RU99126868A - Способ изготовления таблеток флурбипрофена - Google Patents
Способ изготовления таблеток флурбипрофенаInfo
- Publication number
- RU99126868A RU99126868A RU99126868/14A RU99126868A RU99126868A RU 99126868 A RU99126868 A RU 99126868A RU 99126868/14 A RU99126868/14 A RU 99126868/14A RU 99126868 A RU99126868 A RU 99126868A RU 99126868 A RU99126868 A RU 99126868A
- Authority
- RU
- Russia
- Prior art keywords
- tablet
- forming composition
- tablet forming
- flurbiprofen
- mixture
- Prior art date
Links
- SYTBZMRGLBWNTM-UHFFFAOYSA-N Flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 title claims 3
- 229960002390 flurbiprofen Drugs 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- 229960003563 Calcium Carbonate Drugs 0.000 claims 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N Maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 239000000845 maltitol Substances 0.000 claims 2
- 235000010449 maltitol Nutrition 0.000 claims 2
- OSNSWKAZFASRNG-BMZZJELJSA-N (3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol;hydrate Chemical class O.OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O OSNSWKAZFASRNG-BMZZJELJSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H Tricalcium phosphate Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N Xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 Xylitol Drugs 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000000832 lactitol Substances 0.000 claims 1
- 235000010448 lactitol Nutrition 0.000 claims 1
- 229960003451 lactitol Drugs 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 239000002798 polar solvent Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
Claims (9)
1. Способ получения фармацевтической таблеточной лекарственной формы, включающий стадии: 1) грануляция смеси флурбипрофена и вещества наполнителя, выбранного из карбоната кальция, трехзамещенного фосфата кальция или микрокристаллической целлюлозы с раствором связывающего вещества в промышленном метилированном спирте или изопропаноле для формирования гранул; 2) расплавление образующей таблетки композиции; 3) смешивание гранул с расплавленной композицией; 4) формования полученной в таблетки, каждая из которых содержит терапевтически эффективное количество флурбипрофена.
2. Способ по п.1, где веществом-наполнителем является карбонат кальция.
3. Способ по любому из предшествующих пунктов, где связывающим веществом является поливинилпирролидин.
4. Способ по любому из предшествующих пунктов, где полярным растворителем является промышленный метилированный спирт или изопропанол.
5. Способ по п.5, где композиции, образующие таблетки включают один или более сахаров.
6. Способ по п. 5, где образующие таблетки композиции включают смесь сахарозы и глюкозы.
7. Способ по любому одному из пп.1-4, при котором образующая таблетки композиция включает одно или более веществ, выбранных из сорбитола, ксилитола, мальтитола, мальтитолового сиропа, лактитола, маннитола или их производных.
8. Способ по п.7, где образующая таблетки композиция включает примерно эквимолярную смесь альфа-D-глюкопиранозил-1,6-D-сорбитола и альфа-D-глюкопиранозил-1,1-D-маннитола.
9. Способ по п.8, где образующая таблетки композиция также включает сироп гидрогенизированной глюкозы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9710521.7 | 1997-05-22 | ||
| GBGB9710521.7A GB9710521D0 (en) | 1997-05-22 | 1997-05-22 | Process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99126868A true RU99126868A (ru) | 2001-08-27 |
| RU2203046C2 RU2203046C2 (ru) | 2003-04-27 |
Family
ID=10812840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99126868/14A RU2203046C2 (ru) | 1997-05-22 | 1998-05-20 | Способ изготовления таблеток флурбипрофена |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6194003B1 (ru) |
| EP (1) | EP0983059B1 (ru) |
| JP (1) | JP2001527567A (ru) |
| KR (1) | KR20010012739A (ru) |
| CN (1) | CN1154480C (ru) |
| AR (1) | AR015812A1 (ru) |
| AT (1) | ATE245021T1 (ru) |
| AU (1) | AU725760B2 (ru) |
| BG (1) | BG103881A (ru) |
| BR (1) | BR9809651A (ru) |
| CA (1) | CA2290830C (ru) |
| CZ (1) | CZ290816B6 (ru) |
| DE (1) | DE69816440T2 (ru) |
| DK (1) | DK0983059T3 (ru) |
| ES (1) | ES2202871T3 (ru) |
| GB (1) | GB9710521D0 (ru) |
| HU (1) | HU224954B1 (ru) |
| ID (1) | ID22949A (ru) |
| IL (1) | IL132999A0 (ru) |
| IN (1) | IN187837B (ru) |
| MY (1) | MY118410A (ru) |
| NO (1) | NO995681L (ru) |
| NZ (1) | NZ500664A (ru) |
| PL (1) | PL190947B1 (ru) |
| PT (1) | PT983059E (ru) |
| RU (1) | RU2203046C2 (ru) |
| SK (1) | SK283701B6 (ru) |
| TR (1) | TR199902725T2 (ru) |
| UA (1) | UA53714C2 (ru) |
| WO (1) | WO1998052539A1 (ru) |
| ZA (1) | ZA984260B (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK285706B6 (sk) | 1999-12-09 | 2007-06-07 | Reckitt Benckiser Healthcare (Uk) Limited | Lisovaná tabletová kompozícia, spôsob jej prípravy a jej použitie |
| AU2001257022B2 (en) * | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
| JP4886107B2 (ja) * | 2000-10-13 | 2012-02-29 | サンスター株式会社 | 歯周病予防用口腔内溶解錠 |
| EP1603548A4 (en) * | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS |
| KR20060040676A (ko) * | 2003-07-11 | 2006-05-10 | 미리어드 제네틱스, 인크. | 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형 |
| FR2865648B1 (fr) * | 2004-02-03 | 2006-06-30 | Philippe Perovitch | Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede |
| US20070293538A1 (en) * | 2004-04-13 | 2007-12-20 | Myriad Genetics, Incorporated | Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders |
| CN1946906A (zh) * | 2004-04-29 | 2007-04-11 | 吉斯通护岸系统股份有限公司 | 用于墙、护墙和类似物的饰面 |
| WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| WO2006020853A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| UA88943C2 (ru) | 2005-02-03 | 2009-12-10 | Нікомед Фарма Ас | Быстрый способ влажного гранулирования для получения композиций, которые содержат кальций |
| GB2423710A (en) | 2005-03-01 | 2006-09-06 | Boots Healthcare Int Ltd | Lozenge production process |
| JP2009502807A (ja) * | 2005-07-22 | 2009-01-29 | ミリアド ジェネティクス， インコーポレイテッド | 薬剤含有率の高い製剤および投与量形態 |
| EP1942877A4 (en) * | 2005-11-02 | 2011-09-14 | Teikoku Pharma Usa Inc | ORGANOLEPTICALLY ACCEPTABLE ORAL DOSAGE FORMS OF IBUPROFEN, MANUFACTURING METHOD AND APPLICATION |
| WO2008006099A2 (en) * | 2006-07-07 | 2008-01-10 | Myriad Genetics, Inc. | Treatment of psychiatric disorders |
| BRPI0809430A2 (pt) * | 2007-07-23 | 2014-09-09 | Teikoku Pharma Usa Inc | Formulações de dosagem oral, organolepticamente aceitáveis, de um agonista indol do receptor de cerotonina e métodos de utilização das mesmas |
| MY155652A (en) * | 2008-08-22 | 2015-11-13 | Reckitt Benckiser Healthcare | Improvements in or relating to compositions |
| IT1397132B1 (it) | 2009-12-01 | 2013-01-04 | Alfa Wassermann Spa | Composizioni comprendenti antiinfiammatori non steroidei. |
| IT1406107B1 (it) * | 2010-12-13 | 2014-02-14 | Alfa Wassermann Spa | Composizioni solide comprendenti antiinfiammatori non steroidei, processi per la loro preparazione e loro uso. |
| RS55372B1 (sr) | 2011-04-29 | 2017-03-31 | Moberg Pharma Ab | Farmaceutske kompozicije koje sadrže lokalni anestetik kao što je bupivakain, za lokalnu administraciju u ustima ili grlu |
| EP2609911A1 (en) * | 2011-12-29 | 2013-07-03 | Sanovel Ilac Sanayi ve Ticaret A.S. | A novel process for preparing orally disintegrating flurbiprofen formulations |
| FR2997856B1 (fr) * | 2012-11-14 | 2015-04-24 | Pf Medicament | Pastille medicamenteuse a base d'ibuprofene sodique dihydrate |
| US20180228832A1 (en) * | 2015-08-18 | 2018-08-16 | Pharma Seeds Create, Llc | Stomatological composition containing nsaid or heparin compound |
| WO2020013781A2 (en) * | 2018-03-27 | 2020-01-16 | Pisak Mehmet Nevzat | Synergistic effect of flurbiprofen and a gastro protective agent for the treatment of pain and inflammation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4666716A (en) * | 1984-09-04 | 1987-05-19 | Richardson-Vicks Inc. | Antidiarrheal compositions and use thereof |
| IT1243342B (it) * | 1990-07-13 | 1994-06-10 | Farcon Ag | Composizioni farmaceutiche orali liquide ad attivita' antiinfiammatoria |
| US5302394A (en) | 1992-07-14 | 1994-04-12 | Mcneil-Ppc, Inc. | Dextromethorphan continuous lozenge manufacturing process |
| US5458879A (en) * | 1994-03-03 | 1995-10-17 | The Procter & Gamble Company | Oral vehicle compositions |
| TW442287B (en) * | 1995-06-13 | 2001-06-23 | American Home Produits Corp | Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac) |
| US5614207A (en) * | 1995-06-30 | 1997-03-25 | Mcneil-Ppc, Inc. | Dry mouth lozenge |
| GB9523833D0 (en) * | 1995-11-22 | 1996-01-24 | Boots Co Plc | Medical treatment |
-
1997
- 1997-05-22 GB GBGB9710521.7A patent/GB9710521D0/en active Pending
-
1998
- 1998-05-20 AT AT98929394T patent/ATE245021T1/de not_active IP Right Cessation
- 1998-05-20 ZA ZA984260A patent/ZA984260B/xx unknown
- 1998-05-20 BR BR9809651-6A patent/BR9809651A/pt not_active IP Right Cessation
- 1998-05-20 KR KR1019997010700A patent/KR20010012739A/ko not_active Application Discontinuation
- 1998-05-20 PT PT98929394T patent/PT983059E/pt unknown
- 1998-05-20 PL PL336624A patent/PL190947B1/pl unknown
- 1998-05-20 TR TR1999/02725T patent/TR199902725T2/xx unknown
- 1998-05-20 US US09/403,771 patent/US6194003B1/en not_active Expired - Lifetime
- 1998-05-20 JP JP54999298A patent/JP2001527567A/ja not_active Ceased
- 1998-05-20 NZ NZ500664A patent/NZ500664A/xx not_active IP Right Cessation
- 1998-05-20 ID IDW991324A patent/ID22949A/id unknown
- 1998-05-20 ES ES98929394T patent/ES2202871T3/es not_active Expired - Lifetime
- 1998-05-20 CN CNB988051230A patent/CN1154480C/zh not_active Expired - Fee Related
- 1998-05-20 HU HU0002121A patent/HU224954B1/hu not_active IP Right Cessation
- 1998-05-20 CA CA002290830A patent/CA2290830C/en not_active Expired - Fee Related
- 1998-05-20 RU RU99126868/14A patent/RU2203046C2/ru not_active IP Right Cessation
- 1998-05-20 IL IL13299998A patent/IL132999A0/xx not_active IP Right Cessation
- 1998-05-20 DE DE69816440T patent/DE69816440T2/de not_active Expired - Lifetime
- 1998-05-20 AU AU79165/98A patent/AU725760B2/en not_active Ceased
- 1998-05-20 UA UA99127003A patent/UA53714C2/ru unknown
- 1998-05-20 SK SK1588-99A patent/SK283701B6/sk not_active IP Right Cessation
- 1998-05-20 DK DK98929394T patent/DK0983059T3/da active
- 1998-05-20 CZ CZ19994120A patent/CZ290816B6/cs not_active IP Right Cessation
- 1998-05-20 EP EP98929394A patent/EP0983059B1/en not_active Expired - Lifetime
- 1998-05-20 WO PCT/EP1998/003167 patent/WO1998052539A1/en not_active Application Discontinuation
- 1998-05-21 AR ARP980102364A patent/AR015812A1/es not_active Application Discontinuation
- 1998-05-21 IN IN1090MA1998 patent/IN187837B/en unknown
- 1998-05-22 MY MYPI98002295A patent/MY118410A/en unknown
-
1999
- 1999-11-15 BG BG103881A patent/BG103881A/xx unknown
- 1999-11-19 NO NO995681A patent/NO995681L/no not_active Application Discontinuation
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