MX364940B - Compuestos. - Google Patents

Compuestos.

Info

Publication number
MX364940B
MX364940B MX2015001374A MX2015001374A MX364940B MX 364940 B MX364940 B MX 364940B MX 2015001374 A MX2015001374 A MX 2015001374A MX 2015001374 A MX2015001374 A MX 2015001374A MX 364940 B MX364940 B MX 364940B
Authority
MX
Mexico
Prior art keywords
compounds
optionally substituted
hydrogen atom
methods
substituted alkyl
Prior art date
Application number
MX2015001374A
Other languages
English (en)
Other versions
MX2015001374A (es
Inventor
Erik Braenden Jon
Klaveness Jo
Olav Nilsen Nils
Godal Aslak
Barry Charnock Colin
Original Assignee
Photocure Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure Asa filed Critical Photocure Asa
Publication of MX2015001374A publication Critical patent/MX2015001374A/es
Publication of MX364940B publication Critical patent/MX364940B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a nuevos derivados del ácido 5-aminolevulínico (5-ALA) y su uso como agentes fotosensibilizantes. En particular, se relaciona a compuestos de fórmula I general y su sal farmacéuticamente aceptable , a los métodos para la preparación de tales compuestos y su uso médico y cosmético, por ejemplo en métodos de diagnóstico y terapia fotodinámica: (ver fórmula) En donde R1 representa un átomo de hidrógeno o un grupo alquilo o cicloalquilo opcionalmente sustituido; R2, cada uno del cual puede ser el mismo o diferente, representa un átomo de hidrógeno o un grupo de alquilo opcionalmente sustituido; y x es un grupo vinculante.
MX2015001374A 2012-08-03 2013-08-02 Compuestos. MX364940B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12179277 2012-08-03
EP12197305 2012-12-14
PCT/EP2013/066317 WO2014020164A1 (en) 2012-08-03 2013-08-02 Compounds

Publications (2)

Publication Number Publication Date
MX2015001374A MX2015001374A (es) 2015-09-07
MX364940B true MX364940B (es) 2019-05-15

Family

ID=48948407

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001374A MX364940B (es) 2012-08-03 2013-08-02 Compuestos.

Country Status (19)

Country Link
US (1) US9249086B2 (es)
EP (1) EP2880012B1 (es)
JP (1) JP6280117B2 (es)
KR (1) KR102180174B1 (es)
CN (1) CN104661994B (es)
AU (1) AU2013298525B2 (es)
BR (1) BR112015002390B1 (es)
CA (1) CA2880422C (es)
CL (1) CL2015000233A1 (es)
ES (1) ES2908080T3 (es)
HK (1) HK1211283A1 (es)
IL (1) IL236965B (es)
IN (1) IN2015DN00837A (es)
MX (1) MX364940B (es)
NZ (1) NZ629914A (es)
RU (1) RU2635563C2 (es)
SG (1) SG11201500805VA (es)
WO (1) WO2014020164A1 (es)
ZA (1) ZA201500778B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10716855B2 (en) * 2013-12-20 2020-07-21 Galderma Research & Development Pulse photodynamic treatment of photodamaged skin
CA2999367C (en) * 2015-09-23 2023-09-26 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
CN108697800A (zh) * 2015-12-17 2018-10-23 光治疗Asa公司 用于膀胱癌的光动力疗法（pdt）的方法
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN106187793A (zh) * 2016-01-26 2016-12-07 赵鸣 5‑氨基酮戊酸及其衍生物的盐化合物和应用
WO2018234509A1 (en) * 2017-06-21 2018-12-27 Photocure Asa PROCESS FOR PREPARING A LIQUID PHARMACEUTICAL COMPOSITION AND DEVICE FOR USE IN SUCH A METHOD
JP7474773B2 (ja) 2019-02-13 2024-04-25 アルフェウス メディカル，インク． 非侵襲的音響化学療法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07188133A (ja) 1993-12-27 1995-07-25 Asahi Chem Ind Co Ltd δ−アミノレブリン酸またはその同族体の製造法
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6034267A (en) * 1995-03-10 2000-03-07 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
JPH1112197A (ja) 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk 悪性腫瘍診断剤及び治療剤
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
DE10202487A1 (de) 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermales Applikationssystem für Aminolävulinsäure-Derivate
DE10312659A1 (de) 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
JP4417865B2 (ja) 2004-03-30 2010-02-17 コスモ石油株式会社 ５−アミノレブリン酸リン酸塩、その製造方法及びその用途
JP4719483B2 (ja) 2004-03-30 2011-07-06 コスモ石油株式会社 ５−アミノレブリン酸スルホン酸塩の製造方法
ES2355978T3 (es) * 2004-03-30 2011-04-01 Cosmo Oil Co., Ltd. Sal de fosfato de ácido 5-aminolevulinico, proceso para producir la misma y uso de la misma.
GB0424833D0 (en) * 2004-11-10 2004-12-15 Photocure Asa Method
JP5404995B2 (ja) 2006-08-10 2014-02-05 コスモ石油株式会社 植物のポリフェノール増量剤
JP5039389B2 (ja) 2007-02-02 2012-10-03 コスモ石油株式会社 ホップのアルファ酸又はホップオイル含量向上剤
PT2130435E (pt) 2007-03-30 2015-11-30 Cosmo Ala Co Ltd Agente para melhorar a resistência de plantas a bases e método para melhorar a resistência de plantas a bases
JP4705616B2 (ja) 2007-07-20 2011-06-22 コスモ石油株式会社 植物における金属成分の吸収向上剤
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
AU2008337067A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods
ES2822122T3 (es) 2008-04-22 2021-04-29 Sbi Pharmaceuticals Co Ltd Método de detección del cáncer de vejiga
EP2274979B8 (en) 2008-05-13 2016-10-12 COSMO TRaDE & SERVICE CO., LTD. Agent for improving lawn grass qualities
JP5276894B2 (ja) 2008-05-13 2013-08-28 コスモ石油株式会社 イネの健苗育成向上剤
JP5323539B2 (ja) 2009-03-11 2013-10-23 コスモ石油株式会社 農作物の収穫部位の収量向上剤

Also Published As

Publication number Publication date
BR112015002390B1 (pt) 2020-03-24
KR102180174B1 (ko) 2020-11-19
US9249086B2 (en) 2016-02-02
NZ629914A (en) 2017-02-24
AU2013298525B2 (en) 2017-12-14
BR112015002390A2 (pt) 2017-07-04
BR112015002390A8 (pt) 2019-07-30
SG11201500805VA (en) 2015-02-27
US20150191419A1 (en) 2015-07-09
CN104661994B (zh) 2017-08-08
KR20150039208A (ko) 2015-04-09
ES2908080T3 (es) 2022-04-27
MX2015001374A (es) 2015-09-07
CL2015000233A1 (es) 2015-04-24
RU2635563C2 (ru) 2017-11-14
AU2013298525A1 (en) 2015-03-05
CA2880422C (en) 2021-02-09
CA2880422A1 (en) 2014-02-06
JP6280117B2 (ja) 2018-02-14
WO2014020164A1 (en) 2014-02-06
HK1211283A1 (en) 2016-05-20
EP2880012B1 (en) 2021-12-15
ZA201500778B (en) 2016-04-28
CN104661994A (zh) 2015-05-27
IN2015DN00837A (es) 2015-06-12
JP2015528814A (ja) 2015-10-01
RU2015104830A (ru) 2016-09-27
EP2880012A1 (en) 2015-06-10
IL236965B (en) 2019-03-31

Similar Documents

Publication Publication Date Title
MX364940B (es) Compuestos.
CY1124882T1 (el) Αναλογα 1,4-διϋποκατεστημενης πυριδαζινης και μεθοδοι για την θεραπευτικη αγωγη καταστασεων συναφων με ανεπαρκεια smn
EA201490647A1 (ru) Производные бензотиазол-6-илуксусной кислоты и их применение для лечения вич-инфекции
CU20140110A7 (es) Compuestos heterocíclicos como inhibidores de mek
NZ739760A (en) Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
EA201301154A1 (ru) Разветвленные производные 3-фенилпропионовой кислоты и их применение
CR20140399A (es) Pirrolidina-2-carboxamidas sustituidas
NZ627274A (en) Anesthetic compounds and related methods of use
MX361458B (es) Compuestos de pirimido-piridazinona y uso de los mismos.
EA201492023A1 (ru) Регуляторы пути комплемента и их применение
EA201792597A2 (ru) Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения
MX2013008340A (es) Novedosas 4-amino-n-hidroxi-benzamidas para el tratamiento de cancer.
GB201209587D0 (en) Therapeutic compounds
NZ603465A (en) Antimalarial drug which contains 5-aminolevulinic acid or derivative thereof as active ingredient
PH12015502429A1 (en) Dicarboxylic acid compound
TR201902057T4 (tr) Tetrasiklin bileşikleri.
MX348979B (es) Agente de control de enfermedades de las plantas.
PH12015500012B1 (en) Benzodioxole derivative and preparation method and use thereof
MX2013002620A (es) Novedosas n-hidroxi-benzamidas para el tratamiento del cancer.
EA201491878A1 (ru) Замещенные ксантиновые производные
MX345264B (es) Derivado de azol.
MX2015002705A (es) Compuestos de piridinona para usarse en terapia fotodinamica.
NZ620300A (en) Method for treating schizophrenia
BR112015032180A2 (pt) método de preparação de derivados de pirrolidina-2-ácido carboxílico
UA111982C2 (uk) Похідні бензотіазол-6-ілоцтової кислоти та їх застосування для лікування віл-інфекції

Legal Events

Date Code Title Description
FG Grant or registration