RU95115686A - Премерсацидин, промерсацидин, днк, вектор, клетка-хозяин, способ получения - Google Patents
Премерсацидин, промерсацидин, днк, вектор, клетка-хозяин, способ полученияInfo
- Publication number
- RU95115686A RU95115686A RU95115686/13A RU95115686A RU95115686A RU 95115686 A RU95115686 A RU 95115686A RU 95115686/13 A RU95115686/13 A RU 95115686/13A RU 95115686 A RU95115686 A RU 95115686A RU 95115686 A RU95115686 A RU 95115686A
- Authority
- RU
- Russia
- Prior art keywords
- premersacidin
- dna
- host cell
- vector
- producing
- Prior art date
Links
- 229920003013 deoxyribonucleic acid Polymers 0.000 title claims 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 1
Claims (10)
1. Премерсацидин, имеющий аминокислотную последовательность, показанную на фиг.2 (аминокислоты 1-68), приведенной на с.186.
2. Премерсацидин, имеющий аминокислотную последовательность, показанную на фиг.2 (аминокислоты 49-68), приведенной на с.186.
3. ДНК, кодирующая премерсацидин по п.1.
4. ДНК, кодирующая премерсацидин, с нуклеотидной последовательностью, показанной на фиг.2 (нуклеотиды 22-225), приведенной на с.186.
5. ДНК, кодирующая премерсацидин по п.2.
6. ДНК, кодирующая премерсацидин, имеющая нуклеотидную последовательность, показанную на фиг.2 (нуклеотиды 166-225), приведенной на с.186.
7. Вектор, содержащий ДНК по одному из п.3, 4, 5 или 6.
8. Клетка-хозяин, содержащая вектор по п.7.
9. Способ получения премерсацидина, промерсацидина или зрелого мерсацидина, отличающийся тем, что осуществляют: (a) культивирование подходящей клетки-хозяина, содержащей последовательность ДНК по пп.3 - 6, при подходящих условиях; и (b) выделение премерсацидина, промерсацидина или зрелого мерсацидина.
10. Применение премерсацидина или промерсацидина по п.1 или 2 для получения зрелого мерсацидина.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94114298A EP0700998B1 (en) | 1994-09-12 | 1994-09-12 | Recombinant mersacidin and a method for production |
| EP94114298.6 | 1994-09-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95115686A true RU95115686A (ru) | 1998-05-27 |
| RU2198924C2 RU2198924C2 (ru) | 2003-02-20 |
Family
ID=8216276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95115686/13A RU2198924C2 (ru) | 1994-09-12 | 1995-09-11 | Премерсацидин, промерсацидин, днк (варианты), вектор (варианты), способ получения мерсацидина |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5667991A (ru) |
| EP (1) | EP0700998B1 (ru) |
| JP (1) | JPH0898695A (ru) |
| KR (1) | KR100394289B1 (ru) |
| CN (1) | CN1149287C (ru) |
| AT (1) | ATE255165T1 (ru) |
| AU (1) | AU696450B2 (ru) |
| CA (1) | CA2157975C (ru) |
| CZ (1) | CZ285741B6 (ru) |
| DE (1) | DE69433357T2 (ru) |
| DK (1) | DK0700998T3 (ru) |
| ES (1) | ES2207636T3 (ru) |
| FI (1) | FI120100B (ru) |
| HU (1) | HU216619B (ru) |
| IL (1) | IL115242A0 (ru) |
| NZ (1) | NZ272960A (ru) |
| PT (1) | PT700998E (ru) |
| RU (1) | RU2198924C2 (ru) |
| SI (1) | SI9500270B (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1694020B1 (en) * | 1999-03-12 | 2008-05-28 | Aware, Inc. | Multicarrier modulation system and method |
| US6775320B1 (en) | 1999-03-12 | 2004-08-10 | Aware, Inc. | Method and a multi-carrier transceiver supporting dynamic switching between active application sets |
| US6861236B2 (en) | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
| GB0406870D0 (en) * | 2004-03-26 | 2004-04-28 | Novacta Biosystems Ltd | Improvements relating to the production of lantibiotics |
| US7592308B2 (en) | 2004-03-26 | 2009-09-22 | Novacta Biosystems Limited | F3W variants of the lantibiotic mersacidin and its use |
| JP2009509519A (ja) * | 2005-09-27 | 2009-03-12 | ノヴァクタ バイオシステムズ リミティッド | ランチビオティックメルサシジンの変種およびそれらの使用 |
| GB0600928D0 (en) | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
| GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
| GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| CN102046652B (zh) * | 2008-04-02 | 2014-11-05 | 赛诺菲-安万特 | 来自Actinomadura namibiensis的高度桥联的肽 |
| WO2010058238A1 (en) * | 2008-11-24 | 2010-05-27 | Sentinella Pharmaceuticals, Inc. ("Sentinella") | Lantibiotic carboxyamide derivatives with enhanced antibacterial activity |
| US8283371B2 (en) | 2009-01-14 | 2012-10-09 | Novacta Biosystems Limited | Compounds |
| EP2393829A1 (en) | 2009-02-04 | 2011-12-14 | Novacta Biosystems Limited | Actagardine derivatives |
| GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
| GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
| CN106188253B (zh) * | 2016-08-26 | 2020-08-18 | 上海交通大学 | 抗菌肽Lexapeptide及其制备方法和用途 |
| EP3921424A1 (en) | 2019-02-05 | 2021-12-15 | Elanco Us Inc. | A genetically modified lactobacillus and uses thereof |
| CN111235119B (zh) * | 2020-03-05 | 2021-11-23 | 苏州十一方生物科技有限公司 | 一种融合抗菌蛋白的制备及应用 |
| CN114457102B (zh) * | 2022-02-24 | 2023-12-26 | 重庆市畜牧科学院 | 用于编码分泌型Mersacidin的基因表达盒及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5218101A (en) * | 1988-07-05 | 1993-06-08 | The University Of Maryland | Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor |
| IN167138B (ru) * | 1988-08-17 | 1990-09-01 | Hoechst India |
-
1994
- 1994-09-12 AT AT94114298T patent/ATE255165T1/de active
- 1994-09-12 ES ES94114298T patent/ES2207636T3/es not_active Expired - Lifetime
- 1994-09-12 DE DE69433357T patent/DE69433357T2/de not_active Expired - Lifetime
- 1994-09-12 DK DK94114298T patent/DK0700998T3/da active
- 1994-09-12 PT PT94114298T patent/PT700998E/pt unknown
- 1994-09-12 EP EP94114298A patent/EP0700998B1/en not_active Expired - Lifetime
-
1995
- 1995-09-01 SI SI9500270A patent/SI9500270B/sl not_active IP Right Cessation
- 1995-09-08 AU AU30554/95A patent/AU696450B2/en not_active Ceased
- 1995-09-08 US US08/524,677 patent/US5667991A/en not_active Expired - Lifetime
- 1995-09-08 FI FI954220A patent/FI120100B/fi not_active IP Right Cessation
- 1995-09-08 CZ CZ952318A patent/CZ285741B6/cs not_active IP Right Cessation
- 1995-09-08 NZ NZ272960A patent/NZ272960A/en not_active IP Right Cessation
- 1995-09-08 CN CNB951162330A patent/CN1149287C/zh not_active Expired - Fee Related
- 1995-09-11 HU HU9502643A patent/HU216619B/hu not_active IP Right Cessation
- 1995-09-11 RU RU95115686/13A patent/RU2198924C2/ru not_active IP Right Cessation
- 1995-09-11 JP JP7232356A patent/JPH0898695A/ja active Pending
- 1995-09-11 IL IL11524295A patent/IL115242A0/xx not_active IP Right Cessation
- 1995-09-11 CA CA002157975A patent/CA2157975C/en not_active Expired - Fee Related
- 1995-09-12 KR KR1019950029599A patent/KR100394289B1/ko not_active IP Right Cessation
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