MX2018014935A - Lagrima artificial de gelificacion termo-responsiva. - Google Patents

Lagrima artificial de gelificacion termo-responsiva.

Info

Publication number
MX2018014935A
MX2018014935A MX2018014935A MX2018014935A MX2018014935A MX 2018014935 A MX2018014935 A MX 2018014935A MX 2018014935 A MX2018014935 A MX 2018014935A MX 2018014935 A MX2018014935 A MX 2018014935A MX 2018014935 A MX2018014935 A MX 2018014935A
Authority
MX
Mexico
Prior art keywords
composition
artificial tears
present
temperature
viscosity
Prior art date
Application number
MX2018014935A
Other languages
English (en)
Inventor
Yamamura Takeshi
Yamamuro Ayaka
IZUKURA Emi
Kimura Moto
Otsuka Tomohiro
Original Assignee
Wakamotot Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakamotot Pharmaceutical Co Ltd filed Critical Wakamotot Pharmaceutical Co Ltd
Publication of MX2018014935A publication Critical patent/MX2018014935A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención es una solución acuosa que contiene dos tipos de metil celulosas, polietilenglicol, polivinilpirrolidona y ácido cítrico o una sal farmacéuticamente aceptable del mismo. La composición de la presente invención mantiene una baja viscosidad alrededor de la temperatura ambiente, pero la composición se incrementa repentinamente en la viscosidad debido al calor alrededor de la temperatura del cuerpo y tiene tixotropía aún después de la gelificación.
MX2018014935A 2017-04-25 2018-04-25 Lagrima artificial de gelificacion termo-responsiva. MX2018014935A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017086512 2017-04-25
JP2017249891 2017-12-26
PCT/JP2018/016854 WO2018199180A1 (ja) 2017-04-25 2018-04-25 熱ゲル化人工涙液

Publications (1)

Publication Number Publication Date
MX2018014935A true MX2018014935A (es) 2019-04-09

Family

ID=63919901

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018014935A MX2018014935A (es) 2017-04-25 2018-04-25 Lagrima artificial de gelificacion termo-responsiva.

Country Status (16)

Country Link
US (2) US10532026B2 (es)
EP (1) EP3593806B1 (es)
JP (2) JP6473274B1 (es)
KR (2) KR102281853B1 (es)
CN (2) CN113332233B (es)
AU (1) AU2018257301B2 (es)
BR (1) BR112019018368B1 (es)
CA (1) CA3025567C (es)
ES (1) ES2912289T3 (es)
MX (1) MX2018014935A (es)
MY (2) MY196323A (es)
PH (1) PH12019502335A1 (es)
RU (1) RU2710366C1 (es)
SG (1) SG11201909170QA (es)
TW (1) TWI733019B (es)
WO (1) WO2018199180A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020175525A1 (ja) * 2019-02-27 2020-09-03 参天製薬株式会社 ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2125060C (en) * 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
JP3450805B2 (ja) * 2000-08-08 2003-09-29 わかもと製薬株式会社 水性医薬組成物
JP2003095924A (ja) * 2001-07-16 2003-04-03 Wakamoto Pharmaceut Co Ltd 熱ゲル化人工涙液
GB0210794D0 (en) * 2002-05-10 2002-06-19 Chart Heat Exchangers Ltd Heat exchangers
JP4263456B2 (ja) 2002-03-18 2009-05-13 わかもと製薬株式会社 ヒアルロン酸含有熱ゲル化製剤
JP4263418B2 (ja) * 2002-03-18 2009-05-13 わかもと製薬株式会社 熱ゲル化人工涙液
KR101144647B1 (ko) 2003-10-31 2012-05-08 와카모토 세이야꾸 가부시끼가이샤 가역성 열 겔화 수성 조성물
JP5649261B2 (ja) * 2004-05-07 2015-01-07 ロート製薬株式会社 高粘度点眼剤
JP5661981B2 (ja) * 2004-11-26 2015-01-28 大正製薬株式会社 眼科用剤
KR20100031608A (ko) 2007-06-26 2010-03-23 와카모토 세이야꾸 가부시끼가이샤 수성 조성물

Also Published As

Publication number Publication date
WO2018199180A1 (ja) 2018-11-01
CN110913867A (zh) 2020-03-24
ES2912289T3 (es) 2022-05-25
SG11201909170QA (en) 2019-11-28
CN110913867B (zh) 2021-06-11
KR102281853B1 (ko) 2021-07-23
EP3593806A1 (en) 2020-01-15
TWI733019B (zh) 2021-07-11
BR112019018368B1 (pt) 2021-03-02
PH12019502335A1 (en) 2020-09-14
EP3593806A4 (en) 2020-03-25
MY196565A (en) 2023-04-19
RU2710366C1 (ru) 2019-12-26
KR20190110624A (ko) 2019-09-30
KR20200020999A (ko) 2020-02-26
CN113332233A (zh) 2021-09-03
CN113332233B (zh) 2022-02-25
CA3025567C (en) 2019-10-22
JPWO2018199180A1 (ja) 2019-06-27
EP3593806B1 (en) 2022-03-30
JP6736705B2 (ja) 2020-08-05
MY196323A (en) 2023-03-24
US20200121592A1 (en) 2020-04-23
BR112019018368A2 (pt) 2020-04-07
AU2018257301A1 (en) 2019-08-22
US20180360746A1 (en) 2018-12-20
JP2019104740A (ja) 2019-06-27
AU2018257301B2 (en) 2019-10-31
US11096889B2 (en) 2021-08-24
US10532026B2 (en) 2020-01-14
CA3025567A1 (en) 2018-11-01
KR102083253B1 (ko) 2020-03-02
TW201842900A (zh) 2018-12-16
JP6473274B1 (ja) 2019-02-20

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