SE437663B - Cykloalkyltriazoler och forfarande for framstellning derav - Google Patents

Cykloalkyltriazoler och forfarande for framstellning derav

Info

Publication number
SE437663B
SE437663B SE7903327A SE7903327A SE437663B SE 437663 B SE437663 B SE 437663B SE 7903327 A SE7903327 A SE 7903327A SE 7903327 A SE7903327 A SE 7903327A SE 437663 B SE437663 B SE 437663B
Authority
SE
Sweden
Prior art keywords
alk
piperazinyl
hydrazide
carbon atoms
mol
Prior art date
Application number
SE7903327A
Other languages
English (en)
Swedish (sv)
Other versions
SE7903327L (sv
Inventor
B Silvestrini
L Baiocchi
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of SE7903327L publication Critical patent/SE7903327L/xx
Publication of SE437663B publication Critical patent/SE437663B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE7903327A 1978-04-18 1979-04-17 Cykloalkyltriazoler och forfarande for framstellning derav SE437663B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22421/78A IT1094076B (it) 1978-04-18 1978-04-18 Cicloalchiltriazoli

Publications (2)

Publication Number Publication Date
SE7903327L SE7903327L (sv) 1979-10-19
SE437663B true SE437663B (sv) 1985-03-11

Family

ID=11196066

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7903327A SE437663B (sv) 1978-04-18 1979-04-17 Cykloalkyltriazoler och forfarande for framstellning derav

Country Status (22)

Country Link
US (2) US4252721A (da)
JP (1) JPS5817757B2 (da)
AT (1) AT374477B (da)
AU (1) AU520788B2 (da)
BG (2) BG40654A3 (da)
CA (1) CA1104567A (da)
CH (1) CH639847A5 (da)
DE (1) DE2915318A1 (da)
DK (1) DK148480C (da)
FI (1) FI66378C (da)
FR (1) FR2423221A1 (da)
GB (1) GB2020269B (da)
HU (1) HU179917B (da)
IE (1) IE47965B1 (da)
IL (1) IL56926A (da)
IT (1) IT1094076B (da)
NL (1) NL186635C (da)
PL (1) PL116103B1 (da)
PT (1) PT69502A (da)
SE (1) SE437663B (da)
SU (1) SU852174A3 (da)
YU (1) YU41338B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399693A (en) * 1984-04-17 1995-03-21 British Technology Group Limited Substituted piperazine-2-carboxylic acids and derivatives thereof

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2580648B1 (fr) * 1985-04-17 1987-05-15 Adir Nouveaux derives du triazole, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4879294A (en) * 1988-01-28 1989-11-07 Angelini Pharmaceuticals Ltd. Opthalmic composition
IT1224250B (it) * 1988-06-10 1990-09-26 Acraf Associzione del depiprazolo con la morfina
IT1250701B (it) * 1991-07-24 1995-04-21 Angelini Francesco Ist Ricerca Composizione farmaceutica solida per uso orale a base di dapiprazolo
US5288759A (en) * 1992-08-27 1994-02-22 Alcon Laboratories, Inc. Use of certain sulfamoyl-substituted phenethylamine derivatives to reverse drug-induced mydriasis
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
EP1118322A4 (en) 1998-09-30 2004-10-20 Takeda Chemical Industries Ltd MEDICINES FOR IMPROVING BUBBLE EMPTYING STRENGTH
IL141235A (en) * 2000-02-09 2012-04-30 Novartis Int Pharm Ltd Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
US6730691B1 (en) 2000-02-10 2004-05-04 Miles A. Galin Uses of alpha adrenergic blocking agents
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
WO2003004058A1 (en) * 2001-07-02 2003-01-16 Santen Pharmaceutical Co., Ltd. OPTIC NERVE PROTECTING AGENTS CONTAINING α1 RECEPTOR BLOCKER AS THE ACTIVE INGREDIENT
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
ATE502635T1 (de) 2002-08-19 2011-04-15 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
CA2753318A1 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Substituted pyrrole derivatives
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
DE602006003416D1 (de) * 2005-03-21 2008-12-11 Pfizer Ltd Substituierte triazolderivate als oxytocinantagonisten
WO2006100588A1 (en) * 2005-03-21 2006-09-28 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
EP1917257A1 (en) * 2005-08-10 2008-05-07 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
SG166829A1 (en) * 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US20070238716A1 (en) * 2006-03-14 2007-10-11 Murthy Ayanampudi S R Statin stabilizing dosage formulations
WO2008010087A2 (en) * 2006-07-14 2008-01-24 Ranbaxy Laboratories Limited Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
JP2022505950A (ja) 2018-10-26 2022-01-14 オキュフィア・ファーマ・インコーポレイテッド 老眼、散瞳、および他の眼障害の治療のための方法および組成物
EP3911648A4 (en) 2019-01-18 2022-10-26 Astrazeneca AB PCSK9 INHIBITORS AND METHODS OF USE THEREOF
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913454A (en) * 1956-11-23 1959-11-17 Schenley Ind Inc Certain cycloalkanotriazoles, process and intermediates
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
US3472853A (en) * 1967-05-29 1969-10-14 Sterling Drug Inc 1-((pyrido(2,1-c)-s-triazolyl)-lower-alkyl)-4-substituted- piperazines
JPS5070389A (da) * 1973-10-30 1975-06-11

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399693A (en) * 1984-04-17 1995-03-21 British Technology Group Limited Substituted piperazine-2-carboxylic acids and derivatives thereof
US5595983A (en) * 1984-04-17 1997-01-21 British Technology Group Limited Substituted piperazine 2-carboxylic acids useful in the treatment of central nervous system disorders

Also Published As

Publication number Publication date
PL214969A1 (da) 1980-03-10
DK156779A (da) 1979-10-19
AU4583279A (en) 1979-10-25
FI66378B (fi) 1984-06-29
NL7902489A (nl) 1979-10-22
ATA292479A (de) 1983-09-15
IL56926A (en) 1983-09-30
NL186635B (nl) 1990-08-16
DK148480B (da) 1985-07-15
CH639847A5 (it) 1983-12-15
GB2020269A (en) 1979-11-14
GB2020269B (en) 1982-06-03
CA1104567A (en) 1981-07-07
IT7822421A0 (it) 1978-04-18
FI66378C (fi) 1984-10-10
IE47965B1 (en) 1984-08-08
BG40654A3 (en) 1987-01-15
YU41338B (en) 1987-02-28
AU520788B2 (en) 1982-02-25
FR2423221B1 (da) 1983-03-18
IL56926A0 (en) 1979-05-31
AT374477B (de) 1984-04-25
PL116103B1 (en) 1981-05-30
YU86279A (en) 1983-12-31
IT1094076B (it) 1985-07-26
DE2915318A1 (de) 1979-10-31
NL186635C (nl) 1991-01-16
SE7903327L (sv) 1979-10-19
US4307095A (en) 1981-12-22
FI791217A (fi) 1979-10-19
SU852174A3 (ru) 1981-07-30
FR2423221A1 (fr) 1979-11-16
JPS5817757B2 (ja) 1983-04-09
US4252721A (en) 1981-02-24
JPS54157576A (en) 1979-12-12
IE790646L (en) 1979-10-18
DE2915318C2 (da) 1990-12-13
HU179917B (en) 1983-01-28
PT69502A (en) 1979-05-01
BG61367B2 (bg) 1997-06-30
DK148480C (da) 1985-12-16

Similar Documents

Publication Publication Date Title
SE437663B (sv) Cykloalkyltriazoler och forfarande for framstellning derav
NZ236105A (en) 6h-dipyrido[3,2-b:2',3'-e][1,4] diazapin-6-one (and thione) derivative, preparation and pharmaceutical compositions thereof
EP0125607A2 (en) Pyrido(1,5)benzodiazepinone derivatives and pharmacological activities thereof
US3399201A (en) Aminoalkyl-ethano-anthracenes
US3594380A (en) Isoquinolin-1(2h)-ones
EP0463810B1 (en) Heterocyclic compound and psychopharmaceutical composition containing same
HUT65947A (en) Imidazo-pyridine - derivatives with paf/h1 antagonist activity and pharmaceutical compositions containing them and process for the production thereof
KR930007413B1 (ko) 새로운 피리딜- 및 피리미딜 유도체와 약리학적으로 활성인 그의 염 및 그 제조방법과 이들을 이용한 사람 이외의 온혈동물의 정신장해 치료방법
CS259516B2 (en) Method of new heterocyclic compounds production
SK3632003A3 (en) Benzodiazepine derivatives, pharmaceutical composition comprising same and their use
US3177211A (en) 10-[(aminocarbamyl-1-piperidyl)-loweralkyl]-phenothiazines
JPS6335573A (ja) 新規置換ピリド〔２，３−ｂ〕〔１，４〕ベンゾジアゼピン−６−オン，その製法及びその化合物を含む医薬
HU194228B (en) Process for production of new, in 11-position substituated 5,11-dihydro-6h-pirido /2,3-b//1,4/-benzodiozepin-6-on and medical compounds containing thereof
US4325952A (en) Method of treating abstinence syndrome with cycloaklyltriazoles
NZ247637A (en) Thiochroman derivatives and pharmaceutical compositions
JP3117183B2 (ja) ５，６−ジヒドロ−４Ｈ−イミダゾ〔４，５，１−ｉｊ〕キノリン類、その製造方法、それを含む鎮痛剤および中間体化合物
CA1267894A (en) 4-substituted 10-cyanomethylenethieno[4,3-e] benzoazepines
JPH0764844B2 (ja) ピリダジノピロロイソキノリン誘導体
KR820001450B1 (ko) 사이클로알킬 트리아졸의 제조방법
CS207624B2 (en) Method of making the substituted lactanes of the hexahydro-benzopyrano-3,2-c pyridin vinegar acids
US4307096A (en) Method of treating glaucoma with cycloalkyltriazoles
JPS624288A (ja) 新規なジアゼピノン化合物
KR20010014144A (ko) 빈뇨·요실금 치료·예방제 및 트로폰 유도체
JPH03294277A (ja) ピペリジン誘導体
KR890001195B1 (ko) 융합된 방향족 티아제피논 및 이의 황동족체

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 7903327-0

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 7903327-0

Format of ref document f/p: F