SA516371717B1 - مشتقات 1، 2- داي هيدرو -3H- بيرولو [1، 2-c] إيميدازول -3- أون مضادة للبكتريا - Google Patents

مشتقات 1، 2- داي هيدرو -3H- بيرولو [1، 2-c] إيميدازول -3- أون مضادة للبكتريا

Info

Publication number
SA516371717B1
SA516371717B1 SA516371717A SA516371717A SA516371717B1 SA 516371717 B1 SA516371717 B1 SA 516371717B1 SA 516371717 A SA516371717 A SA 516371717A SA 516371717 A SA516371717 A SA 516371717A SA 516371717 B1 SA516371717 B1 SA 516371717B1
Authority
SA
Saudi Arabia
Prior art keywords
antibacterial
pyrrolo
imidazol
dihydro
derivatives
Prior art date
Application number
SA516371717A
Other languages
English (en)
Inventor
فيليب بانشاود
جين- كريستوف جاوفين
جين لوك سبيكلين
جين فيليب سوريفيت
جيل شابوكس
كريستيان شيميت
ازيلى مير
Original Assignee
اكتيليون فارماسوتيكالز ال تي دي
ايدورسيا فارماسوتيكالز ليمتد
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by اكتيليون فارماسوتيكالز ال تي دي, ايدورسيا فارماسوتيكالز ليمتد filed Critical اكتيليون فارماسوتيكالز ال تي دي
Publication of SA516371717B1 publication Critical patent/SA516371717B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

يتعلق الاختراع بمركبات مضادة للبكتريا antibacterial compounds بالصيغة I I حيث R1 هي واحدة من المجموعات الممثلة أدناه MC حيث A هي رابطة، CH=CH أو C≡C؛ U هي N أو CH؛ V هي N أو CH؛ W تمثل N أو CH؛ وR1A، R2A، R3A، R1B وR1C تكون وفقاً لعناصر الحماية؛ وأملاح منها.
SA516371717A 2014-03-04 2016-08-23 مشتقات 1، 2- داي هيدرو -3H- بيرولو [1، 2-c] إيميدازول -3- أون مضادة للبكتريا SA516371717B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04
PCT/EP2015/054358 WO2015132228A1 (en) 2014-03-04 2015-03-03 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
SA516371717B1 true SA516371717B1 (ar) 2018-10-25

Family

ID=50189621

Family Applications (1)

Application Number Title Priority Date Filing Date
SA516371717A SA516371717B1 (ar) 2014-03-04 2016-08-23 مشتقات 1، 2- داي هيدرو -3H- بيرولو [1، 2-c] إيميدازول -3- أون مضادة للبكتريا

Country Status (31)

Country Link
US (1) US10106544B2 (ar)
EP (1) EP3114126B1 (ar)
JP (1) JP6516370B2 (ar)
KR (1) KR20160127127A (ar)
CN (1) CN106061977B (ar)
AR (1) AR099612A1 (ar)
AU (1) AU2015226250B2 (ar)
BR (1) BR112016020278A8 (ar)
CA (1) CA2938383A1 (ar)
CL (1) CL2016002207A1 (ar)
CY (1) CY1121362T1 (ar)
DK (1) DK3114126T3 (ar)
EA (1) EA030708B1 (ar)
ES (1) ES2709382T3 (ar)
HR (1) HRP20190013T1 (ar)
HU (1) HUE042371T2 (ar)
IL (1) IL247544A0 (ar)
LT (1) LT3114126T (ar)
MA (1) MA39707B1 (ar)
MX (1) MX2016011380A (ar)
PH (1) PH12016501699A1 (ar)
PL (1) PL3114126T3 (ar)
PT (1) PT3114126T (ar)
SA (1) SA516371717B1 (ar)
SG (1) SG11201607304WA (ar)
SI (1) SI3114126T1 (ar)
TR (1) TR201900393T4 (ar)
TW (1) TW201542556A (ar)
UA (1) UA118868C2 (ar)
WO (1) WO2015132228A1 (ar)
ZA (1) ZA201606794B (ar)

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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
EA030730B1 (ru) 2013-12-19 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные производные 1h-индазола и 1h-индола
US9796686B2 (en) 2014-05-16 2017-10-24 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3H)-one derivatives
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
JP2018531902A (ja) * 2015-08-28 2018-11-01 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性縮合ピロリジン−２−オン誘導体
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
CN117769548A (zh) * 2021-08-05 2024-03-26 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和用途

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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
EA030730B1 (ru) 2013-12-19 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные производные 1h-индазола и 1h-индола
US9796686B2 (en) 2014-05-16 2017-10-24 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3H)-one derivatives
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JP2018531902A (ja) 2015-08-28 2018-11-01 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性縮合ピロリジン−２−オン誘導体
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
CA3007653A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Substituted benzazinones as antibacterial compounds

Also Published As

Publication number Publication date
MX2016011380A (es) 2016-12-07
EP3114126B1 (en) 2018-10-31
LT3114126T (lt) 2018-12-27
JP2017508746A (ja) 2017-03-30
EA030708B1 (ru) 2018-09-28
CL2016002207A1 (es) 2017-03-24
SG11201607304WA (en) 2016-09-29
WO2015132228A1 (en) 2015-09-11
EA201691775A1 (ru) 2017-03-31
UA118868C2 (uk) 2019-03-25
AU2015226250A1 (en) 2016-10-20
JP6516370B2 (ja) 2019-05-22
EP3114126A1 (en) 2017-01-11
ES2709382T3 (es) 2019-04-16
CA2938383A1 (en) 2015-09-11
KR20160127127A (ko) 2016-11-02
ZA201606794B (en) 2018-11-28
US10106544B2 (en) 2018-10-23
CN106061977A (zh) 2016-10-26
SI3114126T1 (sl) 2019-01-31
TW201542556A (zh) 2015-11-16
AU2015226250B2 (en) 2018-12-13
CY1121362T1 (el) 2020-05-29
HRP20190013T1 (hr) 2019-02-22
TR201900393T4 (tr) 2019-02-21
BR112016020278A8 (pt) 2017-12-26
MA39707B1 (fr) 2019-01-31
PL3114126T3 (pl) 2019-03-29
PT3114126T (pt) 2019-02-06
US20170107223A1 (en) 2017-04-20
AR099612A1 (es) 2016-08-03
IL247544A0 (en) 2016-11-30
HUE042371T2 (hu) 2019-06-28
DK3114126T3 (en) 2019-02-25
PH12016501699A1 (en) 2016-10-03
BR112016020278A2 (ar) 2017-08-15
MA39707A (fr) 2017-01-11
CN106061977B (zh) 2018-10-26

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