RU2706731C2 - Композиция для ухода за полостью рта - Google Patents
Композиция для ухода за полостью рта Download PDFInfo
- Publication number
- RU2706731C2 RU2706731C2 RU2017139874A RU2017139874A RU2706731C2 RU 2706731 C2 RU2706731 C2 RU 2706731C2 RU 2017139874 A RU2017139874 A RU 2017139874A RU 2017139874 A RU2017139874 A RU 2017139874A RU 2706731 C2 RU2706731 C2 RU 2706731C2
- Authority
- RU
- Russia
- Prior art keywords
- salt
- composition
- calcium
- dicarboxylic acid
- phosphate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 204
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 97
- 201000002170 dentin sensitivity Diseases 0.000 claims abstract description 85
- 230000036347 tooth sensitivity Effects 0.000 claims abstract description 85
- 150000003839 salts Chemical class 0.000 claims abstract description 61
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 50
- 239000004480 active ingredient Substances 0.000 claims abstract description 32
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 31
- 229910019142 PO4 Inorganic materials 0.000 claims description 28
- 239000010452 phosphate Substances 0.000 claims description 28
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 28
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 24
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 16
- 235000010216 calcium carbonate Nutrition 0.000 claims description 16
- 239000001488 sodium phosphate Substances 0.000 claims description 12
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 11
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 11
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 10
- 235000006408 oxalic acid Nutrition 0.000 claims description 9
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 8
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 8
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 8
- 239000001361 adipic acid Substances 0.000 claims description 6
- 235000011037 adipic acid Nutrition 0.000 claims description 6
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 6
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 6
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims description 6
- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 claims description 6
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 6
- 235000011132 calcium sulphate Nutrition 0.000 claims description 5
- 235000010261 calcium sulphite Nutrition 0.000 claims description 5
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 4
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 4
- 235000019800 disodium phosphate Nutrition 0.000 claims description 4
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 3
- 239000004151 Calcium iodate Substances 0.000 claims description 3
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 3
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 229910001634 calcium fluoride Inorganic materials 0.000 claims description 3
- 239000000920 calcium hydroxide Substances 0.000 claims description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 3
- UHWJJLGTKIWIJO-UHFFFAOYSA-L calcium iodate Chemical compound [Ca+2].[O-]I(=O)=O.[O-]I(=O)=O UHWJJLGTKIWIJO-UHFFFAOYSA-L 0.000 claims description 3
- 235000019390 calcium iodate Nutrition 0.000 claims description 3
- GBAOBIBJACZTNA-UHFFFAOYSA-L calcium sulfite Chemical compound [Ca+2].[O-]S([O-])=O GBAOBIBJACZTNA-UHFFFAOYSA-L 0.000 claims description 3
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 2
- 235000019797 dipotassium phosphate Nutrition 0.000 claims description 2
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical group [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000404 tripotassium phosphate Inorganic materials 0.000 claims description 2
- 235000019798 tripotassium phosphate Nutrition 0.000 claims description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 2
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 2
- 210000005239 tubule Anatomy 0.000 abstract description 109
- 208000024891 symptom Diseases 0.000 abstract description 55
- 230000000694 effects Effects 0.000 abstract description 44
- 239000000126 substance Substances 0.000 abstract description 9
- 230000002265 prevention Effects 0.000 abstract description 8
- 230000035945 sensitivity Effects 0.000 abstract description 4
- 150000001879 copper Chemical class 0.000 description 41
- 150000003751 zinc Chemical class 0.000 description 39
- 230000000052 comparative effect Effects 0.000 description 37
- 229920000642 polymer Polymers 0.000 description 33
- 235000018102 proteins Nutrition 0.000 description 33
- 102000004169 proteins and genes Human genes 0.000 description 33
- 108090000623 proteins and genes Proteins 0.000 description 33
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 31
- 239000000047 product Substances 0.000 description 26
- 210000000214 mouth Anatomy 0.000 description 24
- 239000000606 toothpaste Substances 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 238000000034 method Methods 0.000 description 23
- -1 polipiridin Polymers 0.000 description 21
- 210000004268 dentin Anatomy 0.000 description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 14
- 239000011575 calcium Substances 0.000 description 14
- 229910052791 calcium Inorganic materials 0.000 description 14
- 239000008213 purified water Substances 0.000 description 14
- 239000000377 silicon dioxide Substances 0.000 description 14
- 239000000600 sorbitol Substances 0.000 description 14
- 235000010356 sorbitol Nutrition 0.000 description 14
- 229940034610 toothpaste Drugs 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 235000003599 food sweetener Nutrition 0.000 description 12
- 239000008177 pharmaceutical agent Substances 0.000 description 12
- 239000003765 sweetening agent Substances 0.000 description 12
- 239000011734 sodium Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 10
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 10
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 10
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 8
- 230000002195 synergetic effect Effects 0.000 description 8
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 7
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 6
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- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 6
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
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- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
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- LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 5
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| JP7405087B2 (ja) * | 2018-10-09 | 2023-12-26 | ライオン株式会社 | 歯牙の再石灰化促進剤及びこれを含有する液体口腔用組成物 |
| AU2019401224B2 (en) * | 2018-12-20 | 2022-09-15 | Colgate-Palmolive Company | Oral care compositions |
| CN113813197B (zh) * | 2021-10-29 | 2023-06-13 | 重庆登康口腔护理用品股份有限公司 | 一种提升抑菌活性组合物及其在口腔制品中的应用 |
| CN117990728B (zh) * | 2024-04-07 | 2024-07-19 | 北京大学口腔医学院 | 蛋白质变性封堵型牙齿脱敏剂的体外功效评价装置和方法 |
Citations (7)
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| KR0169140B1 (ko) * | 1991-12-20 | 1999-01-15 | 앤소니 지. 애이우발라시트 쥬니어 | 상아질 통증제거를 위한 조성물 |
| RU2139034C1 (ru) * | 1994-09-21 | 1999-10-10 | Унилевер Н.В. | Композиция для ухода за полостью рта |
| KR20010041671A (ko) * | 1998-03-06 | 2001-05-25 | 이탈메드 에스.엔.씨. 디 갈리 지. 이 파치니 지. | 제통용 치과조성물 |
| US20120308488A1 (en) * | 2010-01-29 | 2012-12-06 | Colgate-Palmolive Company | Oral care product for sensitive enamel care |
| US20130078197A1 (en) * | 2010-06-23 | 2013-03-28 | Colgate-Palmolive Company | Therapeutic oral composition |
| KR20130083556A (ko) * | 2012-01-13 | 2013-07-23 | (주)아모레퍼시픽 | 시린이를 위한 구강용 조성물 |
| RU2488380C2 (ru) * | 2008-11-25 | 2013-07-27 | Дзе Проктер Энд Гэмбл Компани | Композиции для ухода за полостью рта, содержащие сферические частицы аморфного кварца |
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| JPH0629169B2 (ja) * | 1984-12-28 | 1994-04-20 | ライオン株式会社 | 口腔用組成物 |
| JPH06145020A (ja) * | 1991-06-03 | 1994-05-24 | Shono Yasuo | 結晶生成性歯質前処理剤及び製造方法 |
| EP0651652B1 (en) * | 1992-06-29 | 2000-02-09 | The University Of Melbourne | Treatment for sensitive teeth |
| JP2550909B2 (ja) * | 1994-03-22 | 1996-11-06 | ライオン株式会社 | 口腔用組成物 |
| JP2004059583A (ja) | 1998-09-24 | 2004-02-26 | Fujisawa Pharmaceut Co Ltd | クロモグリク酸ナトリウムを含有する洗眼液及び点鼻液 |
| US6485708B1 (en) * | 1999-05-13 | 2002-11-26 | Church & Dwight Co. Inc. | Products and methods for the remineralization and prevention of demineralization of teeth |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| JP2004059563A (ja) * | 2002-07-31 | 2004-02-26 | Lion Corp | 象牙質知覚過敏用口腔用組成物 |
| JP2006347987A (ja) * | 2005-06-17 | 2006-12-28 | Sunstar Inc | 口腔用組成物および口腔用組成物の泡立性を高める方法 |
| JP4697449B2 (ja) * | 2006-05-19 | 2011-06-08 | ライオン株式会社 | 歯牙美白用組成物 |
| JP2008184436A (ja) * | 2007-01-30 | 2008-08-14 | Sun Medical Co Ltd | 知覚過敏抑制性歯科用研磨材組成物 |
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| US8603442B2 (en) * | 2009-08-03 | 2013-12-10 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
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- 2016-04-14 KR KR1020160045681A patent/KR102095945B1/ko active Active
- 2016-04-15 RU RU2017139874A patent/RU2706731C2/ru active
- 2016-04-15 US US15/567,240 patent/US11103441B2/en active Active
- 2016-04-15 CN CN201680022090.1A patent/CN107530236B/zh active Active
- 2016-04-15 JP JP2017554452A patent/JP6906777B2/ja active Active
- 2016-04-15 TW TW105111871A patent/TWI741982B/zh active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2018511644A (ja) | 2018-04-26 |
| CN107530236B (zh) | 2021-10-26 |
| US20180153789A1 (en) | 2018-06-07 |
| KR102045423B1 (ko) | 2019-11-15 |
| JP6906777B2 (ja) | 2021-07-21 |
| RU2017139874A3 (enExample) | 2019-07-24 |
| KR20160123975A (ko) | 2016-10-26 |
| UA123309C2 (uk) | 2021-03-17 |
| KR20160124009A (ko) | 2016-10-26 |
| KR102076268B1 (ko) | 2020-02-11 |
| TWI741982B (zh) | 2021-10-11 |
| US11103441B2 (en) | 2021-08-31 |
| TW201705934A (zh) | 2017-02-16 |
| HK1248584A1 (zh) | 2018-10-19 |
| CN107530236A (zh) | 2018-01-02 |
| KR102095945B1 (ko) | 2020-04-01 |
| RU2017139874A (ru) | 2019-05-17 |
| KR20160124008A (ko) | 2016-10-26 |
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