RU95104322A - Производные дефинила, способы их получения, фармкомпозиция и способ лечения - Google Patents

Производные дефинила, способы их получения, фармкомпозиция и способ лечения

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Publication number
RU95104322A
RU95104322A RU95104322/04A RU95104322A RU95104322A RU 95104322 A RU95104322 A RU 95104322A RU 95104322/04 A RU95104322/04 A RU 95104322/04A RU 95104322 A RU95104322 A RU 95104322A RU 95104322 A RU95104322 A RU 95104322A
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RU
Russia
Prior art keywords
alkyl
halogenated
hydrogen atom
alkoxy
cyano
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RU95104322/04A
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English (en)
Other versions
RU2125051C1 (ru
Inventor
Акасака Козо
Jp]
Енага Масахиро
Кадзивара Акихару
Хигураси Кунизо
Уено Кохси
Нагато Сатоси
Комацу Макото
Китазава Норитака
Уено Масатака
Яманиси Есихару
Матида Есимаса
Комацу Юки
Симомура Наоюки
Минами Норио
Симизу Тосиказу
Нагаока Ацуси
Original Assignee
Эйсай Ко.
Эйсай Ко., Лтд.
Лтд. (Jp)
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Application filed by Эйсай Ко., Эйсай Ко., Лтд., Лтд. (Jp) filed Critical Эйсай Ко.
Publication of RU95104322A publication Critical patent/RU95104322A/ru
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Publication of RU2125051C1 publication Critical patent/RU2125051C1/ru

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Pyridine Compounds (AREA)

Abstract

Предлагается производное дифенила формулыили его фармакологически приемлемая соль, гдеR- атом водорода, галогена, гидроксильная, амино-, низшая алкильная, галогенированная низшая алкильная, низшая алкокси-, галогенированная низшая алкокси-, низшая алкоксиалкильная, низшая алкоксиалкокси-, арильная, аралкильная, гетероарильная, гетероарилалкильная, галогенированная гетероарилалкильная, циано(низшая)алкильная, гидрокси(низшая)- алкильная, амино(низшая)алкильная, низшая алкоксикарбонильная, арилоксикарбонильная, циано-, формильная, низшая алкилсульфинильная, низшая алкилсульфонильная, низшая алкиламиносульфонильная, ариламиносульфонильная, низшая алкилсульфониламино-, галогенированная низшая алкилсульфониламино- или арилсульфониламоногруппа,Rи Rмогут быть одинаковыми или отличающимися друг от друга и каждый - атом водорода, галогена, низшая алкильная, галогенированная низшая алкильная, низшая алкокси-, галогенированная низшая алкокси- или цианогруппа;R- атом водорода или атом галогена;R- атом водорода, низшая алкильная, галогенированная низшая алкильная, гидрокси(низшая)алкильная, низшая алкоксикарбонильная или арилоксикарбонильная руппа; и n = 0 или целому числу от 1 до 3,которое(ая) проявляет антагонизм по отношению к 2-дофаминрецепторам и/или 2-серотонинрецепторам и клинически пригодно(а) для лечения или улучшения течения (снижения интенсивности симптомов) психических расстройств, таких как нарушение нормальной работы сосудов головного мозга, агрессивное поведение вследствие старческого слабоумия, психическое возбуждение, пориомания, бред, галлюцинация, гиперкинез, шизофрения, эмоциональное расстр

Claims (1)

  1. Предлагается производное дифенила формулы
    Figure 00000001

    или его фармакологически приемлемая соль, где
    R1 - атом водорода, галогена, гидроксильная, амино-, низшая алкильная, галогенированная низшая алкильная, низшая алкокси-, галогенированная низшая алкокси-, низшая алкоксиалкильная, низшая алкоксиалкокси-, арильная, аралкильная, гетероарильная, гетероарилалкильная, галогенированная гетероарилалкильная, циано(низшая)алкильная, гидрокси(низшая)- алкильная, амино(низшая)алкильная, низшая алкоксикарбонильная, арилоксикарбонильная, циано-, формильная, низшая алкилсульфинильная, низшая алкилсульфонильная, низшая алкиламиносульфонильная, ариламиносульфонильная, низшая алкилсульфониламино-, галогенированная низшая алкилсульфониламино- или арилсульфониламоногруппа,
    R2 и R3 могут быть одинаковыми или отличающимися друг от друга и каждый - атом водорода, галогена, низшая алкильная, галогенированная низшая алкильная, низшая алкокси-, галогенированная низшая алкокси- или цианогруппа;
    R4 - атом водорода или атом галогена;
    R5 - атом водорода, низшая алкильная, галогенированная низшая алкильная, гидрокси(низшая)алкильная, низшая алкоксикарбонильная или арилоксикарбонильная руппа; и n = 0 или целому числу от 1 до 3,
    которое(ая) проявляет антагонизм по отношению к 2-дофаминрецепторам и/или 2-серотонинрецепторам и клинически пригодно(а) для лечения или улучшения течения (снижения интенсивности симптомов) психических расстройств, таких как нарушение нормальной работы сосудов головного мозга, агрессивное поведение вследствие старческого слабоумия, психическое возбуждение, пориомания, бред, галлюцинация, гиперкинез, шизофрения, эмоциональное расстройство, депрессия, невроз, психофизиологическое расстройство и невроз страха.
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