RU2718055C2 - Производные 1,3-дигидроимидазол-2-тиона для применения в лечении легочной артериальной гипертензии и повреждения легкого - Google Patents
Производные 1,3-дигидроимидазол-2-тиона для применения в лечении легочной артериальной гипертензии и повреждения легкого Download PDFInfo
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- RU2718055C2 RU2718055C2 RU2015120164A RU2015120164A RU2718055C2 RU 2718055 C2 RU2718055 C2 RU 2718055C2 RU 2015120164 A RU2015120164 A RU 2015120164A RU 2015120164 A RU2015120164 A RU 2015120164A RU 2718055 C2 RU2718055 C2 RU 2718055C2
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- difluorochroman
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- dihydroimidazol
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261726119P | 2012-11-14 | 2012-11-14 | |
| US61/726,119 | 2012-11-14 | ||
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| GB201810395D0 (en) | 2018-06-25 | 2018-08-08 | Bial Portela & Ca Sa | Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation |
| WO2021005623A1 (en) * | 2019-07-08 | 2021-01-14 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A vaccine formulation for protection against enterotoxigenic e. coli (etec) and cholera |
| CN118598820B (zh) * | 2024-02-06 | 2025-07-08 | 石家庄四药有限公司 | 一种二苯基三嗪类化合物及其制备方法和应用 |
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| WO2007081232A1 (en) * | 2006-01-13 | 2007-07-19 | Bial- Portela & Ca, S.A. | Drug combinations |
| RU2332416C2 (ru) * | 2002-10-11 | 2008-08-27 | Портела Энд К.А., С.А. | Производные имидазола, способ их получения, фармацевтическая композиция на их основе, их применение в качестве периферически-селективных ингибиторов дофамин-бета-гидролазы и промежуточные соединения |
| WO2008136695A1 (en) * | 2007-05-08 | 2008-11-13 | Portela & Ca, S.A. | 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine-beta-hydroxylase |
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| JPH0623107B2 (ja) * | 1990-11-16 | 1994-03-30 | 帝人株式会社 | プロスタサイクリン類を有効成分とする薬学的組成物 |
| ES2201104T3 (es) * | 1994-04-26 | 2004-03-16 | Roche Palo Alto Llc | Derivados de benzociclohexilimidazoltiona. |
| TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| US20040102361A1 (en) * | 2002-11-27 | 2004-05-27 | Frederic Bodin | Pharmaceutical composition for the treatment of pulmonary arterial hypertension |
| GB0610804D0 (en) * | 2006-05-31 | 2006-07-12 | Portela & Ca Sa | New crystal forms |
| GB0700635D0 (en) * | 2007-01-12 | 2007-02-21 | Portela & Ca Sa | Therapy |
| WO2008137148A2 (en) * | 2007-05-03 | 2008-11-13 | Abraxis Bioscience, Llc | Methods and compositions for treating pulmonary hypertension |
| JP2011506315A (ja) * | 2007-12-05 | 2011-03-03 | バイアル−ポルテラ アンド シーエー，エス．エー． | 新たな塩、及び結晶形 |
| AU2008347005B2 (en) * | 2008-01-03 | 2013-10-03 | Biomarin Pharmaceutical Inc. | Pterin analog for treating BH4 responsive condition |
| AR070841A1 (es) * | 2008-03-13 | 2010-05-05 | Bial Portela & Ca Sa | Proceso de hidrogenacion catalitica asimetrica |
| AR071632A1 (es) * | 2008-05-06 | 2010-06-30 | Bial Portela & Ca Sa | Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa" |
| DE102008054205A1 (de) * | 2008-10-31 | 2010-05-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Helium-Sauerstoff-Gasgemischen zur Behandlung der pulmonalen arteriellen Hypertonie |
| PT2655363T (pt) * | 2010-12-22 | 2017-07-13 | Bial-Portela & Ca S A | Formas cristalinas e processos para a sua preparação |
| DK2919780T3 (en) | 2012-11-14 | 2018-11-26 | Bial Portela & Ca Sa | 1,3-Dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury |
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- 2013-11-14 EP EP13803292.5A patent/EP2919780B1/en active Active
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- 2013-11-14 WO PCT/PT2013/000065 patent/WO2014077715A1/en not_active Ceased
- 2013-11-14 LT LTEP13803292.5T patent/LT2919780T/lt unknown
- 2013-11-14 ES ES13803292.5T patent/ES2693025T3/es active Active
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- 2013-11-14 RU RU2015120164A patent/RU2718055C2/ru not_active Application Discontinuation
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2332416C2 (ru) * | 2002-10-11 | 2008-08-27 | Портела Энд К.А., С.А. | Производные имидазола, способ их получения, фармацевтическая композиция на их основе, их применение в качестве периферически-селективных ингибиторов дофамин-бета-гидролазы и промежуточные соединения |
| WO2007081232A1 (en) * | 2006-01-13 | 2007-07-19 | Bial- Portela & Ca, S.A. | Drug combinations |
| WO2008136695A1 (en) * | 2007-05-08 | 2008-11-13 | Portela & Ca, S.A. | 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine-beta-hydroxylase |
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