RU2761631C2 - Белки rsv в предшествующей слиянию конформации и их применение - Google Patents
Белки rsv в предшествующей слиянию конформации и их применение Download PDFInfo
- Publication number
- RU2761631C2 RU2761631C2 RU2015142981A RU2015142981A RU2761631C2 RU 2761631 C2 RU2761631 C2 RU 2761631C2 RU 2015142981 A RU2015142981 A RU 2015142981A RU 2015142981 A RU2015142981 A RU 2015142981A RU 2761631 C2 RU2761631 C2 RU 2761631C2
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- Prior art keywords
- rsv
- protein
- immunogen
- polypeptide
- fusion
- Prior art date
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- 102000004169 proteins and genes Human genes 0.000 title claims abstract 9
- 108090000623 proteins and genes Proteins 0.000 title claims abstract 9
- 230000002163 immunogen Effects 0.000 claims abstract 41
- 230000028993 immune response Effects 0.000 claims abstract 8
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims abstract 6
- 230000001939 inductive effect Effects 0.000 claims abstract 5
- 241000724205 Rice stripe tenuivirus Species 0.000 claims 42
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 30
- 239000013598 vector Substances 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 8
- 239000002105 nanoparticle Substances 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 235000018102 proteins Nutrition 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 102000008857 Ferritin Human genes 0.000 claims 5
- 108050000784 Ferritin Proteins 0.000 claims 5
- 238000008416 Ferritin Methods 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 238000005829 trimerization reaction Methods 0.000 claims 5
- 241000283690 Bos taurus Species 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 241000711895 Bovine orthopneumovirus Species 0.000 claims 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 2
- 108030005146 Sulfur oxygenase/reductases Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
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- 235000001014 amino acid Nutrition 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 2
- -1 encapsulin Proteins 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
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- 108010068996 6,7-dimethyl-8-ribityllumazine synthase Proteins 0.000 claims 1
- 241000710929 Alphavirus Species 0.000 claims 1
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- 101710088194 Dehydrogenase Proteins 0.000 claims 1
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- 241000283073 Equus caballus Species 0.000 claims 1
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000711408 Murine respirovirus Species 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 102000002067 Protein Subunits Human genes 0.000 claims 1
- 108010001267 Protein Subunits Proteins 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 241000710961 Semliki Forest virus Species 0.000 claims 1
- 241000710960 Sindbis virus Species 0.000 claims 1
- 230000029662 T-helper 1 type immune response Effects 0.000 claims 1
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 1
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 229940037003 alum Drugs 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
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- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 101710160621 Fusion glycoprotein F0 Proteins 0.000 abstract 2
- 102100023206 Neuromodulin Human genes 0.000 abstract 1
- 101710132548 Protein F1 Proteins 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Images
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/135—Respiratory syncytial virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
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- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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- C—CHEMISTRY; METALLURGY
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- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2760/00011—Details
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- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18523—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
- Rehabilitation Therapy (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361780910P | 2013-03-13 | 2013-03-13 | |
| US61/780,910 | 2013-03-13 | ||
| US201361798389P | 2013-03-15 | 2013-03-15 | |
| US61/798,389 | 2013-03-15 | ||
| US201361857613P | 2013-07-23 | 2013-07-23 | |
| US61/857,613 | 2013-07-23 | ||
| US201361863909P | 2013-08-09 | 2013-08-09 | |
| US61/863,909 | 2013-08-09 | ||
| PCT/US2014/026714 WO2014160463A1 (en) | 2013-03-13 | 2014-03-13 | Prefusion rsv f proteins and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021132097A Division RU2852571C2 (ru) | 2013-03-13 | 2014-03-13 | Белки rsv f в предшествующей слиянию конформации и их применение |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2015142981A RU2015142981A (ru) | 2017-04-17 |
| RU2015142981A3 RU2015142981A3 (https=) | 2018-03-14 |
| RU2761631C2 true RU2761631C2 (ru) | 2021-12-13 |
Family
ID=51625430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015142981A RU2761631C2 (ru) | 2013-03-13 | 2014-03-13 | Белки rsv в предшествующей слиянию конформации и их применение |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US10017543B2 (https=) |
| EP (2) | EP2970398B1 (https=) |
| JP (4) | JP6703475B2 (https=) |
| KR (3) | KR20250023601A (https=) |
| CN (2) | CN105473604B (https=) |
| AU (5) | AU2014243756B2 (https=) |
| CA (1) | CA2902877C (https=) |
| DK (1) | DK2970398T3 (https=) |
| ES (1) | ES2981623T3 (https=) |
| FI (1) | FI2970398T3 (https=) |
| HR (1) | HRP20240996T1 (https=) |
| HU (1) | HUE067333T2 (https=) |
| LT (1) | LT2970398T (https=) |
| MX (2) | MX385818B (https=) |
| PL (1) | PL2970398T3 (https=) |
| PT (1) | PT2970398T (https=) |
| RS (1) | RS65760B1 (https=) |
| RU (1) | RU2761631C2 (https=) |
| SI (1) | SI2970398T1 (https=) |
| SM (1) | SMT202400297T1 (https=) |
| WO (1) | WO2014160463A1 (https=) |
Families Citing this family (155)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| CA2900110A1 (en) | 2013-02-01 | 2014-08-07 | Medimmune, Llc | Respiratory syncytial virus f protein epitopes |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| EP2970398B1 (en) | 2013-03-13 | 2024-05-08 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Prefusion rsv f proteins and their use |
| EP3798310A1 (en) | 2013-03-14 | 2021-03-31 | Emory University | Recombinant rsv with silent mutations, vaccines, and methods related thereto |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| KR102236497B1 (ko) | 2013-04-25 | 2021-04-06 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 예비융합 ｒｓｖ ｆ 폴리펩타이드 |
| CN105408348B (zh) | 2013-06-17 | 2021-07-06 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| US10125172B2 (en) | 2013-07-25 | 2018-11-13 | Calder Biosciences Inc. | Conformationally stabilized RSV pre-fusion F proteins |
| BR112016003361A2 (pt) | 2013-08-21 | 2017-11-21 | Curevac Ag | vacina do vírus sincicial respiratório (rsv) |
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