RU93042100A - Новые 7-(замещенные)-8-(замещенные)-9-[(замещенные глицил) амидо]-6-деметил-6-дезокситетрациклины - Google Patents
Новые 7-(замещенные)-8-(замещенные)-9-[(замещенные глицил) амидо]-6-деметил-6-дезокситетрациклиныInfo
- Publication number
- RU93042100A RU93042100A RU93042100/04A RU93042100A RU93042100A RU 93042100 A RU93042100 A RU 93042100A RU 93042100/04 A RU93042100/04 A RU 93042100/04A RU 93042100 A RU93042100 A RU 93042100A RU 93042100 A RU93042100 A RU 93042100A
- Authority
- RU
- Russia
- Prior art keywords
- substituted
- deoxytetricine
- demethyl
- amido
- new
- Prior art date
Links
- -1 GLYCYL Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/928,578 US5420272A (en) | 1992-08-13 | 1992-08-13 | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US07/928,578 | 1992-08-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93042100A true RU93042100A (ru) | 1996-08-10 |
RU2125985C1 RU2125985C1 (ru) | 1999-02-10 |
Family
ID=25456464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93042100A RU2125985C1 (ru) | 1992-08-13 | 1993-08-12 | Новые 7-(замещенные)-8-(замещенные)-9-[(замещенные глицил)амидо]-6-деметил- 6-дезокситетрациклины или их фармацевтически приемлемые соли или комплексы с металлами, способы их получения и фармацевтическая композиция, обладающая антибиотической активностью in vivo |
Country Status (25)
Country | Link |
---|---|
US (4) | US5420272A (ru) |
EP (1) | EP0582789B1 (ru) |
JP (1) | JP3529106B2 (ru) |
KR (2) | KR100307439B1 (ru) |
CN (1) | CN1033087C (ru) |
AT (1) | ATE206391T1 (ru) |
AU (1) | AU673366B2 (ru) |
CA (1) | CA2103838C (ru) |
CZ (1) | CZ289252B6 (ru) |
DE (1) | DE69330852T2 (ru) |
DK (1) | DK0582789T3 (ru) |
ES (1) | ES2162617T3 (ru) |
FI (1) | FI933564A (ru) |
HU (1) | HU213213B (ru) |
IL (3) | IL106676A (ru) |
MX (1) | MX9304646A (ru) |
NO (1) | NO302168B1 (ru) |
NZ (1) | NZ248356A (ru) |
PH (1) | PH30931A (ru) |
PL (3) | PL174113B1 (ru) |
PT (1) | PT582789E (ru) |
RU (1) | RU2125985C1 (ru) |
SG (1) | SG54203A1 (ru) |
SK (1) | SK281866B6 (ru) |
ZA (1) | ZA935893B (ru) |
Families Citing this family (54)
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NZ194063A (en) * | 1979-06-20 | 1984-09-28 | W J Nugent | Lock with key having variable disc-selective coding |
US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US6165999A (en) * | 1995-05-03 | 2000-12-26 | Pfizer Inc | Tetracycline derivatives |
US6152876A (en) | 1997-04-18 | 2000-11-28 | Rio Grande Medical Technologies, Inc. | Method for non-invasive blood analyte measurement with improved optical interface |
US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6946118B1 (en) | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
CN102336680A (zh) * | 1999-09-14 | 2012-02-01 | 塔夫茨大学信托人 | 用基于过渡金属的化学制备取代四环素的方法 |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US20020128238A1 (en) * | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
AU2001271642B2 (en) * | 2000-07-07 | 2006-01-05 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
MXPA03000055A (es) | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de monociclina sustituidos en posicion 9.. |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
EA201000388A1 (ru) * | 2001-03-13 | 2010-10-29 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
JP2004537544A (ja) | 2001-07-13 | 2004-12-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 標的治療活性を有するテトラサイクリン化合物 |
AU2003235759A1 (en) * | 2002-01-08 | 2003-07-24 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
EA201000491A1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
AU2003218243B2 (en) | 2002-03-21 | 2010-04-01 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
US20040029843A1 (en) * | 2002-06-20 | 2004-02-12 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
EA200900540A1 (ru) | 2002-07-12 | 2009-12-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
CN101863841A (zh) | 2003-07-09 | 2010-10-20 | 帕拉特克药品公司 | 取代的四环素化合物 |
EP2332904A3 (en) | 2004-01-15 | 2012-04-11 | Paratek Pharmaceuticals, Inc. | Derivatives of tetracycline compounds |
CN103224474B (zh) | 2004-05-21 | 2016-08-03 | 哈佛大学校长及研究员协会 | 四环素及其类似物的合成 |
AU2005299294B2 (en) | 2004-10-25 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
EP1807387A2 (en) | 2004-10-25 | 2007-07-18 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
US7534766B2 (en) | 2004-11-05 | 2009-05-19 | Wyeth | Glucuronide metabolites and epimers thereof of tigecycline |
WO2006084265A1 (en) * | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS |
BRPI0607353A2 (pt) * | 2005-02-15 | 2009-09-01 | Wyeth Corp | composto de fórmula (i); composição farmacêutica; uso do composto para o tratamento ou controle de infecções bacterianas em animais de sangue quente; processo para a preparação de tetraciclinas 9-(n-substituìdas-n-substituìdas-glicil) de fórmulas 5; 7; 10; e tetraciclina 9-(n-substituìda-n-substituìda glicil) de fómulas 5; 7; 10 |
US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 10−置換テトラサイクリンおよびその使用方法 |
KR20080080205A (ko) * | 2005-12-22 | 2008-09-02 | 와이어쓰 | 티게사이클린을 포함하는 경구 제형 |
RU2008121238A (ru) * | 2005-12-22 | 2010-01-27 | Вайет (Us) | Способы лечения инфекций желудочно-кишечного тракта с применением тайгециклина |
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US20080039433A1 (en) * | 2006-06-15 | 2008-02-14 | Smith Alexander D | Stabilized Tetracycline Compositions |
PT2682387E (pt) * | 2008-08-08 | 2016-02-03 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
US9073829B2 (en) | 2009-04-30 | 2015-07-07 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
PL2470500T3 (pl) | 2009-08-28 | 2018-03-30 | Tetraphase Pharmaceuticals, Inc. | Związki tetracyklinowe |
PL2890673T3 (pl) | 2012-08-31 | 2019-06-28 | Tetraphase Pharmaceuticals, Inc. | Związki tetracyklinowe |
JP7492335B2 (ja) | 2016-10-19 | 2024-05-29 | テトラフェース ファーマシューティカルズ,インコーポレイテッド | エラバサイクリンの結晶形 |
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US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
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US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
-
1992
- 1992-08-13 US US07/928,578 patent/US5420272A/en not_active Expired - Lifetime
-
1993
- 1993-05-12 EP EP93107718A patent/EP0582789B1/en not_active Expired - Lifetime
- 1993-05-12 PT PT93107718T patent/PT582789E/pt unknown
- 1993-05-12 DK DK93107718T patent/DK0582789T3/da active
- 1993-05-12 AT AT93107718T patent/ATE206391T1/de not_active IP Right Cessation
- 1993-05-12 ES ES93107718T patent/ES2162617T3/es not_active Expired - Lifetime
- 1993-05-12 DE DE69330852T patent/DE69330852T2/de not_active Expired - Fee Related
- 1993-05-12 SG SG1996004073A patent/SG54203A1/en unknown
- 1993-07-01 CN CN93107916A patent/CN1033087C/zh not_active Expired - Fee Related
- 1993-08-02 MX MX9304646A patent/MX9304646A/es unknown
- 1993-08-06 CZ CZ19931616A patent/CZ289252B6/cs not_active IP Right Cessation
- 1993-08-09 NZ NZ248356A patent/NZ248356A/en unknown
- 1993-08-09 JP JP21481693A patent/JP3529106B2/ja not_active Expired - Fee Related
- 1993-08-10 PH PH46660A patent/PH30931A/en unknown
- 1993-08-10 SK SK862-93A patent/SK281866B6/sk unknown
- 1993-08-11 CA CA002103838A patent/CA2103838C/en not_active Expired - Fee Related
- 1993-08-12 IL IL106676A patent/IL106676A/en not_active IP Right Cessation
- 1993-08-12 RU RU93042100A patent/RU2125985C1/ru not_active IP Right Cessation
- 1993-08-12 ZA ZA935893A patent/ZA935893B/xx unknown
- 1993-08-12 PL PL93316738A patent/PL174113B1/pl not_active IP Right Cessation
- 1993-08-12 KR KR1019930015641A patent/KR100307439B1/ko not_active IP Right Cessation
- 1993-08-12 PL PL93316737A patent/PL173899B1/pl not_active IP Right Cessation
- 1993-08-12 NO NO932871A patent/NO302168B1/no not_active IP Right Cessation
- 1993-08-12 HU HU9302329A patent/HU213213B/hu not_active IP Right Cessation
- 1993-08-12 AU AU44613/93A patent/AU673366B2/en not_active Ceased
- 1993-08-12 FI FI933564A patent/FI933564A/fi unknown
- 1993-08-12 IL IL11969993A patent/IL119699A/en not_active IP Right Cessation
- 1993-08-12 PL PL93300062A patent/PL174103B1/pl not_active IP Right Cessation
-
1994
- 1994-02-08 US US08/193,828 patent/US5386041A/en not_active Expired - Lifetime
- 1994-09-26 US US08/312,018 patent/US5457096A/en not_active Expired - Lifetime
- 1994-09-27 US US08/312,593 patent/US5495032A/en not_active Expired - Lifetime
-
1996
- 1996-11-26 IL IL11969996A patent/IL119699A0/xx unknown
-
2000
- 2000-10-31 KR KR1020000064376A patent/KR100309542B1/ko not_active IP Right Cessation
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