RU2710366C1 - Термочувствительная гелеобразующая искусственная слеза - Google Patents

Термочувствительная гелеобразующая искусственная слеза Download PDF

Info

Publication number
RU2710366C1
RU2710366C1 RU2019123442A RU2019123442A RU2710366C1 RU 2710366 C1 RU2710366 C1 RU 2710366C1 RU 2019123442 A RU2019123442 A RU 2019123442A RU 2019123442 A RU2019123442 A RU 2019123442A RU 2710366 C1 RU2710366 C1 RU 2710366C1
Authority
RU
Russia
Prior art keywords
viscosity
present
composition
dost
qty
Prior art date
Application number
RU2019123442A
Other languages
English (en)
Russian (ru)
Inventor
Такеси ЯМАМУРА
Аяка ЯМАМУРО
Эми ИЗУКУРА
Мото КИМУРА
Томохиро ОЦУКА
Original Assignee
Вакамото Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вакамото Фармасьютикал Ко., Лтд. filed Critical Вакамото Фармасьютикал Ко., Лтд.
Application granted granted Critical
Publication of RU2710366C1 publication Critical patent/RU2710366C1/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/717Celluloses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
RU2019123442A 2017-04-25 2018-04-25 Термочувствительная гелеобразующая искусственная слеза RU2710366C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2017-086512 2017-04-25
JP2017086512 2017-04-25
JP2017249891 2017-12-26
JP2017-249891 2017-12-26
PCT/JP2018/016854 WO2018199180A1 (ja) 2017-04-25 2018-04-25 熱ゲル化人工涙液

Publications (1)

Publication Number Publication Date
RU2710366C1 true RU2710366C1 (ru) 2019-12-26

Family

ID=63919901

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019123442A RU2710366C1 (ru) 2017-04-25 2018-04-25 Термочувствительная гелеобразующая искусственная слеза

Country Status (16)

Country Link
US (2) US10532026B2 (https=)
EP (1) EP3593806B1 (https=)
JP (2) JP6473274B1 (https=)
KR (2) KR102281853B1 (https=)
CN (2) CN110913867B (https=)
AU (1) AU2018257301B2 (https=)
BR (1) BR112019018368B1 (https=)
CA (1) CA3025567C (https=)
ES (1) ES2912289T3 (https=)
MX (2) MX379302B (https=)
MY (2) MY196565A (https=)
PH (1) PH12019502335A1 (https=)
RU (1) RU2710366C1 (https=)
SG (1) SG11201909170QA (https=)
TW (1) TWI733019B (https=)
WO (1) WO2018199180A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117137866A (zh) * 2018-02-28 2023-12-01 参天制药株式会社 含有地夸磷索及阳离子性聚合物的眼科用组合物
AU2019228913C1 (en) * 2018-03-01 2024-10-31 Ishihara Sangyo Kaisha, Ltd. Pharmaceutical composition with excellent storage stability
ES2994624T3 (en) * 2019-02-27 2025-01-27 Santen Pharmaceutical Co Ltd Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003095924A (ja) * 2001-07-16 2003-04-03 Wakamoto Pharmaceut Co Ltd 熱ゲル化人工涙液
JP2005343893A (ja) * 2004-05-07 2005-12-15 Rohto Pharmaceut Co Ltd 高粘度点眼剤
JP2006176501A (ja) * 2004-11-26 2006-07-06 Taisho Pharmaceut Co Ltd 眼科用剤
US20060172969A1 (en) * 2000-08-08 2006-08-03 Wakamoto Pharmaceutical Co., Ltd. Aqueous pharmaceutical compositions
WO2009001899A1 (ja) * 2007-06-26 2008-12-31 Wakamoto Pharmaceutical Co., Ltd. 水性組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2125060C (en) * 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
GB0210794D0 (en) * 2002-05-10 2002-06-19 Chart Heat Exchangers Ltd Heat exchangers
JP4263456B2 (ja) 2002-03-18 2009-05-13 わかもと製薬株式会社 ヒアルロン酸含有熱ゲル化製剤
JP4263418B2 (ja) * 2002-03-18 2009-05-13 わかもと製薬株式会社 熱ゲル化人工涙液
JP4947977B2 (ja) 2003-10-31 2012-06-06 わかもと製薬株式会社 可逆性熱ゲル化水性組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060172969A1 (en) * 2000-08-08 2006-08-03 Wakamoto Pharmaceutical Co., Ltd. Aqueous pharmaceutical compositions
JP2003095924A (ja) * 2001-07-16 2003-04-03 Wakamoto Pharmaceut Co Ltd 熱ゲル化人工涙液
JP2005343893A (ja) * 2004-05-07 2005-12-15 Rohto Pharmaceut Co Ltd 高粘度点眼剤
JP2006176501A (ja) * 2004-11-26 2006-07-06 Taisho Pharmaceut Co Ltd 眼科用剤
WO2009001899A1 (ja) * 2007-06-26 2008-12-31 Wakamoto Pharmaceutical Co., Ltd. 水性組成物

Also Published As

Publication number Publication date
JP2019104740A (ja) 2019-06-27
AU2018257301B2 (en) 2019-10-31
CN110913867B (zh) 2021-06-11
CN113332233A (zh) 2021-09-03
TW201842900A (zh) 2018-12-16
KR102281853B1 (ko) 2021-07-23
EP3593806B1 (en) 2022-03-30
MX2018014935A (es) 2019-04-09
MX379302B (es) 2025-03-11
BR112019018368A2 (pt) 2020-04-07
TWI733019B (zh) 2021-07-11
KR20190110624A (ko) 2019-09-30
AU2018257301A1 (en) 2019-08-22
JP6736705B2 (ja) 2020-08-05
WO2018199180A1 (ja) 2018-11-01
MY196323A (en) 2023-03-24
EP3593806A1 (en) 2020-01-15
PH12019502335A1 (en) 2020-09-14
US20200121592A1 (en) 2020-04-23
CA3025567C (en) 2019-10-22
CA3025567A1 (en) 2018-11-01
JPWO2018199180A1 (ja) 2019-06-27
CN113332233B (zh) 2022-02-25
US10532026B2 (en) 2020-01-14
US11096889B2 (en) 2021-08-24
SG11201909170QA (en) 2019-11-28
ES2912289T3 (es) 2022-05-25
KR20200020999A (ko) 2020-02-26
BR112019018368B1 (pt) 2021-03-02
EP3593806A4 (en) 2020-03-25
KR102083253B1 (ko) 2020-03-02
MY196565A (en) 2023-04-19
US20180360746A1 (en) 2018-12-20
JP6473274B1 (ja) 2019-02-20
CN110913867A (zh) 2020-03-24

Similar Documents

Publication Publication Date Title
TWI898399B (zh) 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
RU2700927C2 (ru) Офтальмологическая композиция, содержащая циклоспорин и трегалозу
BR112015018414B1 (pt) Lágrimas artificiais compreendendo hialuronato de sódio e carboximetilcelulose
US20110003816A1 (en) Ophthalmic composition
RU2710366C1 (ru) Термочувствительная гелеобразующая искусственная слеза
JP5649261B2 (ja) 高粘度点眼剤
KR20200085215A (ko) 고농도의 히알루론산 또는 그의 염을 함유하는 점안 조성물
KR102356603B1 (ko) 안구건조증 치료를 위한 레코플라본 함유 점안 조성물
KR102268002B1 (ko) 효과 지속성 점안제 조성물
JP2014167034A (ja) 高粘度点眼剤
EP4454639A1 (en) Ophthalmic composition comprising carbomer and taurine
KR100938233B1 (ko) 프로스타글란딘계 점안용 조성물과 그의 제조 방법
HK40017178A (en) Thermogelling artificial tears
HK40017178B (en) Thermogelling artificial tears
WO2023048174A1 (ja) 角膜疾患治療剤
JP2024528234A (ja) レコフラボン(recoflavone)を含有するドライアイ症候群を処置するための点眼組成物及びそれを製造するための方法
HK40111552A (zh) 用於治疗干眼综合征的包含瑞可黄酮的滴眼剂组合物及其制备方法
EA044372B1 (ru) Офтальмологическая композиция, включающая диквафозол и катионный полимер