RU94038255A - Производные бензодиазепина, способ их получения, фармацевтическая композиция - Google Patents

Производные бензодиазепина, способ их получения, фармацевтическая композиция

Info

Publication number
RU94038255A
RU94038255A RU94038255/04A RU94038255A RU94038255A RU 94038255 A RU94038255 A RU 94038255A RU 94038255/04 A RU94038255/04 A RU 94038255/04A RU 94038255 A RU94038255 A RU 94038255A RU 94038255 A RU94038255 A RU 94038255A
Authority
RU
Russia
Prior art keywords
group
benzodiazepine derivatives
alkyl
ror
independently selected
Prior art date
Application number
RU94038255/04A
Other languages
English (en)
Other versions
RU2139282C1 (ru
Inventor
Райдер Хэмиш
Gb]
Семпл Грэм
Алан Кендрик Дэвид
Желке Майкл
Сатох Масато
Охта Мицуаки
Мията Кейдзи
Нисида Акито
Jp]
Original Assignee
Яманоути Фармасьютикал Ко. Лтд. (JP)
Яманоути Фармасьютикал Ко. Лтд.
Ферринг Рисерч Лимитед (GB)
Ферринг Рисерч Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9204221A external-priority patent/GB2264492B/en
Application filed by Яманоути Фармасьютикал Ко. Лтд. (JP), Яманоути Фармасьютикал Ко. Лтд., Ферринг Рисерч Лимитед (GB), Ферринг Рисерч Лимитед filed Critical Яманоути Фармасьютикал Ко. Лтд. (JP)
Publication of RU94038255A publication Critical patent/RU94038255A/ru
Application granted granted Critical
Publication of RU2139282C1 publication Critical patent/RU2139282C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Предложено производное бензодиазепина формулы, указанной в описании, или его фармацевтически приемлемая соль. Указанные соединения являются антагонистами гастрина и/или рецептора ССК-В.

Claims (1)

  1. Предложено производное бензодиазепина формулы, указанной в описании, или его фармацевтически приемлемая соль. Указанные соединения являются антагонистами гастрина и/или рецептора ССК-В.
RU94038255A 1992-02-27 1993-02-26 Производные бензодиазепина, способ их получения, фармацевтическая композиция RU2139282C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9204221A GB2264492B (en) 1992-02-27 1992-02-27 Benzodiazepine derivatives
GB9204221.7 1992-02-27
GB929212740A GB9212740D0 (en) 1992-02-27 1992-06-16 Benzodiazephine derivatives
GB9212740.6 1992-06-16
PCT/GB1993/000404 WO1993016999A1 (en) 1992-02-27 1993-02-26 Benzodiazepin derivatives useful as cck-receptor antagonists

Publications (2)

Publication Number Publication Date
RU94038255A true RU94038255A (ru) 1996-07-10
RU2139282C1 RU2139282C1 (ru) 1999-10-10

Family

ID=26300386

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94038255A RU2139282C1 (ru) 1992-02-27 1993-02-26 Производные бензодиазепина, способ их получения, фармацевтическая композиция

Country Status (18)

Country Link
US (2) US5688943A (ru)
EP (1) EP0628033B1 (ru)
JP (1) JP2571344B2 (ru)
CN (1) CN1051079C (ru)
AT (1) ATE245632T1 (ru)
AU (1) AU672390B2 (ru)
CA (1) CA2129990C (ru)
DE (1) DE69333108T2 (ru)
DK (1) DK0628033T3 (ru)
ES (1) ES2203616T3 (ru)
FI (1) FI121234B (ru)
HU (1) HU224012B1 (ru)
IL (1) IL104853A (ru)
NO (1) NO311215B1 (ru)
PT (1) PT628033E (ru)
RU (1) RU2139282C1 (ru)
TW (1) TW438783B (ru)
WO (1) WO1993016999A1 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07500589A (ja) * 1991-10-24 1995-01-19 メルク　シヤープ　エンド　ドーム　リミテツド ベンゾジアゼピン誘導体、並びにコレシストキニン及び／又はガストリンレセプターのアンタゴニストとしての該誘導体の使用
GB2282595A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
GB2282594A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
AUPO284396A0 (en) * 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US6100254A (en) * 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
EP1391203A4 (en) * 2001-05-11 2005-09-14 Astellas Pharma Inc ANTITUMORAL AGENTS
US7524837B2 (en) 2003-05-12 2009-04-28 Janssen Pharmaceutica N.V. Benzotriazapinone salts and methods for using same
US8053413B2 (en) * 2005-06-06 2011-11-08 The Board Of Trustees Of The University Of Illinois Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists
CN101669557B (zh) * 2009-08-20 2012-07-25 杭州六易科技有限公司 一种清热解毒凉茶的制作方法
WO2011037128A1 (ja) 2009-09-28 2011-03-31 日本曹達株式会社 含窒素ヘテロ環化合物およびその塩ならびに農園芸用殺菌剤
BR112016011727A2 (pt) 2013-11-22 2017-08-08 CL BioSciences LLC Antagonistas de gastrina para o tratamento e prevenção de osteoporose
GB201414116D0 (en) * 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) * 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
EP3509617A4 (en) * 2016-09-09 2020-05-13 On Target Laboratories, LLC NIR IMAGING AND USE OF THE CHOLECYSTOKININ-2 RECEPTOR
US10881667B2 (en) * 2018-10-30 2021-01-05 City University Of Hong Kong Method and composition for treating epilepsy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA2026856A1 (en) * 1989-10-05 1991-04-06 Mark G. Bock 3-substituted-1,4-benzodiazepines useful as oxytocin
CA2032427A1 (en) * 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepines analogs
CA2032226A1 (en) * 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepine analogs
IL96613A0 (en) * 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
US5218115A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists

Also Published As

Publication number Publication date
JPH07505121A (ja) 1995-06-08
AU672390B2 (en) 1996-10-03
NO943133D0 (no) 1994-08-24
CN1075717A (zh) 1993-09-01
PT628033E (pt) 2003-12-31
DE69333108D1 (de) 2003-08-28
CA2129990C (en) 2006-01-10
TW438783B (en) 2001-06-07
HUT67963A (en) 1995-05-29
US5962451A (en) 1999-10-05
WO1993016999A1 (en) 1993-09-02
FI943941A (fi) 1994-10-26
NO943133L (no) 1994-08-24
IL104853A (en) 1997-11-20
ES2203616T3 (es) 2004-04-16
ATE245632T1 (de) 2003-08-15
CN1051079C (zh) 2000-04-05
HU9402212D0 (en) 1994-09-28
US5688943A (en) 1997-11-18
FI943941A0 (fi) 1994-08-26
HU224012B1 (hu) 2005-04-28
EP0628033A1 (en) 1994-12-14
JP2571344B2 (ja) 1997-01-16
RU2139282C1 (ru) 1999-10-10
AU3639193A (en) 1993-09-13
FI121234B (fi) 2010-08-31
NO311215B1 (no) 2001-10-29
DE69333108T2 (de) 2004-04-15
CA2129990A1 (en) 1993-09-02
EP0628033B1 (en) 2003-07-23
DK0628033T3 (da) 2003-11-10
IL104853A0 (en) 1993-06-10

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