RU2771110C2 - Онколитические вирусные векторы и их применение - Google Patents

Онколитические вирусные векторы и их применение Download PDF

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RU2771110C2
RU2771110C2 RU2020108004A RU2020108004A RU2771110C2 RU 2771110 C2 RU2771110 C2 RU 2771110C2 RU 2020108004 A RU2020108004 A RU 2020108004A RU 2020108004 A RU2020108004 A RU 2020108004A RU 2771110 C2 RU2771110 C2 RU 2771110C2
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mir
cancer
mip
cell
target sequences
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RU2020108004A
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Митчелл Х. ФАЙНЕР
Лорена Лернер
Кристоф КУЭВА
Эдвард КЕННЕДИ
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Онкорус, Инк.
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16645—Special targeting system for viral vectors
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16671—Demonstrated in vivo effect
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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RU2020108004A 2017-07-26 2018-07-26 Онколитические вирусные векторы и их применение RU2771110C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762537359P 2017-07-26 2017-07-26
US62/537,359 2017-07-26
US201862686802P 2018-06-19 2018-06-19
US62/686,802 2018-06-19
PCT/US2018/043938 WO2019023483A1 (en) 2017-07-26 2018-07-26 ONCOLYTIC VIRAL VECTORS AND USES THEREOF

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RU2020108004A RU2020108004A (ru) 2021-08-26
RU2020108004A3 RU2020108004A3 (https=) 2021-10-12
RU2771110C2 true RU2771110C2 (ru) 2022-04-26

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US (2) US11612625B2 (https=)
EP (1) EP3658165A4 (https=)
JP (2) JP7249323B2 (https=)
KR (1) KR20200042904A (https=)
CN (1) CN111212656B (https=)
AU (1) AU2018306455A1 (https=)
BR (1) BR112020001559A2 (https=)
CA (1) CA3070299A1 (https=)
IL (1) IL271993A (https=)
MX (1) MX2020000993A (https=)
RU (1) RU2771110C2 (https=)
SG (1) SG11202000691XA (https=)
WO (1) WO2019023483A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2749050C2 (ru) * 2016-01-27 2021-06-03 Онкорус, Инк. Онколитические вирусные векторы и их применение
AU2018306455A1 (en) 2017-07-26 2020-02-27 Virogin Biotech Canada Ltd Oncolytic viral vectors and uses thereof
US11395832B2 (en) * 2017-12-14 2022-07-26 Unicyte Ev Ag Pharmaceutical carriers containing miRNAs for use in the treatment of renal cancer
JP2022513639A (ja) * 2018-11-29 2022-02-09 ヴァイロジン バイオテック カナダ リミテッド 低神経毒性ｈｓｖベクター
AU2020232264B2 (en) * 2019-03-05 2026-02-19 Amgen Inc. Use of oncolytic viruses for the treatment of cancer
CN110283794B (zh) * 2019-05-30 2021-04-23 伍泽堂 重组溶瘤病毒以及制备方法、应用和药物
CN114514323A (zh) * 2019-08-05 2022-05-17 复诺健生物科技加拿大有限公司 遗传修饰的肠病毒载体
CN111235274A (zh) * 2020-01-18 2020-06-05 山西医科大学第一医院 喉鳞癌血清外泌体标志物筛选方法和外泌体来源miR-941应用
ES2856232B2 (es) * 2020-03-25 2023-11-24 Fundacion Para La Investig Biomedica Del Hospital 12 De Octubre Biomarcadores para predecir la respuesta de un sujeto a una terapia con bcg, metodos y usos basados en los mismos
US20240226208A9 (en) * 2020-04-15 2024-07-11 Humane Genomics Inc. Artificial oncolytic viruses and related methods
TWI845834B (zh) * 2020-04-23 2024-06-21 輔仁大學學校財團法人輔仁大學 癌症化療藥物促敏方法、其促敏劑組合物及其用途
CN113583977B (zh) * 2020-04-30 2025-06-06 杭州康万达医药科技有限公司 可受微小rna调控的分离的重组溶瘤痘病毒及其应用
CN111494636A (zh) * 2020-06-22 2020-08-07 中国人民解放军空军军医大学 Mct1抑制剂的应用及含有其的药物组合物
JP2023540427A (ja) * 2020-07-07 2023-09-25 オリエンジーン バイオテクノロジー リミテッド Ｈｓｖ－１遺伝子編集のためのガイドｒｎａおよびその方法
US20230242994A1 (en) * 2020-07-10 2023-08-03 Shanghai Miran Biotech Co., Ltd. Fluorescent cross-linked rnase h mutant conjugate, mirna combination and application thereof
US11505607B2 (en) * 2020-11-13 2022-11-22 Binhui Biopharmaceutical Co., Ltd. Bispecific single-chain antibody, recombinant oncolytic virus for expressing same and virus composition
CN116744951A (zh) * 2020-12-25 2023-09-12 苏州系统医学研究所 一种包含溶瘤病毒的组合物及其在肿瘤治疗中的应用
WO2022151078A1 (zh) * 2021-01-13 2022-07-21 嘉兴允英医学检验有限公司 溶瘤病毒及其应用
JP2024509084A (ja) * 2021-02-23 2024-02-29 インターギャラクティック セラピューティクス インコーポレイテッド 核酸ベクター及び使用方法
JP2024512053A (ja) * 2021-03-24 2024-03-18 ヴァイロジン バイオテック カナダ リミテッド 転写及び翻訳の二重調節を受ける腫瘍溶解性単純ヘルペスウイルスベクター
EP4395799A4 (en) * 2021-08-31 2025-08-06 Virogin Biotech Canada Ltd GENETICALLY MODIFIED ONCOLYTIC HERPES VIRUS
EP4170022A1 (en) * 2021-10-19 2023-04-26 Consejo Superior De Investigaciones Científicas Recombinant african swine fever virus and uses thereof
CN114010666B (zh) * 2021-10-22 2024-05-07 上海交通大学 溶瘤病毒、parp抑制剂及pd-1抗体在制备抗肿瘤药物中的应用
JP2025508866A (ja) * 2022-02-22 2025-04-10 ヴァイロ バイオ インク． 腫瘍溶解性ウイルスおよび使用方法
CN117379389B (zh) * 2022-07-12 2026-03-06 四川大学 血小板-溶瘤病毒复合物、其制备方法及其应用
WO2024054293A1 (en) * 2022-09-08 2024-03-14 Research Institute At Nationwide Children's Hospital Oncolytic virus combination to maximize oncolytic activity
JP2026501236A (ja) * 2022-12-20 2026-01-14 ヤンセン バイオテツク，インコーポレーテツド 腫瘍溶解性ウイルス及びその使用
GB2634272A (en) * 2023-10-04 2025-04-09 Averywell Ltd Methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170035819A1 (en) * 2013-10-28 2017-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic hsv vector

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244792A (en) 1984-04-06 1993-09-14 Chiron Corporation Expression of recombinant glyoprotein B from herpes simplex virus
JPH0668B2 (ja) 1985-08-30 1994-01-05 財団法人化学及血清療法研究所 単純ヘルペスウイルス遺伝子が組込まれた組換えプラスミド
GB8918616D0 (en) 1989-08-15 1989-09-27 Univ Glasgow Herpes simplex virus type 1 mutant
US5725871A (en) 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
US5849571A (en) 1990-10-10 1998-12-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Latency active herpes virus promoters and their use
US5849572A (en) 1990-10-10 1998-12-15 Regents Of The University Of Michigan HSV-1 vector containing a lat promoter
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5756353A (en) 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
ES2105262T3 (es) 1992-05-18 1997-10-16 Minnesota Mining & Mfg Dispositivo de suministro de farmaco a traves de las mucosas.
US5658724A (en) 1992-07-31 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains deficient for the essential immediate early genes ICP4 and ICP27 and methods for their production, growth and use
US5804413A (en) 1992-07-31 1998-09-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains for gene transfer
US5879934A (en) 1992-07-31 1999-03-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains for gene transfer
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
GB9415319D0 (en) 1994-07-29 1994-09-21 Medical Res Council HSV viral vector
GB9415369D0 (en) 1994-07-29 1994-09-21 Lynxvale Ltd Mutant virus
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US6261552B1 (en) 1997-05-22 2001-07-17 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus vectors
GB9700411D0 (en) 1997-01-10 1997-02-26 Univ London Eukaryotic gene expression cassette and uses thereof
US6071742A (en) 1997-03-05 2000-06-06 Board Of Regents Of The University Of Nebraska Coxsackie virus as a vector for delivery of anti-inflammatory cytokines
US5998174A (en) 1997-05-12 1999-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Multigene vectors
AU8605598A (en) 1997-07-31 1999-02-22 University Of Pittsburgh Targeted hsv vectors
AU742757C (en) 1997-12-17 2007-05-17 Immunex Corporation Cell surface glycoproteins associated with human B cell lymphomas - ULBP, DNA and polypeptides
GB9810423D0 (en) 1998-05-15 1998-07-15 Cancer Res Campaign Tech Ionizing radiation or diathermy-switched gene therapy vectors and their use in antitumour therapy
EP1002864A1 (en) 1998-11-10 2000-05-24 Universita' degli studi di Bologna HIgR and related V domain for the manufacture of a medicament for preventing or treating HSV-1, HSV-2 and BHV infections
US6897057B1 (en) 1999-08-31 2005-05-24 The General Hospital Corporation Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression
GB9930418D0 (en) 1999-12-22 2000-02-16 Neurovex Ltd Replication incompetent herpes virus vectors
CA2441663C (en) 2001-03-27 2013-01-22 Medigene, Inc. Viral vectors and their use in therapeutic methods
WO2002088327A1 (en) 2001-04-06 2002-11-07 Mount Sinai School Of Medicine Of New York University Methods for viral oncoapoptosis in cancer therapy
CA2462790A1 (en) 2001-10-04 2003-04-10 Immunex Corporation Ul16 binding protein 4
KR100900249B1 (ko) 2001-12-07 2009-05-29 포항공과대학교 산학협력단 ＳＩＶｍａｃ239의 면역원성 플라스미드 및 이들을 함유한ＡＩＤＳ ＤＮＡ 백신
AU2003216502B2 (en) 2002-03-01 2008-04-10 Sloan-Kettering Institute For Cancer Research Prevention of recurrence and metastasis of cancer
US8927251B2 (en) 2002-10-07 2015-01-06 The University Of Chicago Targeting of herpes simplex virus to specific receptors
JP4999330B2 (ja) 2004-01-22 2012-08-15 株式会社ディナベック研究所 サイトメガロウイルスエンハンサーおよびニワトリβ−アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖ＲＮＡウイルスベクターの製造方法
GB0406389D0 (en) 2004-03-22 2004-04-21 Istituto Superiore Di Sanito Recombinant herpes simplex virus and uses therefor
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
CA2577692C (en) 2004-08-20 2014-05-06 Viralytics Limited Methods and compositions for treatment of hematologic cancers
WO2006050211A2 (en) 2004-10-28 2006-05-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
WO2006074526A1 (en) 2005-01-17 2006-07-20 Viralytics Limited Method and composition for treatment of neoplasms
PL2002003T3 (pl) 2005-05-27 2016-06-30 Ospedale San Raffaele Srl Wektor genetyczny zawierający mi-RNA
ES2398918T3 (es) 2005-08-26 2013-03-22 Dupont Nutrition Biosciences Aps Un método y una ordenación para soportar verticalmente elementos de resistencia eléctrica pendientes
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
US20080008686A1 (en) 2006-07-10 2008-01-10 The Brigham And Women's Hospital, Inc. Tetracycline repressor regulated oncolytic viruses
SI2049663T1 (sl) 2006-08-11 2015-12-31 Dow Agrosciences Llc Homologna rekombinacija, posredovana z nukleazo s cinkovim prstom
EP2125032A4 (en) 2007-02-20 2011-02-23 Mayo Foundation CANCER TREATMENT WITH VIRAL NUCLEIC ACID
US8586028B2 (en) 2007-05-09 2013-11-19 Board Of Supervisors Of Lousiana State University And Agricultural And Mechanical College Synthetic herpes simplex viruses type-1 for treatment of cancers
WO2008143875A1 (en) 2007-05-14 2008-11-27 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Targeted delivery of glycine receptors to excitable cells
WO2009111892A1 (en) 2008-03-14 2009-09-17 Ottawa Health Research Institute Microrna mediated oncolytic targeting
GB0807424D0 (en) 2008-04-23 2008-05-28 Isis Innovation Virus
EP2307033A4 (en) 2008-05-29 2012-06-13 Gen Hospital Corp USE OF ONCOLYTIC HERPESVIRUS FOR THE KILLING OF CANCER STEM CELLS
EP2700405B1 (en) 2008-05-29 2018-04-04 Alma Mater Studiorum -Universita' di Bologna Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof
GB0810912D0 (en) 2008-06-13 2008-07-23 Inst Animal Health Ltd Vector
WO2010011961A2 (en) 2008-07-25 2010-01-28 University Of Georgia Research Foundation, Inc. Prokaryotic rnai-like system and methods of use
US20100076057A1 (en) 2008-09-23 2010-03-25 Northwestern University TARGET DNA INTERFERENCE WITH crRNA
WO2010054108A2 (en) 2008-11-06 2010-05-14 University Of Georgia Research Foundation, Inc. Cas6 polypeptides and methods of use
MX337838B (es) 2008-11-07 2016-03-22 Dupont Nutrition Biosci Aps Secuencias de repetidos palindromicos cortos regularmente intercalados agrupados de bifidobacterias.
EP2406379A4 (en) 2009-03-13 2012-09-26 Egen Inc COMPOSITIONS AND METHODS FOR RELEASING BIOLOGICALLY ACTIVE RNA
US20100297072A1 (en) 2009-05-19 2010-11-25 Depinho Ronald A Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
WO2011119925A2 (en) 2010-03-25 2011-09-29 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Synthetic herpes simplex viruses for treatment of cancers
WO2011125469A1 (ja) 2010-04-09 2011-10-13 国立大学法人東京大学 マイクロrna制御組換えワクシニアウイルス及びその使用
US9593347B2 (en) 2010-04-16 2017-03-14 University of Pittsburgh—of the Commonwealth System of Higher Education Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-HSV receptors
WO2012006181A2 (en) 2010-06-29 2012-01-12 Mount Sinai School Of Medicine Compositions and methods for inhibiting oncogenic micrornas and treatment of cancer
CN103261213A (zh) 2010-10-20 2013-08-21 杜邦营养生物科学有限公司 乳球菌CRISPR-Cas序列
KR102068107B1 (ko) 2011-04-27 2020-01-20 아미리스 인코퍼레이티드 게놈 변형 방법
WO2012164565A1 (en) 2011-06-01 2012-12-06 Yeda Research And Development Co. Ltd. Compositions and methods for downregulating prokaryotic genes
EP2543734A1 (en) 2011-07-07 2013-01-09 Deutsches Krebsforschungszentrum Adeno-parvovirus chimera with enhanced oncolytical potential
EP2591796A1 (en) 2011-11-10 2013-05-15 Universität Zürich Combination medicament comprising IL-12 and an anti-CTLA-4 ligand for tumor therapy
US11951157B2 (en) 2011-10-11 2024-04-09 Universitat Zurich Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
CA3101783C (en) 2011-10-11 2023-01-31 Universitat Zurich Prorektorat Mnw Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
US20130156808A1 (en) 2011-11-22 2013-06-20 Stipan Jonjic Vaccine comprising beta-herpesvirus
GB201122458D0 (en) 2011-12-30 2012-02-08 Univ Wageningen Modified cascade ribonucleoproteins and uses thereof
US20140363469A1 (en) * 2012-01-19 2014-12-11 Alnylam Pharmaceuticals, Inc. Viral attenuation and vaccine production
RU2650811C2 (ru) 2012-02-24 2018-04-17 Фред Хатчинсон Кэнсер Рисерч Сентер Композиции и способы лечения гемоглобинопатии
WO2013141680A1 (en) 2012-03-20 2013-09-26 Vilnius University RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
US9637739B2 (en) 2012-03-20 2017-05-02 Vilnius University RNA-directed DNA cleavage by the Cas9-crRNA complex
CA2896282C (en) 2013-01-04 2021-07-20 Cytomx Therapeutics, Inc. Compositions and methods for detecting protease activity in biological systems
KR20250012194A (ko) * 2013-06-17 2025-01-23 더 브로드 인스티튜트, 인코퍼레이티드 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
JP6726824B2 (ja) 2013-07-17 2020-07-22 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 効率的な遺伝子送達用途のための非毒性ｈｓｖベクター及びその製造のための補完細胞
WO2015127501A1 (en) 2014-02-27 2015-09-03 Viralytics Limited Combination method for treatment of cancer
JP7348708B2 (ja) * 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
DK3169341T3 (da) 2014-07-16 2019-08-05 Transgene Sa Onkolytisk virus til ekspression af immun-checkpoint-modulatorer
US10647964B2 (en) 2015-03-05 2020-05-12 Northwestern University Non-neuroinvasive viruses and uses thereof
US10083137B2 (en) 2015-04-02 2018-09-25 Atmel Corporation Peripheral interface circuit for serial memory
US9884704B2 (en) 2015-08-04 2018-02-06 Ernesto A. Aguero-Hernandez Clip-clamp with top lock device and method
US10210575B1 (en) 2015-08-12 2019-02-19 State Farm Mutual Automobile Insurance Company System and method of using an image object as a visual data container
RU2766200C1 (ru) * 2015-10-01 2022-02-09 Хит Байолоджикс, Инк. Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков
JP6954648B2 (ja) 2015-10-19 2021-10-27 シージー オンコロジー， インコーポレイテッド 併用療法による固形腫瘍又はリンパ系腫瘍の治療方法
CN108601802A (zh) 2015-12-02 2018-09-28 纪念斯隆-凯特林癌症中心 塞尼卡谷病毒（svv）细胞受体靶向的肿瘤治疗
EA201891022A1 (ru) * 2015-12-17 2019-01-31 Псайоксус Терапьютикс Лимитед Вирус, кодирующий антитело к комплексу tcr или фрагмент указанного антитела
EP3778881A1 (en) 2016-01-08 2021-02-17 Replimune Limited Modified oncolytic virus
RU2749050C2 (ru) 2016-01-27 2021-06-03 Онкорус, Инк. Онколитические вирусные векторы и их применение
PL3426271T3 (pl) 2016-03-10 2025-11-24 Cg Oncology, Inc. Sposoby leczenia guzów litych terapią skojarzoną
KR102211838B1 (ko) 2016-04-22 2021-02-03 임비라 컴퍼니 리미티드 암치료용 종양 용해성 단순 헤르페스 바이러스(oHSV) 절대 벡터 및 그 구조체의 구조
CN109475613B (zh) 2016-06-14 2024-02-20 匹兹堡大学-属高等教育联邦体系 使癌细胞对胞毒免疫细胞攻击敏感的nkg2d活化配体蛋白表达
RU2021127872A (ru) * 2016-06-30 2021-11-09 Онкорус, Инк. Доставка терапевтических полипептидов посредством псевдотипированных онколитических вирусов
JP7200104B2 (ja) 2016-08-01 2023-01-06 ヴァイロジン バイオテック カナダ リミテッド 免疫系刺激分子を発現する腫瘍溶解性単純ヘルペスウイルスベクター
WO2018027316A1 (en) 2016-08-09 2018-02-15 Alkayyal Almohanad Oncolytic rhabdovirus expressing il12
CN119614520A (zh) * 2016-08-29 2025-03-14 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
WO2018049261A1 (en) 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus expressing immune checkpoint modulators
US20190275092A1 (en) 2016-11-01 2019-09-12 Dnatrix, Inc. Combination therapy for treatment of brain cancers
US11298420B2 (en) 2016-12-21 2022-04-12 Memgen, Llc Armed oncolytic viruses
EP3565578A1 (en) 2016-12-21 2019-11-13 Memgen LLC Armed replication-competent oncolytic adenoviruses
GB201700350D0 (en) 2017-01-09 2017-02-22 Replimune Ltd Altered virus
AU2018301701A1 (en) 2017-07-14 2020-02-27 Elevatebio Technologies, Inc. Encapsulated polynucleotides and methods of use
AU2018306455A1 (en) 2017-07-26 2020-02-27 Virogin Biotech Canada Ltd Oncolytic viral vectors and uses thereof
EP3875119A4 (en) 2018-10-30 2022-08-31 The University of Tokyo ONCOLYTIC VIRUS FOR CANCER THERAPY
EP3941514A4 (en) 2019-03-20 2023-08-30 Turnstone Biologics Inc. ONCOLYTIC VIROTHERAPY BY HETEROLOGY SEQUENTIAL BOOSTER
WO2020186356A1 (en) 2019-03-20 2020-09-24 Turnstone Biologics Inc. Methods for inducing an immune response against neoantigens
CA3157063A1 (en) 2019-10-10 2021-04-15 Oncorus, Inc. Dual viruses and dual oncolytic viruses and methods of treatment
US20220409684A1 (en) 2019-11-18 2022-12-29 The Brigham And Women's Hospital, Inc. Codon optimized new generation regulatable fusogenic oncolytic herpes simplex virus type 1 virus and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170035819A1 (en) * 2013-10-28 2017-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic hsv vector

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JHY-MING, et al, MicroRNA-145 regulates oncolytic herpes simplex virus-1 for selective killing of human non-small cell lung cancer cells, Virology journal, article number: 241б 2013, https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-10-241. ZHANG K-X et al, Intravesical treatment of advanced urothelial bladder cancers with oncolytic HSV-1 co-regulated by differentially expressed microRNAs, GENE THERAPY, (2016), vol. 23, no. 5, doi:10.1038/GT.2016.18, ISSN 0969-7128, pages 460 - 468, XP037325612 [I] 1-8,20-32, the whole document. М.В. ТАРАСОВА, и др., Онколитические вирусы в терапии глиом, Учебное пособие, Новосибирск, 2015, с.10-15. *
ZHANG K-X; MATSUI Y; LEE C; OSAMU O; SKINNER L; WANG J; SO A; RENNIE P S; JIA W W: "Intravesical treatment of advanced urothelial bladder cancers with oncolytic HSV-1 co-regulated by differentially expressed microRNAs", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 23, no. 5, 1 January 1900 (1900-01-01), GB , pages 460 - 468, XP037325612, ISSN: 0969-7128, DOI: 10.1038/gt.2016.18 *

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