TR201900393T4 - 1,2-Dihidro-3H-Pirolo[1,2-C]İmidazol-3-On Türevleri Ve Bunların Antibakteriyel Ajanlar Olarak Kullanımı - Google Patents

1,2-Dihidro-3H-Pirolo[1,2-C]İmidazol-3-On Türevleri Ve Bunların Antibakteriyel Ajanlar Olarak Kullanımı Download PDF

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Publication number
TR201900393T4
TR201900393T4 TR2019/00393T TR201900393T TR201900393T4 TR 201900393 T4 TR201900393 T4 TR 201900393T4 TR 2019/00393 T TR2019/00393 T TR 2019/00393T TR 201900393 T TR201900393 T TR 201900393T TR 201900393 T4 TR201900393 T4 TR 201900393T4
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TR
Turkey
Prior art keywords
pyrrolo
imidazol
dihydro
derivatives
antibacterial agents
Prior art date
Application number
TR2019/00393T
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English (en)
Inventor
Chapoux Gaelle
Gauvin Jean-Chri̇stophe
Panchaud Philippe
Specklin Jean-Luc
Surivet Jean-Philippe
Schmitt Christine
Mirre Azely
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of TR201900393T4 publication Critical patent/TR201900393T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Mevcut buluş formül I'in antibakteriyel bileşikleri ile ilgilidir, burada R1 aşağıda (AA) temsil edilen gruplardan biridir, burada A bir bağ, CH=CH veya C&#8801#&C'dir; U, N veya CH'dir; V, N veya CH'dir; W, N veya CH'yi temsil etmektedir; ve R1A, R2A, R3A, R1B ve R1C, ve bunların tuzları istemlerde açıklandığı gibidir.
TR2019/00393T 2014-03-04 2015-03-03 1,2-Dihidro-3H-Pirolo[1,2-C]İmidazol-3-On Türevleri Ve Bunların Antibakteriyel Ajanlar Olarak Kullanımı TR201900393T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04

Publications (1)

Publication Number Publication Date
TR201900393T4 true TR201900393T4 (tr) 2019-02-21

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ID=50189621

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TR2019/00393T TR201900393T4 (tr) 2014-03-04 2015-03-03 1,2-Dihidro-3H-Pirolo[1,2-C]İmidazol-3-On Türevleri Ve Bunların Antibakteriyel Ajanlar Olarak Kullanımı

Country Status (31)

Country Link
US (1) US10106544B2 (tr)
EP (1) EP3114126B1 (tr)
JP (1) JP6516370B2 (tr)
KR (1) KR20160127127A (tr)
CN (1) CN106061977B (tr)
AR (1) AR099612A1 (tr)
AU (1) AU2015226250B2 (tr)
BR (1) BR112016020278A8 (tr)
CA (1) CA2938383A1 (tr)
CL (1) CL2016002207A1 (tr)
CY (1) CY1121362T1 (tr)
DK (1) DK3114126T3 (tr)
EA (1) EA030708B1 (tr)
ES (1) ES2709382T3 (tr)
HR (1) HRP20190013T1 (tr)
HU (1) HUE042371T2 (tr)
IL (1) IL247544A0 (tr)
LT (1) LT3114126T (tr)
MA (1) MA39707B1 (tr)
MX (1) MX2016011380A (tr)
PH (1) PH12016501699A1 (tr)
PL (1) PL3114126T3 (tr)
PT (1) PT3114126T (tr)
SA (1) SA516371717B1 (tr)
SG (1) SG11201607304WA (tr)
SI (1) SI3114126T1 (tr)
TR (1) TR201900393T4 (tr)
TW (1) TW201542556A (tr)
UA (1) UA118868C2 (tr)
WO (1) WO2015132228A1 (tr)
ZA (1) ZA201606794B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
AR100428A1 (es) 2014-05-16 2016-10-05 Actelion Pharmaceuticals Ltd Derivados antibacterianos quinazolina-4(3h)-ona
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
JP2018531902A (ja) * 2015-08-28 2018-11-01 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性縮合ピロリジン−２−オン誘導体
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) * 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
CN117769548A (zh) * 2021-08-05 2024-03-26 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL401637A1 (pl) 2002-03-13 2013-05-27 Array Biopharma Inc. N3 alkilowane pochodne benzimidazolu jako inhibitory MEK
US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
CN101115725A (zh) 2004-12-10 2008-01-30 埃莫里大学 治疗病毒感染和异常细胞增殖的2’和3’-取代的环丁基核苷类似物
JP2008001635A (ja) 2006-06-22 2008-01-10 Toray Ind Inc グリシン誘導体及びその用途
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
KR20120006016A (ko) 2009-04-06 2012-01-17 다이이찌 산쿄 가부시키가이샤 치환 페닐기를 갖는 고리형 화합물
CA2760940A1 (en) 2009-05-20 2010-11-25 Ardea Biosciences, Inc. Methods of modulating uric acid levels
EP2451790A4 (en) 2009-07-07 2012-12-26 Anthem Biosciences Private Ltd INHIBITORS OF HISTONE DEACETYLASE
CA2774250C (en) * 2009-10-13 2013-12-17 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
US8664401B2 (en) 2009-12-16 2014-03-04 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
KR20140023869A (ko) 2010-11-10 2014-02-27 아카오젠, 인코포레이티드 하이드록삼산 유도체 및 세균 감염 치료에서의 이들의 사용
US8853213B2 (en) 2011-01-03 2014-10-07 Hanmi Pharm. Co., Ltd Bicyclic compound for modulating G protein-coupled receptors
AU2012226473B8 (en) * 2011-03-07 2015-10-15 Pfizer Inc. Fluoro-pyridinone derivatives useful as antibacterial agents
WO2012137099A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
KR20130140868A (ko) * 2011-04-08 2013-12-24 화이자 인코포레이티드 항세균제로서 유용한 이속사졸 유도체
US8859559B2 (en) 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
EP2847162A1 (en) 2012-05-09 2015-03-18 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) * 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
AR100428A1 (es) 2014-05-16 2016-10-05 Actelion Pharmaceuticals Ltd Derivados antibacterianos quinazolina-4(3h)-ona
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
JP2018531902A (ja) 2015-08-28 2018-11-01 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性縮合ピロリジン−２−オン誘導体
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
CN108368053A (zh) 2015-12-08 2018-08-03 葛兰素史密斯克莱知识产权发展有限公司 作为抗菌化合物的取代的苯并氮杂环己烯酮

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AR099612A1 (es) 2016-08-03
ZA201606794B (en) 2018-11-28
PH12016501699A1 (en) 2016-10-03
JP6516370B2 (ja) 2019-05-22
AU2015226250B2 (en) 2018-12-13
EP3114126B1 (en) 2018-10-31
AU2015226250A1 (en) 2016-10-20
SG11201607304WA (en) 2016-09-29
CL2016002207A1 (es) 2017-03-24
US20170107223A1 (en) 2017-04-20
SA516371717B1 (ar) 2018-10-25
WO2015132228A1 (en) 2015-09-11
LT3114126T (lt) 2018-12-27
MA39707A (fr) 2017-01-11
DK3114126T3 (en) 2019-02-25
CA2938383A1 (en) 2015-09-11
EA201691775A1 (ru) 2017-03-31
KR20160127127A (ko) 2016-11-02
ES2709382T3 (es) 2019-04-16
IL247544A0 (en) 2016-11-30
BR112016020278A2 (tr) 2017-08-15
JP2017508746A (ja) 2017-03-30
HRP20190013T1 (hr) 2019-02-22
MX2016011380A (es) 2016-12-07
PL3114126T3 (pl) 2019-03-29
BR112016020278A8 (pt) 2017-12-26
CN106061977A (zh) 2016-10-26
HUE042371T2 (hu) 2019-06-28
SI3114126T1 (sl) 2019-01-31
CY1121362T1 (el) 2020-05-29
EP3114126A1 (en) 2017-01-11
MA39707B1 (fr) 2019-01-31
TW201542556A (zh) 2015-11-16
US10106544B2 (en) 2018-10-23
EA030708B1 (ru) 2018-09-28
PT3114126T (pt) 2019-02-06
CN106061977B (zh) 2018-10-26
UA118868C2 (uk) 2019-03-25

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