RU2727911C2 - Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения - Google Patents

Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения Download PDF

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RU2727911C2
RU2727911C2 RU2018100822A RU2018100822A RU2727911C2 RU 2727911 C2 RU2727911 C2 RU 2727911C2 RU 2018100822 A RU2018100822 A RU 2018100822A RU 2018100822 A RU2018100822 A RU 2018100822A RU 2727911 C2 RU2727911 C2 RU 2727911C2
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tau protein
amino acid
seq
antibody
acid sequence
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RU2018100822A
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RU2018100822A3 (enExample
RU2018100822A (ru
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Ян Торлейф ПЕДЕРСЕН
Ларс Остергаард ПЕДЕРСЕН
Джастус Клаус Альфред ДАЧСЕЛ
Эйодеджи Абдур-Рашид Асуни
Нина Розенквист
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Х. Лундбекк А/С
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • AHUMAN NECESSITIES
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
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    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

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RU2018100822A 2015-07-13 2016-07-12 Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения RU2727911C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1512211.2 2015-07-13
GBGB1512211.2A GB201512211D0 (en) 2015-07-13 2015-07-13 Agents, uses and methods
GB1518375.9 2015-10-16
GBGB1518375.9A GB201518375D0 (en) 2015-10-16 2015-10-16 Agents,uses and methods
PCT/EP2016/066470 WO2017009308A2 (en) 2015-07-13 2016-07-12 Antibodies specific for hyperphosphorylated tau and methods of use thereof

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RU2018100822A RU2018100822A (ru) 2019-08-13
RU2018100822A3 RU2018100822A3 (enExample) 2019-12-26
RU2727911C2 true RU2727911C2 (ru) 2020-07-24

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US (4) US10196439B2 (enExample)
EP (1) EP3322442A2 (enExample)
JP (1) JP6878395B2 (enExample)
KR (1) KR20180030047A (enExample)
CN (1) CN107847595B (enExample)
AU (1) AU2016292892B2 (enExample)
BR (1) BR112018000769A2 (enExample)
CL (1) CL2018000096A1 (enExample)
CO (1) CO2017013318A2 (enExample)
CR (1) CR20180026A (enExample)
DO (1) DOP2018000012A (enExample)
EA (1) EA038703B1 (enExample)
EC (1) ECSP18002644A (enExample)
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NI (1) NI201800005A (enExample)
PE (1) PE20180607A1 (enExample)
PH (1) PH12018500062A1 (enExample)
RU (1) RU2727911C2 (enExample)
SG (1) SG10202101343RA (enExample)
SV (1) SV2018005611A (enExample)
TN (1) TN2017000541A1 (enExample)
TW (1) TWI741987B (enExample)
UA (1) UA123862C2 (enExample)
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