HRP20190013T1 - Derivati 1,2-dihidro-3h-pirolo[1,2 -c]imidazol-3-ona i njihova uporaba kao antibakterijska sredstva - Google Patents

Derivati 1,2-dihidro-3h-pirolo[1,2 -c]imidazol-3-ona i njihova uporaba kao antibakterijska sredstva

Info

Publication number
HRP20190013T1
HRP20190013T1 HRP20190013TT HRP20190013T HRP20190013T1 HR P20190013 T1 HRP20190013 T1 HR P20190013T1 HR P20190013T T HRP20190013T T HR P20190013TT HR P20190013 T HRP20190013 T HR P20190013T HR P20190013 T1 HRP20190013 T1 HR P20190013T1
Authority
HR
Croatia
Prior art keywords
pyrrolo
imidazol
dihydro
derivatives
antibacterial agents
Prior art date
Application number
HRP20190013TT
Other languages
English (en)
Inventor
Gaelle CHAPOUX
Jean-Christophe Gauvin
Philippe Panchaud
Jean-Luc Specklin
Jean-Philippe Surivet
Christine Schmitt
Azely MIRRE
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of HRP20190013T1 publication Critical patent/HRP20190013T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HRP20190013TT 2014-03-04 2019-01-02 Derivati 1,2-dihidro-3h-pirolo[1,2 -c]imidazol-3-ona i njihova uporaba kao antibakterijska sredstva HRP20190013T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04
EP15707154.9A EP3114126B1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents
PCT/EP2015/054358 WO2015132228A1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
HRP20190013T1 true HRP20190013T1 (hr) 2019-02-22

Family

ID=50189621

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20190013TT HRP20190013T1 (hr) 2014-03-04 2019-01-02 Derivati 1,2-dihidro-3h-pirolo[1,2 -c]imidazol-3-ona i njihova uporaba kao antibakterijska sredstva

Country Status (31)

Country Link
US (1) US10106544B2 (hr)
EP (1) EP3114126B1 (hr)
JP (1) JP6516370B2 (hr)
KR (1) KR20160127127A (hr)
CN (1) CN106061977B (hr)
AR (1) AR099612A1 (hr)
AU (1) AU2015226250B2 (hr)
BR (1) BR112016020278A8 (hr)
CA (1) CA2938383A1 (hr)
CL (1) CL2016002207A1 (hr)
CY (1) CY1121362T1 (hr)
DK (1) DK3114126T3 (hr)
EA (1) EA030708B1 (hr)
ES (1) ES2709382T3 (hr)
HR (1) HRP20190013T1 (hr)
HU (1) HUE042371T2 (hr)
IL (1) IL247544A0 (hr)
LT (1) LT3114126T (hr)
MA (1) MA39707B1 (hr)
MX (1) MX2016011380A (hr)
PH (1) PH12016501699A1 (hr)
PL (1) PL3114126T3 (hr)
PT (1) PT3114126T (hr)
SA (1) SA516371717B1 (hr)
SG (1) SG11201607304WA (hr)
SI (1) SI3114126T1 (hr)
TR (1) TR201900393T4 (hr)
TW (1) TW201542556A (hr)
UA (1) UA118868C2 (hr)
WO (1) WO2015132228A1 (hr)
ZA (1) ZA201606794B (hr)

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Publication number Priority date Publication date Assignee Title
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
EP3083567B1 (en) 2013-12-19 2018-03-07 Idorsia Pharmaceuticals Ltd Antibacterial 1h-indazole and 1h-indole derivatives
CA2948077A1 (en) 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
EA201890600A1 (ru) * 2015-08-28 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные аннелированные производные пирролидин-2-она
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
CN117769548A (zh) * 2021-08-05 2024-03-26 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和用途

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PT2275102E (pt) 2002-03-13 2015-10-27 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US7495006B2 (en) 2004-12-10 2009-02-24 Emory University 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
JP2008001635A (ja) 2006-06-22 2008-01-10 Toray Ind Inc グリシン誘導体及びその用途
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
AU2010235619A1 (en) 2009-04-06 2011-11-10 Daiichi Sankyo Company, Limited Cyclic compound having substituted phenyl group
US8372807B2 (en) 2009-05-20 2013-02-12 Ardea Biosciences, Inc. Methods of modulating uric acid levels
EP2451790A4 (en) 2009-07-07 2012-12-26 Anthem Biosciences Private Ltd INHIBITORS OF HISTONE DEACETYLASE
EP2488489A2 (en) * 2009-10-13 2012-08-22 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
CA2782453C (en) 2009-12-16 2015-11-24 Matthew Frank Brown N-linked hydroxamic acid derivatives useful as antibacterial agents
BR112013011693A2 (pt) 2010-11-10 2016-08-09 Achaogen Inc derivados de ácido hidroxâmico e seu uso no tratamento de infecções por bactérias
WO2012093809A2 (en) 2011-01-03 2012-07-12 Hanmi Pharm Co., Ltd. New bicyclic compound for modulating g protein-coupled receptors
MX341977B (es) * 2011-03-07 2016-09-07 Pfizer Derivados de fluoro-piridinona utiles como agentes antibacterianos.
CA2830866A1 (en) * 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
CA2830920C (en) * 2011-04-08 2015-07-14 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
US8859559B2 (en) 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
EP2847162A1 (en) 2012-05-09 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
EP3083567B1 (en) 2013-12-19 2018-03-07 Idorsia Pharmaceuticals Ltd Antibacterial 1h-indazole and 1h-indole derivatives
CA2948077A1 (en) 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
EA201890600A1 (ru) 2015-08-28 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные аннелированные производные пирролидин-2-она
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
CA3007653A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Substituted benzazinones as antibacterial compounds

Also Published As

Publication number Publication date
IL247544A0 (en) 2016-11-30
EP3114126A1 (en) 2017-01-11
BR112016020278A2 (hr) 2017-08-15
US10106544B2 (en) 2018-10-23
PH12016501699A1 (en) 2016-10-03
MA39707B1 (fr) 2019-01-31
JP2017508746A (ja) 2017-03-30
SI3114126T1 (sl) 2019-01-31
BR112016020278A8 (pt) 2017-12-26
CL2016002207A1 (es) 2017-03-24
DK3114126T3 (en) 2019-02-25
ES2709382T3 (es) 2019-04-16
PL3114126T3 (pl) 2019-03-29
AU2015226250B2 (en) 2018-12-13
KR20160127127A (ko) 2016-11-02
CA2938383A1 (en) 2015-09-11
EP3114126B1 (en) 2018-10-31
TW201542556A (zh) 2015-11-16
CY1121362T1 (el) 2020-05-29
AU2015226250A1 (en) 2016-10-20
AR099612A1 (es) 2016-08-03
MX2016011380A (es) 2016-12-07
EA030708B1 (ru) 2018-09-28
MA39707A (fr) 2017-01-11
LT3114126T (lt) 2018-12-27
EA201691775A1 (ru) 2017-03-31
TR201900393T4 (tr) 2019-02-21
UA118868C2 (uk) 2019-03-25
HUE042371T2 (hu) 2019-06-28
ZA201606794B (en) 2018-11-28
SA516371717B1 (ar) 2018-10-25
CN106061977B (zh) 2018-10-26
PT3114126T (pt) 2019-02-06
WO2015132228A1 (en) 2015-09-11
US20170107223A1 (en) 2017-04-20
JP6516370B2 (ja) 2019-05-22
CN106061977A (zh) 2016-10-26
SG11201607304WA (en) 2016-09-29

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