SE0400501D0 - Antibody purification - Google Patents
Antibody purificationInfo
- Publication number
- SE0400501D0 SE0400501D0 SE0400501A SE0400501A SE0400501D0 SE 0400501 D0 SE0400501 D0 SE 0400501D0 SE 0400501 A SE0400501 A SE 0400501A SE 0400501 A SE0400501 A SE 0400501A SE 0400501 D0 SE0400501 D0 SE 0400501D0
- Authority
- SE
- Sweden
- Prior art keywords
- cation
- aromatic
- solution
- modal
- exchanging group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3847—Multimodal interactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/07—Processes using organic exchangers in the weakly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400501A SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Antibody purification |
US10/589,718 US7385040B2 (en) | 2004-02-27 | 2005-02-24 | Antibody purification |
AT05722174T ATE440858T1 (de) | 2004-02-27 | 2005-02-24 | Aufreinigung von antikírpern |
CA2552823A CA2552823C (fr) | 2004-02-27 | 2005-02-24 | Purification d'anticorps |
DE602005016220T DE602005016220D1 (de) | 2004-02-27 | 2005-02-24 | Aufreinigung von antikörpern |
JP2007500724A JP4776615B2 (ja) | 2004-02-27 | 2005-02-24 | 抗体精製 |
NZ548127A NZ548127A (en) | 2004-02-27 | 2005-02-24 | Method for antibody purification |
EP05722174A EP1718668B1 (fr) | 2004-02-27 | 2005-02-24 | Purification d'anticorps |
AU2005217348A AU2005217348B2 (en) | 2004-02-27 | 2005-02-24 | Antibody purification |
CN2005800062670A CN1926146B (zh) | 2004-02-27 | 2005-02-24 | 抗体纯化 |
PCT/SE2005/000292 WO2005082926A1 (fr) | 2004-02-27 | 2005-02-24 | Purification d'anticorps |
KR1020067017115A KR101149969B1 (ko) | 2004-02-27 | 2005-02-24 | 항체 정제 |
PCT/SE2005/000293 WO2005082483A1 (fr) | 2004-02-27 | 2005-02-25 | Procede de purification d'anticorps |
CN200580006276XA CN1925898B (zh) | 2004-02-27 | 2005-02-25 | 纯化抗体的工艺 |
US10/589,717 US7750129B2 (en) | 2004-02-27 | 2005-02-25 | Process for the purification of antibodies |
CA2552639A CA2552639C (fr) | 2004-02-27 | 2005-02-25 | Procede de purification d'anticorps |
AU2005216847A AU2005216847B2 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
EP05722175A EP1718386A1 (fr) | 2004-02-27 | 2005-02-25 | Procede de purification d'anticorps |
JP2007500725A JP4848356B2 (ja) | 2004-02-27 | 2005-02-25 | 抗体精製法 |
KR1020067017113A KR101150050B1 (ko) | 2004-02-27 | 2005-02-25 | 항체 정제 방법 |
NZ548126A NZ548126A (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies involving addition of a second resin |
IL176635A IL176635A (en) | 2004-02-27 | 2006-06-29 | Method of purification of antibodies from one or more contaminants by chromatography and a system for such purification |
IL176745A IL176745A (en) | 2004-02-27 | 2006-07-06 | Process for the purification of antibodies |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400501A SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Antibody purification |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0400501D0 true SE0400501D0 (sv) | 2004-02-27 |
Family
ID=32067281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0400501A SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Antibody purification |
Country Status (13)
Country | Link |
---|---|
US (1) | US7385040B2 (fr) |
EP (1) | EP1718668B1 (fr) |
JP (1) | JP4776615B2 (fr) |
KR (1) | KR101149969B1 (fr) |
CN (2) | CN1926146B (fr) |
AT (1) | ATE440858T1 (fr) |
AU (1) | AU2005217348B2 (fr) |
CA (1) | CA2552823C (fr) |
DE (1) | DE602005016220D1 (fr) |
IL (1) | IL176635A (fr) |
NZ (1) | NZ548127A (fr) |
SE (1) | SE0400501D0 (fr) |
WO (1) | WO2005082926A1 (fr) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8658773B2 (en) | 2011-05-02 | 2014-02-25 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
US7589183B2 (en) * | 2006-11-28 | 2009-09-15 | Bio-Rad Laboratories, Inc. | Prevention of leaching of ligands from affinity-based purification systems |
US7691980B2 (en) * | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
US7999085B2 (en) * | 2007-01-09 | 2011-08-16 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
JP2010515917A (ja) * | 2007-01-10 | 2010-05-13 | ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー | クロマトグラフィーレジン |
JP5888481B2 (ja) | 2007-03-28 | 2016-03-22 | ディーピーエックス ホールディングス ビー.ブイ. | 膨張床カラムおよび使い捨て可能なクロマトグラフィー |
AU2008256411B2 (en) * | 2007-06-01 | 2013-08-22 | F. Hoffmann-La Roche Ag | Immunoglobulin purification |
US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
EP2027875A1 (fr) * | 2007-08-23 | 2009-02-25 | Octapharma AG | Processus d'isolation et de purification d'une protéine cible libre de protéine de prion (PrPSC) |
JP5778389B2 (ja) | 2007-10-26 | 2015-09-16 | 旭化成ケミカルズ株式会社 | たんぱく質の精製方法 |
US8158405B2 (en) * | 2008-06-30 | 2012-04-17 | General Electric Company | Process for concentrating and processing fluid samples |
US8546127B2 (en) * | 2008-06-30 | 2013-10-01 | General Electric Company | Bacteria/RNA extraction device |
US8753868B2 (en) | 2008-08-04 | 2014-06-17 | General Electric Company | Method and system for selective isolation of target biological molecules in a general purpose system |
US20100051554A1 (en) * | 2008-08-28 | 2010-03-04 | Dong June Ahn | Molecular basket coated micro particles |
EP2360183B1 (fr) * | 2008-12-19 | 2016-07-27 | Takeda Pharmaceutical Company Limited | Méthode de purification anticorps par chromatographie a mode mixte utilisant une solution de chargement contenant arginine |
CN101797493B (zh) * | 2009-02-06 | 2014-05-21 | 上海抗体药物国家工程研究中心有限公司 | 一种在反应釜中制备亲和层析介质的方法 |
DE102009057993A1 (de) | 2009-06-13 | 2011-01-20 | Sartorius Stedim Biotech Gmbh | Polysaccharidmatrix mit aufgepfropftem Polymer, Verfahren zu ihrer Herstellung und Verwendung |
JPWO2011001963A1 (ja) * | 2009-07-03 | 2012-12-13 | 旭化成ケミカルズ株式会社 | 多孔質基材に固定されたグラフト鎖に結合しているアミノ基及びアルキル基を有する多孔膜を用いた抗体の精製方法 |
WO2011049798A1 (fr) * | 2009-10-20 | 2011-04-28 | Merck Sharp & Dohme Corp. | Utilisation de la chromatographie en mode mixte pour la capture et la purification de produits d'anticorps de base |
US8277649B2 (en) * | 2009-12-14 | 2012-10-02 | General Electric Company | Membranes and associated methods for purification of antibodies |
WO2011090719A2 (fr) * | 2009-12-29 | 2011-07-28 | Dr. Reddy's Laboratories Ltd. | Purification des protéines par échange d'ions |
KR101152036B1 (ko) | 2010-04-27 | 2012-06-08 | (주)셀트리온 | 컬럼 순환 및 시료 연속주입법을 이용한 단백질 a 크로마토그래피 정제 방법 |
WO2012015908A2 (fr) | 2010-07-30 | 2012-02-02 | Millipore Corporation | Phase de chromatographie et procédé |
EP2726496B1 (fr) | 2011-07-01 | 2018-04-04 | F.Hoffmann-La Roche Ag | Procédé de séparation des polypeptides monomères de polypeptides agrégés |
CN103906762A (zh) * | 2011-10-26 | 2014-07-02 | 生物辐射实验室股份有限公司 | 在混合式层析中去除杀病毒剂 |
GB201202762D0 (en) | 2012-02-17 | 2012-04-04 | Autology Health Ltd | High efficiency cell capture |
CN103506079B (zh) * | 2012-06-19 | 2016-04-06 | 汪志友 | 一种用于分离纯化抗体的介质及其制备方法 |
JP6335785B2 (ja) * | 2012-09-03 | 2018-05-30 | 株式会社カネカ | ミックスモード抗体アフィニティー分離マトリックスとそれを用いた精製方法および標的分子 |
KR102196230B1 (ko) | 2012-09-17 | 2020-12-29 | 더블유.알. 그레이스 앤드 캄파니-콘. | 크로마토그래피 매질 및 장치 |
EP2919902B1 (fr) | 2012-11-13 | 2020-01-01 | GE Healthcare BioProcess R&D AB | Matrices d'échange d'anions multimodales |
US20140238935A1 (en) | 2013-02-26 | 2014-08-28 | Natrix Separations Inc. | Mixed-Mode Chromatography Membranes |
AR096713A1 (es) | 2013-06-25 | 2016-01-27 | Cadila Healthcare Ltd | Proceso de purificación para anticuerpos monoclonales |
EP3048109A4 (fr) * | 2013-09-17 | 2017-04-19 | Kaneka Corporation | Nouveau procédé de purification d'anticorps et anticorps obtenu au moyen de ce procédé, nouveau procédé de purification d'anticorps à l'aide d'un échangeur de cations et anticorps obtenu au moyen de ce procédé |
CA2967901A1 (fr) * | 2013-11-17 | 2015-05-21 | New Proteintech Inc. | Procede de preparation de materiaux chromatographiques |
EP3094390B1 (fr) | 2014-01-16 | 2021-07-07 | W.R. Grace & CO. - CONN. | Supports de chromatographie d'affinité et dispositifs de chromatographie |
CN107847907A (zh) | 2014-05-02 | 2018-03-27 | 格雷斯公司 | 官能化载体材料以及制备和使用官能化载体材料的方法 |
DE102014010353A1 (de) | 2014-07-10 | 2016-01-14 | Sartorius Stedim Biotech Gmbh | Vorrichtung, Verwendung dieser Vorrichtung und Verfahren für die Stofftrennung mit verbesserter Ausnutzung der Kapazität chromatographischer Medien |
EP3173783B1 (fr) | 2014-07-25 | 2019-02-27 | Asahi Kasei Medical Co., Ltd. | Support de chromatographie d'échange de cations et son procédé d'utilisation |
WO2016071376A2 (fr) | 2014-11-06 | 2016-05-12 | F. Hoffmann-La Roche Ag | Variants du fragment fc caractérisés par une liaison fcrn modifiée et leurs procédés d'utilisation |
KR102162753B1 (ko) | 2014-12-08 | 2020-10-07 | 이엠디 밀리포어 코포레이션 | 혼합층 이온 교환 흡착제 |
KR102566292B1 (ko) | 2015-06-05 | 2023-08-10 | 더블유.알. 그레이스 앤드 캄파니-콘. | 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법 |
JP2019070528A (ja) * | 2016-02-26 | 2019-05-09 | Jsr株式会社 | 多孔質担体、アフィニティクロマトグラフィー用多孔質担体、標的物の精製方法、及び抗体 |
CN108883414B (zh) * | 2016-04-29 | 2021-06-01 | 建奥迪斯有限公司 | 用于分子回收的方法和组件 |
MY196321A (en) | 2016-08-16 | 2023-03-24 | Regeneron Pharma | Methods for Quantitating Individual Antibodies From a Mixture |
WO2018081203A1 (fr) | 2016-10-25 | 2018-05-03 | Regeneron Pharmaceuticals, Inc. | Procédés et systèmes d'analyse de données de chromatographie |
WO2018187074A1 (fr) | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Administration par voie sous-cutanée de conjugués anticorps-médicament à titre de thérapie anticancéreuse |
CN111818980B (zh) * | 2018-03-08 | 2022-10-11 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水混合模式色谱树脂 |
CN111902720A (zh) | 2018-03-21 | 2020-11-06 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
EP3816177A4 (fr) * | 2018-06-29 | 2021-12-01 | Mitsubishi Chemical Corporation | Procédé d'isolement de polypeptide, procédé de production de polypeptide et appareil de purification de polypeptide |
TW202005694A (zh) | 2018-07-02 | 2020-02-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
US11896969B2 (en) | 2019-09-05 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode chromatography resins |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8204810L (sv) | 1982-08-23 | 1984-02-24 | Pharmacia Fine Chemicals Ab | Hybrid-dna-molekyl, transformerad mikroorganism och sett att framstella protein a |
US5151350A (en) * | 1982-10-27 | 1992-09-29 | Repligen Corporation | Cloned genes encoding recombinant protein a |
US4983722A (en) | 1988-06-08 | 1991-01-08 | Miles Inc. | Removal of protein A from antibody preparations |
US5429746A (en) * | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
GB9519197D0 (en) * | 1995-09-20 | 1995-11-22 | Affinity Chromatography Ltd | Novel affinity ligands and their use |
US6117996A (en) * | 1995-09-20 | 2000-09-12 | Novo Nordisk A/S | Triazine based ligands and use thereof |
CA2264177C (fr) * | 1996-08-30 | 2015-03-17 | Upfront Chromatography A/S | Isolement d'immunoglobulines |
SE0002688D0 (sv) | 2000-07-17 | 2000-07-17 | Amersham Pharm Biotech Ab | Adsorption method and ligands |
AU2002235795A1 (en) * | 2000-12-31 | 2002-07-16 | Amersham Biosciences Ab | A method for the manufacture of compositions containing low concentrations of salts |
JP2004517310A (ja) * | 2001-01-05 | 2004-06-10 | プロ・ケム インク | 精製器具及び方法 |
SE0103084D0 (sv) | 2001-09-14 | 2001-09-14 | Amersham Pharm Biotech Ab | Generation of ion exchange media |
DE10155984A1 (de) | 2001-11-15 | 2003-05-28 | Boehringer Ingelheim Pharma | Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices |
ATE417858T1 (de) * | 2002-02-05 | 2009-01-15 | Genentech Inc | Proteinaufreinigung |
EP1601697B1 (fr) | 2003-02-28 | 2007-05-30 | Lonza Biologics plc | Purification d'anticorps par chromatographie d'affinité sur Proteine A et chromatographie par echange d'ions |
-
2004
- 2004-02-27 SE SE0400501A patent/SE0400501D0/xx unknown
-
2005
- 2005-02-24 KR KR1020067017115A patent/KR101149969B1/ko active IP Right Grant
- 2005-02-24 WO PCT/SE2005/000292 patent/WO2005082926A1/fr active Application Filing
- 2005-02-24 EP EP05722174A patent/EP1718668B1/fr active Active
- 2005-02-24 CN CN2005800062670A patent/CN1926146B/zh active Active
- 2005-02-24 AT AT05722174T patent/ATE440858T1/de not_active IP Right Cessation
- 2005-02-24 DE DE602005016220T patent/DE602005016220D1/de active Active
- 2005-02-24 AU AU2005217348A patent/AU2005217348B2/en active Active
- 2005-02-24 JP JP2007500724A patent/JP4776615B2/ja active Active
- 2005-02-24 CA CA2552823A patent/CA2552823C/fr active Active
- 2005-02-24 NZ NZ548127A patent/NZ548127A/en not_active IP Right Cessation
- 2005-02-24 US US10/589,718 patent/US7385040B2/en active Active
- 2005-02-25 CN CN200580006276XA patent/CN1925898B/zh active Active
-
2006
- 2006-06-29 IL IL176635A patent/IL176635A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1718668A1 (fr) | 2006-11-08 |
CN1925898A (zh) | 2007-03-07 |
CA2552823A1 (fr) | 2005-09-09 |
ATE440858T1 (de) | 2009-09-15 |
DE602005016220D1 (de) | 2009-10-08 |
AU2005217348B2 (en) | 2011-03-31 |
CN1926146B (zh) | 2010-06-16 |
JP4776615B2 (ja) | 2011-09-21 |
AU2005217348A1 (en) | 2005-09-09 |
WO2005082926A1 (fr) | 2005-09-09 |
US7385040B2 (en) | 2008-06-10 |
EP1718668B1 (fr) | 2009-08-26 |
US20070112178A1 (en) | 2007-05-17 |
CN1925898B (zh) | 2010-09-01 |
NZ548127A (en) | 2009-09-25 |
CA2552823C (fr) | 2013-11-19 |
KR20070001969A (ko) | 2007-01-04 |
KR101149969B1 (ko) | 2012-07-05 |
CN1926146A (zh) | 2007-03-07 |
IL176635A0 (en) | 2006-10-31 |
JP2008505851A (ja) | 2008-02-28 |
IL176635A (en) | 2011-07-31 |
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