KR102076268B1 - 구강용 조성물 - Google Patents
구강용 조성물 Download PDFInfo
- Publication number
- KR102076268B1 KR102076268B1 KR1020150184839A KR20150184839A KR102076268B1 KR 102076268 B1 KR102076268 B1 KR 102076268B1 KR 1020150184839 A KR1020150184839 A KR 1020150184839A KR 20150184839 A KR20150184839 A KR 20150184839A KR 102076268 B1 KR102076268 B1 KR 102076268B1
- Authority
- KR
- South Korea
- Prior art keywords
- zinc
- composition
- soluble
- alcohol
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 229920000642 polymer Polymers 0.000 claims abstract description 31
- 210000000214 mouth Anatomy 0.000 claims abstract description 27
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 15
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 15
- 150000001879 copper Chemical class 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 23
- 150000003751 zinc Chemical class 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- -1 polypyridine Polymers 0.000 claims description 9
- 229920001451 polypropylene glycol Polymers 0.000 claims description 5
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000000556 agonist Substances 0.000 claims description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 4
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 claims description 4
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical group [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims description 4
- 229930002875 chlorophyll Natural products 0.000 claims description 3
- 235000019804 chlorophyll Nutrition 0.000 claims description 3
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 3
- 235000005074 zinc chloride Nutrition 0.000 claims description 3
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910021591 Copper(I) chloride Inorganic materials 0.000 claims description 2
- 229910021595 Copper(I) iodide Inorganic materials 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- 229960002684 aminocaproic acid Drugs 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 229960003260 chlorhexidine Drugs 0.000 claims description 2
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical group [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 claims description 2
- LSXDOTMGLUJQCM-UHFFFAOYSA-M copper(i) iodide Chemical compound I[Cu] LSXDOTMGLUJQCM-UHFFFAOYSA-M 0.000 claims description 2
- 229960003280 cupric chloride Drugs 0.000 claims description 2
- 229940045803 cuprous chloride Drugs 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 239000002831 pharmacologic agent Substances 0.000 claims description 2
- 229920000128 polypyrrole Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 2
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 2
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 2
- 239000011775 sodium fluoride Substances 0.000 claims description 2
- 235000013024 sodium fluoride Nutrition 0.000 claims description 2
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 claims description 2
- 229940042585 tocopherol acetate Drugs 0.000 claims description 2
- 239000004246 zinc acetate Substances 0.000 claims description 2
- 239000011667 zinc carbonate Substances 0.000 claims description 2
- 235000004416 zinc carbonate Nutrition 0.000 claims description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims description 2
- 229940007718 zinc hydroxide Drugs 0.000 claims description 2
- 229910021511 zinc hydroxide Inorganic materials 0.000 claims description 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 2
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
- 229960001763 zinc sulfate Drugs 0.000 claims description 2
- XAEWLETZEZXLHR-UHFFFAOYSA-N zinc;dioxido(dioxo)molybdenum Chemical compound [Zn+2].[O-][Mo]([O-])(=O)=O XAEWLETZEZXLHR-UHFFFAOYSA-N 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- WIVXEZIMDUGYRW-UHFFFAOYSA-L copper(i) sulfate Chemical compound [Cu+].[Cu+].[O-]S([O-])(=O)=O WIVXEZIMDUGYRW-UHFFFAOYSA-L 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940050410 gluconate Drugs 0.000 claims 1
- ZPEJZWGMHAKWNL-UHFFFAOYSA-L zinc;oxalate Chemical compound [Zn+2].[O-]C(=O)C([O-])=O ZPEJZWGMHAKWNL-UHFFFAOYSA-L 0.000 claims 1
- 210000005239 tubule Anatomy 0.000 abstract description 42
- 208000024891 symptom Diseases 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 16
- 229960005486 vaccine Drugs 0.000 abstract description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 210000004268 dentin Anatomy 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 16
- 235000018102 proteins Nutrition 0.000 description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 229940034610 toothpaste Drugs 0.000 description 8
- 239000000606 toothpaste Substances 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 230000000903 blocking effect Effects 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000006920 protein precipitation Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000004088 foaming agent Substances 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
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- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
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- 238000004519 manufacturing process Methods 0.000 description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
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- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 2
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- Health & Medical Sciences (AREA)
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Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW105111871A TWI741982B (zh) | 2015-04-17 | 2016-04-15 | 口腔用組合物 |
| RU2017139874A RU2706731C2 (ru) | 2015-04-17 | 2016-04-15 | Композиция для ухода за полостью рта |
| CN201680022090.1A CN107530236B (zh) | 2015-04-17 | 2016-04-15 | 口腔用组合物 |
| UAA201711190A UA123309C2 (uk) | 2015-04-17 | 2016-04-15 | Композиція для догляду за порожниною рота |
| HK18108448.1A HK1248584B (zh) | 2015-04-17 | 2016-04-15 | 口腔用组合物 |
| JP2017554452A JP6906777B2 (ja) | 2015-04-17 | 2016-04-15 | 口腔用組成物 |
| US15/567,240 US11103441B2 (en) | 2015-04-17 | 2016-04-15 | Oral composition |
| PCT/KR2016/003945 WO2016167600A1 (ko) | 2015-04-17 | 2016-04-15 | 구강용 조성물 |
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| Application Number | Priority Date | Filing Date | Title |
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| KR20160123975A KR20160123975A (ko) | 2016-10-26 |
| KR102076268B1 true KR102076268B1 (ko) | 2020-02-11 |
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| KR1020160045670A Active KR102045423B1 (ko) | 2015-04-17 | 2016-04-14 | 구강용 조성물 |
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| UA (1) | UA123309C2 (enExample) |
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| KR102300090B1 (ko) * | 2016-03-10 | 2021-09-07 | 주식회사 엘지생활건강 | 자화지정 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 |
| JP7405087B2 (ja) * | 2018-10-09 | 2023-12-26 | ライオン株式会社 | 歯牙の再石灰化促進剤及びこれを含有する液体口腔用組成物 |
| AU2019401224B2 (en) * | 2018-12-20 | 2022-09-15 | Colgate-Palmolive Company | Oral care compositions |
| CN113813197B (zh) * | 2021-10-29 | 2023-06-13 | 重庆登康口腔护理用品股份有限公司 | 一种提升抑菌活性组合物及其在口腔制品中的应用 |
| CN117990728B (zh) * | 2024-04-07 | 2024-07-19 | 北京大学口腔医学院 | 蛋白质变性封堵型牙齿脱敏剂的体外功效评价装置和方法 |
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| JPH0629169B2 (ja) * | 1984-12-28 | 1994-04-20 | ライオン株式会社 | 口腔用組成物 |
| JPH06145020A (ja) * | 1991-06-03 | 1994-05-24 | Shono Yasuo | 結晶生成性歯質前処理剤及び製造方法 |
| US5270031A (en) * | 1991-12-20 | 1993-12-14 | Block Drug Company Inc. | Dentinal desensitizing compositions |
| EP0651652B1 (en) * | 1992-06-29 | 2000-02-09 | The University Of Melbourne | Treatment for sensitive teeth |
| JP2550909B2 (ja) * | 1994-03-22 | 1996-11-06 | ライオン株式会社 | 口腔用組成物 |
| CA2199027C (en) * | 1994-09-21 | 2001-02-20 | Peter George Vernon | Oral compositions |
| ITFI980051A1 (it) * | 1998-03-06 | 1999-09-06 | Italmed Di Galli Giovanna E Pa | Composizione ad uso odontoiatrico per la desensibilizzazione della dentina esposta |
| JP2004059583A (ja) | 1998-09-24 | 2004-02-26 | Fujisawa Pharmaceut Co Ltd | クロモグリク酸ナトリウムを含有する洗眼液及び点鼻液 |
| US6485708B1 (en) * | 1999-05-13 | 2002-11-26 | Church & Dwight Co. Inc. | Products and methods for the remineralization and prevention of demineralization of teeth |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| JP2004059563A (ja) * | 2002-07-31 | 2004-02-26 | Lion Corp | 象牙質知覚過敏用口腔用組成物 |
| JP2006347987A (ja) * | 2005-06-17 | 2006-12-28 | Sunstar Inc | 口腔用組成物および口腔用組成物の泡立性を高める方法 |
| JP4697449B2 (ja) * | 2006-05-19 | 2011-06-08 | ライオン株式会社 | 歯牙美白用組成物 |
| JP2008184436A (ja) * | 2007-01-30 | 2008-08-14 | Sun Medical Co Ltd | 知覚過敏抑制性歯科用研磨材組成物 |
| ITFI20080034A1 (it) * | 2008-02-26 | 2009-08-27 | Italmed S R L | Composizione odontoiatrica per la desensibilizzazione disinfezione e protezione della dentina esposta. |
| US8795637B2 (en) | 2008-11-25 | 2014-08-05 | The Procter & Gamble Company | Oral care compositions with fused silica |
| US8603442B2 (en) * | 2009-08-03 | 2013-12-10 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
| JP2013520402A (ja) * | 2010-01-29 | 2013-06-06 | コルゲート・パーモリブ・カンパニー | 敏感なエナメル質のケアのための口腔ケア製品 |
| WO2011162756A1 (en) | 2010-06-23 | 2011-12-29 | Colgate-Palmolive Company | Therapeutic oral composition |
| AU2010363052B2 (en) | 2010-10-27 | 2014-11-20 | Colgate-Palmolive Company | Oral care composition comprising arginine and calcium carbonate |
| KR101262293B1 (ko) * | 2011-01-18 | 2013-05-08 | 주식회사 바이오알파 | 중성에서 안정한 고농도 인산칼슘 수용액의 제조방법 |
| BR112013025952B1 (pt) * | 2011-04-18 | 2018-04-03 | Unilever N.V. | Composição de cuidado oral, método para branquear e remineralizar dentes e uso de uma composição |
| KR101883753B1 (ko) * | 2011-11-04 | 2018-07-31 | (주)아모레퍼시픽 | 시린이 방지용 조성물 및 분사기 |
| KR101569348B1 (ko) | 2012-01-13 | 2015-11-27 | (주)아모레퍼시픽 | 시린이를 위한 구강용 조성물 |
| EP2906182B1 (en) * | 2012-10-12 | 2016-11-30 | Unilever N.V. | Oral care composition |
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2015
- 2015-12-23 KR KR1020150184839A patent/KR102076268B1/ko active Active
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2016
- 2016-04-14 KR KR1020160045670A patent/KR102045423B1/ko active Active
- 2016-04-14 KR KR1020160045681A patent/KR102095945B1/ko active Active
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- 2016-04-15 US US15/567,240 patent/US11103441B2/en active Active
- 2016-04-15 CN CN201680022090.1A patent/CN107530236B/zh active Active
- 2016-04-15 JP JP2017554452A patent/JP6906777B2/ja active Active
- 2016-04-15 TW TW105111871A patent/TWI741982B/zh active
- 2016-04-15 UA UAA201711190A patent/UA123309C2/uk unknown
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| JP2018511644A (ja) | 2018-04-26 |
| CN107530236B (zh) | 2021-10-26 |
| US20180153789A1 (en) | 2018-06-07 |
| KR102045423B1 (ko) | 2019-11-15 |
| JP6906777B2 (ja) | 2021-07-21 |
| RU2017139874A3 (enExample) | 2019-07-24 |
| KR20160123975A (ko) | 2016-10-26 |
| UA123309C2 (uk) | 2021-03-17 |
| KR20160124009A (ko) | 2016-10-26 |
| TWI741982B (zh) | 2021-10-11 |
| US11103441B2 (en) | 2021-08-31 |
| TW201705934A (zh) | 2017-02-16 |
| RU2706731C2 (ru) | 2019-11-20 |
| HK1248584A1 (zh) | 2018-10-19 |
| CN107530236A (zh) | 2018-01-02 |
| KR102095945B1 (ko) | 2020-04-01 |
| RU2017139874A (ru) | 2019-05-17 |
| KR20160124008A (ko) | 2016-10-26 |
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