A (en) * | 1982-11-15 | 1984-07-18 | Procter & Gamble | Enteric-coated anti-inflammatory compositions |
| US4503031A (en) * | 1982-12-17 | 1985-03-05 | Glassman Jacob A | Super-fast-starting-sustained release tablet |
| US4556552A (en) * | 1983-09-19 | 1985-12-03 | Colorcon, Inc. | Enteric film-coating compositions |
| DE3586600T2 (de) * | 1984-02-10 | 1993-02-18 | Benzon Pharma As | Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend. |
| US4568560A (en) * | 1984-03-16 | 1986-02-04 | Warner-Lambert Company | Encapsulated fragrances and flavors and process therefor |
| WO1986007348A1 (en) * | 1985-06-03 | 1986-12-18 | Hughes Aircraft Company | Method for introducing dopants in optical fiber preforms |
| SE450087B (sv) * | 1985-10-11 | 1987-06-09 | Haessle Ab | Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial |
| FR2593065B1 (fr) * | 1986-01-22 | 1988-09-09 | Smith Kline French Lab | Couples effervescents, compositions effervescentes d'antagonistes h2 de l'histamine les contenant et leur preparation. |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| GB8724763D0 (en) * | 1987-10-22 | 1987-11-25 | Aps Research Ltd | Sustained-release formulations |
| JPH0768125B2 (ja) * | 1988-05-18 | 1995-07-26 | エーザイ株式会社 | 酸不安定化合物の内服用製剤 |
| FR2633181B1 (fr) * | 1988-06-24 | 1992-01-10 | Glaxo Lab Sa | Composition pharmaceutique a base de ranitidine et son procede de preparation |
| US5026559A (en) * | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
| JP3142919B2 (ja) * | 1991-11-06 | 2001-03-07 | 旭化成株式会社 | セルロース誘導体ラテックス及びその製法 |
| US5160742A (en) * | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
| EP0555931A1 (en) * | 1992-02-14 | 1993-08-18 | Shell Internationale Researchmaatschappij B.V. | Isoxazole derivatives and their use as pesticides |
| JPH0733659A (ja) * | 1992-07-17 | 1995-02-03 | Yoshitomi Pharmaceut Ind Ltd | 抗潰瘍剤含有製剤 |
| KR970011587B1 (ko) * | 1992-07-31 | 1997-07-12 | 삼성전자 주식회사 | Mac 시스템의 프레임 싱크 검출회로 |
| DE69331906T2 (de) * | 1992-08-05 | 2002-12-19 | Faulding F H & Co Ltd | Granulierte pharmazeutische zusammensetzung |
| US5330759A (en) * | 1992-08-26 | 1994-07-19 | Sterling Winthrop Inc. | Enteric coated soft capsules and method of preparation thereof |
| US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
| SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
| JP3017906B2 (ja) * | 1993-10-08 | 2000-03-13 | 信越化学工業株式会社 | 腸溶性コーティング剤分散液 |
| CA2173506C (en) * | 1993-10-12 | 2006-05-09 | Tomohisa Matsushita | Enteric granule-containing tablets |
| GB2285989A (en) * | 1994-01-28 | 1995-08-02 | Merck Frosst Canada Inc | Aqueous formulations for enteric coatings |
| DK0723436T3 (da) * | 1994-07-08 | 2001-11-26 | Astrazeneca Ab | Tabletteret flerenhedsdoseringsform |
| SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| US5840737A (en) * | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| SE512835C2 (sv) * | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
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| Date | Code | Title | Description |
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| NUG | Patent has lapsed |