SE460790B - Nya karbapenemderivat samt foerfarande foer framstaellning daerav - Google Patents

Nya karbapenemderivat samt foerfarande foer framstaellning daerav

Info

Publication number
SE460790B
SE460790B SE8301929A SE8301929A SE460790B SE 460790 B SE460790 B SE 460790B SE 8301929 A SE8301929 A SE 8301929A SE 8301929 A SE8301929 A SE 8301929A SE 460790 B SE460790 B SE 460790B
Authority
SE
Sweden
Prior art keywords
compounds according
formula
mmol
pharmaceutically acceptable
pyridinium
Prior art date
Application number
SE8301929A
Other languages
English (en)
Swedish (sv)
Other versions
SE8301929L (sv
SE8301929D0 (sv
Inventor
C U Kim
Jr P F Misco
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8301929D0 publication Critical patent/SE8301929D0/xx
Publication of SE8301929L publication Critical patent/SE8301929L/xx
Publication of SE460790B publication Critical patent/SE460790B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE8301929A 1982-04-09 1983-04-07 Nya karbapenemderivat samt foerfarande foer framstaellning daerav SE460790B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36691082A 1982-04-09 1982-04-09
US06/471,379 US4552696A (en) 1982-04-09 1983-03-08 Carbapenem antibiotics

Publications (3)

Publication Number Publication Date
SE8301929D0 SE8301929D0 (sv) 1983-04-07
SE8301929L SE8301929L (sv) 1983-12-02
SE460790B true SE460790B (sv) 1989-11-20

Family

ID=27003573

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8301929A SE460790B (sv) 1982-04-09 1983-04-07 Nya karbapenemderivat samt foerfarande foer framstaellning daerav
SE8901032A SE8901032D0 (sv) 1982-04-09 1989-03-22 Mellanprodukter foer framstaellning av karbapenemderivat

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8901032A SE8901032D0 (sv) 1982-04-09 1989-03-22 Mellanprodukter foer framstaellning av karbapenemderivat

Country Status (23)

Country Link
US (1) US4552696A (ko)
KR (1) KR880001069B1 (ko)
AT (1) AT382620B (ko)
AU (1) AU572090B2 (ko)
BE (1) BE896418A (ko)
CA (2) CA1283659C (ko)
CH (2) CH666272A5 (ko)
DE (1) DE3312533A1 (ko)
DK (1) DK157083A (ko)
ES (2) ES8405799A1 (ko)
FI (1) FI76801C (ko)
FR (1) FR2524890B1 (ko)
GB (2) GB2119371B (ko)
GR (1) GR78185B (ko)
HU (1) HU190083B (ko)
IE (1) IE54769B1 (ko)
IL (1) IL68148A0 (ko)
IT (1) IT1200926B (ko)
LU (1) LU84740A1 (ko)
NL (1) NL8301212A (ko)
OA (1) OA07390A (ko)
PT (1) PT76525B (ko)
SE (2) SE460790B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
US4642341A (en) * 1982-04-09 1987-02-10 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater
CA1285940C (en) * 1984-07-02 1991-07-09 Merck & Co., Inc. Carbapenems having a 2-quaternary heteroarylalkylthio substituent
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4725594A (en) * 1984-12-13 1988-02-16 Merck & Co., Inc. Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4952397A (en) * 1985-06-17 1990-08-28 Merck & Co., Inc. 2-quaternary heteroarylalkylthio carbapenems having an acid moiety substituent
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4880922A (en) * 1985-11-22 1989-11-14 Bristol-Myers Company Carbapenems with quaternized heterothioalkylthio substitution at position 2
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235920A (en) * 1975-11-21 1980-11-25 Merck & Co., Inc. N-Alkylated derivatives of thienamycin
DE2652676A1 (de) * 1975-11-21 1977-06-02 Merck & Co Inc N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4235917A (en) * 1977-05-05 1980-11-25 Merck & Co., Inc. N-Alkyl-N-acyl derivatives of thienamycin
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
DE3169321D1 (en) * 1980-03-27 1985-04-25 Merck & Co Inc Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
EP0074599A1 (en) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-cis-Carbapenem derivatives, their production and use
WO1983002614A1 (en) * 1982-02-02 1983-08-04 Takeda Chemical Industries Ltd 5,6-cis-carbapenem-3-carboxylic acid derivatives and process for their preparation
WO1983000867A1 (en) * 1981-09-09 1983-03-17 Takeda Chemical Industries Ltd 5,6-cis-carbapenem-3-carboxylic acid derivatives and process for their preparation
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater

Also Published As

Publication number Publication date
CA1283659C (en) 1991-04-30
FI831170L (fi) 1983-10-10
ES521293A0 (es) 1984-06-16
KR840004430A (ko) 1984-10-15
CA1284500C (en) 1991-05-28
ES8405799A1 (es) 1984-06-16
DK157083A (da) 1983-10-10
GR78185B (ko) 1984-09-26
GB8309566D0 (en) 1983-05-11
GB8515162D0 (en) 1985-07-17
LU84740A1 (fr) 1983-12-05
GB2119371A (en) 1983-11-16
CH666272A5 (fr) 1988-07-15
DK157083D0 (da) 1983-04-08
US4552696A (en) 1985-11-12
FI76801C (fi) 1988-12-12
FI76801B (fi) 1988-08-31
GB2159818A (en) 1985-12-11
IT8348068A0 (it) 1983-04-08
FI831170A0 (fi) 1983-04-06
PT76525B (en) 1986-02-06
SE8901032L (sv) 1989-03-22
AU1272683A (en) 1983-10-13
AU572090B2 (en) 1988-05-05
SE8301929L (sv) 1983-12-02
ATA125683A (de) 1986-08-15
GB2159818B (en) 1986-07-23
IL68148A0 (en) 1983-06-15
HU190083B (en) 1986-08-28
IE830806L (en) 1983-10-09
GB2119371B (en) 1986-07-09
KR880001069B1 (ko) 1988-06-20
FR2524890A1 (fr) 1983-10-14
PT76525A (en) 1983-05-01
FR2524890B1 (fr) 1987-08-28
ES8601118A1 (es) 1985-11-01
CH657854A5 (fr) 1986-09-30
AT382620B (de) 1987-03-25
IE54769B1 (en) 1990-01-31
OA07390A (fr) 1984-11-30
BE896418A (fr) 1983-10-10
IT1200926B (it) 1989-01-27
SE8301929D0 (sv) 1983-04-07
NL8301212A (nl) 1983-11-01
ES528079A0 (es) 1985-11-01
SE8901032D0 (sv) 1989-03-22
DE3312533C2 (ko) 1991-08-14
DE3312533A1 (de) 1983-10-13

Similar Documents

Publication Publication Date Title
US4168314A (en) 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
KR890001426B1 (ko) 카르바페넴 화합물의 제조방법
EP0001628B1 (en) 3-substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it
US4536335A (en) Carbapenem antibiotics
SE436130B (sv) Sett att framstella 1-karba-2-penem-3-karboxylsyror
EP0001627A1 (en) 3-Substituted-6-(1'hydroxethyl)-7-oxo-1-azabicyclo(3.2.0.)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it
EP0050334B1 (en) 2-carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, a process for preparing and an antibiotic composition comprising the same
SE460790B (sv) Nya karbapenemderivat samt foerfarande foer framstaellning daerav
EP0037082B1 (en) Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
JPH06179674A (ja) カルバペネム、それを含有する抗生物質医薬組成物及びその製法及びその製造中間体
EP0160876A1 (en) 1-Hetero-6-/1-Hydroxyethyl/-2-SR8-1-carbadethiapen-2-EM-3-carboxylic acids
US4310538A (en) 3-Halo-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
SE461734B (sv) Nya karbapenem-antibiotika samt foerfarande foer framstaellning daerav
IE840549L (en) Carbapenem process and intermediates
EP0235823B1 (en) Carbapenem antibiotics, a process for preparing them and pharmaceutical compositions containing them
US4347368A (en) 3-Substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4880922A (en) Carbapenems with quaternized heterothioalkylthio substitution at position 2
US4640799A (en) Carbapenem antibiotics
KR100189667B1 (ko) 카바페넴 유도체
KR910006807B1 (ko) 카바펜엠 항생제의 제조방법
US4665170A (en) Carbapenem antibiotics
KR910009270B1 (ko) 카바펜엠 항생제의 제조방법
US4369187A (en) 3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
SE454779B (sv) 2,6-disubstituerade penemforeningar, forfarande for framstellning derav samt farmaceutisk komposition derav med antibakteriell verkan
SE460197B (sv) Nya karbapenemderivat och foerfarande foer framstaellning daerav

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8301929-9

Effective date: 19941110

Format of ref document f/p: F