RU94038255A - Benzodiazepine derivatives, process for preparation thereof, and pharmaceutical composition - Google Patents

Benzodiazepine derivatives, process for preparation thereof, and pharmaceutical composition

Info

Publication number
RU94038255A
RU94038255A RU94038255/04A RU94038255A RU94038255A RU 94038255 A RU94038255 A RU 94038255A RU 94038255/04 A RU94038255/04 A RU 94038255/04A RU 94038255 A RU94038255 A RU 94038255A RU 94038255 A RU94038255 A RU 94038255A
Authority
RU
Russia
Prior art keywords
group
benzodiazepine derivatives
alkyl
ror
independently selected
Prior art date
Application number
RU94038255/04A
Other languages
Russian (ru)
Other versions
RU2139282C1 (en
Inventor
Райдер Хэмиш
Gb]
Семпл Грэм
Алан Кендрик Дэвид
Желке Майкл
Сатох Масато
Охта Мицуаки
Мията Кейдзи
Нисида Акито
Jp]
Original Assignee
Яманоути Фармасьютикал Ко. Лтд. (JP)
Яманоути Фармасьютикал Ко. Лтд.
Ферринг Рисерч Лимитед (GB)
Ферринг Рисерч Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9204221A external-priority patent/GB2264492B/en
Application filed by Яманоути Фармасьютикал Ко. Лтд. (JP), Яманоути Фармасьютикал Ко. Лтд., Ферринг Рисерч Лимитед (GB), Ферринг Рисерч Лимитед filed Critical Яманоути Фармасьютикал Ко. Лтд. (JP)
Publication of RU94038255A publication Critical patent/RU94038255A/en
Application granted granted Critical
Publication of RU2139282C1 publication Critical patent/RU2139282C1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

FIELD: medicine. SUBSTANCE: benzodiazepine derivatives or pharmaceutically acceptable salts thereof of formula (I):wherein Ris group CHCHOH Ror ketone group CHCO R, in which a is 0 or 1 and Ror Ris selected from alkyl or cycloalkyl group and saturated heterocyclic group optionally having substituent at heteroatom; Rand Rare independently selected from aromatic carbocyclic or heterocyclic fragments; and W and X are independently selected from halogen and hydrogen atoms or alkyl or alkoxy groups, said compounds are gastrin and/or CCK-B receptor antagonists. EFFECT: improved properties of the title compounds.

Claims (1)

Предложено производное бензодиазепина формулы, указанной в описании, или его фармацевтически приемлемая соль. Указанные соединения являются антагонистами гастрина и/или рецептора ССК-В.A benzodiazepine derivative of the formula described herein or a pharmaceutically acceptable salt thereof is provided. These compounds are antagonists of gastrin and / or CCK-B receptor.
RU94038255A 1992-02-27 1993-02-26 Derivatives of benzodiazepine, method of their synthesis, pharmaceutical composition RU2139282C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9204221A GB2264492B (en) 1992-02-27 1992-02-27 Benzodiazepine derivatives
GB9204221.7 1992-02-27
GB929212740A GB9212740D0 (en) 1992-02-27 1992-06-16 Benzodiazephine derivatives
GB9212740.6 1992-06-16
PCT/GB1993/000404 WO1993016999A1 (en) 1992-02-27 1993-02-26 Benzodiazepin derivatives useful as cck-receptor antagonists

Publications (2)

Publication Number Publication Date
RU94038255A true RU94038255A (en) 1996-07-10
RU2139282C1 RU2139282C1 (en) 1999-10-10

Family

ID=26300386

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94038255A RU2139282C1 (en) 1992-02-27 1993-02-26 Derivatives of benzodiazepine, method of their synthesis, pharmaceutical composition

Country Status (18)

Country Link
US (2) US5688943A (en)
EP (1) EP0628033B1 (en)
JP (1) JP2571344B2 (en)
CN (1) CN1051079C (en)
AT (1) ATE245632T1 (en)
AU (1) AU672390B2 (en)
CA (1) CA2129990C (en)
DE (1) DE69333108T2 (en)
DK (1) DK0628033T3 (en)
ES (1) ES2203616T3 (en)
FI (1) FI121234B (en)
HU (1) HU224012B1 (en)
IL (1) IL104853A (en)
NO (1) NO311215B1 (en)
PT (1) PT628033E (en)
RU (1) RU2139282C1 (en)
TW (1) TW438783B (en)
WO (1) WO1993016999A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008176A1 (en) * 1991-10-24 1993-04-29 Merck Sharp & Dohme Limited Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
GB2282595A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
GB2282594A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
AUPO284396A0 (en) * 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US6100254A (en) * 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US20040138207A1 (en) * 2001-05-11 2004-07-15 Mayumi Yamano Antitumor agents
US7524837B2 (en) 2003-05-12 2009-04-28 Janssen Pharmaceutica N.V. Benzotriazapinone salts and methods for using same
US8053413B2 (en) * 2005-06-06 2011-11-08 The Board Of Trustees Of The University Of Illinois Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists
CN101669557B (en) * 2009-08-20 2012-07-25 杭州六易科技有限公司 Method for preparing heat-clearing and detoxifying herbal tea
US9062024B2 (en) 2009-09-28 2015-06-23 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and salt thereof, and a fungicide for agricultural and horticultural use
EP3071206B1 (en) 2013-11-22 2021-02-17 CL Biosciences LLC Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
CN110177565A (en) * 2016-09-09 2019-08-27 目标实验室有限责任公司 2 receptor target near infrared imaging of cholecystokinin and application thereof
US10881667B2 (en) * 2018-10-30 2021-01-05 City University Of Hong Kong Method and composition for treating epilepsy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA2026856A1 (en) * 1989-10-05 1991-04-06 Mark G. Bock 3-substituted-1,4-benzodiazepines useful as oxytocin
IL96613A0 (en) * 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
IE904560A1 (en) * 1989-12-18 1991-06-19 Merck & Co Inc New benzodiazepine analogs
CA2032226A1 (en) * 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepine analogs
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
US5218115A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists

Also Published As

Publication number Publication date
ES2203616T3 (en) 2004-04-16
WO1993016999A1 (en) 1993-09-02
NO943133L (en) 1994-08-24
US5962451A (en) 1999-10-05
TW438783B (en) 2001-06-07
FI943941A0 (en) 1994-08-26
NO943133D0 (en) 1994-08-24
ATE245632T1 (en) 2003-08-15
JPH07505121A (en) 1995-06-08
FI121234B (en) 2010-08-31
HU224012B1 (en) 2005-04-28
JP2571344B2 (en) 1997-01-16
IL104853A0 (en) 1993-06-10
EP0628033B1 (en) 2003-07-23
HU9402212D0 (en) 1994-09-28
IL104853A (en) 1997-11-20
CA2129990C (en) 2006-01-10
DE69333108T2 (en) 2004-04-15
CN1075717A (en) 1993-09-01
CA2129990A1 (en) 1993-09-02
CN1051079C (en) 2000-04-05
NO311215B1 (en) 2001-10-29
DE69333108D1 (en) 2003-08-28
AU672390B2 (en) 1996-10-03
PT628033E (en) 2003-12-31
RU2139282C1 (en) 1999-10-10
HUT67963A (en) 1995-05-29
US5688943A (en) 1997-11-18
EP0628033A1 (en) 1994-12-14
FI943941A (en) 1994-10-26
AU3639193A (en) 1993-09-13
DK0628033T3 (en) 2003-11-10

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