|
US3740385A
(en)
|
1970-05-07 |
1973-06-19 |
M Ondetti |
N-terminal derivatives of secretin
|
|
US4450150A
(en)
|
1973-05-17 |
1984-05-22 |
Arthur D. Little, Inc. |
Biodegradable, implantable drug delivery depots, and method for preparing and using the same
|
|
US4275152A
(en)
|
1977-02-03 |
1981-06-23 |
Eastman Kodak Company |
Hydrolysis of protein-bound cholesterol esters
|
|
DK119785D0
(da)
|
1985-03-15 |
1985-03-15 |
Nordisk Gentofte |
Insulinpraeparat
|
|
PH25772A
(en)
|
1985-08-30 |
1991-10-18 |
Novo Industri As |
Insulin analogues, process for their preparation
|
|
PT83613B
(en)
|
1985-10-28 |
1988-11-21 |
Lilly Co Eli |
Process for the selective chemical removal of a protein amino-terminal residue
|
|
US4741897A
(en)
|
1986-07-08 |
1988-05-03 |
Baxter Travenol |
Thyroxine analogs and reagents for thyroid hormone assays
|
|
US4876242A
(en)
|
1987-09-21 |
1989-10-24 |
Merck & Co., Inc. |
Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast
|
|
GB8728561D0
(en)
|
1987-12-07 |
1988-01-13 |
Glaxo Group Ltd |
Chemical compounds
|
|
US5514646A
(en)
|
1989-02-09 |
1996-05-07 |
Chance; Ronald E. |
Insulin analogs modified at position 29 of the B chain
|
|
DK0458841T3
(da)
|
1989-02-17 |
1995-11-20 |
Chiron Mimotopes Pty Ltd |
Fremgangsmåde til anvendelse og fremstilling af peptider
|
|
US6225449B1
(en)
|
1991-10-04 |
2001-05-01 |
Washington University |
Hormone analogs with multiple CTP extensions
|
|
WO1990012814A1
(en)
|
1989-04-20 |
1990-11-01 |
Mount Sinai School Of Medicine Of The City University Of New York |
Hepatospecific insulin analogues
|
|
US5545618A
(en)
|
1990-01-24 |
1996-08-13 |
Buckley; Douglas I. |
GLP-1 analogs useful for diabetes treatment
|
|
US5510459A
(en)
|
1991-01-17 |
1996-04-23 |
Zymogenetics, Inc. |
Glucagon antagonists
|
|
US5268453A
(en)
|
1991-08-08 |
1993-12-07 |
Scios Inc. |
Tissue-selective insulin analogs
|
|
JPH08507686A
(ja)
|
1993-03-09 |
1996-08-20 |
アボツト・ラボラトリーズ |
遺伝子操作酵素及びそれらの診断アッセイ用結合体
|
|
US5359030A
(en)
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
US5480867A
(en)
|
1993-12-29 |
1996-01-02 |
The Rockefeller University |
Glucagon analogs with serine replacements
|
|
US5512549A
(en)
|
1994-10-18 |
1996-04-30 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
|
|
US5869602A
(en)
|
1995-03-17 |
1999-02-09 |
Novo Nordisk A/S |
Peptide derivatives
|
|
US6476290B1
(en)
|
1995-04-19 |
2002-11-05 |
Dalhousie University |
Transgenic tilapia comprising a humanized insulin gene
|
|
AU5724996A
(en)
|
1995-05-05 |
1996-11-21 |
Eli Lilly And Company |
Single chain insulin with high bioactivity
|
|
US6180767B1
(en)
|
1996-01-11 |
2001-01-30 |
Thomas Jefferson University |
Peptide nucleic acid conjugates
|
|
NZ334595A
(en)
|
1996-09-09 |
2000-08-25 |
Zealand Pharmaceuticals As |
Peptide prodrugs containing an alpha-hydroxyacid linker that have increased stability against enzymatic cleavage
|
|
UA65549C2
(uk)
|
1996-11-05 |
2004-04-15 |
Елі Ліллі Енд Компані |
Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
|
|
CA2320193A1
(en)
|
1998-02-10 |
1999-08-19 |
Welfide Corporation |
Controlled release preparation
|
|
IL137904A0
(en)
|
1998-02-23 |
2001-10-31 |
Neurocrine Biosciences Inc |
Peptide analogues of insulin and pharmaceutical compositions containing the same
|
|
CA2321026A1
(en)
|
1998-03-09 |
1999-09-16 |
Zealand Pharmaceuticals A/S |
Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
|
|
DE19828113A1
(de)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
|
US6875741B2
(en)
|
1998-09-02 |
2005-04-05 |
Renuka Pillutla |
Insulin and IGF-1 receptor agonists and antagonists
|
|
US20030236190A1
(en)
|
1998-09-02 |
2003-12-25 |
Renuka Pillutla |
Isulin and IGF-1 receptor agonists and antagonists
|
|
GB2344287A
(en)
|
1998-12-03 |
2000-06-07 |
Ferring Bv |
Controlled release pharmaceutical formulation
|
|
DE19908041A1
(de)
|
1999-02-24 |
2000-08-31 |
Hoecker Hartwig |
Kovalent verbrückte Insulindimere
|
|
MXPA01009805A
(es)
|
1999-03-29 |
2004-07-30 |
Univ Ulster |
Peptido.
|
|
CN1191273C
(zh)
|
1999-05-17 |
2005-03-02 |
康久化学公司 |
长效促胰岛肽
|
|
US6746853B1
(en)
|
1999-05-19 |
2004-06-08 |
Xencor, Inc. |
Proteins with insulin-like activity useful in the treatment of diabetes
|
|
AUPQ661800A0
(en)
|
2000-03-31 |
2000-05-04 |
Metabolic Pharmaceuticals Limited |
Insulin-potentiating compounds
|
|
US6677136B2
(en)
|
2000-05-03 |
2004-01-13 |
Amgen Inc. |
Glucagon antagonists
|
|
EP1290019A2
(en)
|
2000-06-14 |
2003-03-12 |
Cytovax Biotechnologies Inc. |
Use of coiled-coil structural scaffold to generate structure-specific peptides
|
|
ATE309385T1
(de)
|
2000-06-28 |
2005-11-15 |
Glycofi Inc |
Verfahren für die herstellung modifizierter glykoproteine
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
WO2002010195A2
(en)
|
2000-08-02 |
2002-02-07 |
Theratechnologies Inc. |
Modified peptides with increased potency
|
|
AU2001284697A1
(en)
|
2000-08-04 |
2002-02-18 |
Dmi Biosciences, Inc. |
Method of synthesizing diketopiperazines
|
|
ES2367891T3
(es)
|
2000-09-29 |
2011-11-10 |
Schering Corporation |
Interleucina-10 pegilada.
|
|
DE60104069T2
(de)
|
2000-10-02 |
2005-08-25 |
Yonsei University |
Einkettige Insulinanaloge
|
|
KR100449454B1
(ko)
|
2000-10-02 |
2004-09-21 |
이현철 |
단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
|
|
KR101229995B1
(ko)
|
2000-12-11 |
2013-02-06 |
씨제이 주식회사 |
생체내 에리스로포이에틴 활성이 증진된 융합단백질
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
JP2005502322A
(ja)
|
2001-04-19 |
2005-01-27 |
ザ スクリップス リサーチ インスティテュート |
非天然アミノ酸のインビボ組込み
|
|
EP1572885A2
(en)
|
2001-08-08 |
2005-09-14 |
Genzyme Corporation |
Methods for treating diabetes and other blood sugar disorders
|
|
CA2452044A1
(en)
|
2001-08-28 |
2003-03-13 |
Eli Lilly And Company |
Pre-mixes of glp-1 and basal insulin
|
|
GB0121709D0
(en)
|
2001-09-07 |
2001-10-31 |
Imp College Innovations Ltd |
Food inhibition agent
|
|
AR036711A1
(es)
|
2001-10-05 |
2004-09-29 |
Bayer Corp |
Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
|
|
US7041646B2
(en)
|
2001-10-05 |
2006-05-09 |
Bayer Pharmaceuticals Corporation |
Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists
|
|
HRP20040343A2
(en)
|
2001-10-18 |
2005-08-31 |
Bristol-Myers Squibb Company |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
|
|
CZ2004710A3
(cs)
|
2001-12-20 |
2005-02-16 |
Eli Lilly And Company |
Inzulínová sloučenina s protrahovaným účinkem
|
|
AU2002351752A1
(en)
|
2001-12-29 |
2003-07-30 |
Novo Nordisk A/S |
Combined use of a glp-1 compound and another drug for treating dyslipidemia
|
|
AU2003239478A1
(en)
|
2002-06-04 |
2003-12-22 |
Eli Lilly And Company |
Modified glucagon-like peptide-1 analogs
|
|
FR2842209B1
(fr)
|
2002-07-09 |
2007-11-23 |
|
Nouvelle protease aspartique dite saspase et son utilisation dans le domaine cosmetique et therapeutique
|
|
ATE458534T1
(de)
|
2002-10-04 |
2010-03-15 |
Microchips Inc |
Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
|
|
US7192922B2
(en)
|
2002-11-19 |
2007-03-20 |
Allegheny-Singer Research Institute |
Method of treating left ventricular dysfunction
|
|
US20050059605A1
(en)
|
2003-01-31 |
2005-03-17 |
Krishna Peri |
Chemically modified metabolites of regulatory peptides and methods of producing and using same
|
|
EP1626981A4
(en)
|
2003-03-04 |
2006-11-22 |
Biorexis Pharmaceutical Corp |
PROTEINS PROTECTED AGAINST DIPEPTIDYLPEPTIDASE
|
|
EA009366B1
(ru)
|
2003-03-19 |
2007-12-28 |
Эли Лилли Энд Компани |
Связанные с полиэтиленгликолем соединения гпп-1
|
|
PL1620118T3
(pl)
|
2003-04-08 |
2014-11-28 |
Yeda Res & Dev |
Leki odwracalnie pegylowane
|
|
ATE525395T1
(de)
|
2003-06-12 |
2011-10-15 |
Lilly Co Eli |
Fusions proteine von glp-1-analoga
|
|
WO2004111078A2
(en)
|
2003-06-18 |
2004-12-23 |
Theratechnologies Inc. |
Compounds that modulate the glucagon response and uses thereof
|
|
TW200526254A
(en)
|
2003-09-19 |
2005-08-16 |
Novo Nordisk As |
Novel GLP-1 derivatives
|
|
WO2005035003A2
(en)
|
2003-09-22 |
2005-04-21 |
Dihedron Corporation |
Compositions and methods for increasing drug efficiency
|
|
US7364875B2
(en)
|
2003-10-30 |
2008-04-29 |
Cresent Innovations, Inc. |
Method for producing medical and commercial grade poly-gamma-glutamic acid of high molecular weight
|
|
DK2332968T3
(en)
|
2003-11-05 |
2016-08-22 |
Dana Farber Cancer Inst Inc |
Alpha-helix peptides suitable for activating or inhibiting cell death
|
|
KR20060135661A
(ko)
|
2003-12-18 |
2006-12-29 |
노보 노르디스크 에이/에스 |
신규 ｇｌｐ-1 화합물
|
|
US20060286129A1
(en)
|
2003-12-19 |
2006-12-21 |
Emisphere Technologies, Inc. |
Oral GLP-1 formulations
|
|
US20080318837A1
(en)
|
2003-12-26 |
2008-12-25 |
Nastech Pharmaceutical Company Inc. |
Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
|
|
IN2012DN03921A
(OSRAM)
|
2004-02-11 |
2015-09-04 |
Amylin Pharmaceuticals Inc |
|
|
US7442682B2
(en)
|
2004-10-19 |
2008-10-28 |
Nitto Denko Corporation |
Transepithelial delivery of peptides with incretin hormone activities
|
|
JP2008517917A
(ja)
|
2004-10-21 |
2008-05-29 |
アイジーエフ オンコロジー エルエルシー |
癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド
|
|
WO2006086769A2
(en)
|
2005-02-11 |
2006-08-17 |
Amylin Pharmaceuticals, Inc. |
Gip analog and hybrid polypeptides with selectable properties
|
|
US8263545B2
(en)
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
|
WO2006097521A1
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Pegylated single-chain insulin
|
|
JP2008533104A
(ja)
|
2005-03-18 |
2008-08-21 |
ノボ ノルディスク アクティーゼルスカブ |
Ｇｌｐ−１受容体の二量体ペプチドアゴニスト
|
|
US7521211B2
(en)
|
2005-04-05 |
2009-04-21 |
Regeneron Pharmaceuticals, Inc |
IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof
|
|
WO2006113452A2
(en)
|
2005-04-13 |
2006-10-26 |
University Of Medicine And Dentistry Of New Jersey |
Glycoprotein hormone analogs
|
|
CN101534846B
(zh)
|
2005-11-07 |
2014-11-05 |
印第安纳大学研究及科技有限公司 |
显示生理学溶解性和稳定性的胰高血糖素类似物
|
|
US8304386B2
(en)
|
2006-02-03 |
2012-11-06 |
Prolor Biotech, Inc. |
Long-acting growth hormone and methods of producing same
|
|
WO2007096332A1
(en)
|
2006-02-21 |
2007-08-30 |
Novo Nordisk A/S |
Single-chain insulin analogues and pharmaceutical formulations thereof
|
|
JP5312054B2
(ja)
|
2006-03-15 |
2013-10-09 |
ノボ・ノルデイスク・エー／エス |
アミリンとインスリンの混合物
|
|
WO2007109354A2
(en)
|
2006-03-21 |
2007-09-27 |
Amylin Pharmaceuticals, Inc. |
Peptide-peptidase inhibitor conjugates and methods of using same
|
|
EP2054437A2
(en)
|
2006-08-07 |
2009-05-06 |
Teva Biopharmaceuticals USA, Inc. |
Albumin-insulin fusion proteins
|
|
AU2007284365A1
(en)
|
2006-08-17 |
2008-02-21 |
Amylin Pharmaceuticals, Inc. |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
|
CL2007002502A1
(es)
|
2006-08-31 |
2008-05-30 |
Hoffmann La Roche |
Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
|
|
CN106008699A
(zh)
|
2006-09-08 |
2016-10-12 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
|
EP2124974B1
(en)
|
2007-01-05 |
2017-03-15 |
Indiana University Research and Technology Corporation |
Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
|
|
US20090098130A1
(en)
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
|
BRPI0807728A2
(pt)
|
2007-02-15 |
2012-04-17 |
Univ Indiana Res & Tech Corp |
co-agonistas de receptor glucagon/glp-1
|
|
KR20080092839A
(ko)
|
2007-04-12 |
2008-10-16 |
칫소가부시키가이샤 |
잉크젯용 잉크
|
|
NZ580700A
(en)
|
2007-04-19 |
2012-01-12 |
Dong A Pharm Co Ltd |
A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
|
|
WO2008152403A1
(en)
|
2007-06-15 |
2008-12-18 |
Zealand Pharma A/S |
Glucagon analogues
|
|
EP2036539A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Stable formulations of amylin and its analogues
|
|
EP2036923A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Improved derivates of amylin
|
|
ES2558155T3
(es)
|
2007-10-30 |
2016-02-02 |
Indiana University Research And Technology Corporation |
Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1
|
|
ES2632504T3
(es)
|
2007-11-20 |
2017-09-13 |
Ambrx, Inc. |
Polipéptidos de insulina modificados y sus usos
|
|
WO2009099763A1
(en)
*
|
2008-01-30 |
2009-08-13 |
Indiana University Research And Technology Corporation |
Ester-based peptide prodrugs
|
|
EP2237799B1
(en)
|
2008-02-01 |
2019-04-10 |
Ascendis Pharma A/S |
Prodrug comprising a self-cleavable linker
|
|
WO2009148089A1
(ja)
|
2008-06-05 |
2009-12-10 |
東芝機械株式会社 |
ハンドリング装置、制御装置、制御方法およびプログラム
|
|
SG192405A1
(en)
|
2008-06-17 |
2013-08-30 |
Univ Indiana Res & Tech Corp |
Gip-based mixed agonists for treatment of metabolic disorders and obesity
|
|
CN102123723B
(zh)
|
2008-06-17 |
2016-05-25 |
印第安纳大学研究及科技有限公司 |
胰高血糖素/glp-1受体共激动剂
|
|
KR20110039230A
(ko)
|
2008-06-17 |
2011-04-15 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
생리학적 ｐＨ 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체
|
|
WO2010011313A2
(en)
|
2008-07-23 |
2010-01-28 |
President And Fellows Of Harvard College |
Ligation of stapled polypeptides
|
|
MX2011006527A
(es)
|
2008-12-19 |
2011-08-17 |
Univ Indiana Res & Tech Corp |
Agentes medicinales unidos a dipeptido.
|
|
CA2747490C
(en)
|
2008-12-19 |
2017-02-14 |
Indiana University Research And Technology Corporation |
Insulin analogs
|
|
EP2376097A4
(en)
|
2008-12-19 |
2012-10-03 |
Univ Indiana Res & Tech Corp |
PEPTIDE PRODRUGS OF AMIDE-BASED GLUCAGON SUPERFAMILY
|
|
CN102307584A
(zh)
|
2008-12-19 |
2012-01-04 |
印第安纳大学研究及科技有限公司 |
表现出对胰岛素受体的高活性的基于yl的胰岛素-样生长因子
|
|
EP2376521B1
(en)
*
|
2008-12-19 |
2016-04-13 |
Indiana University Research and Technology Corporation |
Amide-based insulin prodrugs
|
|
WO2010107520A1
(en)
*
|
2009-03-20 |
2010-09-23 |
Smartcells, Inc. |
Soluble non-depot insulin conjugates and uses thereof
|
|
MX2012008603A
(es)
|
2010-01-27 |
2013-01-25 |
Univ Indiana Res & Tech Corp |
Conjugados de antagonista de glucagon-agonista de gip y composiciones para el tratamiento de desordenes metabolicos y obesidad.
|
|
WO2011159882A2
(en)
|
2010-06-16 |
2011-12-22 |
Indiana University Research And Technology Corporation |
Novel stabilized insulin agonists
|
|
US8940860B2
(en)
|
2010-06-16 |
2015-01-27 |
Indiana University Research And Technology Corporation |
Single-chain insulin agonists exhibiting high activity at the insulin receptor
|
|
WO2011163460A1
(en)
|
2010-06-24 |
2011-12-29 |
Indiana University Research And Technology Corporation |
Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor
|
|
MX2012014576A
(es)
|
2010-06-24 |
2013-02-21 |
Univ Indiana Res & Tech Corp |
Profarmacos de peptido de la superfamilia de glucagon basado en amida.
|
|
US8946147B2
(en)
|
2010-06-24 |
2015-02-03 |
Indiana University Research And Technology Corporation |
Amide-based insulin prodrugs
|
|
WO2011163473A1
(en)
|
2010-06-25 |
2011-12-29 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological ph buffers
|
|
CN103764673A
(zh)
*
|
2011-06-10 |
2014-04-30 |
北京韩美药品有限公司 |
葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用
|
|
JP6392123B2
(ja)
*
|
2011-12-20 |
2018-09-19 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ |
糖尿病治療のためのｃｔｐ系インスリンアナローグ
|
|
BR112015023071A2
(pt)
|
2013-03-14 |
2017-07-18 |
Univ Indiana Res & Tech Corp |
conjugados de insulina-incretina
|
