JP6473274B1 - 熱ゲル化人工涙液 - Google Patents

熱ゲル化人工涙液 Download PDF

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Publication number
JP6473274B1
JP6473274B1 JP2018527825A JP2018527825A JP6473274B1 JP 6473274 B1 JP6473274 B1 JP 6473274B1 JP 2018527825 A JP2018527825 A JP 2018527825A JP 2018527825 A JP2018527825 A JP 2018527825A JP 6473274 B1 JP6473274 B1 JP 6473274B1
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viscosity
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comparative example
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Japanese (ja)
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JPWO2018199180A1 (ja
Inventor
雄 山村
雄 山村
彩香 山室
彩香 山室
恵美 伊豆倉
恵美 伊豆倉
基 木村
基 木村
智裕 大塚
智裕 大塚
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Wakamoto Pharmaceutical Co Ltd
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Wakamoto Pharmaceutical Co Ltd
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Publication of JPWO2018199180A1 publication Critical patent/JPWO2018199180A1/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP2018527825A 2017-04-25 2018-04-25 熱ゲル化人工涙液 Active JP6473274B1 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2017086512 2017-04-25
JP2017086512 2017-04-25
JP2017249891 2017-12-26
JP2017249891 2017-12-26
PCT/JP2018/016854 WO2018199180A1 (ja) 2017-04-25 2018-04-25 熱ゲル化人工涙液

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019010213A Division JP6736705B2 (ja) 2017-04-25 2019-01-24 熱ゲル化人工涙液

Publications (2)

Publication Number Publication Date
JP6473274B1 true JP6473274B1 (ja) 2019-02-20
JPWO2018199180A1 JPWO2018199180A1 (ja) 2019-06-27

Family

ID=63919901

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018527825A Active JP6473274B1 (ja) 2017-04-25 2018-04-25 熱ゲル化人工涙液
JP2019010213A Active JP6736705B2 (ja) 2017-04-25 2019-01-24 熱ゲル化人工涙液

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019010213A Active JP6736705B2 (ja) 2017-04-25 2019-01-24 熱ゲル化人工涙液

Country Status (16)

Country Link
US (2) US10532026B2 (https=)
EP (1) EP3593806B1 (https=)
JP (2) JP6473274B1 (https=)
KR (2) KR102281853B1 (https=)
CN (2) CN110913867B (https=)
AU (1) AU2018257301B2 (https=)
BR (1) BR112019018368B1 (https=)
CA (1) CA3025567C (https=)
ES (1) ES2912289T3 (https=)
MX (2) MX379302B (https=)
MY (2) MY196565A (https=)
PH (1) PH12019502335A1 (https=)
RU (1) RU2710366C1 (https=)
SG (1) SG11201909170QA (https=)
TW (1) TWI733019B (https=)
WO (1) WO2018199180A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117137866A (zh) * 2018-02-28 2023-12-01 参天制药株式会社 含有地夸磷索及阳离子性聚合物的眼科用组合物
AU2019228913C1 (en) * 2018-03-01 2024-10-31 Ishihara Sangyo Kaisha, Ltd. Pharmaceutical composition with excellent storage stability
ES2994624T3 (en) * 2019-02-27 2025-01-27 Santen Pharmaceutical Co Ltd Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003095924A (ja) * 2001-07-16 2003-04-03 Wakamoto Pharmaceut Co Ltd 熱ゲル化人工涙液
JP2005343893A (ja) * 2004-05-07 2005-12-15 Rohto Pharmaceut Co Ltd 高粘度点眼剤
JP2006176501A (ja) * 2004-11-26 2006-07-06 Taisho Pharmaceut Co Ltd 眼科用剤
WO2009001899A1 (ja) * 2007-06-26 2008-12-31 Wakamoto Pharmaceutical Co., Ltd. 水性組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2125060C (en) * 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
JP3450805B2 (ja) 2000-08-08 2003-09-29 わかもと製薬株式会社 水性医薬組成物
GB0210794D0 (en) * 2002-05-10 2002-06-19 Chart Heat Exchangers Ltd Heat exchangers
JP4263456B2 (ja) 2002-03-18 2009-05-13 わかもと製薬株式会社 ヒアルロン酸含有熱ゲル化製剤
JP4263418B2 (ja) * 2002-03-18 2009-05-13 わかもと製薬株式会社 熱ゲル化人工涙液
JP4947977B2 (ja) 2003-10-31 2012-06-06 わかもと製薬株式会社 可逆性熱ゲル化水性組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003095924A (ja) * 2001-07-16 2003-04-03 Wakamoto Pharmaceut Co Ltd 熱ゲル化人工涙液
JP2005343893A (ja) * 2004-05-07 2005-12-15 Rohto Pharmaceut Co Ltd 高粘度点眼剤
JP2006176501A (ja) * 2004-11-26 2006-07-06 Taisho Pharmaceut Co Ltd 眼科用剤
WO2009001899A1 (ja) * 2007-06-26 2008-12-31 Wakamoto Pharmaceutical Co., Ltd. 水性組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
改訂 医薬品添加物ハンドブック, vol. 第１刷, JPN6018026701, 28 February 2007 (2007-02-28), pages 825 - 831, ISSN: 0003902177 *

Also Published As

Publication number Publication date
JP2019104740A (ja) 2019-06-27
AU2018257301B2 (en) 2019-10-31
CN110913867B (zh) 2021-06-11
CN113332233A (zh) 2021-09-03
TW201842900A (zh) 2018-12-16
KR102281853B1 (ko) 2021-07-23
EP3593806B1 (en) 2022-03-30
MX2018014935A (es) 2019-04-09
MX379302B (es) 2025-03-11
BR112019018368A2 (pt) 2020-04-07
TWI733019B (zh) 2021-07-11
KR20190110624A (ko) 2019-09-30
AU2018257301A1 (en) 2019-08-22
JP6736705B2 (ja) 2020-08-05
WO2018199180A1 (ja) 2018-11-01
MY196323A (en) 2023-03-24
EP3593806A1 (en) 2020-01-15
PH12019502335A1 (en) 2020-09-14
US20200121592A1 (en) 2020-04-23
CA3025567C (en) 2019-10-22
CA3025567A1 (en) 2018-11-01
JPWO2018199180A1 (ja) 2019-06-27
CN113332233B (zh) 2022-02-25
US10532026B2 (en) 2020-01-14
RU2710366C1 (ru) 2019-12-26
US11096889B2 (en) 2021-08-24
SG11201909170QA (en) 2019-11-28
ES2912289T3 (es) 2022-05-25
KR20200020999A (ko) 2020-02-26
BR112019018368B1 (pt) 2021-03-02
EP3593806A4 (en) 2020-03-25
KR102083253B1 (ko) 2020-03-02
MY196565A (en) 2023-04-19
US20180360746A1 (en) 2018-12-20
CN110913867A (zh) 2020-03-24

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