CY1120953T1 - Παραγωγα 1,3-διυδροϊμιδαζολο-2-θειονης για χρηση στην αγωγη πνευμονικης αρτηριακης υπερτασης και πνευμονικης βλαβης - Google Patents
Παραγωγα 1,3-διυδροϊμιδαζολο-2-θειονης για χρηση στην αγωγη πνευμονικης αρτηριακης υπερτασης και πνευμονικης βλαβηςInfo
- Publication number
- CY1120953T1 CY1120953T1 CY20181101117T CY181101117T CY1120953T1 CY 1120953 T1 CY1120953 T1 CY 1120953T1 CY 20181101117 T CY20181101117 T CY 20181101117T CY 181101117 T CY181101117 T CY 181101117T CY 1120953 T1 CY1120953 T1 CY 1120953T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pulmonary
- treatment
- dihydroimidazole
- damage
- artery hypertension
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση αφορά ενώσεις του τύπου I: για χρήση στην αγωγή της πνευμονικής αρτηριακής υπέρτασης και σχετιζομένων παθήσεων, όπου τα R1, R2 και R3 είναι τα ίδια ή διαφορετικά και σημαίνουν υδρογόνα, αλογόνα, αλκύλιο, αλκυλαρύλιο, αλκυλοξυ, υδροξυ, νιτρο, αμινο, αλκυλοκαρβονυλαμινο, αλκυλαμινο ή διαλκυλαμινο ομάδα· το R4 σημαίνει υδρογόνο, αλκύλιο, - αλκυλαρύλιο ή -αλκυλετεροαρύλιο· το Χ σημαίνει CH2, άτομο οξυγόνου ή άτομο θείου· το n είναι 1, 2 ή 3, με τον όρο ότι όταν το n είναι 1, το Χ δεν είναι CH2· και τα ξεχωριστά (R)- και (S)-εναντιομερή ή μείγματα εναντιομερών και φαρμακευτικά αποδεκτά άλατα αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261726119P | 2012-11-14 | 2012-11-14 | |
| PCT/PT2013/000065 WO2014077715A1 (en) | 2012-11-14 | 2013-11-14 | 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120953T1 true CY1120953T1 (el) | 2020-05-29 |
Family
ID=49759506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181101117T CY1120953T1 (el) | 2012-11-14 | 2018-10-30 | Παραγωγα 1,3-διυδροϊμιδαζολο-2-θειονης για χρηση στην αγωγη πνευμονικης αρτηριακης υπερτασης και πνευμονικης βλαβης |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US9604970B2 (el) |
| EP (1) | EP2919780B1 (el) |
| JP (1) | JP6373275B2 (el) |
| KR (1) | KR102259938B1 (el) |
| CN (1) | CN105025895B (el) |
| AU (1) | AU2013345494B2 (el) |
| BR (1) | BR112015010969B1 (el) |
| CA (1) | CA2890920C (el) |
| CY (1) | CY1120953T1 (el) |
| DK (1) | DK2919780T3 (el) |
| ES (1) | ES2693025T3 (el) |
| HK (1) | HK1215393A1 (el) |
| HR (1) | HRP20181651T1 (el) |
| IN (1) | IN2015DN04089A (el) |
| LT (1) | LT2919780T (el) |
| MX (1) | MX355422B (el) |
| PL (1) | PL2919780T3 (el) |
| PT (1) | PT2919780T (el) |
| RS (1) | RS57874B1 (el) |
| RU (1) | RU2718055C2 (el) |
| SI (1) | SI2919780T1 (el) |
| TR (1) | TR201815850T4 (el) |
| WO (1) | WO2014077715A1 (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2015DN04089A (el) | 2012-11-14 | 2015-10-09 | BIAL PORTELA & Cª S A | |
| GB201810395D0 (en) * | 2018-06-25 | 2018-08-08 | Bial Portela & Ca Sa | Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation |
| WO2021005623A1 (en) * | 2019-07-08 | 2021-01-14 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A vaccine formulation for protection against enterotoxigenic e. coli (etec) and cholera |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0623107B2 (ja) * | 1990-11-16 | 1994-03-30 | 帝人株式会社 | プロスタサイクリン類を有効成分とする薬学的組成物 |
| HUT76295A (en) * | 1994-04-26 | 1997-07-28 | Syntex Inc | Imidazolyl- and triazolyl-thion derivatives, pharmaceutical compositions containing them and process for producing them |
| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
| CA2412856A1 (en) * | 2002-11-27 | 2004-05-27 | Frederic Bodin | Pharmaceutical composition for the treatment of pulmonary arterial hypertension |
| GB0600709D0 (en) | 2006-01-13 | 2006-02-22 | Portela & Ca Sa | Drug combinations |
| GB0610804D0 (en) * | 2006-05-31 | 2006-07-12 | Portela & Ca Sa | New crystal forms |
| GB0700635D0 (en) | 2007-01-12 | 2007-02-21 | Portela & Ca Sa | Therapy |
| CA2686736A1 (en) * | 2007-05-03 | 2008-11-13 | Abraxis Bioscience, Llc | Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension |
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| JP2011506315A (ja) * | 2007-12-05 | 2011-03-03 | バイアル−ポルテラ アンド シーエー，エス．エー． | 新たな塩、及び結晶形 |
| AU2008347005B2 (en) * | 2008-01-03 | 2013-10-03 | Biomarin Pharmaceutical Inc. | Pterin analog for treating BH4 responsive condition |
| AR070841A1 (es) * | 2008-03-13 | 2010-05-05 | Bial Portela & Ca Sa | Proceso de hidrogenacion catalitica asimetrica |
| AR071632A1 (es) * | 2008-05-06 | 2010-06-30 | Bial Portela & Ca Sa | Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa" |
| DE102008054205A1 (de) * | 2008-10-31 | 2010-05-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Helium-Sauerstoff-Gasgemischen zur Behandlung der pulmonalen arteriellen Hypertonie |
| CN103380128B (zh) * | 2010-12-22 | 2017-03-01 | 拜欧波尔特拉及正大有限公司 | 晶型及其制备方法 |
| IN2015DN04089A (el) | 2012-11-14 | 2015-10-09 | BIAL PORTELA & Cª S A |
-
2013
- 2013-11-14 IN IN4089DEN2015 patent/IN2015DN04089A/en unknown
- 2013-11-14 DK DK13803292.5T patent/DK2919780T3/en active
- 2013-11-14 AU AU2013345494A patent/AU2013345494B2/en not_active Ceased
- 2013-11-14 RU RU2015120164A patent/RU2718055C2/ru not_active Application Discontinuation
- 2013-11-14 CN CN201380059547.2A patent/CN105025895B/zh not_active Expired - Fee Related
- 2013-11-14 ES ES13803292.5T patent/ES2693025T3/es active Active
- 2013-11-14 PL PL13803292T patent/PL2919780T3/pl unknown
- 2013-11-14 JP JP2015542997A patent/JP6373275B2/ja not_active Expired - Fee Related
- 2013-11-14 LT LTEP13803292.5T patent/LT2919780T/lt unknown
- 2013-11-14 BR BR112015010969-1A patent/BR112015010969B1/pt not_active IP Right Cessation
- 2013-11-14 PT PT13803292T patent/PT2919780T/pt unknown
- 2013-11-14 SI SI201331204T patent/SI2919780T1/sl unknown
- 2013-11-14 WO PCT/PT2013/000065 patent/WO2014077715A1/en active Application Filing
- 2013-11-14 TR TR2018/15850T patent/TR201815850T4/tr unknown
- 2013-11-14 US US14/441,043 patent/US9604970B2/en active Active
- 2013-11-14 MX MX2015005910A patent/MX355422B/es active IP Right Grant
- 2013-11-14 KR KR1020157014363A patent/KR102259938B1/ko active IP Right Grant
- 2013-11-14 RS RS20181204A patent/RS57874B1/sr unknown
- 2013-11-14 CA CA2890920A patent/CA2890920C/en not_active Expired - Fee Related
- 2013-11-14 EP EP13803292.5A patent/EP2919780B1/en active Active
-
2016
- 2016-03-23 HK HK16103398.4A patent/HK1215393A1/zh not_active IP Right Cessation
-
2017
- 2017-02-14 US US15/432,616 patent/US10308640B2/en not_active Expired - Fee Related
-
2018
- 2018-10-11 HR HRP20181651TT patent/HRP20181651T1/hr unknown
- 2018-10-30 CY CY20181101117T patent/CY1120953T1/el unknown
-
2019
- 2019-04-16 US US16/385,350 patent/US20190241545A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124117T1 (el) | Ετεροκυκλικες αλκυνυλοβενζολικες ενωσεις και ιατρικες συνθεσεις και χρησεις αυτων | |
| CY1122614T1 (el) | 11-υδροξυλ-6-υποκατεστημενα-παραγωγα χολικων οξεων και συζευγματα αμινοξεων αυτων ως ρυθμιστες υποδοχεων χ φαρνεσοειδων | |
| CY1119530T1 (el) | Συνθεσεις και μεθοδοι ρυθμισης toy fxr | |
| CY1120073T1 (el) | Παραγωγα πυραζολο-αμινοπυριμιδινης ως ρυθμιστες της lrrk2 | |
| CY1122610T1 (el) | Αλκοξυ πυραζολια ως ενεργοποιητες διαλυτης γουανυλικης κυκλασης | |
| CY1118102T1 (el) | Αλατα διαμινιου φαινοθειαζινης και η χρηση αυτων | |
| CY1119252T1 (el) | Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40 | |
| CY1111517T1 (el) | Παραγωγα 1,3-δ1υδροιμιδαζολο-2-θειονης ως αναστολεις της ντοπαμινης-βητα-υδροξυλασης | |
| EA201490647A1 (ru) | Производные бензотиазол-6-илуксусной кислоты и их применение для лечения вич-инфекции | |
| CY1117200T1 (el) | Παραγωγα βενζυλαμινης ως αναστολεις καλλικρεϊνης πλασματος | |
| CY1120953T1 (el) | Παραγωγα 1,3-διυδροϊμιδαζολο-2-θειονης για χρηση στην αγωγη πνευμονικης αρτηριακης υπερτασης και πνευμονικης βλαβης | |
| DOP2014000204A (es) | Compuestos de heterociclilo como inhibidores de mek | |
| EA201390766A1 (ru) | БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПОЛУЧЕНИЯ | |
| TR201905009T4 (tr) | Polisiklik-karbamoilpiridon bileşikleri ve bunların farmasötik kullanımları. | |
| CY1117792T1 (el) | Ανταγωνιστες toy trpv4 | |
| EA201490774A1 (ru) | Новые производные оксазина и их применение при лечении заболевания | |
| EA201591195A1 (ru) | Новые хинолоновые производные | |
| CY1119296T1 (el) | Ενωση δικαρβοξυλικου οξεος | |
| UY36073A (es) | ?2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4-d][1,3]TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILAMIDAS?. | |
| TR201900393T4 (tr) | 1,2-Dihidro-3H-Pirolo[1,2-C]İmidazol-3-On Türevleri Ve Bunların Antibakteriyel Ajanlar Olarak Kullanımı | |
| MX2012007896A (es) | Derivados de piridino-piridinonas arilsulfonamidas, su preparacion y su uso en terapeutica. | |
| CY1124643T1 (el) | Νεα ενωση και φαρμακευτικα αποδεκτο αλας αυτης | |
| TR201902057T4 (tr) | Tetrasiklin bileşikleri. | |
| MX364940B (es) | Compuestos. | |
| EA201001087A1 (ru) | Новые дигидроиндолоновые соединения, способ их получения и фармацевтические композиции, содержащие их |